LOCUS       NM_001362026            3676 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus cyclic AMP-regulated phosphoprotein, 21 (Arpp21),
            transcript variant 36, mRNA.
ACCESSION   NM_001362026
VERSION     NM_001362026.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3676)
  AUTHORS   Xu,M., Ito-Kureha,T., Kang,H.S., Chernev,A., Raj,T., Hoefig,K.P.,
            Hohn,C., Giesert,F., Wang,Y., Pan,W., Zietara,N., Straub,T.,
            Feederle,R., Daniel,C., Adler,B., Konig,J., Feske,S., Tsokos,G.C.,
            Wurst,W., Urlaub,H., Sattler,M., Kisielow,J., Wulczyn,F.G.,
            Lyszkiewicz,M. and Heissmeyer,V.
  TITLE     The thymocyte-specific RNA-binding protein Arpp21 provides TCR
            repertoire diversity by binding to the 3'-UTR and promoting Rag1
            mRNA expression
  JOURNAL   Nat Commun 15 (1), 2194 (2024)
   PUBMED   38467629
  REMARK    GeneRIF: The thymocyte-specific RNA-binding protein Arpp21 provides
            TCR repertoire diversity by binding to the 3'-UTR and promoting
            Rag1 mRNA expression.
            Erratum:[Nat Commun. 2024 Aug 5;15(1):6632. doi:
            10.1038/s41467-024-50610-8.. PMID: 39103338]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3676)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3676)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3676)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3676)
  AUTHORS   Tan,Y.Y., Zhang,Y., Li,B., Ou,Y.W., Xie,S.J., Chen,P.P., Mei,S.Q.,
            Huang,Q.J., Zheng,L.L. and Qu,L.H.
  TITLE     PERK Signaling Controls Myoblast Differentiation by Regulating
            MicroRNA Networks
  JOURNAL   Front Cell Dev Biol 9, 670435 (2021)
   PUBMED   34124052
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3676)
  AUTHORS   Rakhilin,S.V., Olson,P.A., Nishi,A., Starkova,N.N., Fienberg,A.A.,
            Nairn,A.C., Surmeier,D.J. and Greengard,P.
  TITLE     A network of control mediated by regulator of
            calcium/calmodulin-dependent signaling
  JOURNAL   Science 306 (5696), 698-701 (2004)
   PUBMED   15499021
  REMARK    GeneRIF: Through a molecular mechanism that amplifies GPCR- &
            PKA-mediated signaling & attenuates GPCR- & PP2B-mediated
            signaling, RCS (ARPP-21) synergistically increases phosphorylation
            of key proteins whose phosphorylation is regulated by PKA and PP2B
            [RCS]
REFERENCE   7  (bases 1 to 3676)
  AUTHORS   Kim,J., Lee,J., Yadav,N., Wu,Q., Carter,C., Richard,S., Richie,E.
            and Bedford,M.T.
  TITLE     Loss of CARM1 results in hypomethylation of thymocyte cyclic
            AMP-regulated phosphoprotein and deregulated early T cell
            development
  JOURNAL   J Biol Chem 279 (24), 25339-25344 (2004)
   PUBMED   15096520
  REMARK    GeneRIF: CARM1 plays a significant role in promoting the
            differentiation of early thymocyte progenitors, possibly through
            its direct action on TARPP.
REFERENCE   8  (bases 1 to 3676)
  AUTHORS   Kisielow,J., Nairn,A.C. and Karjalainen,K.
  TITLE     TARPP, a novel protein that accompanies TCR gene rearrangement and
            thymocyte education
  JOURNAL   Eur J Immunol 31 (4), 1141-1149 (2001)
   PUBMED   11298339
REFERENCE   9  (bases 1 to 3676)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3676)
  AUTHORS   Ivkovic,S., Blau,S., Polanskaya,O. and Ehrlich,M.E.
  TITLE     ARPP-21: murine gene structure and promoter identification of a
            neuronal phosphoprotein enriched in the limbic striatum
  JOURNAL   Brain Res 709 (1), 10-16 (1996)
   PUBMED   8869551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100550.7 and AC130551.4.
            
            Transcript Variant: This variant (36), as well as variants 32-35,
            encodes isoform 9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC100550.7         96880-97140         c
            262-438             AC100550.7         53554-53730         c
            439-599             AC100550.7         51573-51733         c
            600-641             AC100550.7         50233-50274         c
            642-731             AC100550.7         49459-49548         c
            732-876             AC100550.7         44992-45136         c
            877-955             AC100550.7         43622-43700         c
            956-1015            AC100550.7         42898-42957         c
            1016-1156           AC100550.7         42059-42199         c
            1157-1265           AC100550.7         23654-23762         c
            1266-1364           AC100550.7         21382-21480         c
            1365-1402           AC100550.7         15299-15336         c
            1403-1462           AC100550.7         13387-13446         c
            1463-1692           AC130551.4         189248-189477       c
            1693-1920           AC130551.4         182393-182620       c
            1921-2102           AC130551.4         173218-173399       c
            2103-2207           AC130551.4         172374-172478       c
            2208-2468           AC130551.4         170679-170939       c
            2469-2595           AC130551.4         165122-165248       c
            2596-2744           AC130551.4         113100-113248       c
            2745-3676           AC130551.4         111030-111961       c
FEATURES             Location/Qualifiers
     source          1..3676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 62.46 cM"
     gene            1..3676
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="cyclic AMP-regulated phosphoprotein, 21"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
     exon            1..261
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            262..438
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            439..599
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..3002
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="isoform 9 is encoded by transcript variant 36;
                     cAMP-regulated phosphoprotein 21; thymocyte ARPP; protein
                     phosphatase 1, regulatory (inhibitory) subunit 1C;
                     regulator of calmodulin signaling; thymocyte
                     cAMP-regulated phosphoprotein"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 9"
                     /protein_id="NP_001348955.1"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
                     /translation="MSEQGGLTPTILEEGQTEPESAPENGILKSESLDEEEKLELQRR
                     LAAQNQERRKSKSGAGKGKLTRSLAVCEESSARSGGESHQDQESIHLQLSSFPSLQEE
                     DKSRKDDSEREKEKDKNREKLSERPKIRMLSKDCSQEYTDSTGIDLHGFLINTLKNNS
                     RDRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSV
                     IINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQNRMHPFRDDRRS
                     KSIEEREEEYQRVRERIFAHDSVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRD
                     SSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTASFGGITVLTRGD
                     STSSTRSAGKLSKTGSESSSSAGSSGSLSRTHPQSTALTSSVAAGSPGCMAYSENGMG
                     GQVPPSSTSYILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPGSQQTLRGT
                     VGGQPQQPPQQQPSPQPQQQVQASQPQMAGPLVTQSVQSLQPSSQSVQYPAVSFPPQH
                     LLPMSPTQHFPLREELAAQFSQLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYVI
                     TSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTSQ
                     QYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQGVMSSQQG
                     APVHGVMVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQGSLPATGMPVYCNV
                     TPPNPQNNLRLMGPHCPSSTVPVMSASCRTNCGNVSNAGWQVKF"
     exon            600..641
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            642..731
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            732..876
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            877..955
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1015
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1156
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1265
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1364
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1402
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1462
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1692
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1920
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2102
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2207
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2468
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2595
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2744
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..3676
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="hexamer: AATAAA"
     polyA_site      3534
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="major polyA site"
ORIGIN      
        1 tttggacaag ataatgataa gcttcatgag cagagcttga agtgagtcag cttctgcaga
       61 tagaaagtag ccaggaacca ggcatggata tgatggagaa ttcttctaga gtaaggagat
      121 agtttgaaat ccagagggct ggacactgaa atttcactat ttgtttgcca gtcagtgtca
      181 tttgaatcta atctctgata agactagata agaatggggc acctaaaact gtagcagaca
      241 tggaaagcca tttcgtcggg ggttgtcgac catgtgtcaa gctgtgtaag gaaactgcct
      301 cgagatggac actctggact gctaatgggg acatgggacg gcagttacct ctgatcactt
      361 gcgtggattc tcccggaaca gaacgacaga agccgccagt cattcgccca gatctacagc
      421 tggaattctg tgctgaaggg tctaaaaact ctttttaatt tggatctggg agaatgtctg
      481 agcaaggagg actgactccg accatactgg aagaagggca gacggagcca gagtctgccc
      541 cagaaaatgg catcctcaag tcagaaagtc tggatgagga ggagaagctg gaactgcagc
      601 ggcgactggc ggctcagaac caagagagga gaaaatccaa gtcaggagca ggcaaaggga
      661 agctgaccag aagtcttgct gtctgtgaag agtcttcagc tagatctgga ggggaaagtc
      721 accaggatca ggaatcaatt cacttacagc tttccagttt ccccagcctg caagaggagg
      781 ataaatctag gaaggatgat tctgagagag aaaaagaaaa ggataagaac agagagaaac
      841 tctctgagag acccaagatc agaatgttat caaaagattg cagccaagaa tacacagatt
      901 ctacaggcat agacttacat gggtttctaa ttaacacgct gaagaacaat tccagggaca
      961 ggatgatact cttgaaaatg gagcaggaaa tgattgattt cattgctgac agcaataacc
     1021 actataaaaa gttcccccag atgtcatcct atcaaaggat gctggtccat cgggtggcag
     1081 cgtactttgg attggaccac aacgtggatc aaactggaaa atctgtcatc atcaacaaga
     1141 ccagcagcac caggatacca gagcaaaggt tttgtgaaca tttaaaagat gaaaaaagtg
     1201 aagaatccca gaagcggttt atcttgaagc gagataactc tagtattgat aaagaagaca
     1261 atcagaacag aatgcaccca tttagagatg acagacgaag taaatcaatt gaagagagag
     1321 aagaggaata tcagagagtg agggagagaa tatttgcaca tgattcagtt tgctcacagg
     1381 aaagcctatt tttggacaac agtaggctcc aggaagacat gcacatatgc aatgagacct
     1441 ataagaaaag acagctcttt cgggctcacc gagacagctc aggaagaact tccgggagcc
     1501 ggcagagcag ctcagagact gagctcaggt ggccagacca ccagcgggct tggagcagca
     1561 cagattcgga cagttccaac cgcaatctga agcccaccat gaccaagacg gcaagttttg
     1621 ggggcatcac ggtgctgacc aggggcgaca gcacgtccag taccaggagt gctgggaaac
     1681 tgtccaaaac aggttctgag tcttccagca gtgcgggctc ctcaggatca ctgtcccgca
     1741 cccacccaca gagcacggcc ctgacctcta gcgtggcagc tggttctcct ggctgtatgg
     1801 cctattcaga gaatggaatg ggaggccagg ttcctcccag cagcaccagc tacatcctcc
     1861 tcccacttga aagtgcgact ggcatcccac ccggaagcat ccttcttaat ccacacacag
     1921 gtcagccctt tgtgaacccg gatggaacgc ctgcgatata caaccctccc ggaagtcagc
     1981 agacactgcg tggcactgtt ggtgggcagc cccagcaacc tccacagcag caaccttcgc
     2041 ctcagcctca gcagcaggtc caggcatcac agccccagat ggcagggcca ctggtcactc
     2101 agtctgtcca gagcctgcag ccatcttccc agtctgtgca atatccagcg gtctcttttc
     2161 ctccccagca tctcctgcct atgtcgccaa cgcagcactt ccccttgaga gaagaactgg
     2221 ctgcccagtt cagccagctg agcatgagcc ggcagtcctc gggagacact cctgaacctc
     2281 cctctggtac agtctaccca gcctctctcc tgccacaaac ggctcagcca cagagttatg
     2341 tcatcacttc tgcaggccag cagctctcta cagggggctt ctcggactct ggcccgccca
     2401 tctcccagca ggtcctgcag gccccgccct ctccccaggg atttgtacag cagcctccac
     2461 ctgcacagat gtccgtctat tactacccat ctggtcagta ccctacctca acctcacagc
     2521 agtaccgacc cctcgcctca gtccagtaca gtgctcagcg gagtcagcaa ataccacaga
     2581 ccacacagca agcaggttac cagccagtct tgtctggtca gcagggcttc caaggcatga
     2641 tgggagtaca gcagtcagcg cacagccagg gtgtgatgag cagtcagcaa ggagccccgg
     2701 tgcatggtgt gatggtctcc tacccaacca tgtcttctta tcaggtgcca atgacccaag
     2761 gctctcaagc agtgccccag cagacatacc aaccaccaat catgctgccc agtcaggcag
     2821 gccaagggtc actcccagcc accggaatgc ctgtgtactg taacgtcaca ccgccaaacc
     2881 ctcagaacaa cctaaggttg atgggtccac actgcccctc cagcacggtt cctgtcatgt
     2941 ccgctagttg cagaacaaac tgtgggaacg tgagcaacgc aggctggcag gtcaagttct
     3001 gagagctcag gctgcctgct gtccacttca tcagatgtta actcatggcc ttcaaaggaa
     3061 gaggagactg acgactggct gaggacttcc atatacactc aacgtgcaaa cgattgctgc
     3121 tggtattctg tacaaactaa tcaaagacta atacacacat tagctggtta atggtgcata
     3181 attccgtcat gtctgctagg tatgcctttc tagcttagct agtgacatga attcatcaag
     3241 gtaagatttt ctcctaccac tgaataccac tgtgtagatt acaatatccc tgattcggat
     3301 tagttttgta cttcgtgttg agtttgtgat gctaaaagta tttaaaaata tatatataaa
     3361 ctaaatcaca cggtaccaaa gctgtaatgg aaaaaggaaa gagttaagga atggaaggaa
     3421 taatttatat acactataga gttttctttt ttaaatggat atatatggta ttgtagtgtt
     3481 taatccaaat aaaagcttat ttgaccttac ggaggaaggt catgttttta ccaccagttt
     3541 gtttccgtct ctctttccat gtgctgttta cctatttagt taatggtttc attagcagat
     3601 agatgttaat tttaagaatg acatttccat acttgtacag aatacatttt gaccacatta
     3661 aaactcaatg tctcct
//
