LOCUS       NM_001042592            3903 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus arrestin domain containing 4 (Arrdc4), transcript
            variant 1, mRNA.
ACCESSION   NM_001042592
VERSION     NM_001042592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Nakayama,Y., Kobayashi,S., Masihuddin,A., Abdali,S.A.,
            Seneviratne,A.M.P.B., Ishii,S., Iida,J., Liang,Q. and Yoshioka,J.
  TITLE     Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise
            Capacity in Diabetes
  JOURNAL   Circ Res 135 (3), 416-433 (2024)
   PUBMED   38946541
  REMARK    GeneRIF: Systemic Deletion of ARRDC4 Improves Cardiac Reserve and
            Exercise Capacity in Diabetes.
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Dagdeviren,S., Hoang,M.F., Sarikhani,M., Meier,V., Benoit,J.C.,
            Okawa,M.C., Melnik,V.Y., Ricci-Blair,E.M., Foot,N., Friedline,R.H.,
            Hu,X., Tauer,L.A., Srinivasan,A., Prigozhin,M.B., Shenoy,S.K.,
            Kumar,S., Kim,J.K. and Lee,R.T.
  TITLE     An insulin-regulated arrestin domain protein controls hepatic
            glucagon action
  JOURNAL   J Biol Chem 299 (8), 105045 (2023)
   PUBMED   37451484
  REMARK    GeneRIF: An insulin-regulated arrestin domain protein controls
            hepatic glucagon action.
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Nakayama,Y., Mukai,N., Kreitzer,G., Patwari,P. and Yoshioka,J.
  TITLE     Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the
            Ischemic Heart
  JOURNAL   Circ Res 131 (6), 510-527 (2022)
   PUBMED   35950500
  REMARK    GeneRIF: Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress
            in the Ischemic Heart.
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Mackenzie,K., Foot,N.J., Anand,S., Dalton,H.E., Chaudhary,N.,
            Collins,B.M., Mathivanan,S. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter via membrane
            budding
  JOURNAL   Cell Discov 2, 16011 (2016)
   PUBMED   27462458
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3903)
  AUTHORS   Symmons,O., Uslu,V.V., Tsujimura,T., Ruf,S., Nassari,S.,
            Schwarzer,W., Ettwiller,L. and Spitz,F.
  TITLE     Functional and topological characteristics of mammalian regulatory
            domains
  JOURNAL   Genome Res 24 (3), 390-400 (2014)
   PUBMED   24398455
REFERENCE   9  (bases 1 to 3903)
  AUTHORS   Patwari,P., Chutkow,W.A., Cummings,K., Verstraeten,V.L.,
            Lammerding,J., Schreiter,E.R. and Lee,R.T.
  TITLE     Thioredoxin-independent regulation of metabolism by the
            alpha-arrestin proteins
  JOURNAL   J Biol Chem 284 (37), 24996-25003 (2009)
   PUBMED   19605364
  REMARK    GeneRIF: Txnip regulates cellular metabolism independent of its
            binding to thioredoxin and the arrestin domains are crucial
            structural elements in metabolic functions of alpha-arrestin
            proteins
REFERENCE   10 (bases 1 to 3903)
  AUTHORS   Patwari,P., Higgins,L.J., Chutkow,W.A., Yoshioka,J. and Lee,R.T.
  TITLE     The interaction of thioredoxin with Txnip. Evidence for formation
            of a mixed disulfide by disulfide exchange
  JOURNAL   J Biol Chem 281 (31), 21884-21891 (2006)
   PUBMED   16766796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY738896.1, AK037198.1 and AV245884.1.
            
            On Aug 16, 2006 this sequence version replaced NM_001042592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037198.1, DQ861996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY738896.1         2-37
            37-3768             AK037198.1         4-3735
            3769-3852           AK037198.1         3738-3821
            3853-3903           AV245884.1         250-300
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 37.81 cM"
     gene            1..3903
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /note="arrestin domain containing 4"
                     /db_xref="GeneID:66412"
                     /db_xref="MGI:MGI:1913662"
     exon            1..470
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1420
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arrestin domain-containing protein 4"
                     /codon_start=1
                     /product="arrestin domain-containing protein 4 isoform 1"
                     /protein_id="NP_001036057.1"
                     /db_xref="CCDS:CCDS39985.1"
                     /db_xref="GeneID:66412"
                     /db_xref="MGI:MGI:1913662"
                     /translation="MGGEAGADGPRGRVKSLGLVFEDESKGCYSSGETVAGHVLLEAA
                     EPVALRGLRLEAQGRATSAWGPSAGARVCIGGGSPAASSEVEYLNLRLSLLEAPAGEG
                     VTLLQPGKHEFPFRFQLPSEPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVV
                     SHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENC
                     SSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTP
                     SILDCCIIRVDYSLAVYIHIPGAKRLMLELPLVIGTIPYSGFGRRNSSVASQFSMDMC
                     WLALALPEQPEAPPNYADVVSEEEFSRHVPPYPQPSDCDGEACYSMFACIQEFRFQPP
                     PLYSEVDPHPGDAQETQPVSFIL"
     exon            471..537
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..685
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            686..788
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1045
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1208
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1363
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..3903
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3900
                     /gene="Arrdc4"
                     /gene_synonym="2410003C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggtgtgtt aaagagacag ggccccagtg cgggtgtttc acccggctgg gcgctgtggc
       61 cgtagtggcc ctgggtgtgc ggccggcgcc cgtgacagca gcgtcgcgga gccggctacc
      121 ccgacctggg gccactgcgg atcttggtgg cagagccgca tcgcctggcg gaatgggagg
      181 cgaggcggga gccgatggtc ctcggggccg tgtcaagagc ttggggctag tgttcgaaga
      241 tgagagcaag ggctgctact caagcggcga gacagtggcc gggcacgtgc tgctggaggc
      301 ggcagagccg gtggccctgc gcggactgcg cctggaggcc cagggccgtg ccacctctgc
      361 ctggggcccg agcgctgggg ccagggtctg catcggtggg ggctctcccg cagcctcctc
      421 agaagtggaa tacttgaacc tgcggttgag tctgctggag gccccagctg gtgaaggtgt
      481 caccttgtta caaccaggaa aacacgagtt tccctttcgc tttcagcttc cgtctgaacc
      541 tttggcaaca tcgtttactg ggaagtatgg cagtattcag tactgtgtga gggctgtttt
      601 ggaacgaccc caagttccag atcagagcgt cagacgagag ctccaggttg tcagtcacgt
      661 ggatgtcaac acaccgccct tattgactcc tatgctgaag acgcaggaga aaatggttgg
      721 ctgttggctt ttcacctctg gtcctgtgtc actgagcgtc aagatcgaga gaaagggcta
      781 ctgtaacgga gaagctatcc ctatctatgc agaaatagaa aattgttcat ctcggctggt
      841 tgttcccaag gcagccatat tccaaaccca gacgtacttg gctagtggaa agacaaagac
      901 agtccggcac atggttgcca atgttcgagg aaaccacatt ggttctggga gtacggacac
      961 ctggaatggg aagatgctga agatcccacc tgtcacccca tccatcctgg attgctgcat
     1021 catcagagtg gactactcct tagctgtata cattcatatc cctggtgcta aaagattgat
     1081 gctggagctg cctttggtta ttggtacaat tccatacagt ggctttggcc gcagaaacag
     1141 cagtgtcgca agccagttca gtatggacat gtgctggttg gcactggccc taccggagca
     1201 gcctgaagca ccaccaaatt atgcagatgt ggtatcggaa gaagaattct cccgacacgt
     1261 tcctccgtac cctcagccct ctgactgtga cggggaagcc tgctactcaa tgtttgcctg
     1321 catacaagaa ttccgtttcc agcctccccc cctttattca gaggttgatc cacatcctgg
     1381 tgatgcccaa gagacccagc ctgtatcctt cattctctga acagactcca gacttcactg
     1441 tgttgttacc aacttagaat atcggttctt tcgcctgcct tgttggatga aagagaaagt
     1501 taacttcaga acatcggtga acttcaagtc cgaagatgag agaaatgaaa gaagatgaga
     1561 acgtttagtg ggccagggga atggttacac ggattctagg gtgggctccc ttgcacgctt
     1621 taaaagtgga tgaaaatagg aattggaaaa cgggaagtcc tggtggtgag agaggaagtg
     1681 aaagagtgcc cagactgttg agcagaggcg tcttaggacc tgggatgtta ctgaatgtta
     1741 ctggagtgtg ctttgaccag ggctcacaca cagttgtgaa cttatggact tggtaggaag
     1801 acatgatttg gggaacaaga cagctttgaa atgagtgaga atgagcgagt ggtctacttt
     1861 caatgcagtt gaactcccca gaccttgggg tcttcatgat ttcttatcat gttaccatag
     1921 caaggatcca ggtccttgct ggagtcagtg gtcatgtgac atcctgatgg aactgacagt
     1981 ggctccaggc tttcgtgagg aagctagaag ggattcctta acagcttgcc atatcaaaag
     2041 gaaaagagga actgttcatg aaagtgtgtg ttgtgaaggg ctgtacttac acttttaaga
     2101 actgcttgca gggtctatgt ttgattttcc tcgtccctta tttacctagg gaatattaga
     2161 aaaaggagga gtaggcggga catctttggg atacctgata ctgacacaga acagagtgtt
     2221 ctcttatcct acctctagtg gctttgtcag acctgctctc aaaagtccag gcctggctga
     2281 cctctggggt ttctgctcta tgcagttagc agactcctct caacctgtca cttgacctga
     2341 aaactagacc aagggaaatg tccacgagct cagcattaaa tagaaataaa tataaacacc
     2401 taagatctta agaaatccca aatcaaaaga ggacaggagc gtgcctaaac ttggttcctg
     2461 tgaagaggcc ccagtgggtg ggtgacagtt tccgtgtagt gcatttgtgt tccagtacat
     2521 tagtaattac attgatactg tgattttttt taattgtttt ggtgcaatat tttgttgtct
     2581 ttgagcctca ggatattaag acctaaggac tgtgttgttg ctggcagagt cagccatgtc
     2641 tctaccagcc tcctccctct gttcacagtc acatgctcag cctccagtct gttgctccca
     2701 tgaactgaga aaattttctg acaccaggtg ggagggagcc tctcacagtt aagagctgga
     2761 caagccaaat tctaagggtt tgatttagaa accctggtgc ttcccaggca gagtgttgtg
     2821 ccacacccat cgtggagatg gacttacctt tcagtcacca tgtttcctta gagacattct
     2881 cctagtgtga aattttatat caaaagtcag tggagcattc gttcagggat ttttgtacca
     2941 atgtccagta aatgtgtact tctccccgct gagcatacct ctcctgtggt catcctagcg
     3001 tcagtcacat gtatgtcact gtatgccatt ttcaaaaatg ccaaatggta ttgccagtaa
     3061 ctgtggtgtg tgagaatcac cacggaaccc tatttcttgt tttggttttt tagagatttc
     3121 tttcttttct tttctgttat gtgtctgtaa acagttagga ttgttcacat tccatctaaa
     3181 ctgcttttat ttttgccatg gaaaagatgg tgagctgtcc tttttttagc ttccagcctg
     3241 tagtttacgt gctatgtcaa gtcatggtcc atccataaaa ccaaaatgga gggaaagaaa
     3301 gcaacagtac ggagtggaca gagagaaaat ggagcgccgt ggctcactgt agataagccc
     3361 tggcagtcgg gttggttaga gaaatcatga agtcccccac agaacggaag cacagctaac
     3421 agtggcattg aagagtgcaa agatataact ttatacctgt ctgtctggcc tgaagcttat
     3481 acccaggata acaggaatgt agaaaactac atctgaaacc ctgtgactga agatcagact
     3541 tttagctgct aacacttgcc tgtctagtcc cctcttgctc tcatttagtt tgggaaaaac
     3601 gaaaagtgcc cttaggattt tcttttggat gcacaaagct tgcgattcaa agtgagcatc
     3661 ttttggtgca cacagaccct tcccttcccc tggagcacaa ctttactttc tgtgtctctg
     3721 ttttgcacaa taagaaactc agtaggcaaa ggttgtgttt ttttttttgg taagttcact
     3781 tgctttttaa aatttttatt aaaaatgtaa taatttaacc aaggggaaaa taaagattgt
     3841 attttgtatt cttctttgaa ccccatgggt tcctttttgt taataaaatg gttatactaa
     3901 tga
//
