LOCUS       NM_001362020            3639 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus cyclic AMP-regulated phosphoprotein, 21 (Arpp21),
            transcript variant 30, mRNA.
ACCESSION   NM_001362020 XM_006512334
VERSION     NM_001362020.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Xu,M., Ito-Kureha,T., Kang,H.S., Chernev,A., Raj,T., Hoefig,K.P.,
            Hohn,C., Giesert,F., Wang,Y., Pan,W., Zietara,N., Straub,T.,
            Feederle,R., Daniel,C., Adler,B., Konig,J., Feske,S., Tsokos,G.C.,
            Wurst,W., Urlaub,H., Sattler,M., Kisielow,J., Wulczyn,F.G.,
            Lyszkiewicz,M. and Heissmeyer,V.
  TITLE     The thymocyte-specific RNA-binding protein Arpp21 provides TCR
            repertoire diversity by binding to the 3'-UTR and promoting Rag1
            mRNA expression
  JOURNAL   Nat Commun 15 (1), 2194 (2024)
   PUBMED   38467629
  REMARK    GeneRIF: The thymocyte-specific RNA-binding protein Arpp21 provides
            TCR repertoire diversity by binding to the 3'-UTR and promoting
            Rag1 mRNA expression.
            Erratum:[Nat Commun. 2024 Aug 5;15(1):6632. doi:
            10.1038/s41467-024-50610-8.. PMID: 39103338]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Tan,Y.Y., Zhang,Y., Li,B., Ou,Y.W., Xie,S.J., Chen,P.P., Mei,S.Q.,
            Huang,Q.J., Zheng,L.L. and Qu,L.H.
  TITLE     PERK Signaling Controls Myoblast Differentiation by Regulating
            MicroRNA Networks
  JOURNAL   Front Cell Dev Biol 9, 670435 (2021)
   PUBMED   34124052
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Rakhilin,S.V., Olson,P.A., Nishi,A., Starkova,N.N., Fienberg,A.A.,
            Nairn,A.C., Surmeier,D.J. and Greengard,P.
  TITLE     A network of control mediated by regulator of
            calcium/calmodulin-dependent signaling
  JOURNAL   Science 306 (5696), 698-701 (2004)
   PUBMED   15499021
  REMARK    GeneRIF: Through a molecular mechanism that amplifies GPCR- &
            PKA-mediated signaling & attenuates GPCR- & PP2B-mediated
            signaling, RCS (ARPP-21) synergistically increases phosphorylation
            of key proteins whose phosphorylation is regulated by PKA and PP2B
            [RCS]
REFERENCE   7  (bases 1 to 3639)
  AUTHORS   Kim,J., Lee,J., Yadav,N., Wu,Q., Carter,C., Richard,S., Richie,E.
            and Bedford,M.T.
  TITLE     Loss of CARM1 results in hypomethylation of thymocyte cyclic
            AMP-regulated phosphoprotein and deregulated early T cell
            development
  JOURNAL   J Biol Chem 279 (24), 25339-25344 (2004)
   PUBMED   15096520
  REMARK    GeneRIF: CARM1 plays a significant role in promoting the
            differentiation of early thymocyte progenitors, possibly through
            its direct action on TARPP.
REFERENCE   8  (bases 1 to 3639)
  AUTHORS   Kisielow,J., Nairn,A.C. and Karjalainen,K.
  TITLE     TARPP, a novel protein that accompanies TCR gene rearrangement and
            thymocyte education
  JOURNAL   Eur J Immunol 31 (4), 1141-1149 (2001)
   PUBMED   11298339
REFERENCE   9  (bases 1 to 3639)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3639)
  AUTHORS   Ivkovic,S., Blau,S., Polanskaya,O. and Ehrlich,M.E.
  TITLE     ARPP-21: murine gene structure and promoter identification of a
            neuronal phosphoprotein enriched in the limbic striatum
  JOURNAL   Brain Res 709 (1), 10-16 (1996)
   PUBMED   8869551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100550.7 and AC130551.4.
            
            On Mar 31, 2018 this sequence version replaced XM_006512334.3.
            
            Transcript Variant: This variant (30), as well as variant 31,
            encodes isoform 4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC100550.7         99056-99276         c
            222-398             AC100550.7         53554-53730         c
            399-559             AC100550.7         51573-51733         c
            560-601             AC100550.7         50233-50274         c
            602-691             AC100550.7         49459-49548         c
            692-836             AC100550.7         44992-45136         c
            837-915             AC100550.7         43622-43700         c
            916-975             AC100550.7         42898-42957         c
            976-1116            AC100550.7         42059-42199         c
            1117-1225           AC100550.7         23654-23762         c
            1226-1327           AC100550.7         21382-21483         c
            1328-1365           AC100550.7         15299-15336         c
            1366-1425           AC100550.7         13387-13446         c
            1426-1655           AC130551.4         189248-189477       c
            1656-1883           AC130551.4         182393-182620       c
            1884-2065           AC130551.4         173218-173399       c
            2066-2170           AC130551.4         172374-172478       c
            2171-2431           AC130551.4         170679-170939       c
            2432-2558           AC130551.4         165122-165248       c
            2559-2707           AC130551.4         113100-113248       c
            2708-3639           AC130551.4         111030-111961       c
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 62.46 cM"
     gene            1..3639
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="cyclic AMP-regulated phosphoprotein, 21"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
     exon            1..221
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            222..398
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            399..559
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..2965
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="isoform 8 is encoded by transcript variant 30;
                     cAMP-regulated phosphoprotein 21; thymocyte ARPP; protein
                     phosphatase 1, regulatory (inhibitory) subunit 1C;
                     regulator of calmodulin signaling; thymocyte
                     cAMP-regulated phosphoprotein"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 8"
                     /protein_id="NP_001348949.1"
                     /db_xref="GeneID:74100"
                     /db_xref="MGI:MGI:107562"
                     /translation="MSEQGGLTPTILEEGQTEPESAPENGILKSESLDEEEKLELQRR
                     LAAQNQERRKSKSGAGKGKLTRSLAVCEESSARSGGESHQDQESIHLQLSSFPSLQEE
                     DKSRKDDSEREKEKDKNREKLSERPKIRMLSKDCSQEYTDSTGIDLHGFLINTLKNNS
                     RDRMILLKMEQEMIDFIADSNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSV
                     IINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRR
                     SKSIEEREEEYQRVRERIFAHDSVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHR
                     DSSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTASFGGITVLTRG
                     DSTSSTRSAGKLSKTGSESSSSAGSSGSLSRTHPQSTALTSSVAAGSPGCMAYSENGM
                     GGQVPPSSTSYILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPGSQQTLRG
                     TVGGQPQQPPQQQPSPQPQQQVQASQPQMAGPLVTQSVQSLQPSSQSVQYPAVSFPPQ
                     HLLPMSPTQHFPLREELAAQFSQLSMSRQSSGDTPEPPSGTVYPASLLPQTAQPQSYV
                     ITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTS
                     QQYRPLASVQYSAQRSQQIPQTTQQAGYQPVLSGQQGFQGMMGVQQSAHSQGVMSSQQ
                     GAPVHGVMVSYPTMSSYQVPMTQGSQAVPQQTYQPPIMLPSQAGQGSLPATGMPVYCN
                     VTPPNPQNNLRLMGPHCPSSTVPVMSASCRTNCGNVSNAGWQVKF"
     exon            560..601
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..691
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            692..836
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            837..915
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            916..975
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1116
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1225
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1327
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1365
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1425
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1655
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1883
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2065
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2170
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2431
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2558
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2707
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..3639
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="hexamer: AATAAA"
     polyA_site      3497
                     /gene="Arpp21"
                     /gene_synonym="0710001E13Rik; ARPP-21; D9Bwg1012e; R3hdm3;
                     Tarpp"
                     /note="major polyA site"
ORIGIN      
        1 gtgaaaatca gagagccttt gatatgctct tcagcctaag tagaccctct ctttcaggat
       61 tatgttacta tagggcttga tgtctgagtg gcattttagc taatgtcatt ttcatgaaag
      121 acagtcattt ggaaggcact agggctagtt atgcttcctt caaatagcag agtgatctta
      181 acatgagaga ccctgtcttc ggggttatgt agcccttcaa ggttgtcgac catgtgtcaa
      241 gctgtgtaag gaaactgcct cgagatggac actctggact gctaatgggg acatgggacg
      301 gcagttacct ctgatcactt gcgtggattc tcccggaaca gaacgacaga agccgccagt
      361 cattcgccca gatctacagc tggaattctg tgctgaaggg tctaaaaact ctttttaatt
      421 tggatctggg agaatgtctg agcaaggagg actgactccg accatactgg aagaagggca
      481 gacggagcca gagtctgccc cagaaaatgg catcctcaag tcagaaagtc tggatgagga
      541 ggagaagctg gaactgcagc ggcgactggc ggctcagaac caagagagga gaaaatccaa
      601 gtcaggagca ggcaaaggga agctgaccag aagtcttgct gtctgtgaag agtcttcagc
      661 tagatctgga ggggaaagtc accaggatca ggaatcaatt cacttacagc tttccagttt
      721 ccccagcctg caagaggagg ataaatctag gaaggatgat tctgagagag aaaaagaaaa
      781 ggataagaac agagagaaac tctctgagag acccaagatc agaatgttat caaaagattg
      841 cagccaagaa tacacagatt ctacaggcat agacttacat gggtttctaa ttaacacgct
      901 gaagaacaat tccagggaca ggatgatact cttgaaaatg gagcaggaaa tgattgattt
      961 cattgctgac agcaataacc actataaaaa gttcccccag atgtcatcct atcaaaggat
     1021 gctggtccat cgggtggcag cgtactttgg attggaccac aacgtggatc aaactggaaa
     1081 atctgtcatc atcaacaaga ccagcagcac caggatacca gagcaaaggt tttgtgaaca
     1141 tttaaaagat gaaaaaagtg aagaatccca gaagcggttt atcttgaagc gagataactc
     1201 tagtattgat aaagaagaca atcagcagaa cagaatgcac ccatttagag atgacagacg
     1261 aagtaaatca attgaagaga gagaagagga atatcagaga gtgagggaga gaatatttgc
     1321 acatgattca gtttgctcac aggaaagcct atttttggac aacagtaggc tccaggaaga
     1381 catgcacata tgcaatgaga cctataagaa aagacagctc tttcgggctc accgagacag
     1441 ctcaggaaga acttccggga gccggcagag cagctcagag actgagctca ggtggccaga
     1501 ccaccagcgg gcttggagca gcacagattc ggacagttcc aaccgcaatc tgaagcccac
     1561 catgaccaag acggcaagtt ttgggggcat cacggtgctg accaggggcg acagcacgtc
     1621 cagtaccagg agtgctggga aactgtccaa aacaggttct gagtcttcca gcagtgcggg
     1681 ctcctcagga tcactgtccc gcacccaccc acagagcacg gccctgacct ctagcgtggc
     1741 agctggttct cctggctgta tggcctattc agagaatgga atgggaggcc aggttcctcc
     1801 cagcagcacc agctacatcc tcctcccact tgaaagtgcg actggcatcc cacccggaag
     1861 catccttctt aatccacaca caggtcagcc ctttgtgaac ccggatggaa cgcctgcgat
     1921 atacaaccct cccggaagtc agcagacact gcgtggcact gttggtgggc agccccagca
     1981 acctccacag cagcaacctt cgcctcagcc tcagcagcag gtccaggcat cacagcccca
     2041 gatggcaggg ccactggtca ctcagtctgt ccagagcctg cagccatctt cccagtctgt
     2101 gcaatatcca gcggtctctt ttcctcccca gcatctcctg cctatgtcgc caacgcagca
     2161 cttccccttg agagaagaac tggctgccca gttcagccag ctgagcatga gccggcagtc
     2221 ctcgggagac actcctgaac ctccctctgg tacagtctac ccagcctctc tcctgccaca
     2281 aacggctcag ccacagagtt atgtcatcac ttctgcaggc cagcagctct ctacaggggg
     2341 cttctcggac tctggcccgc ccatctccca gcaggtcctg caggccccgc cctctcccca
     2401 gggatttgta cagcagcctc cacctgcaca gatgtccgtc tattactacc catctggtca
     2461 gtaccctacc tcaacctcac agcagtaccg acccctcgcc tcagtccagt acagtgctca
     2521 gcggagtcag caaataccac agaccacaca gcaagcaggt taccagccag tcttgtctgg
     2581 tcagcagggc ttccaaggca tgatgggagt acagcagtca gcgcacagcc agggtgtgat
     2641 gagcagtcag caaggagccc cggtgcatgg tgtgatggtc tcctacccaa ccatgtcttc
     2701 ttatcaggtg ccaatgaccc aaggctctca agcagtgccc cagcagacat accaaccacc
     2761 aatcatgctg cccagtcagg caggccaagg gtcactccca gccaccggaa tgcctgtgta
     2821 ctgtaacgtc acaccgccaa accctcagaa caacctaagg ttgatgggtc cacactgccc
     2881 ctccagcacg gttcctgtca tgtccgctag ttgcagaaca aactgtggga acgtgagcaa
     2941 cgcaggctgg caggtcaagt tctgagagct caggctgcct gctgtccact tcatcagatg
     3001 ttaactcatg gccttcaaag gaagaggaga ctgacgactg gctgaggact tccatataca
     3061 ctcaacgtgc aaacgattgc tgctggtatt ctgtacaaac taatcaaaga ctaatacaca
     3121 cattagctgg ttaatggtgc ataattccgt catgtctgct aggtatgcct ttctagctta
     3181 gctagtgaca tgaattcatc aaggtaagat tttctcctac cactgaatac cactgtgtag
     3241 attacaatat ccctgattcg gattagtttt gtacttcgtg ttgagtttgt gatgctaaaa
     3301 gtatttaaaa atatatatat aaactaaatc acacggtacc aaagctgtaa tggaaaaagg
     3361 aaagagttaa ggaatggaag gaataattta tatacactat agagttttct tttttaaatg
     3421 gatatatatg gtattgtagt gtttaatcca aataaaagct tatttgacct tacggaggaa
     3481 ggtcatgttt ttaccaccag tttgtttccg tctctctttc catgtgctgt ttacctattt
     3541 agttaatggt ttcattagca gatagatgtt aattttaaga atgacatttc catacttgta
     3601 cagaatacat tttgaccaca ttaaaactca atgtctcct
//
