LOCUS       NP_001033588             573 aa            linear   ROD 27-APR-2025
DEFINITION  arylsulfatase I precursor [Mus musculus].
ACCESSION   NP_001033588 XP_619544 XP_918892
VERSION     NP_001033588.1
DBSOURCE    REFSEQ: accession NM_001038499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Ratzka,A., Mundlos,S. and Vortkamp,A.
  TITLE     Expression patterns of sulfatase genes in the developing mouse
            embryo
  JOURNAL   Dev Dyn 239 (6), 1779-1788 (2010)
   PUBMED   20503373
REFERENCE   2  (residues 1 to 573)
  AUTHORS   Barlow,J.L., Drynan,L.F., Hewett,D.R., Holmes,L.R.,
            Lorenzo-Abalde,S., Lane,A.L., Jolin,H.E., Pannell,R.,
            Middleton,A.J., Wong,S.H., Warren,A.J., Wainscoat,J.S.,
            Boultwood,J. and McKenzie,A.N.
  TITLE     A p53-dependent mechanism underlies macrocytic anemia in a mouse
            model of human 5q- syndrome
  JOURNAL   Nat Med 16 (1), 59-66 (2010)
   PUBMED   19966810
REFERENCE   3  (residues 1 to 573)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139759.4 and AC124431.4.
            
            On or before Jan 6, 2006 this sequence version replaced
            XP_619544.2, XP_918892.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141169.1, BN000748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     Protein         1..573
                     /product="arylsulfatase I precursor"
                     /note="ASI"
                     /calculated_mol_wt=61831
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2554
     mat_peptide     24..573
                     /product="Arylsulfatase I. /id=PRO_0000356284"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32KI9.1)"
                     /calculated_mol_wt=61831
     Region          47..478
                     /region_name="4-S"
                     /note="N-acetylgalactosamine 4-sulfatase, also called
                     arylsulftase B; cd16029"
                     /db_xref="CDD:293753"
     Site            order(55..56,93,147,149,239,297..298)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:293753"
     Site            order(55..56,93,147,149,239,298)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:293753"
     Site            276
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KI9.1)"
     Site            288
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KI9.1)"
     Site            466
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KI9.1)"
     Site            496
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q32KI9.1)"
     Region          515..550
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32KI9.1)"
     CDS             1..573
                     /gene="Arsi"
                     /coded_by="NM_001038499.2:250..1971"
                     /db_xref="CCDS:CCDS29275.1"
                     /db_xref="GeneID:545260"
                     /db_xref="MGI:MGI:2670959"
ORIGIN      
        1 mhalsgfslv sllslgylsw dwakpglvad gpaeagdqps vappqpphii filtddqgyh
       61 dvgyhgsdie tptldrlaae gvklenyyiq pictpsrsql ltgryqihtg lqhsiirprq
      121 pnclpldqvt lpqklqeagy sthmvgkwhl gfyrkeclpt rrgfdtflgs ltgnvdyyty
      181 dncdgpgvcg fdlhegesva wglsgqystm lyaqrashil ashnpqnplf lyvafqavht
      241 plqspreyly ryrtmgnvar rkyaamvtcm deavrnitwa lkrygfynns viifssdngg
      301 qtfsggsnwp lrgrkgtywe ggvrglgfvh spllkkkrrt sralvhitdw yptlvglagg
      361 ttsaadgldg ydvwpaiseg rasprteilh nidplynhar hgsleggfgi wntavqaair
      421 vgewklltgd pgygdwippq tlasfpgsww nlermasirq avwlfnisad pyeredlagq
      481 rpdvvrtlla rladynrtai pvrypaanpr ahpdfnggaw gpwaseeeee eeeeeeegra
      541 rsfsrgrrkk kckicklrsf frklntrlms hri
//
