LOCUS       NM_133205               1359 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus arrestin 3, retinal (Arr3), mRNA.
ACCESSION   NM_133205
VERSION     NM_133205.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Ahmed,M.R., Zheng,C., Dunning,J.L., Ahmed,M.S., Ge,C., Pair,F.S.,
            Gurevich,V.V. and Gurevich,E.V.
  TITLE     Arrestin-3-assisted activation of JNK3 mediates dopaminergic
            behavioral sensitization
  JOURNAL   Cell Rep Med 5 (7), 101623 (2024)
   PUBMED   38936368
  REMARK    GeneRIF: Arrestin-3-assisted activation of JNK3 mediates
            dopaminergic behavioral sensitization.
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Zhang,H., Cuenca,N., Ivanova,T., Church-Kopish,J., Frederick,J.M.,
            MacLeish,P.R. and Baehr,W.
  TITLE     Identification and light-dependent translocation of a cone-specific
            antigen, cone arrestin, recognized by monoclonal antibody 7G6
  JOURNAL   Invest Ophthalmol Vis Sci 44 (7), 2858-2867 (2003)
   PUBMED   12824223
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Zhang,H., Huang,W., Zhang,H., Zhu,X., Craft,C.M., Baehr,W. and
            Chen,C.K.
  TITLE     Light-dependent redistribution of visual arrestins and transducin
            subunits in mice with defective phototransduction
  JOURNAL   Mol Vis 9, 231-237 (2003)
   PUBMED   12802257
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Zhu,X., Li,A., Brown,B., Weiss,E.R., Osawa,S. and Craft,C.M.
  TITLE     Mouse cone arrestin expression pattern: light induced translocation
            in cone photoreceptors
  JOURNAL   Mol Vis 8, 462-471 (2002)
   PUBMED   12486395
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Zhu,X., Ma,B., Babu,S., Murage,J., Knox,B.E. and Craft,C.M.
  TITLE     Mouse cone arrestin gene characterization: promoter targets
            expression to cone photoreceptors
  JOURNAL   FEBS Lett 524 (1-3), 116-122 (2002)
   PUBMED   12135752
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Hong,D.H., Pawlyk,B.S., Shang,J., Sandberg,M.A., Berson,E.L. and
            Li,T.
  TITLE     A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse
            model for X-linked retinitis pigmentosa (RP3)
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3649-3654 (2000)
   PUBMED   10725384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671299.18 and BX276129.7.
            
            On Apr 30, 2010 this sequence version replaced NM_133205.2.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments. This RefSeq contains a uAUG
            that could extend the N-terminus 15 aa, however, the uAUG has a
            weak Kozak signal and all other mammals have frameshifting indels
            in this 15-codon-region and so the extension would be
            mouse-specific. The extension adds no protein features and has no
            support outside of mouse, therefore, the dAUG is annotated as the
            start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL671299.18        210913-210999
            88-115              AL671299.18        212032-212059
            116-146             AL671299.18        212299-212329
            147-207             AL671299.18        212480-212540
            208-252             AL671299.18        212738-212782
            253-452             BX276129.7         4167-4366
            453-512             BX276129.7         4471-4530
            513-580             BX276129.7         5209-5276
            581-716             BX276129.7         5917-6052
            717-801             BX276129.7         6248-6332
            802-874             BX276129.7         6550-6622
            875-1012            BX276129.7         7021-7158
            1013-1096           BX276129.7         9319-9402
            1097-1120           BX276129.7         9649-9672
            1121-1185           BX276129.7         9844-9908
            1186-1195           BX276129.7         10138-10147
            1196-1359           BX276129.7         10749-10912
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..1359
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /note="arrestin 3, retinal"
                     /db_xref="GeneID:170735"
                     /db_xref="MGI:MGI:2159617"
     exon            1..87
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            88..115
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1253
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /note="X-arrestin; retinal cone arrestin-3; arrestin 4"
                     /codon_start=1
                     /product="arrestin-C"
                     /protein_id="NP_573468.1"
                     /db_xref="CCDS:CCDS41075.1"
                     /db_xref="GeneID:170735"
                     /db_xref="MGI:MGI:2159617"
                     /translation="MSTVFKKTSSNGKFSIYLGKRDFVDDVDTVEPIDGVVLVDPEYL
                     EGRKLFVRLTCAFRYGRDDLDVIGLTFRKDLYVQTKQVAPAEPTSIQGPLTALQERLL
                     HKLGVNAYPFTLQMVANLPCSVTLQPGPEDSGKPCGVDFEVKSFCAENLEEKIPKSDS
                     VQLVVRKVQFSALEPGPGPSAQTIRSFFLSSQPLQLQAWMDREVHYHGEAISVHVSIN
                     NYTNKVIRRIKIAVVQTTDVVLYSLDKYTKTVFVQEFTETVAANSSFSQTFAVTPLLA
                     ANCQKQGLALDGKLKHEDTNLASSTILRPGMNKELLGILVSYKVRVNLVVSYGGILGG
                     LPASDVGVELPVILIHPKPSPGERAVATSSEDIVIEEFMQHNSQTQS"
     exon            116..146
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            147..207
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            208..252
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            253..452
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            453..512
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            513..580
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            581..716
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            717..801
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            802..874
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1012
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1096
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1120
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1185
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1195
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1359
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1338..1343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /note="hexamer: AATAAA"
     polyA_site      1357
                     /gene="Arr3"
                     /gene_synonym="Arr4; Car; Carfl; Carr"
                     /note="major polyA site"
ORIGIN      
        1 attcagagga ttgtggatat aagaggctgg gaggccagct tagcaaccag agctggaggc
       61 tgatgcgagc ttcatctctt ccctcaggaa agattcaact ggccagcatg tccacagtgt
      121 ttaagaagac tagctccaat gggaagtttt ccatctacct ggggaaacga gacttcgtgg
      181 atgatgtgga cactgtggag cccattgatg gagtcgtcct tgttgacccc gagtacttag
      241 aaggtcgaaa gttgtttgtc aggttgacct gtgcttttcg ctatggccgt gatgacttgg
      301 atgtgattgg tctgacattt cgcaaagatc tctatgtaca aaccaagcaa gtggctccag
      361 ctgaacccac cagcatccag ggccccctca cagccttaca ggagcggctt ctgcacaagc
      421 tcggggtcaa tgcctatcct tttacacttc agatggttgc taacctgccc tgttcagtaa
      481 cactgcagcc tgggcctgaa gattcaggaa agccctgtgg ggttgacttt gaagtgaaga
      541 gtttctgtgc agaaaatctg gaagagaaaa tccctaagag tgattctgtg cagctggttg
      601 tacggaaagt gcagttttca gccctggaac ccggccctgg tccttcggca cagaccattc
      661 gaagcttctt tttgtcatct cagcccctac aactgcaggc ctggatggac agggaggttc
      721 attaccatgg agaagctatt tctgtacatg tttctatcaa caactatacc aacaaggtca
      781 tcagaagaat caagattgca gttgtccaga ccacagatgt tgtcctgtat tcactagaca
      841 agtacacgaa gactgtgttt gttcaggagt tcacagagac agtagctgct aactccagct
      901 tctcccagac ctttgcagta accccactcc tggctgccaa ctgtcagaag cagggcctgg
      961 cactggatgg caaactcaag catgaagaca ccaatctggc ctctagcaca attcttcgac
     1021 ctggaatgaa caaggagctt ctggggatcc tggtgtccta caaagttaga gtcaacttgg
     1081 tggtgtccta tgggggcatt ctaggaggtc tgccagccag tgatgttggt gtggagctgc
     1141 ccgtgatctt gatccatcca aagccatctc ctggggagag agcagtggct accagctcgg
     1201 aggacatagt catcgaagag tttatgcagc acaacagcca gacacagagc tagaaagctc
     1261 caacagcaga cagagttaag aggatccgat agcctatctc tgataattct gtgtggaagc
     1321 ccccactgca acactctaat aaatcatttt gtccagaca
//
