LOCUS       NM_009713               3491 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus arylsulfatase A (Arsa), mRNA.
ACCESSION   NM_009713
VERSION     NM_009713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3491)
  AUTHORS   Montgomery,M.K., Bayliss,J., Nie,S., De Nardo,W., Keenan,S.N.,
            Miotto,P.M., Karimkhanloo,H., Huang,C., Schittenhelm,R.B.,
            Don,A.S., Ryan,A., Williamson,N.A., Ooi,G.J., Brown,W.A.,
            Burton,P.R., Parker,B.L. and Watt,M.J.
  TITLE     Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic
            steatohepatitis inducible hepatokine and regulator of glycemic
            control
  JOURNAL   Nat Commun 13 (1), 1259 (2022)
   PUBMED   35273160
  REMARK    GeneRIF: Deep proteomic profiling unveils arylsulfatase A as a
            non-alcoholic steatohepatitis inducible hepatokine and regulator of
            glycemic control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3491)
  AUTHORS   Miyake,N., Miyake,K., Sakai,A., Yamamoto,M., Suzuki,H. and
            Shimada,T.
  TITLE     Treatment of adult metachromatic leukodystrophy model mice using
            intrathecal administration of type 9 AAV vector encoding
            arylsulfatase A
  JOURNAL   Sci Rep 11 (1), 20513 (2021)
   PUBMED   34654893
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3491)
  AUTHORS   Babcock,M.C., Mikulka,C.R., Wang,B., Chandriani,S., Chandra,S.,
            Xu,Y., Webster,K., Feng,Y., Nelvagal,H.R., Giaramita,A., Yip,B.K.,
            Lo,M., Jiang,X., Chao,Q., Woloszynek,J.C., Shen,Y., Bhagwat,S.,
            Sands,M.S. and Crawford,B.E.
  TITLE     Substrate reduction therapy for Krabbe disease and metachromatic
            leukodystrophy using a novel ceramide galactosyltransferase
            inhibitor
  JOURNAL   Sci Rep 11 (1), 14486 (2021)
   PUBMED   34262084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3491)
  AUTHORS   Kongmanas,K., Saewu,A., Kiattiburut,W., Baker,M.A., Faull,K.F.,
            Burger,D. and Tanphaichitr,N.
  TITLE     Accumulation of Seminolipid in Sertoli Cells Is Associated with
            Increased Levels of Reactive Oxygen Species and Male Subfertility:
            Studies in Aging Arsa Null Male Mice
  JOURNAL   Antioxidants (Basel) 10 (6), 912 (2021)
   PUBMED   34199863
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3491)
  AUTHORS   Stein,A., Stroobants,S., Gieselmann,V., D'Hooge,R. and Matzner,U.
  TITLE     Anti-inflammatory Therapy With Simvastatin Improves
            Neuroinflammation and CNS Function in a Mouse Model of
            Metachromatic Leukodystrophy
  JOURNAL   Mol Ther 23 (7), 1160-1168 (2015)
   PUBMED   25896249
REFERENCE   6  (bases 1 to 3491)
  AUTHORS   Gieselmann,V., Matzner,U., Hess,B., Lullmann-Rauch,R., Coenen,R.,
            Hartmann,D., D'Hooge,R., DeDeyn,P. and Nagels,G.
  TITLE     Metachromatic leukodystrophy: molecular genetics and an animal
            model
  JOURNAL   J Inherit Metab Dis 21 (5), 564-574 (1998)
   PUBMED   9728336
  REMARK    Review article
REFERENCE   7  (bases 1 to 3491)
  AUTHORS   Hess,B., Saftig,P., Hartmann,D., Coenen,R., Lullmann-Rauch,R.,
            Goebel,H.H., Evers,M., von Figura,K., D'Hooge,R., Nagels,G., De
            Deyn,P., Peters,C. and Gieselmann,V.
  TITLE     Phenotype of arylsulfatase A-deficient mice: relationship to human
            metachromatic leukodystrophy
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14821-14826 (1996)
   PUBMED   8962139
REFERENCE   8  (bases 1 to 3491)
  AUTHORS   Kreysing,J., Polten,A., Hess,B., von Figura,K., Menz,K., Steiner,F.
            and Gieselmann,V.
  TITLE     Structure of the mouse arylsulfatase A gene and cDNA
  JOURNAL   Genomics 19 (2), 249-256 (1994)
   PUBMED   7910580
REFERENCE   9  (bases 1 to 3491)
  AUTHORS   Grompe,M., Pieretti,M., Caskey,C.T. and Ballabio,A.
  TITLE     The sulfatase gene family: cross-species PCR cloning using the
            MOPAC technique
  JOURNAL   Genomics 12 (4), 755-760 (1992)
   PUBMED   1572648
REFERENCE   10 (bases 1 to 3491)
  AUTHORS   Francke,U., Tetri,P., Taggart,R.T. and Oliver,N.
  TITLE     Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and
            human (HSA) chromosome 22: assignment of a gene for arylsulfatase A
            to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22
  JOURNAL   Cytogenet Cell Genet 31 (2), 58-69 (1981)
   PUBMED   6118238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137513.3.
            
            On Apr 7, 2010 this sequence version replaced NM_009713.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098075.1, SRR17784645.1324951.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC137513.3         48494-48768
            276-1423            AC137513.3         49263-50410
            1424-1664           AC137513.3         50556-50796
            1665-1883           AC137513.3         50913-51131
            1884-2053           AC137513.3         51209-51378
            2054-2178           AC137513.3         51566-51690
            2179-2306           AC137513.3         51784-51911
            2307-2409           AC137513.3         52147-52249
            2410-3491           AC137513.3         52361-53442
FEATURES             Location/Qualifiers
     source          1..3491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.94 cM"
     gene            1..3491
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /note="arylsulfatase A"
                     /db_xref="GeneID:11883"
                     /db_xref="MGI:MGI:88077"
     exon            1..275
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            276..1423
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     CDS             1209..2729
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /EC_number="3.1.6.8"
                     /note="cerebroside-sulfatase"
                     /codon_start=1
                     /product="arylsulfatase A precursor"
                     /protein_id="NP_033843.2"
                     /db_xref="CCDS:CCDS27753.1"
                     /db_xref="GeneID:11883"
                     /db_xref="MGI:MGI:88077"
                     /translation="MALGTLFLALAAGLSTASPPNILLIFADDLGYGDLGSYGHPSST
                     TPNLDQLAEGGLRFTDFYVPVSLCTPSRAALLTGRLPVRSGMYPGVLGPSSQGGLPLE
                     EVTLAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTC
                     FPPDIPCKGGCDQGLVPIPLLANLTVEAQPPWLPGLEARYVSFSRDLMADAQRQGRPF
                     FLYYASHHTHYPQFSGQSFTKRSGRGPFGDSLMELDGAVGALMTTVGDLGLLEETLVI
                     FTADNGPELMRMSNGGCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSLD
                     LLPTLAALTGAPLPNVTLDGVDISPLLLGTGKSPRKSVFFYPPYPDEIHGVFAVRNGK
                     YKAHFFTQGSAHSDTTSDPACHAANRLTAHEPPLLYDLSQDPGENYNVLESIEGVSPE
                     ALQALKHIQLLKAQYDAAMTFGPSQIAKGEDPALQICCQPSCTPHPVCCHCPGSQS"
     exon            1424..1664
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1883
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2053
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2178
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2306
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2409
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..3491
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2871
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /note="major polyA site"
     regulatory      3452..3457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /note="hexamer: AATAAA"
     regulatory      3458..3463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /note="hexamer: AATAAA"
     polyA_site      3473
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
                     /note="major polyA site"
     polyA_site      3477
                     /gene="Arsa"
                     /gene_synonym="As-2; AS-A; As2; ASA; TISP73"
ORIGIN      
        1 ctgacctgag cctgtgttag accactgggt gatcctgagt ctgatccgct actgtagtcg
       61 ggaggccctt ccagaaccct gtttatctcc cccctggctc cagcgtcttc cttcctgggt
      121 gcgcaggtcg tgaccatctt gacgccagag gtcttagagt gccactctgt cttggagagg
      181 aatcaaagcc aagaatctgg acaaatgact tccctaggaa cagccacctg caaggaaata
      241 ccctggaaga gacttgctcc ggaaaagtga ctcagtcaga ctccatggtt tttgcctctt
      301 tgctcagtca gaagggggat gctgatgttt tttcaacaag gatccctcaa gtatctcatc
      361 agaggaaatg agacaaacag cccaccattc gccagaggaa ctccagacac gcatttaaga
      421 gcgacacagc aggagagcca gatagctgta gtgctgcact gctaggcagt cctgagccta
      481 gcgcgcagga gcaaagaacg taaggttacc aagcccagca cgggacaccc caaccggcgc
      541 agataaggat cgggagcacg cgagcaatct ccagcctcac cctatcccgc cccggtccca
      601 ggtccgcagc agccccaccc ggaaggttcc cataggcaca caaacccgct tggctcggct
      661 ccccagctcc gcctcgcccg gtcccagctc cacctagccc cgactctgta ccgcccagtc
      721 ccagagcccg ccccttctgg gtcagccaat tgtcacgtga ccgcgggcgt atccgagact
      781 gcctgagatc gacgctgtct accaccagtt cctcctcaat ttcgaaccgc ccttgtccca
      841 tggcgctgga gcctcccggg tcaatgtgaa gtgacttctg ctcctgatcc caagcctgtg
      901 ctggcacctc tgggtgaaca gggtcagatc cccgctcgtg acgttaatga agccctggtc
      961 ctttaggggc tctgtggagt tacaccccag gccaccccct tccgagttct gacagattcg
     1021 ctggagcttc agagagtgga cctacagaca gaaggattat ttgggtctgg cggctcaggg
     1081 gaggaggagg gctcgggact ggggcctcag gtaggggctg gcctgggcgc tcaaggaacg
     1141 agcctgctgg aatcgctctg ccttccctac caagggactg aggacacagg cccatctgta
     1201 tctctgtcat ggccctgggg accctctttt tggcattggc tgcaggcctg agcactgcca
     1261 gcccacctaa catcctgctg atctttgcgg atgacctggg ctatggggac ctcggctcct
     1321 atgggcaccc cagttctacc acccctaacc tggatcagtt ggctgaaggt ggactacggt
     1381 tcacagattt ctatgtgcct gtgtctctgt gcacgccatc tcgggccgcc ctcctgactg
     1441 gccggctccc agttcgatca ggcatgtacc ctggagttct ggggcccagt tcccaagggg
     1501 gcttgccctt ggaggaggtg actttagccg aagtcctggc tgctcgaggc taccttacag
     1561 ggatggctgg caagtggcat cttggagtgg ggccagaggg ggccttcctg cccccgcatc
     1621 agggcttcca ccgattcctg ggcatcccat attcccatga ccagggtccc tgtcagaacc
     1681 taacgtgctt cccaccagac atcccctgca aaggtggctg tgaccaaggc cttgttccca
     1741 tcccactact ggccaacctg acagtggagg cccagccccc ttggctgcct ggactggagg
     1801 cccggtatgt gtctttctcc cgagacctca tggctgatgc ccagcgccag ggccgaccgt
     1861 tcttcctgta ctacgcttcc caccacactc actaccctca gttcagtgga caaagcttca
     1921 ccaagcgctc aggccgtggg ccatttgggg actccttgat ggagctggat ggagctgtag
     1981 gggccttgat gacaactgtg ggggacctcg gtctgctgga agagacacta gtcatcttca
     2041 ctgcagataa cggtcctgag ttgatgcgca tgtccaatgg cggctgctct ggcctcttga
     2101 gatgtggaaa aggaacaact tttgaaggtg gcgtccgaga gcctgccttg gtctactggc
     2161 caggtcacat tactcctggt gtaacccatg agctggccag ctctctggac ctgctgccca
     2221 ccctggcagc cctgaccggg gctccgctgc ccaacgtcac cttggatggt gttgacatca
     2281 gccccttgct gctaggcaca ggcaagagcc cacggaagtc tgtcttcttc tacccgccct
     2341 acccagacga gatccatggg gtctttgctg ttcggaatgg gaaatacaag gctcatttct
     2401 tcacccaggg ctccgcccac agtgacacca cttcagatcc tgcctgtcat gctgccaacc
     2461 gtctgacggc tcatgagccc ccactgctct acgacttatc tcaggaccct ggggagaact
     2521 acaatgtttt ggaaagtata gagggggtct ccccagaagc cctccaggct ttgaaacaca
     2581 tccaactcct caaggcccag tacgatgcag ccatgacctt tggccccagc cagatagcca
     2641 agggcgagga ccctgcccta cagatctgct gtcagccgag ctgcactccc caccctgtct
     2701 gctgccactg cccaggctcc cagtcctgag gggactggag aaatcacggg ggtccttcaa
     2761 gggtagccca ggacccctag ccctgtcctg agtgtgtgat ggttcaccag agggacaggg
     2821 acaagtgtgt agtttgtatc tggtaatgta ataacaccag ctgagacttg agacgtgcta
     2881 attcatctag tccttgtggt aactctgagg tcagtactat tctgctgtgc tacaagacaa
     2941 ggacattgac gcatagggaa tctcgtggac ctttccaagt ccgatgccac cttaccagaa
     3001 agagcttgag ctaggatttg aacccaggca ccctgggttt aaaatttgtc ccaccctggt
     3061 gatctgcgtg tgtccatgga cacaccgctg aagcgaagac atgtcccttc acagaaaccg
     3121 gtaatgagtt caagtgccag gaactggggg tggggggagt ggtgagggca gaggaaccct
     3181 aaagatgcaa agcacctgga agacaggctt tcctcaagaa gcaatgccag aggccctgga
     3241 actggtcagc ttggttcttt aaagaaatca gctgtctgga gttaggtgat aaactgatca
     3301 ttccgggtag agttaaagga cctggggacc ctgctagatc ccaggaagga ccatcagcag
     3361 cttctgagac tgcctcatgg ggctcacttg tctctcaagc tctgaatttc tcctttgtgc
     3421 atacttcaag taattttcta caaaaaaaaa taataaaaat aaataaaata aaataaagtt
     3481 gtctacaaag t
//
