LOCUS       NP_033842                534 aa            linear   ROD 27-APR-2025
DEFINITION  arylsulfatase B precursor [Mus musculus].
ACCESSION   NP_033842 NP_082199
VERSION     NP_033842.3
DBSOURCE    REFSEQ: accession NM_009712.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Hwang-Wong,E., Amar,G., Das,N., Zhang,X., Aaron,N., Gale,K.,
            Rothman,N., Fante,M., Baik,A., Bhargava,A., Fricker,A.,
            McAlister,M., Rabinowitz,J., Lees-Shepard,J., Nannuru,K.,
            Economides,A.N. and Cygnar,K.D.
  TITLE     Skeletal phenotype amelioration in mucopolysaccharidosis VI
            requires intervention at the earliest stages of postnatal
            development
  JOURNAL   JCI Insight 8 (21), e171312 (2023)
   PUBMED   37751300
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Tuyaa-Boustugue,P., Jantzen,I., Zhang,H., Young,S.P., Broqua,P.,
            Tallandier,M. and Entchev,E.
  TITLE     Reduction of lysosome abundance and GAG accumulation after
            odiparcil treatment in MPS I and MPS VI models
  JOURNAL   Mol Genet Metab Rep 37, 101011 (2023)
   PUBMED   38053941
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Bhattacharyya,S. and Tobacman,J.K.
  TITLE     Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in
            Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice
  JOURNAL   J Alzheimers Dis Rep 7 (1), 527-534 (2023)
   PUBMED   37313486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Nagpal,R., Georgi,G., Knauth,S., Schmid-Herrmann,C., Muschol,N.,
            Braulke,T., Kahl-Nieke,B., Amling,M., Schinke,T., Koehne,T. and
            Petersen,J.
  TITLE     Early enzyme replacement therapy prevents dental and craniofacial
            abnormalities in a mouse model of mucopolysaccharidosis type VI
  JOURNAL   Front Physiol 13, 998039 (2022)
   PUBMED   36213247
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Hwa,J.J., Zollman,S., Warden,C.H., Taylor,B.A., Edwards,P.A.,
            Fogelman,A.M. and Lusis,A.J.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Grompe,M., Pieretti,M., Caskey,C.T. and Ballabio,A.
  TITLE     The sulfatase gene family: cross-species PCR cloning using the
            MOPAC technique
  JOURNAL   Genomics 12 (4), 755-760 (1992)
   PUBMED   1572648
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Daniel,W.L.
  TITLE     Genetic control of heat sensitivity and activity level of murine
            arylsulfatase B
  JOURNAL   Biochem Genet 14 (11-12), 1003-1018 (1976)
   PUBMED   1016219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158312.1, AK140163.1 and AC136976.5.
            
            On or before Feb 13, 2007 this sequence version replaced
            NP_082199.1, NP_033842.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.228507.1,
                                           SRR1660819.165550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.88 cM"
     Protein         1..534
                     /product="arylsulfatase B precursor"
                     /EC_number="3.1.6.12"
                     /note="ASB; G4S; N-acetylgalactosamine-4-sulfatase;
                     arylsulfatase B complex; arylsulfatase B temporal
                     regulation; arylsulfatase B regulation; arylsulfatase B
                     structural"
                     /calculated_mol_wt=55517
     sig_peptide     1..41
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
                     /calculated_mol_wt=4206
     mat_peptide     42..534
                     /product="Arylsulfatase B. /id=PRO_0000033423"
                     /note="propagated from UniProtKB/Swiss-Prot (P50429.3)"
                     /calculated_mol_wt=55517
     Region          46..489
                     /region_name="4-S"
                     /note="N-acetylgalactosamine 4-sulfatase, also called
                     arylsulftase B; cd16029"
                     /db_xref="CDD:293753"
     Site            order(54..55,92,146,148,243,301..302)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:293753"
     Site            order(54..55,92,146,148,243,302)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:293753"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     Site            280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     Site            292
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     Site            367
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     Site            427
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     Site            459
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50429.3)"
     CDS             1..534
                     /gene="Arsb"
                     /gene_synonym="1110007C02Rik; As-1; As-1r; As-1s; As-1t;
                     As1; As1-r; As1-s; As1-t; Asr-1; Ast-1"
                     /coded_by="NM_009712.3:100..1704"
                     /db_xref="CCDS:CCDS36749.1"
                     /db_xref="GeneID:11881"
                     /db_xref="MGI:MGI:88075"
ORIGIN      
        1 mgklspctgr srpggpgpql pllllllqll llllsparas gatqpphvvf vladdlgwnd
       61 lgfhgsvirt phldalaagg vvldnyyvqp lctpsrsqll tgryqihlgl qhylimtcqp
      121 scvpldekll pqllkeagya thmvgkwhlg myrkeclptr rgfdtyfgyl lgsedyythe
      181 acapieslng trcaldlrdg eepakeynni ystniftkra ttvianhppe kplflylafq
      241 svhdplqvpe eymepygfiq dkhrriyagm vslmdeavgn vtkalkshgl wnntvfifst
      301 dnggqtrsgg nnwplrgrkg tlweggirgt gfvaspllkq kgvksrelmh itdwlptlvd
      361 laggstngtk pldgfnmwkt iseghpsprv ellhnidqdf fdglpcpgkn mtpakddsfp
      421 lehsafntsi hagiryknwk lltghpgcgy wfpppsqsnv seippvdppt ktlwlfdinq
      481 dpeerhdvsr ehphivqnll srlqyyhehs vpshfppldp rcdpkstgvw spwm
//
