LOCUS       NM_001042591            4099 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus arrestin domain containing 3 (Arrdc3), transcript
            variant 1, mRNA.
ACCESSION   NM_001042591
VERSION     NM_001042591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   La Marca,J.E., Aubrey,B.J., Yang,B., Chang,C., Wang,Z., Kueh,A.,
            Tai,L., Wilcox,S., Milla,L., Heinzel,S., Vremec,D., Whelan,L.,
            Konig,C., Kaloni,D., Voss,A.K., Strasser,A., Diepstraten,S.T.,
            Herold,M.J. and Kelly,G.L.
  TITLE     Genome-wide CRISPR screening identifies a role for ARRDC3 in
            TRP53-mediated responses
  JOURNAL   Cell Death Differ 31 (2), 150-158 (2024)
   PUBMED   38097622
  REMARK    GeneRIF: Genome-wide CRISPR screening identifies a role for ARRDC3
            in TRP53-mediated responses.
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Ross,J.A., Arcos-Villacis,N., Battey,E., Boogerd,C., Orellana,C.A.,
            Marhuenda,E., Swiatlowska,P., Hodzic,D., Prin,F., Mohun,T.,
            Catibog,N., Tapia,O., Gerace,L., Iskratsch,T., Shah,A.M. and
            Stroud,M.J.
  TITLE     Lem2 is essential for cardiac development by maintaining nuclear
            integrity
  JOURNAL   Cardiovasc Res 119 (11), 2074-2088 (2023)
   PUBMED   37067297
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   Zapparoli,E., Briata,P., Rossi,M., Brondolo,L., Bucci,G. and
            Gherzi,R.
  TITLE     Comprehensive multi-omics analysis uncovers a group of
            TGF-beta-regulated genes among lncRNA EPR direct transcriptional
            targets
  JOURNAL   Nucleic Acids Res 48 (16), 9053-9066 (2020)
   PUBMED   32756918
  REMARK    GeneRIF: Comprehensive multi-omics analysis uncovers a group of
            TGF-beta-regulated genes among lncRNA EPR direct transcriptional
            targets.
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Liu,Y.G., Teng,Y.S., Shan,Z.G., Cheng,P., Hao,C.J., Lv,Y.P.,
            Mao,F.Y., Yang,S.M., Chen,W., Zhao,Y.L., You,N., Zou,Q.M. and
            Zhuang,Y.
  TITLE     Arrestin domain containing 3 promotes Helicobacter
            pylori-associated gastritis by regulating protease-activated
            receptor 1
  JOURNAL   JCI Insight 5 (15), 135849 (2020)
   PUBMED   32634127
  REMARK    GeneRIF: Arrestin domain containing 3 promotes Helicobacter
            pylori-associated gastritis by regulating protease-activated
            receptor 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4099)
  AUTHORS   Batista,T.M., Dagdeviren,S., Carroll,S.H., Cai,W., Melnik,V.Y.,
            Noh,H.L., Saengnipanthkul,S., Kim,J.K., Kahn,C.R. and Lee,R.T.
  TITLE     Arrestin domain-containing 3 (Arrdc3) modulates insulin action and
            glucose metabolism in liver
  JOURNAL   Proc Natl Acad Sci U S A 117 (12), 6733-6740 (2020)
   PUBMED   32156724
REFERENCE   6  (bases 1 to 4099)
  AUTHORS   O'Leary,J. and Osborne,L.R.
  TITLE     Global analysis of gene expression in the developing brain of
            Gtf2ird1 knockout mice
  JOURNAL   PLoS One 6 (8), e23868 (2011)
   PUBMED   21909369
REFERENCE   7  (bases 1 to 4099)
  AUTHORS   Patwari,P., Chutkow,W.A., Cummings,K., Verstraeten,V.L.,
            Lammerding,J., Schreiter,E.R. and Lee,R.T.
  TITLE     Thioredoxin-independent regulation of metabolism by the
            alpha-arrestin proteins
  JOURNAL   J Biol Chem 284 (37), 24996-25003 (2009)
   PUBMED   19605364
  REMARK    GeneRIF: Txnip regulates cellular metabolism independent of its
            binding to thioredoxin and the arrestin domains are crucial
            structural elements in metabolic functions of alpha-arrestin
            proteins
REFERENCE   8  (bases 1 to 4099)
  AUTHORS   Patwari,P., Higgins,L.J., Chutkow,W.A., Yoshioka,J. and Lee,R.T.
  TITLE     The interaction of thioredoxin with Txnip. Evidence for formation
            of a mixed disulfide by disulfide exchange
  JOURNAL   J Biol Chem 281 (31), 21884-21891 (2006)
   PUBMED   16766796
REFERENCE   9  (bases 1 to 4099)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 4099)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009711.11.
            
            On Oct 5, 2022 this sequence version replaced NM_001042591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054844.1, SRR13862062.45824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               CT009711.11        85667-86184
            519-600             CT009711.11        89661-89742
            601-748             CT009711.11        91344-91491
            749-851             CT009711.11        92351-92453
            852-1108            CT009711.11        92789-93045
            1109-1271           CT009711.11        93317-93479
            1272-1426           CT009711.11        93743-93897
            1427-4099           CT009711.11        95625-98297
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 41.95 cM"
     gene            1..4099
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /note="arrestin domain containing 3"
                     /db_xref="GeneID:105171"
                     /db_xref="MGI:MGI:2145242"
     exon            1..518
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1483
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /codon_start=1
                     /product="arrestin domain-containing protein 3"
                     /protein_id="NP_001036056.1"
                     /db_xref="CCDS:CCDS36736.1"
                     /db_xref="GeneID:105171"
                     /db_xref="MGI:MGI:2145242"
                     /translation="MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRV
                     KSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGF
                     HTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFE
                     HIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCS
                     SRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPS
                     ILDCSIIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSRTSSVSSQCSMSMNW
                     LALALPERPEAPPSYAEVVTEEQRRNNLAPVGACDDFERALQGPLFAYIQEFRFLPPP
                     LYSEIDPNPDQSSEDRPSCPSR"
     exon            519..600
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            601..748
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            749..851
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1108
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1271
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1426
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..4099
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4065..4070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /note="hexamer: AATAAA"
     polyA_site      4099
                     /gene="Arrdc3"
                     /gene_synonym="mKIAA1376"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgtaa ggagaccact gagacgagca ggagcgtgga gcagcggctt ctctgctgcc
       61 ctgacttttt aagaaatctc aatgaactat ttgtagacaa tcactgatcc tgcctgcatg
      121 attttttttt cttgcacggc aaagacaccc atcagtgtta agtgaagatc acatcttata
      181 tgcgatcttg actttttttt tggtcttaca ttatattttt atagattttg ttataatcat
      241 ggtgctggga aaggtaaaga gtttgacaat aagctttgac tgtcttaatg acagtaatgt
      301 ccccgtgtat tctagcgggg acactgtctc aggaagggta aatttagaag ttaccgggga
      361 gatcagagta aaatctctta aaattcacgc aagaggacat gcgaaagtac ggtggacgga
      421 atcaagaaac gccggctcca atactgccta tacacagaat tacactgaag aagtagaata
      481 tttcaaccat aaagacatct taattgggca cgaaagagat gatgataatt ctgaagaagg
      541 cttccacact attcattcag gaaggcatga atatgcattt agcttcgagc ttccacagac
      601 accacttgct acctcattcg aaggccgaca tggcagtgtg cgctattggg tgaaagccga
      661 attgcatagg ccttggcttc taccagtaaa attaaagaag gaatttacag tctttgagca
      721 catagatatc aacactcctt cattactgtc accccaagca ggcacaaaag aaaagacact
      781 ctgttgctgg ttctgcacct caggccccat atccttaagt gccaagattg aaaggaaggg
      841 ctacacccca ggtgaatcaa tccagatatt tgccgagatt gagaactgct cttcccgaat
      901 ggtagtgcca aaggcggcca tttaccagac gcaggccttc tatgccaaag ggaaaatgaa
      961 ggaagtaaaa cagcttgtgg caaacttacg tggcgagtct ttatcctctg ggaagacaga
     1021 gacgtggaat ggcaagctgc tcaaaatccc accggtttca ccctccatcc tcgactgtag
     1081 tataatccga gtggaatatt cgctaatggt gtacgtggat attcctgggg ccatggattt
     1141 gcttctcagt ttgcccctcg tcatcgggac catccctctg cacccgtttg gtagcagaac
     1201 ctcaagtgtg agcagtcagt gtagcatgag tatgaactgg ctggctctgg cccttcctga
     1261 aagacctgaa gcaccaccca gctatgcaga ggttgtaacg gaggaacaga gacggaataa
     1321 tctcgcccca gtgggtgctt gtgatgattt tgagagagct ctccaaggac cactgtttgc
     1381 ttatatccag gagtttcggt tcctgccccc acctctctat tcagagattg atccaaatcc
     1441 tgatcagtca tccgaggaca gaccatcatg cccctctcgc tgaagcaaca cttgactgag
     1501 tcaagttgac atgggttctg aactgtatct cttccagctg aggacagaga agtatcttgg
     1561 agacacgttt gcagaggaag tggaattgcc tttgcccaga cagatggcaa acacatgaaa
     1621 caaccagtga tcatgcttta gaatcctaca gcatcatttg gggctgttcc aacatgcttg
     1681 aagatctgag ctttccttct ttaaaactgg cacatgttaa gggcagtctt cttagcctgt
     1741 ggtcatccgt gtcaagacac cattgcaaag aaggatgttg tccttcctat ttgaaaattt
     1801 gcacatgctc aatgcttaca ttgtgcagtt cagtgtcact acagcatttt ttttccattt
     1861 atgccagact cttgatactc ttacaacttg tttatggtca gcacaacatg gaacaaaaga
     1921 aagctttgaa aaactttgac attaaaaaaa caaaacaaaa tgcactgaca ggtttttttt
     1981 cttagttttt tgttttgttt tgttttttgg gttttttgtt tgtttgttaa gttaatgtag
     2041 cctggactct acctgcatat gcacatgctc agaattgtcc tactaggctg accatgtatc
     2101 acctcttcag cttggatcct actgtggatt tatttacaaa catcaaatgc cttcaagcca
     2161 atccttttgc tgtatgtttt gcagcctact gtagtagata agcaacagat acaaggagaa
     2221 aagagacaag aggaggaggc tgacaagaga ctttgtatgg ctgttgtttg gttttctgtg
     2281 agagtgttgc ctttctacta ttgatagcag agcagccttg tgttactgac tgcctaacat
     2341 cactcaatct caggtgaatg catcacttgc caaactgttg gaatgccgtc tatgtttgtt
     2401 gcactgttat gttgttgttg ttgttgttaa ttgttgttat ttggttggat tttttggaga
     2461 gggatattcg gaaatgggac atacacaaaa ctgataaccc acccacattc ccctttttat
     2521 cattacatat aagaagaaac aaagctcaga gtggagaaag acagtagggc gggcaccagc
     2581 agaggcaagg gctgttgctc tggaaaaata tttttattat tttaaaaacg agtggaagct
     2641 gcccggtcac tagggaaggg agggaaaagt gcatttattt ttatacagag ttacttaatt
     2701 acctccaaaa cacatatgtt ggaaatcagt tttgctgatg caaggtactt caataagcca
     2761 gaatatatca aggtcatgat gggggaagct tcatttatac atttgctcaa gtttgagaga
     2821 ataaaatccc aaatttgttt ccaaagtgtg taactttata agtagaaaaa ctagaatgtt
     2881 tgctgggata agtagcttta gtttgtacac gtgtataata ttgtttttca acaatttttc
     2941 ctgtcatcta agaaacattg ataggtctct agctttgagt atatataggt agagcaacac
     3001 atgagtaaat tatttttaaa gataatttat ggttggattg taaccatata ctaacattca
     3061 tgaaacaact aaaaccccca ccttctcaaa gtacaaaata gagtgatttt gtaagagttg
     3121 gcttgtgttc ttagtgacac cagcatctct gatgttacaa catcatgtgt gagatggagc
     3181 ttgtcatctg cccaccttgc cctctgcccc acagttacag tgcctgagaa gactcggaac
     3241 gctggcctgg tgcttgacct ggttaaatac tgtcttaaag cttcatacaa aataggcttt
     3301 tccataagtg gcctttaaga aaacatggaa gataattcat gtttgaaata atgctgacag
     3361 ggtgaagaaa gcccgttgta aaaatgaatc gcgttttaag tgattcagtt aaagggtttg
     3421 tgctcccata gcaaactaat actagataat aaggaaatgg ggtgaattat ttttttaatt
     3481 gttaaatcat tttgtgaatg tcccccaccc ccagaagaag ctgatgggat atttggcata
     3541 aagggcattt ggtggttttg ttttcgttgg tagggattgt ctgaaaacac ctgactctgt
     3601 gttatgtcta actagggaac aattgttggt gtgcatggcc ttgggcactc actaccatgt
     3661 tcgacaaagt actctattag caagaatgac caatattctg attaattggc actggtgaca
     3721 aaattctttt acgatttggc aaaataaggt tttacttttc ccattaatta tttctttact
     3781 ctttagaggc attatacttc taaatattgg tcaattcttg acataacacc tgagggccac
     3841 agtcatgctc tagtattcaa gatagcttcc taatttttca tttaggaaaa gtcaaatcca
     3901 aaatgtttga gaaacaaagt gcaatattaa atgtttgctt tatagattat attctatggc
     3961 tgttgtaatc ttttatttgg tgctgaatat gtccttgtag gctctgtttt aagaaaacca
     4021 tgtgggaaat gatttaactt ttcctattgc tcttccttgt ggaaaataaa agtgtttttt
     4081 tttttctgtt tttgtataa
//
