LOCUS       NM_178220               7088 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus arrestin, beta 1 (Arrb1), transcript variant b, mRNA.
ACCESSION   NM_178220
VERSION     NM_178220.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7088)
  AUTHORS   Zhao,M., Cao,N., Gu,H., Xu,J., Xu,W., Zhang,D., Wei,T.W., Wang,K.,
            Guo,R., Cui,H., Wang,X., Guo,X., Li,Z., He,K., Li,Z., Zhang,Y.,
            Shyy,J.Y., Dong,E. and Xiao,H.
  TITLE     AMPK Attenuation of beta-Adrenergic Receptor-Induced Cardiac Injury
            via Phosphorylation of beta-Arrestin-1-ser330
  JOURNAL   Circ Res 135 (6), 651-667 (2024)
   PUBMED   39082138
  REMARK    GeneRIF: AMPK Attenuation of beta-Adrenergic Receptor-Induced
            Cardiac Injury via Phosphorylation of beta-Arrestin-1-ser330.
REFERENCE   2  (bases 1 to 7088)
  AUTHORS   Wang,K.Y., Gao,M.X., Qi,H.B., An,W.T., Lin,J.Y., Ning,S.L.,
            Yang,F., Xiao,P., Cheng,J., Pan,W., Cheng,Q.X., Wang,J., Fang,L.,
            Sun,J.P. and Yu,X.
  TITLE     Differential contributions of G protein- or arrestin
            subtype-mediated signalling underlie urocortin 3-induced
            somatostatin secretion in pancreatic delta cells
  JOURNAL   Br J Pharmacol 181 (15), 2600-2621 (2024)
   PUBMED   38613153
REFERENCE   3  (bases 1 to 7088)
  AUTHORS   Huang,G., Geng,Y., Kulur,V., Liu,N., Liu,X., Taghavifar,F.,
            Liang,J., Noble,P.W. and Jiang,D.
  TITLE     Arrestin beta 1 Regulates Alveolar Progenitor Renewal and Lung
            Fibrosis
  JOURNAL   J Respir Biol Transl Med 1 (2) (2024)
   PUBMED   38736470
REFERENCE   4  (bases 1 to 7088)
  AUTHORS   George,K., Hoang,H.T.M., Tibbs,T., Nagaraja,R.Y., Li,G.,
            Troyano-Rodriguez,E. and Ahmad,M.
  TITLE     Robust GRK2/3/6-dependent desensitization of oxytocin receptor in
            neurons
  JOURNAL   iScience 27 (6), 110047 (2024)
   PUBMED   38883814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7088)
  AUTHORS   Ke,P., Zhu,D.N., Liu,M.Z., Yan,H., Zhao,Q.J., Du,J., Wei,W.,
            Chen,X.W. and Liu,C.
  TITLE     Macrophage beta-arrestin-1 deteriorates DSS-induced colitis through
            interaction with NF-kappaB signaling
  JOURNAL   Int Immunopharmacol 130, 111676 (2024)
   PUBMED   38367465
  REMARK    GeneRIF: Macrophage beta-arrestin-1 deteriorates DSS-induced
            colitis through interaction with NF-kappaB signaling.
REFERENCE   6  (bases 1 to 7088)
  AUTHORS   Fleury,C., Neverova,M., Collins,S., Raimbault,S., Champigny,O.,
            Levi-Meyrueis,C., Bouillaud,F., Seldin,M.F., Surwit,R.S.,
            Ricquier,D. and Warden,C.H.
  TITLE     Uncoupling protein-2: a novel gene linked to obesity and
            hyperinsulinemia
  JOURNAL   Nat Genet 15 (3), 269-272 (1997)
   PUBMED   9054939
REFERENCE   7  (bases 1 to 7088)
  AUTHORS   Kingsmore,S.F., Peppel,K., Suh,D., Caron,M.G., Lefkowitz,R.J. and
            Seldin,M.F.
  TITLE     Genetic mapping of the beta-arrestin 1 and 2 genes on mouse
            chromosomes 7 and 11 respectively
  JOURNAL   Mamm Genome 6 (4), 306-307 (1995)
   PUBMED   7613043
REFERENCE   8  (bases 1 to 7088)
  AUTHORS   McGinnis,J.F., Austin,B.J., Stepanik,P.L. and Lerious,V.
  TITLE     Light-dependent regulation of the transcriptional activity of the
            mammalian gene for arrestin
  JOURNAL   J Neurosci Res 38 (4), 479-482 (1994)
   PUBMED   7932878
REFERENCE   9  (bases 1 to 7088)
  AUTHORS   Kikuchi,T., Raju,K., Breitman,M.L. and Shinohara,T.
  TITLE     The proximal promoter of the mouse arrestin gene directs gene
            expression in photoreceptor cells and contains an evolutionarily
            conserved retinal factor-binding site
  JOURNAL   Mol Cell Biol 13 (7), 4400-4408 (1993)
   PUBMED   8321239
REFERENCE   10 (bases 1 to 7088)
  AUTHORS   Shinohara,T., Kikuchi,T., Tsuda,M. and Yamaki,K.
  TITLE     A family of retinal S-antigens (arrestins) and their genes:
            comparative analysis of human, mouse, rat, bovine and Drosophila
  JOURNAL   Comp Biochem Physiol B 103 (3), 505-509 (1992)
   PUBMED   1458825
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147508.1, AK090090.1 and AK147566.1.
            
            On Nov 4, 2005 this sequence version replaced NM_178220.2.
            
            Transcript Variant: This variant (b) lacks an alternate exon in the
            3' coding region compared to variant a. The resulting protein
            (isoform B) is shorter but has the same N- and C-termini compared
            to isoform A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090090.1, BC108969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AK147508.1         2-177
            177-1994            AK090090.1         4-1821
            1995-7088           AK147566.1         2041-7134
FEATURES             Location/Qualifiers
     source          1..7088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.09 cM"
     gene            1..7088
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /note="arrestin, beta 1"
                     /db_xref="GeneID:109689"
                     /db_xref="MGI:MGI:99473"
     exon            1..313
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            314..344
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..405
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            406..450
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            451..647
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..707
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..775
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            776..911
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..996
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1069
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1207
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1291
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1362
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1414
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..7088
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7063..7068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7087
                     /gene="Arrb1"
                     /gene_synonym="1200006I17Rik; G430100A01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggaccagc cgcggccggc cacgcagccc tcactctctg ggcgcgcaca cgcagagccg
       61 cgcacggagg catacacgcg cgctcacacc cgcacgctcc acgcccctgg cggcggcctg
      121 ggcgctgtgc tgctcgagcg acgggcgggg acccgggcgg gggcggcggc ggcgacagcg
      181 gaggaggcgg agcggggtag ccgggagcgg gctggcccgc gcttctcctg gcggccgggg
      241 attttccagc ctggacgctg acgccgcgga cctccctgcg gccgccgcgg accatgggcg
      301 acaaagggac acgagtgttc aagaaggcaa gccccaatgg aaagctcact gtctacctgg
      361 gaaagcggga ctttgtggac cacattgacc tcgtggaccc cgtggatggt gtggtcctgg
      421 tggatcctga gtatctcaaa gaaaggcgag tctacgtgac actgacctgc gccttccggt
      481 atggccggga agacctggat gtcttgggtc tgacttttcg gaaagacctg tttgtggcca
      541 atgtgcagtc cttcccaccg gcccccgagg acaagaagcc actgacacgg ctacaggagc
      601 gactcatcaa gaagctgggc gagcatgcct gccccttcac ctttgagatc ccgccaaacc
      661 ttccatgctc agtcactctg cagcctgggc ctgaggacac aggaaaggcc tgtggtgtgg
      721 attatgaagt caaagccttc tgtgctgaga acctggagga gaagatccac aaaaggaact
      781 ctgtgcggct agtcatccgg aaggttcagt atgcccctga gagacctggc cctcagccca
      841 cggctgagac taccagacag ttccttatgt cagacaagcc cctacacctt gaggcatcac
      901 tggataagga gatctattac cacggagaac ccatcagcgt taatgtccac gtcaccaaca
      961 acaccaacaa gactgtgaag aagatcaaga tctcggtgcg ccagtatgca gacatctgtc
     1021 tcttcaacac agctcagtac aagtgcccag tggccatgga ggaggctgat gacaatgtgg
     1081 cacccagctc aacattctgc aaggtctata cgctgactcc cttcctggcc aacaaccgag
     1141 agaagcgggg actcgccctc gacgggaagc tcaagcatga ggacacgaat ctggcttcca
     1201 gcacgctgtt gcgggaaggt gccaaccgtg aaatcctggg catcatcgtt tcctacaaag
     1261 tcaaggtgaa actggtggtg tcccggggcg gtgatgtggc cgtggagctg ccttttaccc
     1321 taatgcaccc caagcctaag gaggagcccc cacatcggga agttccagag agcgagactc
     1381 cagtagacac caatctcata gagcttgaca ccaatgatga cgacattgta tttgaggact
     1441 ttgctcgcca gcggctgaaa ggcatgaagg atgacaagga cgaagaggat gacggcaccg
     1501 gctctccgca cctcaacaac agatagacta gggccggcct cagcccggca gctccaggtt
     1561 cactctcgca ctcggatgct ttctcgtctc cttcccattc tggttcttcc ttttgttctt
     1621 ccagtttcta ccaaggggcc ccagtggtct tccaagtctc ggtgatgggc ctctcgcatc
     1681 accacgccag caggaccacg tcctcagcca tctctctgca atcacctgcc cacctccttc
     1741 tcatgctcat tcccaggaag gccacactgc ctggccttgg gatttggctt gagatgggga
     1801 gcagaaaggg gagggtgggg cctgaaggca caatgatgat gggtgtgaag atgtggaggg
     1861 ggtgggcaag atggctcaag acacacaaga agatgtctgt agtcccagta ggtgacagtt
     1921 ttggcagcta aatgatgacc agattgaagg tgggagaggg caggactgtg aatagattct
     1981 caatgctttt ttgtgtgtgt gtgtggtcca gggccactag agactcctcc ccctccatcc
     2041 tcatccttgg tccatgcccc tatgtctcat gggggaggca catagacccc aggaatgaag
     2101 agcagtggac tgactttcta accagatgac acctagattg aagcaggcca catatgtcag
     2161 aactgataga ctgagatatc atagcttcat tgcatttttg tgtgctggca cagagagggg
     2221 aagtgggtgt ttaacaaaca ccagccccta gcagtgagcc aaagctactg aggatgttgt
     2281 ctgaggggag tttaagtgat agggccgggt agggaggcat ccatcctctt ttgtagtgga
     2341 tagtccttag ggaaacaagg atggagggac ataggcagct ggagccacct gtatctccca
     2401 gcttcctcta gttcttctcc agtgactggc cctgtaaggt aggagagaga aagagacaga
     2461 ggtgcctgag gccattattt ccactgctaa gggatcccgt tcccagaagg tggcatccat
     2521 ccatccagat gtactcccag gacgaaggca gctcctctcc taaaggagtt ggttttatta
     2581 gtacccagag tcatgggtac ccggtttcca ccaggtggtg ttagtatgac ttgaccaggg
     2641 tgaatctcag ggtaacaggg catacaagtg gtaaaacaga aaatgctcaa agatatcctt
     2701 gtttggtctt cgatgctagc ttgttgtgtg accttgggcc agttccttcc cctctttggg
     2761 cctcagtttc ttgttggaaa agccaggagg tcgaccagat gattccgaga gtttcttgtt
     2821 caagtttctg taagtttgtg gctctcaaga gcttctgatc ttccagttgg agctggggct
     2881 gctaactgct ccgtctgcct tcagaagagg ttcatggtga ggacccagga cagagcagat
     2941 cactgagtgt accttcctgc cgaggcaggg ctgctcttgg acctagtcag cttatctgat
     3001 atcaggttgt ggccagagct tttgtggact tctctatccc agagcttctg tgtgtggaga
     3061 cttgcatgag aagtgtggga acaaccttgg gtttatcaaa cataattgct tgttagggca
     3121 agaggatctc atctccgttt ctgttcctct ctcttagttc cacacttgcc ggagaaggga
     3181 ggccacagct tgtgtttggt tttgagacag cgtatcatga ggtgtaggct agccatgaat
     3241 tcactacata gccgcgaatg actttgaatt cctgatccta ttgtttcaag tgctgggatt
     3301 gcaggcatgc ccctgccact gctggcgcca tgctttattg tacagattag atcccagcca
     3361 ttcttagtcc atcatgccca gtgtttgttg ttatttcttc tggtgagatg gtccaggccc
     3421 actgctctga acctcctaca tttcataagc agtcaactca aggaacctct tcccaggtta
     3481 ggacagccgt cttggggcag ccacattgcc tggccagctc agatcataac tgcaagctcc
     3541 cctgacatct agcccctgcc agagctagct ggatactttt gcacctatag aattgattaa
     3601 aaccttgaac agtgtaaggc aagcatgtgc cctccaactg gcttccatta aaacctctgg
     3661 agctgatacc agacccttta gcatttggac taacctctcc tgtcccccat ccttaactga
     3721 tacgagcaaa aggtctccca atctggtttc tcaggcttcc tacacgtcag catccacatt
     3781 ctttccgttt atcccacaga tctacctgca ggggagcatc agagccctgg ctgcctcttt
     3841 gtgttttgag ctacgcctgc ataagggcaa tgatcaagtt agagtctagc caaaccatcc
     3901 tttgatgata gctttgttct tttatgctgt atactactaa gatggatctc accctagaat
     3961 ccctgtctct agaaaccttc tggccagggg aaatctagaa gaccgcattg acggttctgg
     4021 ctacagctag tccacacagt gccttgatgt gagtttgaat acagtgtcct tcctaggtgg
     4081 attcaaaccc tggaaatgac actgtaaggg gctggaattt ggtgtcattt gtccctactc
     4141 cacagtctta tgctgccata ctgggtgaga tacacaggct cacgtatttc tttggcctct
     4201 tcttttcttg tcgtgcccca cccccatcac atgacataac ccagtacttc tctgtagggc
     4261 tcttttttgt tctggagttt tcctggccag gcagcacttg ggagtgaaac tggaggcgga
     4321 ggtttccagg caccatccag tgagattggg ttttcttgtg ctgacagatt gggacttggg
     4381 ccaccaaaca gcccacattg ggactttcca gtagaccaaa gggcacatgt taatgccaat
     4441 ctgggcaaga agagcatgct ttgtaaaagc tcatcaattg aggacgactg gacttgccca
     4501 gtaccccagc caagagaaga atttgtctcc tagaaacata agaattgaga tgcttggctg
     4561 gaccccatgg ccacttcagc ttcaaagcgc aactggcatc cccctggagg gtagctgatt
     4621 cccatctgat gcagtgaaag tcctgaaagt ccccaaggcc acctctcagt ctctcctcac
     4681 tggaacaata gcctttgtct gctttatttg agggcttgct gtgggtttga agtgagatgt
     4741 aggccaactg gctgcacagg tgtggccctg ttgctgcagg gaggaggccc gaggtcacac
     4801 aggaagcttg ctgtggaatg agccctctgt ttaccagtct ttgtccctgt gtcccaggtt
     4861 agatatcagc catgattatc atcgtggctt tgtggctttg ctgatcacac tggggaagaa
     4921 gtgtaggtgc tattgtccta ggatgggtcc cgtggcaacc aggacacgga aggcttggat
     4981 gttgtcagtg actggggggc agggaggagc atttgagcct cgactcacct cccagaagcc
     5041 cacagaagtg aggaaaactg ggctctgacc acaggtcagg gagctgagct cagtactgtg
     5101 atcacccaag acatccgagg gcaagaggaa atagctgttg cctcttctaa gtatacggtc
     5161 ccatcttggg tcagaagaac caccacagct ccttggagac ctttggcaat gtccagccct
     5221 cttgcactga gagctgagcc ctagctgacc cactcacaga cgcttcatgt cctggggcag
     5281 ctccttccca ccaatggcta aggcctgtat gtgtggctcc caaccctcag tgaagggctg
     5341 gtctccagcc tttatctccc aggacacaaa cttgtgtctc ttctgatatt tactcttttt
     5401 aaacttaagg accaaatgag acttctctga tttttatccg aacagcctgt cttgggcctg
     5461 gtccaggcag ctccataact tctgccctcc ccgctcctgg cctgaagcag cctagtgatg
     5521 ggggcagatc cacatcttgg ccaccccaat ccatgcacac tagcacctcc ctcaatatca
     5581 ccaacttgtt acccctaaag ggaggtcaaa gttgaagcac aggtccctgg gacccactgt
     5641 ctgcagacca ggcacacctc tcagtgttcc acacagcctg gctgggggct gctgccaggg
     5701 gaaactgagg aaaggggaga ggagggtgag tctccagccc tccccccatt cctactttct
     5761 ccagagtaac tgcttttaac tctcttgtct attgaggttt cacttttaaa ctctttgaag
     5821 aataacttca aaccaccatt ttgtggtttg gtcttagacc agcaagcaca ggttctcttt
     5881 tggtttttat gtgttggggt gactccagca tcctggcaca gagacacttg ttgggactca
     5941 ggtcatctgg tccaagcatt agagcacaca tacactggtt ttctagttga ccaccctgca
     6001 ccttgggaat gaatttgatg tgggctgggt ctgctgctcg gggcttggtc ccgatagtac
     6061 gtgtgcttcg tggagaccac ggagtgagga gccaggccca gtgtccactc gggacacatt
     6121 ctcagggcaa tgggaggaga acccagggct ggctccctat gcacagctaa ggggtgggga
     6181 gccagggtca tgtaagagat gcaccaccag ggagggcttt tacgaggcag gattcctcag
     6241 gcatttgaag caagtcttcc ttcctccagt gaatctccta agattccact tccacccctg
     6301 tggatgtcca tgtgcacaac agcaggcttt tatgcctaaa gagagactga tcccccttct
     6361 gcagtccaca cagcttctct ctgctggcct gcactgccat gggcattcac ttgcaggaca
     6421 actcattggt gagatttggg ctagcctttg gcaaaaagtc ctgcctgggc tcacctccta
     6481 gggcattcta ggtgaggagc tgaagctcag ggcattgtca atcatggcac aggggaaaag
     6541 aatgccaact agtgttttat tcagtccaag tgtggcctgg gagaccccac tggcctcagg
     6601 ttccccatgt gtgaagggct agtaccaggc tctgccccaa tcacagggac tactgaaagg
     6661 gatatgaggg tgaagagagg ccggatgagg cagcagcctg tgtgagggga tagggtctta
     6721 gcctgagttg ctgacccaca tagcccacaa caaatgacag tgcaggatat cctgtcttac
     6781 gtgggtatct ctgcgcagtg ttaggtccag tcataggtgc tgcggggctg cctcttccga
     6841 ccggtgggag ttgatgtgtg tcctgggtgt ggtgtcgagg ggtggctggg gcgccctcag
     6901 gcctgtgacc ctctgtgaag tgatgatttg tgtggcacat tcattcctgg accacgtcca
     6961 ggtcaacctg tcgtacctgt ggctgccctt gtcccgtgaa gtcattatag tttattcagc
     7021 tgcaacagga caaatgagca aaagaacctt gaacgagagg tcattaaagg ccttttgtga
     7081 tggaggac
//
