LOCUS       NM_173451               3627 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus arylsulfatase J (Arsj), mRNA.
ACCESSION   NM_173451
VERSION     NM_173451.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3627)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3627)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3627)
  AUTHORS   Ratzka,A., Mundlos,S. and Vortkamp,A.
  TITLE     Expression patterns of sulfatase genes in the developing mouse
            embryo
  JOURNAL   Dev Dyn 239 (6), 1779-1788 (2010)
   PUBMED   20503373
REFERENCE   4  (bases 1 to 3627)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114551.12 and AC091322.8.
            
            On Oct 6, 2022 this sequence version replaced NM_173451.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034454.1, AK034584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1249              AC114551.12        25342-26590         c
            1250-3627           AC091322.8         146354-148731       c
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 55.97 cM"
     gene            1..3627
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /note="arylsulfatase J"
                     /db_xref="GeneID:271970"
                     /db_xref="MGI:MGI:2443513"
     exon            1..1249
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /inference="alignment:Splign:2.1.0"
     CDS             858..2654
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /EC_number="3.1.6.12"
                     /note="ASJ"
                     /codon_start=1
                     /product="arylsulfatase J precursor"
                     /protein_id="NP_775627.1"
                     /db_xref="CCDS:CCDS17822.1"
                     /db_xref="GeneID:271970"
                     /db_xref="MGI:MGI:2443513"
                     /translation="MAPRDSAEPLPPLSPQAWAWSGKFLAMGALAGFSVLSLLTYGYL
                     CWGQDLEEEGSLKAQVDERPEAGTAGTSQPHLIFILADDQGFRDVGYHGSEIKTPTLD
                     KLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQ
                     KLKEVGYSTHMVGKWHLGFYRKDCMPTKRGFDTFFGSLLGSGDYYTHYKCDSPGVCGY
                     DLYENDNAAWDYDNGIYSTQMYTQRVQQILATHDPTKPLFLYVAYQAVHSPLQAPGRY
                     FEHYRSIININRRRYAAMLSCLDEAIHNVTLALKRYGFYNNSIIIYSSDNGGQPTAGG
                     SNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDE
                     DIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQ
                     HWKLLTGNPGYSDWVPPQAFSNLGPNRWHNERITLSTGKSIWLFNITADPYERVDLSS
                     RYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEENKKKKSNKTK
                     AKKMQKKKSKARMRKQLAAHSSIKCHPSVATG"
     exon            1250..3627
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /note="hexamer: TATAAA"
     polyA_site      3322
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
     regulatory      3604..3609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /note="hexamer: ATTAAA"
     polyA_site      3627
                     /gene="Arsj"
                     /gene_synonym="9330196J05Rik; D830047F08"
                     /note="major polyA site"
ORIGIN      
        1 agaggaggaa agcacagatg gctagaacta agtcagccac ccaagggcac gctggagcag
       61 ctgcagcacc cacaggggac acgtgcgctc tgcgatcgcc gcccaggact ctgtgaatgt
      121 ccccaagcgc ttcggggtag agaaggaatt gctgaagagg aggccggctg gggcaggatc
      181 ctttctcact tcgggggccc ggagaggggt caagaagatt gacaaacgct cagcggaaaa
      241 tggggaacta gccttgaaaa ggtaggagta gcggccagca ggaagaaggt cccctcggct
      301 cagcctgtca ttcatccata agcaaggggt tccttggggc aacttggcaa ggcttcccgg
      361 gtgcctggaa cgctggaccg atgtcagtcc caccacgcct ggtgcttgcc tgcgcatgga
      421 cacagtcctg ctccccgaag atgtggagga tgatatgact gccagacgtt cctgtcctgt
      481 gtggctctca gtccctttct tgtcctttat tatttttatt atttcttcgt gagaactttt
      541 gggtgaagat gctaactttt tttttctttc ctgcaagctg ccgggtgatg ttaggaggta
      601 aaagaaaaat tgaaaagtaa agaactgcaa gtcagtgaag aggacatctg ctcccttcta
      661 gtttttccaa tgttcatgag ttaaaccgtt acctccagag gattgaagtt gtgggaagtg
      721 gtggcatctg gggaagggag caggattccc tcgcagcctt ccttcagctg tctctacccc
      781 ttcgcatgta tgagtggacc agcagcagca aagggggcag ggttctgctt gtggagtctc
      841 ctgtgggacc agagtgaatg gcccccaggg acagtgcgga gcctctgcct ccgctatctc
      901 cacaggcctg ggcctggtct ggaaagttct tagcgatggg tgccctggca ggcttctcgg
      961 tcctcagcct gctcacctat ggctacctgt gctggggcca ggacttagaa gaggaggggt
     1021 ccctaaaagc tcaagttgat gagagacctg aagcaggcac agcaggcacc tcccagcccc
     1081 atctcatttt tatcttagct gatgatcagg gatttagaga tgtgggttac cacggatctg
     1141 agataaagac gcccaccctt gataaactcg ctgcagaagg agttaagcta gagaactact
     1201 atgtccagcc tatttgcaca ccgtccagga gccagtttat taccggaaag tatcagatac
     1261 acacgggact tcagcattct atcattagac ctacccaacc caactgtcta cctctggaca
     1321 atgcaaccct acctcagaag ctaaaggagg tcggctattc aacccatatg gttgggaagt
     1381 ggcacttggg attttacaga aaagactgca tgcccaccaa gagaggattt gatacctttt
     1441 ttggctctct tttgggaagt ggtgattatt atacacacta caaatgtgac agtcctgggg
     1501 tgtgtggcta tgacttgtac gaaaacgaca atgcagcttg ggactatgac aatggcatct
     1561 attcaacaca gatgtacacg cagagagtgc agcaaatctt agccacccat gatcccacaa
     1621 aacctctatt tttatatgtg gcttaccaag ctgtccactc accacttcaa gcccctggca
     1681 ggtactttga acactacaga tccattatca acataaacag gaggaggtac gcagccatgc
     1741 tctcctgctt ggatgaagca atccacaatg tgaccctggc cctaaagagg tatggtttct
     1801 ataacaatag cattatcatt tactcctcag ataatggtgg gcagcccaca gcaggaggaa
     1861 gtaactggcc actcagaggc agcaaaggaa catattggga aggaggcatc cgggcagttg
     1921 gctttgtgca tagcccactt ctaaaaaaca agggaacggt atgtaaggaa cttgtgcaca
     1981 tcaccgattg gtacccaacc ttgatttcac tggctgaagg acagattgat gaagacattc
     2041 agctagatgg atacgatatc tgggagacca taagcgaagg tcttcgttca ccccgagtgg
     2101 atattttgca caacattgac cccatttaca ccaaggcgaa aaatggctcc tgggcagcag
     2161 gctatgggat ctggaacact gcaatccagt cggccatccg ggtacaacac tggaaactgc
     2221 tcacaggcaa tcctggctac agtgactggg tcccccctca ggctttcagc aatctgggcc
     2281 caaaccggtg gcacaatgaa aggattacct tgtcaactgg caagagtatc tggcttttca
     2341 acatcacggc tgatccgtat gagagggtgg acctatccag caggtatcca ggcatcgtga
     2401 agaagctgct gcggagactg tcacaattca acaagactgc cgtgcctgtc aggtaccccc
     2461 cgaaggatcc cagaagcaac cctaggctca acggaggagt ctggggtccg tggtataaag
     2521 aggaaaacaa gaaaaagaag tcaaacaaaa ccaaggctaa gaaaatgcaa aagaaaaaaa
     2581 gtaaggcaag gatgaggaag cagttggcag ctcactcctc aataaaatgc cacccaagtg
     2641 ttgccactgg ctaaatgcaa aactttctgc cttggttaaa cttagactgc ctggtttcta
     2701 ggtaattcaa agaaattggc tcagaaatac ctcggccaac cgcctcgggc ttgttttcac
     2761 attgctctgt gccagagact tctggtacct ggctaccaca tggacaaaac taccctcctg
     2821 tgtgccaaag gctatgcttc tgcaggccac acagggagga ggacacagtt atttatttat
     2881 ccctagtctg tgtaaaccgt gatgaatcat gagtgagttg accaaacaga atgctttgaa
     2941 tcccttgaat cacgagagga actgtgaccc accgtgtact tgagtgcagg gtaattacag
     3001 ggtaacatga taaaaagatg acttttgatg ccgtcagagg ttgtatcctc tcaaaggtct
     3061 aaaagctgta cttctaaata aaaaaaaaaa tagtatgtat cacatgaaac ttgggctttt
     3121 aagctaattc tattttgtat tgcagtctcc tgttctctga gaaaaagctg cttctcttcg
     3181 tggacagctt gtatctcatc ttatcctgct taaagaaacg gcagatagtg tctgaacatt
     3241 gccagaaatg aatgtaacta cgtcccaaac actttgatag aacaagaatt tcaatataaa
     3301 gtgcctaatt tatttctcaa aagagttaca caagtgattt taattatttt atttttaggt
     3361 tctacgttag aattttattt caattcttta aggttactaa gttatgtaat accataagtt
     3421 actgtaaaat ttttgttcat aaaatataag aggaaactca ttcagaaaaa ttacagccat
     3481 catattttac cattatttag atgttagaag atgaatatat tttttaaatt ttgtaaattt
     3541 gttgttatac agagttgatt tgactttact gtctccaaca taaactattt atgtatgtta
     3601 attattaaag tgatttattt tatggca
//
