LOCUS       NM_001362024            3636 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus cyclic AMP-regulated phosphoprotein, 21 (Arpp21),
            transcript variant 34, mRNA.
ACCESSION   NM_001362024 XM_017313636
VERSION     NM_001362024.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3636)
  AUTHORS   Xu,M., Ito-Kureha,T., Kang,H.S., Chernev,A., Raj,T., Hoefig,K.P.,
            Hohn,C., Giesert,F., Wang,Y., Pan,W., Zietara,N., Straub,T.,
            Feederle,R., Daniel,C., Adler,B., Konig,J., Feske,S., Tsokos,G.C.,
            Wurst,W., Urlaub,H., Sattler,M., Kisielow,J., Wulczyn,F.G.,
            Lyszkiewicz,M. and Heissmeyer,V.
  TITLE     The thymocyte-specific RNA-binding protein Arpp21 provides TCR
            repertoire diversity by binding to the 3'-UTR and promoting Rag1
            mRNA expression
  JOURNAL   Nat Commun 15 (1), 2194 (2024)
   PUBMED   38467629
  REMARK    GeneRIF: The thymocyte-specific RNA-binding protein Arpp21 provides
            TCR repertoire diversity by binding to the 3'-UTR and promoting
            Rag1 mRNA expression.
            Erratum:[Nat Commun. 2024 Aug 5;15(1):6632. doi:
            10.1038/s41467-024-50610-8.. PMID: 39103338]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3636)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3636)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3636)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3636)
  AUTHORS   Tan,Y.Y., Zhang,Y., Li,B., Ou,Y.W., Xie,S.J., Chen,P.P., Mei,S.Q.,
            Huang,Q.J., Zheng,L.L. and Qu,L.H.
  TITLE     PERK Signaling Controls Myoblast Differentiation by Regulating
            MicroRNA Networks
  JOURNAL   Front Cell Dev Biol 9, 670435 (2021)
   PUBMED   34124052
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3636)
  AUTHORS   Rakhilin,S.V., Olson,P.A., Nishi,A., Starkova,N.N., Fienberg,A.A.,
            Nairn,A.C., Surmeier,D.J. and Greengard,P.
  TITLE     A network of control mediated by regulator of
            calcium/calmodulin-dependent signaling
  JOURNAL   Science 306 (5696), 698-701 (2004)
   PUBMED   15499021
  REMARK    GeneRIF: Through a molecular mechanism that amplifies GPCR- &
            PKA-mediated signaling & attenuates GPCR- & PP2B-mediated
            signaling, RCS (ARPP-21) synergistically increases phosphorylation
            of key proteins whose phosphorylation is regulated by PKA and PP2B
            [RCS]
REFERENCE   7  (bases 1 to 3636)
  AUTHORS   Kim,J., Lee,J., Yadav,N., Wu,Q., Carter,C., Richard,S., Richie,E.
            and Bedford,M.T.
  TITLE     Loss of CARM1 results in hypomethylation of thymocyte cyclic
            AMP-regulated phosphoprotein and deregulated early T cell
            development
  JOURNAL   J Biol Chem 279 (24), 25339-25344 (2004)
   PUBMED   15096520
  REMARK    GeneRIF: CARM1 plays a significant role in promoting the
            differentiation of early thymocyte progenitors, possibly through
            its direct action on TARPP.
REFERENCE   8  (bases 1 to 3636)
  AUTHORS   Kisielow,J., Nairn,A.C. and Karjalainen,K.
  TITLE     TARPP, a novel protein that accompanies TCR gene rearrangement and
            thymocyte education
  JOURNAL   Eur J Immunol 31 (4), 1141-1149 (2001)
   PUBMED   11298339
REFERENCE   9  (bases 1 to 3636)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3636)
  AUTHORS   Ivkovic,S., Blau,S., Polanskaya,O. and Ehrlich,M.E.
  TITLE     ARPP-21: murine gene structure and promoter identification of a
            neuronal phosphoprotein enriched in the limbic striatum
  JOURNAL   Brain Res 709 (1), 10-16 (1996)
   PUBMED   8869551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100550.7 and AC130551.4.
            
            On Mar 31, 2018 this sequence version replaced XM_017313636.1.
            
            Transcript Variant: This variant (34), as well as variants 32, 33,
            35, and 36, encodes isoform 9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC100550.7         99056-99276         c
            222-398             AC100550.7         53554-53730         c
            399-559             AC100550.7         51573-51733         c
            560-601             AC100550.7         50233-50274         c
            602-691             AC100550.7         49459-49548         c
            692-836             AC100550.7         44992-45136         c
            837-915             AC100550.7         43622-43700         c
            916-975             AC100550.7         42898-42957         c
            976-1116            AC100550.7         42059-42199         c
            1117-1225           AC100550.7         23654-23762         c
            1226-1324           AC100550.7         21382-21480         c
            1325-1362           AC100550.7         15299-15336         c
            1363-1422           AC100550.7         13387-13446         c
            1423-1652           AC130551.4         189248-189477       c
            1653-1880           AC130551.4         182393-182620       c
            1881-2062           AC130551.4         173218-173399       c
            2063-2167           AC130551.4         172374-172478       c
            2168-2428           AC130551.4         170679-170939       c
            2429-2555           AC130551.4         165122-165248       c
            2556-2704           AC130551.4         113100-113248       c
            2705-3636           AC130551.4         111030-111961       c
FEATURES             Location/Qualifiers
     source          1..3636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 62.46 cM"
     gene            1..3636
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="cyclic AMP-regulated phosphoprotein, 21"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
     exon            1..221
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            222..398
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            399..559
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..2962
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="isoform 9 is encoded by transcript variant 34;
                     cAMP-regulated phosphoprotein 21; thymocyte ARPP; protein
                     phosphatase 1, regulatory (inhibitory) subunit 1C;
                     regulator of calmodulin signaling; thymocyte
                     cAMP-regulated phosphoprotein"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 9"
                     /protein_id="NP_001348953.1"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
                     /translation="MSEQGGLTPTILEEGQTEPESAPENGILKSESLDEEEKLELQRR
                     LAAQNQERRKSKSGAGKGKLTRSLAVCEESSARSGGESHQDQESIHLQLSSFPSLQEE
                     DKSRKDDSEREKEKDKNREKLSERPKIRMLSKDCSQEYTDSTGIDLHGFLINTLKNNS
                     RDRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSV
                     IINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQNRMHPFRDDRRS
                     KSIEEREEEYQRVRERIFAHDSVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRD
                     SSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTASFGGITVLTRGD
                     STSSTRSAGKLSKTGSESSSSAGSSGSLSRTHPQSTALTSSVAAGSPGCMAYSENGMG
                     GQVPPSSTSYILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPGSQQTLRGT
                     VGGQPQQPPQQQPSPQPQQQVQASQPQMAGPLVTQSVQSLQPSSQSVQYPAVSFPPQH
                     LLPMSPTQHFPLREELAAQFSQLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYVI
                     TSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTSQ
                     QYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQGVMSSQQG
                     APVHGVMVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQGSLPATGMPVYCNV
                     TPPNPQNNLRLMGPHCPSSTVPVMSASCRTNCGNVSNAGWQVKF"
     exon            560..601
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..691
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            692..836
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            837..915
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            916..975
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1116
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1225
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1324
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1362
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1422
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1652
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1880
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2062
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2167
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2428
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2555
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2704
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..3636
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3448..3453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="hexamer: AATAAA"
     polyA_site      3494
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="major polyA site"
ORIGIN      
        1 gtgaaaatca gagagccttt gatatgctct tcagcctaag tagaccctct ctttcaggat
       61 tatgttacta tagggcttga tgtctgagtg gcattttagc taatgtcatt ttcatgaaag
      121 acagtcattt ggaaggcact agggctagtt atgcttcctt caaatagcag agtgatctta
      181 acatgagaga ccctgtcttc ggggttatgt agcccttcaa ggttgtcgac catgtgtcaa
      241 gctgtgtaag gaaactgcct cgagatggac actctggact gctaatgggg acatgggacg
      301 gcagttacct ctgatcactt gcgtggattc tcccggaaca gaacgacaga agccgccagt
      361 cattcgccca gatctacagc tggaattctg tgctgaaggg tctaaaaact ctttttaatt
      421 tggatctggg agaatgtctg agcaaggagg actgactccg accatactgg aagaagggca
      481 gacggagcca gagtctgccc cagaaaatgg catcctcaag tcagaaagtc tggatgagga
      541 ggagaagctg gaactgcagc ggcgactggc ggctcagaac caagagagga gaaaatccaa
      601 gtcaggagca ggcaaaggga agctgaccag aagtcttgct gtctgtgaag agtcttcagc
      661 tagatctgga ggggaaagtc accaggatca ggaatcaatt cacttacagc tttccagttt
      721 ccccagcctg caagaggagg ataaatctag gaaggatgat tctgagagag aaaaagaaaa
      781 ggataagaac agagagaaac tctctgagag acccaagatc agaatgttat caaaagattg
      841 cagccaagaa tacacagatt ctacaggcat agacttacat gggtttctaa ttaacacgct
      901 gaagaacaat tccagggaca ggatgatact cttgaaaatg gagcaggaaa tgattgattt
      961 cattgctgac agcaataacc actataaaaa gttcccccag atgtcatcct atcaaaggat
     1021 gctggtccat cgggtggcag cgtactttgg attggaccac aacgtggatc aaactggaaa
     1081 atctgtcatc atcaacaaga ccagcagcac caggatacca gagcaaaggt tttgtgaaca
     1141 tttaaaagat gaaaaaagtg aagaatccca gaagcggttt atcttgaagc gagataactc
     1201 tagtattgat aaagaagaca atcagaacag aatgcaccca tttagagatg acagacgaag
     1261 taaatcaatt gaagagagag aagaggaata tcagagagtg agggagagaa tatttgcaca
     1321 tgattcagtt tgctcacagg aaagcctatt tttggacaac agtaggctcc aggaagacat
     1381 gcacatatgc aatgagacct ataagaaaag acagctcttt cgggctcacc gagacagctc
     1441 aggaagaact tccgggagcc ggcagagcag ctcagagact gagctcaggt ggccagacca
     1501 ccagcgggct tggagcagca cagattcgga cagttccaac cgcaatctga agcccaccat
     1561 gaccaagacg gcaagttttg ggggcatcac ggtgctgacc aggggcgaca gcacgtccag
     1621 taccaggagt gctgggaaac tgtccaaaac aggttctgag tcttccagca gtgcgggctc
     1681 ctcaggatca ctgtcccgca cccacccaca gagcacggcc ctgacctcta gcgtggcagc
     1741 tggttctcct ggctgtatgg cctattcaga gaatggaatg ggaggccagg ttcctcccag
     1801 cagcaccagc tacatcctcc tcccacttga aagtgcgact ggcatcccac ccggaagcat
     1861 ccttcttaat ccacacacag gtcagccctt tgtgaacccg gatggaacgc ctgcgatata
     1921 caaccctccc ggaagtcagc agacactgcg tggcactgtt ggtgggcagc cccagcaacc
     1981 tccacagcag caaccttcgc ctcagcctca gcagcaggtc caggcatcac agccccagat
     2041 ggcagggcca ctggtcactc agtctgtcca gagcctgcag ccatcttccc agtctgtgca
     2101 atatccagcg gtctcttttc ctccccagca tctcctgcct atgtcgccaa cgcagcactt
     2161 ccccttgaga gaagaactgg ctgcccagtt cagccagctg agcatgagcc ggcagtcctc
     2221 gggagacact cctgaacctc cctctggtac agtctaccca gcctctctcc tgccacaaac
     2281 ggctcagcca cagagttatg tcatcacttc tgcaggccag cagctctcta cagggggctt
     2341 ctcggactct ggcccgccca tctcccagca ggtcctgcag gccccgccct ctccccaggg
     2401 atttgtacag cagcctccac ctgcacagat gtccgtctat tactacccat ctggtcagta
     2461 ccctacctca acctcacagc agtaccgacc cctcgcctca gtccagtaca gtgctcagcg
     2521 gagtcagcaa ataccacaga ccacacagca agcaggttac cagccagtct tgtctggtca
     2581 gcagggcttc caaggcatga tgggagtaca gcagtcagcg cacagccagg gtgtgatgag
     2641 cagtcagcaa ggagccccgg tgcatggtgt gatggtctcc tacccaacca tgtcttctta
     2701 tcaggtgcca atgacccaag gctctcaagc agtgccccag cagacatacc aaccaccaat
     2761 catgctgccc agtcaggcag gccaagggtc actcccagcc accggaatgc ctgtgtactg
     2821 taacgtcaca ccgccaaacc ctcagaacaa cctaaggttg atgggtccac actgcccctc
     2881 cagcacggtt cctgtcatgt ccgctagttg cagaacaaac tgtgggaacg tgagcaacgc
     2941 aggctggcag gtcaagttct gagagctcag gctgcctgct gtccacttca tcagatgtta
     3001 actcatggcc ttcaaaggaa gaggagactg acgactggct gaggacttcc atatacactc
     3061 aacgtgcaaa cgattgctgc tggtattctg tacaaactaa tcaaagacta atacacacat
     3121 tagctggtta atggtgcata attccgtcat gtctgctagg tatgcctttc tagcttagct
     3181 agtgacatga attcatcaag gtaagatttt ctcctaccac tgaataccac tgtgtagatt
     3241 acaatatccc tgattcggat tagttttgta cttcgtgttg agtttgtgat gctaaaagta
     3301 tttaaaaata tatatataaa ctaaatcaca cggtaccaaa gctgtaatgg aaaaaggaaa
     3361 gagttaagga atggaaggaa taatttatat acactataga gttttctttt ttaaatggat
     3421 atatatggta ttgtagtgtt taatccaaat aaaagcttat ttgaccttac ggaggaaggt
     3481 catgttttta ccaccagttt gtttccgtct ctctttccat gtgctgttta cctatttagt
     3541 taatggtttc attagcagat agatgttaat tttaagaatg acatttccat acttgtacag
     3601 aatacatttt gaccacatta aaactcaatg tctcct
//
