LOCUS       NM_027560               2346 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus arrestin domain containing 2 (Arrdc2), mRNA.
ACCESSION   NM_027560 XM_134227
VERSION     NM_027560.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Laskin,G.R., Cabrera,A.R., Greene,N.P., Tomko,R.J. Jr., Vied,C. and
            Gordon,B.S.
  TITLE     The mechanosensitive gene arrestin domain containing 2 regulates
            myotube diameter with direct implications for disuse atrophy with
            aging
  JOURNAL   Am J Physiol Cell Physiol 326 (3), C768-C783 (2024)
   PUBMED   38314723
  REMARK    GeneRIF: The mechanosensitive gene arrestin domain containing 2
            regulates myotube diameter with direct implications for disuse
            atrophy with aging.
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Nott,A., Cheng,J., Gao,F., Lin,Y.T., Gjoneska,E., Ko,T., Minhas,P.,
            Zamudio,A.V., Meng,J., Zhang,F., Jin,P. and Tsai,L.H.
  TITLE     Histone deacetylase 3 associates with MeCP2 to regulate FOXO and
            social behavior
  JOURNAL   Nat Neurosci 19 (11), 1497-1505 (2016)
   PUBMED   27428650
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Patwari,P., Higgins,L.J., Chutkow,W.A., Yoshioka,J. and Lee,R.T.
  TITLE     The interaction of thioredoxin with Txnip. Evidence for formation
            of a mixed disulfide by disulfide exchange
  JOURNAL   J Biol Chem 281 (31), 21884-21891 (2006)
   PUBMED   16766796
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   Nichols,C.D. and Sanders-Bush,E.
  TITLE     Molecular genetic responses to lysergic acid diethylamide include
            transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta
            and ILAD-1, a novel gene with homology to arrestins
  JOURNAL   J Neurochem 90 (3), 576-584 (2004)
   PUBMED   15255935
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK014582.1.
            
            On Jan 24, 2005 this sequence version replaced XM_134227.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014582.1, AK137175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.26 cM"
     gene            1..2346
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /note="arrestin domain containing 2"
                     /db_xref="GeneID:70807"
                     /db_xref="MGI:MGI:1918057"
     exon            1..593
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1543
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /note="induced by lysergic acid diethylamide-1"
                     /codon_start=1
                     /product="arrestin domain-containing protein 2"
                     /protein_id="NP_081836.1"
                     /db_xref="CCDS:CCDS40376.1"
                     /db_xref="GeneID:70807"
                     /db_xref="MGI:MGI:1918057"
                     /translation="MLFDKVKAFVVEIDGARTGTEPVFHGGQAVAGRVLLELAGAARV
                     GALRLRARGRARAHWTESRSAGSSTAYTQSYSERVEVVNHRATLLAPDSGDIATLPAG
                     RHEFPFSFQLPISLVTSFEGKHGSVRYSIKATLHRPWVPARCARKVFTVIEPVDINTP
                     ALLEPQAGAREKVARSWYCTRGLVSLSAKIDRKGYTPGEVIPIFAEIDNGSTRAVQPR
                     AALVQTQTFMARGARKQKRAVVASVDGEPVGPNRRALWPGRALRIPPVGPSILQCRVL
                     SVDYSLKVFVDIPGSSKLLLELPLVIGTVPLHPLGSRSASVGSRASFLQDWGLCTMMD
                     RPEAPPEYSEVVRESQLVCASPGPSSLLHDLGVTTEGPYFACLQEFRYCPPPLYSEED
                     PNPPSEAVRPRCMTC"
     exon            594..660
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..808
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..911
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1168
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1331
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1489
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2346
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2346
                     /gene="Arrdc2"
                     /gene_synonym="4632416I05Rik; Ilad1"
                     /note="putative"
ORIGIN      
        1 gagtcttctc ctgaaggtgt ggctttctcc tcaggccatt ccttcgccgc gctattggcc
       61 tagtcttttc tggggtcccg ttccctactg ctgtgtttgc ggagtctctt ccggtaggtg
      121 cggtcttctc ctcaggcccc gccctccaac cgtcctataa gtgcgacgca gctgcgggtc
      181 cccagcggtc ttccgtcctg ttgtcccgct tgtgtgtgta cgtagttcga gcccgctgcg
      241 ttcgcagtct ctagctcttt cttttcgcgg gttcgagcac ctggccgatc tcttttttgg
      301 gttcgcgacc gtcaccgcaa tgctgttcga taaggtgaag gcgttcgtag tagagataga
      361 cggggcgcgc acgggcaccg agcccgtgtt ccacggaggc caggccgtgg caggccgggt
      421 actgttggag cttgcgggcg cggcacgcgt gggcgcgctc aggctgcgcg ctcggggccg
      481 cgcgcgcgcg cactggacgg agtcgcgcag cgcgggctcc agcactgctt atactcagag
      541 ttacagcgag cgcgtggaag tcgtgaacca ccgcgccacg ctgctcgcgc cagactcggg
      601 ggatatcgcc acgcttcccg ctggacgcca cgagtttccc ttcagcttcc agctgcctat
      661 ctccctggtg acatccttcg agggcaaaca cggcagcgtc cgctattcca tcaaagccac
      721 tctgcaccgg ccatgggtcc ctgcacgctg cgcccggaag gtgttcactg tcattgaacc
      781 tgtggacata aacacacctg ccctgctgga accccaggct ggagcccggg agaaggtggc
      841 acgatcctgg tactgcacac gtggcctcgt gtccctctcg gccaagattg accgcaaagg
      901 ctacactcca ggcgaggtca tccctatctt tgcggagatt gacaatggtt ccacgcgagc
      961 tgtgcagccc cgtgctgccc tagtacagac acagaccttc atggcccgag gtgcccgcaa
     1021 gcagaagcgt gctgtggtgg ccagtgtgga cggggagcct gtgggcccga atcgccgtgc
     1081 gctgtggccc ggtcgtgcgc tgcgtatccc cccggtgggc ccgtccatct tgcagtgccg
     1141 cgtgcttagt gtggactact cactcaaggt cttcgtggac attccaggct cgtccaagct
     1201 gctgctggag ctgcctctgg tcataggcac ggtccccctg catcctctgg gcagccgctc
     1261 cgctagtgtg ggcagccgcg ccagcttcct gcaagactgg ggcctgtgca ccatgatgga
     1321 tcggccagag gccccacctg agtactccga ggtggtgagg gagagccagc tggtatgtgc
     1381 gtcaccgggg ccctcctccc tcctacacga cctaggtgtg accacagaag ggccctactt
     1441 tgcctgtctc caggagttcc gctactgccc gcctcctctg tactccgagg aggaccctaa
     1501 cccaccctca gaggctgtga ggccacgctg catgacctgc tgatccatgg gctgacaact
     1561 tcggtaccag gttcacactc tttggccatg aagtcccgcc atctgctttg ggaacacagg
     1621 gttaaatgag gcaatgtgtc tcccaacatt gcaaaggagc agcatggctt ccaaggacag
     1681 tccatcttct caaagcttct ggttctctgc gtttagaccc accaacgagg ctgtggagca
     1741 atgctcggct cctctaggga actgtagttt gggagagatg aatctaggaa tggacacttc
     1801 cagtctcaag gaaccagaac cagctagaag tccagagggg agacagaaga cttccaaagg
     1861 gcatttcggc tgaggctttg agatatgaac aggagctcag caagcagaca agcacagagg
     1921 aaatggtcag agcagatagc gcccattcct tcttcctacg gttgggagcc caggcattaa
     1981 ggtgtcttag acatggcctc actgtgaggt tagcagggca gagggctcag ggacagacac
     2041 aaaggagaag tcattgggac ctgaaggtcc agaggctcca gcttttgtga actggtggcc
     2101 caggtgaacc cagagctgca gttgtgatct gccatgttca gaacctgcag cctccctcag
     2161 gggtcaggat acagacaagt acatcgcaag gagaacaggc aactggggca gctggggaca
     2221 tcacaaggag aacaggcaac tgggggcagc tgggcaaatc ccccacatcc cagacctgcc
     2281 agggacttgc catttcaatg gtctgaagaa ttgttcactt ttatatatta aataaataaa
     2341 aatggg
//
