LOCUS       NM_145429               1955 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus arrestin, beta 2 (Arrb2), transcript variant 3, mRNA.
ACCESSION   NM_145429 XM_993633
VERSION     NM_145429.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Chen,T.T., Li,X.Q., Li,N., Xu,Y.P., Wang,Y.H., Wang,Z.Y.,
            Zhang,S.N., Qi,M., Zhang,S.H., Wei,W., Wang,H. and Sun,W.Y.
  TITLE     beta-arrestin2 deficiency ameliorates S-100-induced autoimmune
            hepatitis in mice by inhibiting infiltration of monocyte-derived
            macrophage and attenuating hepatocyte apoptosis
  JOURNAL   Acta Pharmacol Sin 44 (10), 2048-2064 (2023)
   PUBMED   37225848
  REMARK    GeneRIF: beta-arrestin2 deficiency ameliorates S-100-induced
            autoimmune hepatitis in mice by inhibiting infiltration of
            monocyte-derived macrophage and attenuating hepatocyte apoptosis.
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Li Feng,G., Grynpas,M.D. and Mitchell,J.
  TITLE     beta-Arrestin 2 knockout prevents bone loss in response to
            continuous parathyroid hormone stimulation in male and female mice
  JOURNAL   Connect Tissue Res 64 (4), 350-361 (2023)
   PUBMED   37046359
  REMARK    GeneRIF: beta-Arrestin 2 knockout prevents bone loss in response to
            continuous parathyroid hormone stimulation in male and female mice.
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Nardou,R., Sawyer,E., Song,Y.J., Wilkinson,M.,
            Padovan-Hernandez,Y., de Deus,J.L., Wright,N., Lama,C., Faltin,S.,
            Goff,L.A., Stein-O'Brien,G.L. and Dolen,G.
  TITLE     Psychedelics reopen the social reward learning critical period
  JOURNAL   Nature 618 (7966), 790-798 (2023)
   PUBMED   37316665
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Martinez,J.M., Shen,A., Xu,B., Jovanovic,A., de Chabot,J., Zhang,J.
            and Xiang,Y.K.
  TITLE     Arrestin-dependent nuclear export of phosphodiesterase 4D promotes
            GPCR-induced nuclear cAMP signaling required for learning and
            memory
  JOURNAL   Sci Signal 16 (778), eade3380 (2023)
   PUBMED   36976866
  REMARK    GeneRIF: Arrestin-dependent nuclear export of phosphodiesterase 4D
            promotes GPCR-induced nuclear cAMP signaling required for learning
            and memory.
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Palczewski,K., Van Hooser,J.P., Garwin,G.G., Chen,J., Liou,G.I. and
            Saari,J.C.
  TITLE     Kinetics of visual pigment regeneration in excised mouse eyes and
            in mice with a targeted disruption of the gene encoding
            interphotoreceptor retinoid-binding protein or arrestin
  JOURNAL   Biochemistry 38 (37), 12012-12019 (1999)
   PUBMED   10508404
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Xu,J., Dodd,R.L., Makino,C.L., Simon,M.I., Baylor,D.A. and Chen,J.
  TITLE     Prolonged photoresponses in transgenic mouse rods lacking arrestin
  JOURNAL   Nature 389 (6650), 505-509 (1997)
   PUBMED   9333241
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Kingsmore,S.F., Peppel,K., Suh,D., Caron,M.G., Lefkowitz,R.J. and
            Seldin,M.F.
  TITLE     Genetic mapping of the beta-arrestin 1 and 2 genes on mouse
            chromosomes 7 and 11 respectively
  JOURNAL   Mamm Genome 6 (4), 306-307 (1995)
   PUBMED   7613043
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   McGinnis,J.F., Austin,B.J., Stepanik,P.L. and Lerious,V.
  TITLE     Light-dependent regulation of the transcriptional activity of the
            mammalian gene for arrestin
  JOURNAL   J Neurosci Res 38 (4), 479-482 (1994)
   PUBMED   7932878
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Shinohara,T., Kikuchi,T., Tsuda,M. and Yamaki,K.
  TITLE     A family of retinal S-antigens (arrestins) and their genes:
            comparative analysis of human, mouse, rat, bovine and Drosophila
  JOURNAL   Comp Biochem Physiol B 103 (3), 505-509 (1992)
   PUBMED   1458825
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY201367.1, AK159317.1 and AL596096.7.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_145429.6.
            
            On Sep 19, 2012 this sequence version replaced NM_145429.4.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded isoform (b) is shorter than isoform a. Variants 3 and 4
            encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162889.1, AK159317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BY201367.1         1-77
            78-1801             AK159317.1         6-1729
            1802-1955           AL596096.7         123253-123406
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1955
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /note="arrestin, beta 2"
                     /db_xref="GeneID:216869"
                     /db_xref="MGI:MGI:99474"
     exon            1..174
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1384
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /note="isoform b is encoded by transcript variant 3; beta
                     arr2; beta-arrestin-2; arrestin 3"
                     /codon_start=1
                     /product="beta-arrestin-2 isoform b"
                     /protein_id="NP_663404.1"
                     /db_xref="CCDS:CCDS24946.1"
                     /db_xref="GeneID:216869"
                     /db_xref="MGI:MGI:99474"
                     /translation="MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLV
                     DPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPMPNPPRPPTRLQ
                     DRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSIEEKSH
                     KRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRSLHLEASLDKELYYHGEPLNV
                     NVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTI
                     TPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRG
                     GDVSVELPFVLMHPKPHDHITLPRPQSAPRETDVPVDTNLIEFDTNYATDDDIVFEDF
                     ARLRLKGMKDDDCDDQFC"
     exon            175..205
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..266
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            267..311
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..508
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..568
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..636
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..775
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..860
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..933
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1071
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1155
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1235
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1290
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1955
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /note="hexamer: AATAAA"
     polyA_site      1802
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /note="major polyA site"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
                     /note="hexamer: AATAAA"
     polyA_site      1930
                     /gene="Arrb2"
                     /gene_synonym="Arr3"
ORIGIN      
        1 gacccagacc gcgaggggag gggaaggagg agaaagagtg aggacgcgcg tgcgcagtgg
       61 cgcggggagg agcggggacc tggcagcagg cgaggaggct gcgagcgagc cgcgaacccg
      121 gcgggcggag ggcggcgagc gcgcgcgcac catgggagaa aaacccggga ccagggtctt
      181 caagaagtcg agccctaact gcaagctcac cgtgtacttg ggcaagcgcg actttgtaga
      241 tcacctggac aaagtggacc ctgtggatgg cgtggtgctt gtggatcctg actacttgaa
      301 ggaccggaaa gtgttcgtga ccctcacctg tgccttccgc tatggccgag aagacctgga
      361 tgtactgggc ctgtctttcc gcaaagatct gttcatcgcc acctaccagg ccttcccccc
      421 catgcccaac ccacctcggc cccccacccg cctacaggac cgactgctga agaagttggg
      481 ccaacacgcc caccccttct ttttcacgat accccaaaat ttgccttgct ccgtcacact
      541 gcagccagga ccagaggaca cagggaaggc ttgtggagta gactttgaga ttcgagcttt
      601 ctgtgccaaa tcaatagaag aaaaaagtca caagaggaac tctgtgcggc ttatcatcag
      661 aaaggtacag tttgctcctg agacacccgg tccccagccc tcagctgaaa ccacacgcca
      721 cttcctcatg tctgaccgga ggtccctcca cctagaggct tccctggaca aagagctgta
      781 ctaccacggg gagcccctta atgtcaacgt ccatgtcacc aacaattctg ccaagaccgt
      841 caagaagatc agagtgtctg tgagacagta cgccgacatt tgcctcttca gcaccgcgca
      901 gtacaagtgt cccgtggctc agctagaaca agatgaccag gtgtctccta gttccacgtt
      961 ctgcaaggtg tacaccatca ccccgctgct cagtgacaac cgagagaagc gtggccttgc
     1021 cttggatggg cagctcaaac atgaagacac caacctggct tccagcacca ttgtgaagga
     1081 gggagccaac aaggaggtgc tggggatcct ggtatcctac agggtcaagg tgaagctggt
     1141 ggtgtctcga ggcggagatg tctccgtgga gctacccttc gtcctaatgc accccaagcc
     1201 ccatgaccac atcacccttc ccagacccca gtcagccccc cgggaaacag acgtgcctgt
     1261 ggataccaac ctcatcgaat tcgataccaa ctatgccaca gacgatgaca tcgtgtttga
     1321 ggactttgcc cggctccggc tgaagggaat gaaggatgat gactgtgatg accagttttg
     1381 ctaggacgag gggctgggag aggtaggggc gggcaggact caggtcccac ggccctcgag
     1441 ggtgggaggg tcccagcctc tcctccttcc ccgtctgtcc gtctgtccac ccgagataca
     1501 cactggaccc atcacttgtt gaaagtgggc attaatcttc tgacttcagc tcgctgcccc
     1561 agccccgctc cctagggcgg caagctgtgt acacacctaa agttttggga agggaacagt
     1621 gaacgcaagg agtgaatgta gagaaaaggt gtagaaagaa cgcccatgtt tggcctcaca
     1681 ccaactcgcc cccagtcacc acttctgcct cccaatcctt gaagacgaga ctttggggag
     1741 gggtgagcaa ggccatttct ttgtttctga gcatagggaa gaaataaacc ttttaatagg
     1801 catgaatgtg tatgtgttct gtcagcggag tttaaggggt gtccagtgta cccatccatg
     1861 atgctttttt ctacatctgc agggtacctt acttgggtta tcaataaatg tttgctggat
     1921 gactgtgcta tgccagtgtt ccaaggtaaa tattg
//
