LOCUS       NM_009712               3989 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus arylsulfatase B (Arsb), mRNA.
ACCESSION   NM_009712 NM_027923
VERSION     NM_009712.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Hwang-Wong,E., Amar,G., Das,N., Zhang,X., Aaron,N., Gale,K.,
            Rothman,N., Fante,M., Baik,A., Bhargava,A., Fricker,A.,
            McAlister,M., Rabinowitz,J., Lees-Shepard,J., Nannuru,K.,
            Economides,A.N. and Cygnar,K.D.
  TITLE     Skeletal phenotype amelioration in mucopolysaccharidosis VI
            requires intervention at the earliest stages of postnatal
            development
  JOURNAL   JCI Insight 8 (21), e171312 (2023)
   PUBMED   37751300
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Tuyaa-Boustugue,P., Jantzen,I., Zhang,H., Young,S.P., Broqua,P.,
            Tallandier,M. and Entchev,E.
  TITLE     Reduction of lysosome abundance and GAG accumulation after
            odiparcil treatment in MPS I and MPS VI models
  JOURNAL   Mol Genet Metab Rep 37, 101011 (2023)
   PUBMED   38053941
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Bhattacharyya,S. and Tobacman,J.K.
  TITLE     Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in
            Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice
  JOURNAL   J Alzheimers Dis Rep 7 (1), 527-534 (2023)
   PUBMED   37313486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Nagpal,R., Georgi,G., Knauth,S., Schmid-Herrmann,C., Muschol,N.,
            Braulke,T., Kahl-Nieke,B., Amling,M., Schinke,T., Koehne,T. and
            Petersen,J.
  TITLE     Early enzyme replacement therapy prevents dental and craniofacial
            abnormalities in a mouse model of mucopolysaccharidosis type VI
  JOURNAL   Front Physiol 13, 998039 (2022)
   PUBMED   36213247
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Hwa,J.J., Zollman,S., Warden,C.H., Taylor,B.A., Edwards,P.A.,
            Fogelman,A.M. and Lusis,A.J.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Grompe,M., Pieretti,M., Caskey,C.T. and Ballabio,A.
  TITLE     The sulfatase gene family: cross-species PCR cloning using the
            MOPAC technique
  JOURNAL   Genomics 12 (4), 755-760 (1992)
   PUBMED   1572648
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Daniel,W.L.
  TITLE     Genetic control of heat sensitivity and activity level of murine
            arylsulfatase B
  JOURNAL   Biochem Genet 14 (11-12), 1003-1018 (1976)
   PUBMED   1016219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158312.1, AK140163.1 and AC136976.5.
            
            On or before Feb 13, 2007 this sequence version replaced
            NM_027923.1, NM_009712.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.228507.1,
                                           SRR1660819.165550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AK158312.1         2-1151
            1151-1155           AK140163.1         1201-1205
            1156-1473           AK158312.1         1157-1474
            1474-1893           AK140163.1         1529-1948
            1894-3989           AC136976.5         94702-96797         c
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.88 cM"
     gene            1..3989
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /note="arylsulfatase B"
                     /db_xref="GeneID:11881"
                     /db_xref="MGI:MGI:88075"
     exon            1..414
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1704
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /EC_number="3.1.6.12"
                     /note="ASB; G4S; N-acetylgalactosamine-4-sulfatase;
                     arylsulfatase B complex; arylsulfatase B temporal
                     regulation; arylsulfatase B regulation; arylsulfatase B
                     structural"
                     /codon_start=1
                     /product="arylsulfatase B precursor"
                     /protein_id="NP_033842.3"
                     /db_xref="CCDS:CCDS36749.1"
                     /db_xref="GeneID:11881"
                     /db_xref="MGI:MGI:88075"
                     /translation="MGKLSPCTGRSRPGGPGPQLPLLLLLLQLLLLLLSPARASGATQ
                     PPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTG
                     RYQIHLGLQHYLIMTCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKECLPTR
                     RGFDTYFGYLLGSEDYYTHEACAPIESLNGTRCALDLRDGEEPAKEYNNIYSTNIFTK
                     RATTVIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYGFIQDKHRRIYAGMVSLMDE
                     AVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGTGFVA
                     SPLLKQKGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVEL
                     LHNIDQDFFDGLPCPGKNMTPAKDDSFPLEHSAFNTSIHAGIRYKNWKLLTGHPGCGY
                     WFPPPSQSNVSEIPPVDPPTKTLWLFDINQDPEERHDVSREHPHIVQNLLSRLQYYHE
                     HSVPSHFPPLDPRCDPKSTGVWSPWM"
     exon            415..601
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..792
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1000
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1244
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1315
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1438
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..3989
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /note="hexamer: AATAAA"
     polyA_site      3989
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcccgccca ggtggatgaa atcttgctgg ggagcccggc cgctcagttc ccgattctgt
       61 cgggggtgcc cgcagcacgg gctctgcagg ctgctaagga tgggcaagct tagcccgtgc
      121 actggcagga gccggcctgg aggtcccggg ccgcagctgc cactcttgct gctgctgctg
      181 cagctgctgc tgctgctgct gtcgccggcc cgggcctccg gagctaccca gcctccgcat
      241 gtggtcttcg tgctggcgga cgacctgggc tggaacgact tgggttttca cggctcggtc
      301 atccgcacgc cgcacctgga tgcgctggcg gccggcggcg tggtcctgga caactactac
      361 gtgcagccgc tgtgcacgcc ctcgcggagc cagctgctca ccggccgcta tcagatccat
      421 ttgggcttac agcattacct catcatgacc tgtcagccca gctgtgttcc cctagacgaa
      481 aaactcctgc cccagctttt aaaggaagca ggctatgcta cgcacatggt cgggaaatgg
      541 cacctgggga tgtaccggaa agaatgtctg ccgacacgcc gaggattcga tacctacttc
      601 ggatacctcc taggcagtga agactattac acccacgagg cctgtgcgcc gattgagtct
      661 ttgaatggta cccgctgtgc gcttgactta agagatggtg aagaacctgc aaaagagtat
      721 aacaatattt actcaacaaa catatttacc aaaagggcta caaccgtcat agctaaccac
      781 ccaccggaga aaccactgtt cctctacctt gctttccagt ctgtccacga tcccctgcag
      841 gtccctgagg agtacatgga gccatatggc ttcatccaag ataagcacag acgtatttat
      901 gcagggatgg tgtccctcat ggatgaagca gtggggaacg tcaccaaagc cttgaaaagc
      961 cacgggctct ggaacaacac ggtcttcatc ttctccacag ataacggtgg gcagactagg
     1021 tctggaggca acaactggcc actccgagga aggaagggga ccctgtggga agggggcatc
     1081 cgaggaacgg gcttcgtggc aagccccttg ctgaaacaga aaggcgtgaa gagccgggaa
     1141 ctcatgcaca tcaccgattg gctccccaca ctcgtagatc tggctggggg aagcactaat
     1201 ggaaccaaac ctctggatgg cttcaacatg tggaagacaa tcagtgaagg acacccatcc
     1261 ccgagagtgg agctgctaca caacatcgat caggactttt ttgatggctt gccatgtcct
     1321 ggcaagaaca tgactccagc aaaggacgat tcttttccgt tagaacattc tgcctttaac
     1381 acgtctatcc atgctgggat cagatacaaa aattggaaac tcctcacggg ccacccaggc
     1441 tgtggttact ggttcccgcc tccgtctcag tccaacgtct ctgagatacc tccagtggac
     1501 ccaccaacca agactctctg gctttttgat atcaatcagg accctgaaga aagacacgac
     1561 gtgtcccgag agcaccccca catcgtccag aaccttcttt cccgcctgca gtactaccat
     1621 gaacattctg tgccttctca cttcccaccc ttggaccccc gctgcgatcc caagagcact
     1681 ggtgtgtgga gcccctggat gtagggctct ggggagtaag gggggctgga gcccatttct
     1741 gggcaggcta gacctcaggc ccctactccc ctggcttctc ttctttatca tcccccaccc
     1801 tgtcacctgg ccctcatgct acataaccca ccaaaggagt ccaatttcaa cccacagtac
     1861 attctaaaag ccagtaaaat ctggaaggat cttgctgttg gctggagtta gtgtctgggg
     1921 ccagggtggc cgggttcatc ctgcttccta aactacagac gctgggaact tgacatagga
     1981 agttatccct gagtcctgga ggccaggaca gctggctctt tttgcttcac aagtcagctg
     2041 ttagaactcc ctctgctaat aaccagcttt attggcaaga cacatttctt gtaacaaagg
     2101 cagggagcag atgttgctag tggttctgtt ggctgtgagt gctccctgtc tgtgagctct
     2161 tactcgggct ttccgcaccc atgaccctaa ccctaaccct aaccctaacc ctaaccctaa
     2221 ccctaaccct aaccctagcc ctagccctag ccctagccct agccctaacc catccgctca
     2281 ctcatcttcc tgtggagcgc acagcccatt gcagtaagcc agcatggaga catgcctgtg
     2341 ccgtggtttt ggtttccatg ataactaaat gtgtttttat ctccaccccc acccccaccc
     2401 actattgctc attctgtcta gacttctgct acccagcttg tgtggctctg ttcctgtcat
     2461 gcctttggac ttcactgtcc tgtgcctgag gtctctctcc cctctgcttc acccattctg
     2521 agctttagga tagtcctaag ccctgcccag aggaggtgga ctggtcattc tgtgtccatg
     2581 ctaatgggag ttgtgggtct gtggcatctg ctaaggagga ttattcacag ttgcatggaa
     2641 tctgtcaaga ttgtggctat atctcccact atgccatggt ctatgctgtt ttctcaagca
     2701 gtggcaagaa aggccaggat agcacttctt cgccctgagc agtctcagaa aggaagtggc
     2761 catggaatgt tggcctcagt aaggcagagg agacaccatc catgtccctt tcattctctg
     2821 tttcactgcc ctgttctggg gctctggatt ctgggcttgg agaatgagga tacactattt
     2881 gactgtcagc cctttctcag accctcatac atcttaccga tgtgagtcca ccagattcgc
     2941 agcagggtgt gtcaaaccca gtggtacttc tcattaacac ctctgtctca ttcacagttt
     3001 atcaccaaca tcagcaacca tgtctgcgac ataatagata gccagtactt tttaaaaatg
     3061 aattaataaa caaagtaaac gagaaagagt tacctggcat ttactagtcc agtgagctga
     3121 ctgtaagggc agaataaata tcctccagcc cttccgattc tgtcctcaag ctgtcccctc
     3181 ccacctctgc gctagcggga gaatgatctg ggcagtcaat gaatggcagg tctgtgatgg
     3241 cctctgcagg tagacaaaag agaattctgc ttcccgggaa gtctcctttg ccagcaatct
     3301 ccatttccat tcttcactgc acactaggaa ttaaaaccac caaataatat gatatgcaca
     3361 gtcatcttca gttcagtagc agcatctcct ggtcattaat attctgtatt ttattatggt
     3421 aagagtatta taagaaaatg gtactatggc taatgacatc ttttaccaac ctttacccaa
     3481 cttggctgac atatagcctg ccattaggac actttttact ccaaagactg tgacagagtc
     3541 tgagtgacat gagtctgaat actcctcctg tgtcctcctg tagctatagg tggactgacg
     3601 gtccctactt cataacacct acctgatcgt tccttagtgt tctcagaaca gctgtcctca
     3661 gttccagctg tgactgtagg cagtgtttgg aatattagca taactaatgg atttaagaag
     3721 actttcagaa agtgattctt aaaaataact ggaggttttg tctgataaaa caaatagaat
     3781 ggaatatgtc tcagattata tctcattgga ttttcatgtt tgatacaaaa gtaaaagctt
     3841 gataacctat ttttagagat attaatgtta gttctttcca attttgttta accttgaaga
     3901 ttttatttaa cttgtgaact tactcctttg ttatgccatg attgttccag atttgaggaa
     3961 caaaataaaa taaaatcttt ctaaaacta
//
