LOCUS       NM_001038499            2764 bp    mRNA    linear   ROD 05-APR-2024
DEFINITION  Mus musculus arylsulfatase i (Arsi), mRNA.
ACCESSION   NM_001038499 XM_619544 XM_913799
VERSION     NM_001038499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Ratzka,A., Mundlos,S. and Vortkamp,A.
  TITLE     Expression patterns of sulfatase genes in the developing mouse
            embryo
  JOURNAL   Dev Dyn 239 (6), 1779-1788 (2010)
   PUBMED   20503373
REFERENCE   2  (bases 1 to 2764)
  AUTHORS   Barlow,J.L., Drynan,L.F., Hewett,D.R., Holmes,L.R.,
            Lorenzo-Abalde,S., Lane,A.L., Jolin,H.E., Pannell,R.,
            Middleton,A.J., Wong,S.H., Warren,A.J., Wainscoat,J.S.,
            Boultwood,J. and McKenzie,A.N.
  TITLE     A p53-dependent mechanism underlies macrocytic anemia in a mouse
            model of human 5q- syndrome
  JOURNAL   Nat Med 16 (1), 59-66 (2010)
   PUBMED   19966810
REFERENCE   3  (bases 1 to 2764)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139759.4 and AC124431.4.
            
            On Feb 7, 2019 this sequence version replaced NM_001038499.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141169.1, BN000748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AC139759.4         196946-197505
            561-2764            AC124431.4         33216-35419
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..2764
                     /gene="Arsi"
                     /note="arylsulfatase i"
                     /db_xref="GeneID:545260"
                     /db_xref="MGI:MGI:2670959"
     exon            1..560
                     /gene="Arsi"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1971
                     /gene="Arsi"
                     /note="ASI"
                     /codon_start=1
                     /product="arylsulfatase I precursor"
                     /protein_id="NP_001033588.1"
                     /db_xref="CCDS:CCDS29275.1"
                     /db_xref="GeneID:545260"
                     /db_xref="MGI:MGI:2670959"
                     /translation="MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAGDQPSVAPP
                     QPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLT
                     GRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPT
                     RRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASH
                     ILASHNPQNPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRN
                     ITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLL
                     KKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNI
                     DPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWW
                     NLERMASIRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLADYNRTAIPVRYPAAN
                     PRAHPDFNGGAWGPWASEEEEEEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNT
                     RLMSHRI"
     exon            561..2764
                     /gene="Arsi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagcact tttgggaagc ctccactcca cgactcaggc tggcccgtca gagctggggg
       61 agagggctgc gggaggaggc tcggcgggag cctgaccttc cgggagcgcc ctgctgcctg
      121 tccgagggtc ctggaccaga gccccgaggg ctctgactgc atccaggcgg gcgggagagc
      181 aggcgttgcg cccctagcgc ggcaggctct gaggtcctgg gaaccccgct cgcccagacc
      241 ggcgtcgcaa tgcatgctct ctcaggattc tccctggtca gcctactcag cttgggctac
      301 ctgtcctggg attgggctaa gcccggcctt gtggctgatg ggcctgccga ggctggcgat
      361 cagccttcgg tggctccacc gcagcctcca cacattatct tcatcctcac cgacgaccaa
      421 gggtaccacg acgtgggata ccatggctcg gatatcgaga ccccaacgct ggaccggcta
      481 gcagctgagg gcgtcaaact ggagaattat tacatccagc ccatatgtac accttcgagg
      541 agtcaactcc tcaccggcag gtaccagatc catacaggat tgcagcactc cattatccgc
      601 ccacggcagc ccaactgtct gcccctggac caggtgacgc tgccccagaa gctacaggag
      661 gcaggctact ccacccacat ggtgggcaag tggcatctgg gcttctaccg gaaggagtgc
      721 ttgcctaccc gccggggctt cgacaccttc ctgggttccc tcacaggcaa tgtggattac
      781 tacacctacg acaactgtga tggcccaggg gtttgtgggt ttgacctgca cgagggtgag
      841 agcgtggcct gggggctcag cggccagtac tccactatgc tctacgctca gcgtgcaagc
      901 cacatcctgg ccagccacaa tccccagaat cccctctttc tctatgtggc cttccaggca
      961 gtacacacgc ccctacagtc acctcgagaa tacctatacc gctaccgcac gatgggcaac
     1021 gtagcacggc gcaagtacgc agccatggtg acctgcatgg acgaggctgt gcgtaacatc
     1081 acctgggccc tcaagcgcta tggtttctat aacaacagtg tcattatctt ctccagtgac
     1141 aatggtggcc agaccttctc agggggtagc aactggcccc ttcgaggacg caagggtact
     1201 tactgggaag gtggtgtgag gggcctgggt tttgtccaca gcccactgct caagaaaaag
     1261 agacggacca gtcgggccct ggtccatatc acagactggt acccaacact ggtgggtctg
     1321 gcaggcggta ctacatcagc agctgatggg ctggatggct atgatgtatg gccagccatt
     1381 agtgagggcc gggcctcacc acgcacagag atcctacaca acatcgaccc cctctacaac
     1441 catgcccggc atggatcctt ggagggtggc tttgggatct ggaatacagc agtgcaggct
     1501 gctatccgag ttggggagtg gaagctgctc actggagacc caggctatgg tgactggatt
     1561 ccacctcaga cactggcctc cttccctggc agctggtgga acctggagcg gatggccagc
     1621 atccgccagg ctgtgtggct ctttaacatc agtgctgacc cttacgaacg agaggacctg
     1681 gctggccagc gacccgatgt agtccgcacc cttctggctc gcctggctga ttataaccgt
     1741 actgccatcc ccgtgcgtta cccagctgcg aaccctcggg cccatcctga ctttaatggg
     1801 ggtgcttggg ggccctgggc cagtgaggag gaggaagagg aggaggagga agaggaggaa
     1861 ggcagagcta gaagtttctc ccggggtcgc cgcaagaaga aatgcaagat ttgcaagctt
     1921 cgatcttttt tccgtaaact caataccagg ctgatgtccc accggatctg atggcttagg
     1981 gtggcaggga atctcagttc ccctcagaca ctctcccttt gctggttctc agggaggagg
     2041 caaggtcaag tcttcatctg taggcacgtg gagggagggc acagaagccc tcagctgaat
     2101 agggtgggac ttggggaagg gcagcaacca ggctgggttg cctgggtcac aatcctgcct
     2161 ctttcctgat gagtttcctt tttgccctca ggttacctat agcagcattc tgcctcaatc
     2221 tcacccctaa gatgagctct ggtgacttta ggactccagt gtacacatgt gtctggggcc
     2281 atggcagggt ttcttgctga ccttgtcacc ttccagacaa cttgagtcca tgaccctctt
     2341 tccagctctc tgtggtgctc ttggatatca gctggagtat ggccagctgg ctgctgctct
     2401 gttgaacaac tcaatgagag aacggacagg gtaggctctg agaaatcttt acgttcctgg
     2461 agcctcatga cttgggagcc tagtggaatt cttctctttt ggtccccaac atctgggggg
     2521 agggggaact ggctgagcct gagccactgt atagtgaggg tgggggaagc agctgtgaaa
     2581 ggagcctttg atttggtctt gaacacagtt cttccccaca gggccttgat ttccctactt
     2641 gcaaaggagt agggaaatat gagccttggc tctgcctacc tcacgttgct ggtgctgtag
     2701 aaaactggcc aggctgatgg ttgtggagga gcctgtgaac ttgattaaag tgccattatc
     2761 caga
//
