LOCUS       NM_001162485            1695 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus arrestin domain containing 1 (Arrdc1), transcript
            variant 1, mRNA.
ACCESSION   NM_001162485
VERSION     NM_001162485.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Mackenzie,K., Foot,N.J., Anand,S., Dalton,H.E., Chaudhary,N.,
            Collins,B.M., Mathivanan,S. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter via membrane
            budding
  JOURNAL   Cell Discov 2, 16011 (2016)
   PUBMED   27462458
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732525.13.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004091.1, AK170018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AL732525.13        198040-198293       c
            255-365             AL732525.13        190741-190851       c
            366-416             AL732525.13        190138-190188       c
            417-571             AL732525.13        189890-190044       c
            572-754             AL732525.13        189557-189739       c
            755-931             AL732525.13        189284-189460       c
            932-1370            AL732525.13        188768-189206       c
            1371-1695           AL732525.13        188364-188688       c
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.84 cM"
     gene            1..1695
                     /gene="Arrdc1"
                     /note="arrestin domain containing 1"
                     /db_xref="GeneID:215705"
                     /db_xref="MGI:MGI:2446136"
     exon            1..254
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1441
                     /gene="Arrdc1"
                     /note="isoform a is encoded by transcript variant 1;
                     arrestin domain-containing protein 1; alpha-arrestin 1"
                     /codon_start=1
                     /product="arrestin domain-containing protein 1 isoform a"
                     /protein_id="NP_001155957.1"
                     /db_xref="CCDS:CCDS50521.1"
                     /db_xref="GeneID:215705"
                     /db_xref="MGI:MGI:2446136"
                     /translation="MGRVQLFEIRLSQGRVVYGPGEPLAGTVHLRLGAPLPFRAIRVT
                     CMGSCGVSTKANDGAWVVEESYFNSSLSLADKGSLPAGEHNFPFQFLLPATAPTSFEG
                     PFGKIVHQVRASIDTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASTTKKFSYKL
                     VKTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAKRWIYD
                     VRTIAEVEGTGVKAWRRAQWQEQILVPALPQSALPGCSLIHIDYYLQVSMKAPEATVT
                     LPLFVGNIAVNQTPLSPCPGRESSPGTLSLVVPSAPPQEEAEAVASGPHFSDPVSLST
                     KSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHSLHPPLCISIGATVPYFAEGSAGPV
                     PTTSALILPPEYSSWGYPYEAPPSYEQSCGAAGTDLGLIPGS"
     exon            255..365
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..416
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..571
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..754
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..931
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1370
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1695
                     /gene="Arrdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrdc1"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="Arrdc1"
                     /note="major polyA site"
ORIGIN      
        1 gggggggcag cagctagtat tccggtccag gcgggtcctg cggcctgggc gtgtcctctg
       61 tcggggaggg gaagaggggc gggcctcgaa gccactactc tagcaggcgt cagaccgcgg
      121 cgcgggagac cgcggtatgg ggagggtgca gctcttcgag atccgcctga gtcagggccg
      181 cgtcgtctac ggtcctgggg agccgctggc tgggaccgtg cacttgcgcc tgggagcgcc
      241 actgcccttc cgagctatcc gggtgacctg catgggttcc tgtggggtct ccaccaaggc
      301 caacgatggg gcatgggtgg tggaggagag ctacttcaac agctccctgt cactggctga
      361 caagggaagt ctgccggctg gagagcacaa cttccctttt cagttcctgc ttcctgccac
      421 agcacccaca tcttttgagg gaccctttgg gaagattgta caccaggtga gggcgtccat
      481 cgacactcca cgtttttcca aggatcacaa atgtagcctc gtgttctaca tcctgagccc
      541 cttgaacctg aacagcatcc cagatattga gcaacccaat gtggcctcca ctaccaagaa
      601 gttctcctat aagctggtga agactggcaa tgtggttctc acagctagca ctgaccttcg
      661 tggctatgtg gtgggacagg tgctgcggct gcaggctgac attgagaacc agtcaggcaa
      721 ggacaccagc cctgtggtgg ccagcttgct acagaaggta tcctataagg ccaagcgctg
      781 gatctatgat gtgcggacca ttgcagaggt ggagggtaca ggtgtcaagg cctggaggcg
      841 tgctcagtgg caagaacaga tcctggtgcc tgccctgccc cagtcagccc tgcctggctg
      901 cagccttatc catatcgact attaccttca ggtctccatg aaggcacctg aggccaccgt
      961 gactctccca ctatttgttg gcaatattgc tgtgaaccaa actccactga gtccctgtcc
     1021 aggccgagag tcttctcctg ggaccctatc cctagtggtg ccctctgcac caccccagga
     1081 agaggctgag gcagtggcta gtggccctca cttctcagac ccagtttctc tctccaccaa
     1141 gagccactct cagcagcagc cactgtcggc tcccttgggt tctgtgtctg tcaccaccac
     1201 tgagccctgg gttcaggttg gaagccctgc tagacattct ctgcaccctc ccttgtgcat
     1261 ctctataggt gccactgtcc cctactttgc agaaggctct gcgggcccag tacccaccac
     1321 cagcgccttg atcctccctc cagagtacag ttcatggggc tacccctatg aggccccgcc
     1381 gtcctatgag cagagctgtg gtgctgctgg tacagacctt ggcctgatcc caggaagctg
     1441 accctggtgt gctaacccat accaccttgt tcggtggttc tggcctttgc cttggcatgg
     1501 aatgtccagg gcctcgtgcc tttgctctct acctggctca gctactcagg acctgcagct
     1561 gtcgggatga ccccttgtgg accagccact cctggctcct ctggaattac tcagtcctcc
     1621 tcttaagagg ttggggtagg gcggcagaga tctgggcctg gagagactgt ataaataaag
     1681 cgctttattt gtaga
//
