LOCUS       NM_028710               3292 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus arylsulfatase G (Arsg), transcript variant 1, mRNA.
ACCESSION   NM_028710
VERSION     NM_028710.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3292)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3292)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   4  (bases 1 to 3292)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3292)
  AUTHORS   Kruszewski,K., Lullmann-Rauch,R., Dierks,T., Bartsch,U. and
            Damme,M.
  TITLE     Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient
            Mice
  JOURNAL   Invest Ophthalmol Vis Sci 57 (3), 1120-1131 (2016)
   PUBMED   26975023
REFERENCE   6  (bases 1 to 3292)
  AUTHORS   Ratzka,A., Mundlos,S. and Vortkamp,A.
  TITLE     Expression patterns of sulfatase genes in the developing mouse
            embryo
  JOURNAL   Dev Dyn 239 (6), 1779-1788 (2010)
   PUBMED   20503373
REFERENCE   7  (bases 1 to 3292)
  AUTHORS   Otsuki,B., Matsumura,T., Shimizu,M., Mori,M., Okudaira,S.,
            Nakanishi,R., Higuchi,K., Hosokawa,M., Tsuboyama,T. and Nakamura,T.
  TITLE     Quantitative trait locus that determines the cross-sectional shape
            of the femur in SAMP6 and SAMP2 mice
  JOURNAL   J Bone Miner Res 22 (5), 675-685 (2007)
   PUBMED   17295603
REFERENCE   8  (bases 1 to 3292)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   9  (bases 1 to 3292)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3292)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158726.1 and BC084731.1.
            
            On Oct 10, 2009 this sequence version replaced NM_028710.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 3
            both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1678              AK158726.1         2-1679
            1679-3292           BC084731.1         1369-2982
FEATURES             Location/Qualifiers
     source          1..3292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.98 cM"
     gene            1..3292
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /note="arylsulfatase G"
                     /db_xref="GeneID:74008"
                     /db_xref="MGI:MGI:1921258"
     exon            1..48
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            49..146
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            147..198
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            199..1081
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     CDS             864..2441
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /EC_number="3.1.6.1"
                     /EC_number="3.1.6.15"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; N-sulfoglucosamine-3-sulfatase"
                     /codon_start=1
                     /product="arylsulfatase G isoform 1 precursor"
                     /protein_id="NP_082986.3"
                     /db_xref="CCDS:CCDS25581.1"
                     /db_xref="GeneID:74008"
                     /db_xref="MGI:MGI:1921258"
                     /translation="MGWLFLKVLLVGMAFSGFFYPLVDFSISGKTRAPQPNIVIILAD
                     DMGWGDLGANWAETKDTTNLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV
                     THNFAVTSVGGLPVNETTLAEVLRQEGYVTAMIGKWHLGHHGSYHPNFRGFDYYFGIP
                     YSNDMGCTDAPGYNYPPCPACPQRDGLWRNPGRDCYTDVALPLYENLNIVEQPVNLSG
                     LAQKYAERAVEFIEQASTSGRPFLLYVGLAHMHVPLSVTPPLAHPQRQSLYRASLREM
                     DSLVGQIKDKVDHVARENTLLWFTGDNGPWAQKCELAGSVGPFFGLWQTHQGGSPTKQ
                     TTWEGGHRVPALAYWPGRVPANVTSTALLSLLDIFPTVIALAGASLPPNRKFDGRDVS
                     EVLFGKSQMGHRVLFHPNSGAAGEYGALQTVRLNHYKAFYITGGAKACDGSVGPEQHH
                     VAPLIFNLEDAADEGMPLQKGSPEYQEVLQQVTRALADVLQDIADDNSSRADYTQDPS
                     VIPCCNPYQTTCRCQPV"
     exon            1082..1269
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1317
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1429
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1567
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1764
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1845
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1954
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2075
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2166
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..3278
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /note="hexamer: AATAAA"
     polyA_site      3278
                     /gene="Arsg"
                     /gene_synonym="6330406P08Rik; ASG"
                     /note="major polyA site"
ORIGIN      
        1 aaggcacgcg ccccgcctgc cggctgccgg ggctgggggt cacggaaggt taaagcgcta
       61 gcacacatgg ggtgcgccaa cgatccagtg cctgggagaa ccacctttga cctcatgtgg
      121 acagctggtg cccaaggccc ctcctgttca tccgaaagct tcgtttctgg aaaaccaaca
      181 gagccccgag ccagcaaggg ggaagaaacc gatgaggcag ttgaacatct gaagaaggaa
      241 aacatctgtt ggcatggaaa agtgattctt ttcccaagct actgagtaaa acaccacaga
      301 cctggctgtt ccaactctgg tttcttgtca gattttgttc ctccaggaaa ccttacagaa
      361 acctctacca tctggaactc agaaactcat ctcagggctg actgtggctt ctagaacatg
      421 caggtgttct gcagatgtga gactgtatcc cgcagtcacc agatgaaatc ctaagcagat
      481 gcaaggcttg ctttgtggcc ttagctcccc tgagtgcaaa gggccacttc tctgctaagt
      541 ggccaagagt ggatattgac attgatgtct gaatgctgca cccagccagt catcttatta
      601 agctgcgatg agaagacatc ttgaggggac caacccaact taggggtgac acattcctga
      661 ctttcttgga ttaggattcc acatggggac cttgtgtctg tagccctgta gccattacta
      721 actccagtgt attcttgaca actggactcc ttggagactt cctgcactga aagtgaacaa
      781 agagaaaact ctaaaattcc agagattcac agtggtgctc ggttatcatt tatccaagac
      841 aacgggagtc ttcgtgtctt acaatgggct ggctctttct aaaggttttg ttggttggca
      901 tggctttttc tggatttttc taccctctcg tggatttctc tatcagtggg aaaacaagag
      961 ccccccaacc aaacatcgtg atcattttgg ctgatgacat gggatggggt gatctgggag
     1021 caaactgggc agaaacaaag gacaccacca atcttgacaa gatggcttcc gaaggaatga
     1081 ggtttgtaga cttccacgca gctgcttcta cctgctcccc atcccgagcc tccctgctca
     1141 ctggccggct gggtctacgg aacggagtca cgcacaactt cgcagtcacc tctgtagggg
     1201 ggcttccagt caacgagacc accttggcag aggtgctgcg acaggagggt tacgtcactg
     1261 ccatgatagg caagtggcat cttgggcatc atggctctta tcatcccaat ttccgtggct
     1321 tcgattacta ctttggaatc ccatatagca atgacatggg ttgcactgat gctccaggct
     1381 acaactaccc tccttgtcca gcgtgtccac agagagatgg cctatggagg aaccctggga
     1441 gggactgtta cacagatgtt gcccttcctc tctatgaaaa cctgaacatc gtggagcagc
     1501 ctgtgaacct gagcggcctt gcacagaagt acgcagaaag ggcagtggag ttcattgagc
     1561 aggcaagcac cagtggaaga cccttcctgc tctacgtggg cctggctcac atgcatgtgc
     1621 ctttgtctgt aactccacca ttggcacacc cacagcgcca aagcctgtac cgtgcaagtc
     1681 tccgggagat ggacagtctg gtagggcaga tcaaggacaa agttgaccat gtggcaagag
     1741 aaaacacact cctctggttt acaggagaca atggcccatg ggctcagaag tgtgagctgg
     1801 caggcagcgt gggtcccttc ttcgggttgt ggcaaaccca tcaaggggga agtccaacca
     1861 agcagaccac ctgggaaggt gggcatcggg ttccagcact ggcttactgg cctggcagag
     1921 ttccagccaa cgtcactagc accgccttgt taagcttgct agacatcttc cccaccgtga
     1981 tagctctggc aggagccagc ttgcccccaa accggaaatt tgatggacgg gatgtctctg
     2041 aggtgctctt tggcaagtca cagatggggc acagggtgct attccacccc aacagtgggg
     2101 ctgctggaga gtatggcgcc ctgcagactg tccgcctaaa ccattacaaa gctttctaca
     2161 tcactggtgg agccaaagct tgtgatggga gcgtgggtcc tgagcagcac cacgtggccc
     2221 ctctcatttt caacctagaa gatgctgctg atgaagggat gcctctacag aaggggagcc
     2281 ccgagtacca ggaggtgctg cagcaggtca ccagggctct cgcagatgtc ctccaagaca
     2341 tcgctgatga caacagctcc cgagcagact acactcagga tccttcagtg attccttgct
     2401 gtaaccccta tcaaactacc tgccgttgcc aaccggtctg agggctcatt gttcccccca
     2461 tgagaaacac tacctgaaaa ctgtagacag gtgggtttac ttccaaactt gggtgtggtc
     2521 atggatgtct gctttagaaa ggaagctgca gcatttggtt agaaagcaac ggcgttacct
     2581 ctgtgtgtgt ggactgtctc ctctgcatgc agacttgaga agccctgagt gctggtacag
     2641 tggacacggc atggttaagc actagcgagt aatggggtca ggtctgagcc ctgggtttaa
     2701 agctcaggca atgccttaaa cctcaattgc aagttgaagg ttaaagtaac ccacgaaact
     2761 gtgtgtaacc cacgaactga caccaggcag attctcgatc ggtattttag tttctatctc
     2821 gtgtccccag tttcaggggc cattttggca cagactcgtc tggtttgctg gtgggtaggg
     2881 gtccgggagc ctacactgtt gcctttgaga tgacttgagc aagctaaacc aaagtgaggt
     2941 tttcccaggc cttggaccct tctctcctgt aaatgtcaag tggatgtatt ataaagatgt
     3001 aagcattcag ggctgaagtg gtggcccgtt ggttaagagc ttggcccact tgctcagttc
     3061 ccagcaccta catggtagca taaactgtct gcaactctag ctctagggga accttgtcct
     3121 cttctctggc ctctgagaat gccagacaca cacgtggtgt atatacatgt aggtaaaaca
     3181 ctcatatatt aaaacatact cttttcaaaa aaattgggat ttcttcccag cccctaaaac
     3241 ttctaagaaa caaaataaaa atgtaaacaa ctcacaaaaa aaaaaaaaaa aa
//
