LOCUS       NM_021548               4032 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus cAMP-regulated phosphoprotein 19 (Arpp19), transcript
            variant 1, mRNA.
ACCESSION   NM_021548
VERSION     NM_021548.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4032)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   2  (bases 1 to 4032)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4032)
  AUTHORS   Hached,K., Goguet,P., Charrasse,S., Vigneron,S., Sacristan,M.P.,
            Lorca,T. and Castro,A.
  TITLE     ENSA and ARPP19 differentially control cell cycle progression and
            development
  JOURNAL   J Cell Biol 218 (2), 541-558 (2019)
   PUBMED   30626720
  REMARK    GeneRIF: during mouse embryogenesis, the Arpp19 and Ensa paralog
            genes display specific functions by differentially controlling cell
            cycle progression.
REFERENCE   4  (bases 1 to 4032)
  AUTHORS   Andrade,E.C., Musante,V., Horiuchi,A., Matsuzaki,H., Brody,A.H.,
            Wu,T., Greengard,P., Taylor,J.R. and Nairn,A.C.
  TITLE     ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A
            Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast
            3 Kinase)
  JOURNAL   J Neurosci 37 (10), 2709-2722 (2017)
   PUBMED   28167675
REFERENCE   5  (bases 1 to 4032)
  AUTHORS   Adhikari,D., Diril,M.K., Busayavalasa,K., Risal,S., Nakagawa,S.,
            Lindkvist,R., Shen,Y., Coppola,V., Tessarollo,L., Kudo,N.R.,
            Kaldis,P. and Liu,K.
  TITLE     Mastl is required for timely activation of APC/C in meiosis I and
            Cdk1 reactivation in meiosis II
  JOURNAL   J Cell Biol 206 (7), 843-853 (2014)
   PUBMED   25246615
REFERENCE   6  (bases 1 to 4032)
  AUTHORS   White,R.E. and Giffard,R.G.
  TITLE     MicroRNA-320 induces neurite outgrowth by targeting ARPP-19
  JOURNAL   Neuroreport 23 (10), 590-595 (2012)
   PUBMED   22617447
  REMARK    GeneRIF: ARPP-19 is validated by showing reduced mRNA and protein
            levels when miR-320 is overexpressed in neurites.
REFERENCE   7  (bases 1 to 4032)
  AUTHORS   Hitzemann,R., Reed,C., Malmanger,B., Lawler,M., Hitzemann,B.,
            Cunningham,B., McWeeney,S., Belknap,J., Harrington,C., Buck,K.,
            Phillips,T. and Crabbe,J.
  TITLE     On the integration of alcohol-related quantitative trait loci and
            gene expression analyses
  JOURNAL   Alcohol Clin Exp Res 28 (10), 1437-1448 (2004)
   PUBMED   15597075
  REMARK    Erratum:[Alcohol Clin Exp Res. 2004 Dec;28(12):1930]
REFERENCE   8  (bases 1 to 4032)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4032)
  AUTHORS   Dulubova,I., Horiuchi,A., Snyder,G.L., Girault,J.A., Czernik,A.J.,
            Shao,L., Ramabhadran,R., Greengard,P. and Nairn,A.C.
  TITLE     ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated
            phosphoproteins
  JOURNAL   J Neurochem 77 (1), 229-238 (2001)
   PUBMED   11279279
REFERENCE   10 (bases 1 to 4032)
  AUTHORS   Girault,J.A., Shalaby,I.A., Rosen,N.L. and Greengard,P.
  TITLE     Regulation by cAMP and vasoactive intestinal peptide of
            phosphorylation of specific proteins in striatal cells in culture
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7790-7794 (1988)
   PUBMED   2845422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033761.14.
            
            On Nov 17, 2006 this sequence version replaced NM_021548.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 2. The resulting isoform (1) is
            shorter at the N-terminus compared to isoform 2. Variants 1, 3, and
            4 all encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040206.1, AK049760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               CT033761.14        28897-29126
            231-353             CT033761.14        43398-43520
            354-4032            CT033761.14        47800-51478
FEATURES             Location/Qualifiers
     source          1..4032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.25 cM"
     gene            1..4032
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /note="cAMP-regulated phosphoprotein 19"
                     /db_xref="GeneID:59046"
                     /db_xref="MGI:MGI:1891691"
     exon            1..230
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /inference="alignment:Splign:2.1.0"
     exon            231..353
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /inference="alignment:Splign:2.1.0"
     exon            354..4032
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      524..529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /note="hexamer: ATTAAA"
     polyA_site      542
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /note="major polyA site"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
                     /note="hexamer: AATAAA"
     polyA_site      4032
                     /gene="Arpp19"
                     /gene_synonym="19kDa; 2700024H10Rik; ARPP-19; Arpp12"
ORIGIN      
        1 gcggcgcggg agcctggcgg gcctgggctg cgggagctac ggcgggcggg agcccggggc
       61 ccgtgtcgtc acaaggcggc ggtagccgcc ggcccggcgg gcagcggggc aggcagaagg
      121 tggcgggcgg tcttgcctcc cggtaatctg tcttctcccg gcgtctcttc tgcagaagga
      181 gcaccatgtc cgcggaagtc cccgaggcag cgtctgcgga ggagcaaaag gaaatggaag
      241 ataaagtaac tagtccagag aaagctgaag aagcaaagtt aaaggcaagg tatcctcact
      301 tgggacaaaa gcctggaggg tctgattttt taaggaaaag attgcagaaa gggcaaaagt
      361 attttgattc tggggactac aacatggcaa aagcaaagat gaagaacaag cagcttcctg
      421 ctgcagcccc ggataagaca gaggtcactg gtgaccacat tcccactcca caggacctcc
      481 ctcagcggaa accgtccctg gttgctagca agctggctgg ctgattaaag agctgaactg
      541 catgagtcct ctactgtcct ttatttctct gactacgtta cttacccact tgtgttccct
      601 tcactcactg tcgttggaga ctgacagctt tgcaggtagt ggtagtgtgt gctactgttg
      661 taagggagca tacatgtgta gaggtttgga ttagtttcac agtgcactga tgcaaaggac
      721 atgtaacagc aacataagta aatgacgtga caataattgt acacattacc tagctggtgt
      781 agggctggct ccaacaagta gcaagcaagt tttacagctt taatgctctg gctttcttta
      841 ctttctcatg attacagctt tgtatgttac tcttatttaa caggacctct gttgtattga
      901 tttcttctgt atcttccttt tgaatcttgt aagacagaag tttaagacca cgagttggaa
      961 gacaagtcac ataatccaaa cacaagtaaa tggctgcaaa agatttgagt aactgcttgg
     1021 acttgacggc cttaaacctg ctgttccagc tttaacaaga gcatcttacc tgggcgatat
     1081 ttgcccgttc tggtgtgact tgtgtgactc caatgcttac cagctgtcac tgaaactagt
     1141 gctcttcctc attctgcagt gtgtggagac agctttcttt gttgaagatg tgaatgggtg
     1201 tgcatgtgca ctgactattg cattcacttt tgtgccattt ttgtaaatac aatagttttg
     1261 cacaaccttt tacaaatgtc tgtattaatt tcaccgtatt agaaagtaga taatgtgcca
     1321 accagaagca caaaaattcc tacacaaatc tgcctgccat tactgctttt gtataagaat
     1381 agtttacaat cttgagcata ttagaatacc aaactgaaat atactcagcc tgctacagag
     1441 ttaagctttt tcatttatta ctaatattca tgactttcag tggccttgta caaatatgat
     1501 atgttgctta ggcatatctt ttgttctatg cagaacattt cattttgact tttacaaaaa
     1561 aattacaatt catataattt atataaactt tcttagtgta gaaacttttt acttccacat
     1621 tcagctttgg ggatactaaa gtataacact tgcatcctct gtcttctgtt atcttctcag
     1681 cccctgcctt ctctttactt ggcttctgtg actcgtattg gtttatctca tttatataaa
     1741 agcgtatgtg tctatcttta ctttttaagc ttgcttaaat aaaagaattt ttgtgagggt
     1801 tttttgttat gctgagaatc aaacctctgt ctcacatgtg cttagcaagc actgtaccac
     1861 agaactacac tcttattcct aagggaactt tataatgaag tgaggagttg aaaagactta
     1921 tccagaatta gctagattct gttaaataat taggaggaac taggtgagta gggctaataa
     1981 ttacagtgat ttatgtggta ggtaagacat tcatattaga atatttaggt atctcctata
     2041 catgtcattt taataaaata tcaatttact tgtggtttat gtattagtgg aaacattagt
     2101 agactttatt cggacacatt tattattaga gctctccccg ggatgtcagg ctacggcata
     2161 ttgaacagta gcagccggag ctgatacagt ttttcctctt catcttgggc tagagtgagg
     2221 cctcctcccc tatggaatac aggcatcatt tgtatcatga ctacatttgt gcacctgctt
     2281 tcctgtggtt ccacactagt gattgatcct gttccactca atgtgaggca gaaaagcaac
     2341 ataatttaca ctccacattg ccaattttag agctcaattc tatgtaaata tatttgtaat
     2401 gagcaaacga attattccat aatatgtgca attcatcata agattgctag atagcttttt
     2461 cccccctgtg gatatttgca agcccatccc cattgagttc agtagatgaa cctgaggtaa
     2521 gagtgaccat gctcttcctg aacatcagac taacagtcta ccaagtgagc aacacttttt
     2581 tgctttgtaa aataggactc tgatgtttaa cctacctcaa gacttgagga tctgtgaaat
     2641 actaagtgcc ccaaatatta ctatcttttc aaaagtcaat ttcatcacta aaccaacctg
     2701 ccttctataa agtagcagtg cttaaaatct caggattttc cacgaggaaa gacctgtaag
     2761 gatttgtacg tatcactaca tggcttccat tggtgcttga gagagaggtt ttacattttc
     2821 ctggtttttg ttctacttca aagctcagtt gtagatactt ttgcaggctc tttggtcatg
     2881 atatagtgaa gattttgatg aaatgagctt aatttctgtg ttaaagctgt gtctgaggaa
     2941 tggctaattt caatgttaga gtaaattgag gttgatgaaa atactaaagg caaactggct
     3001 aaaacctaaa tgtgttttgt tcagtagctc atataagaat caccttgaag gttacgtctg
     3061 actaacagtt gcaccttgtg tctagttgga atagcatttg gatagattgg tgggaatatg
     3121 tttgcatttc tacgggttgt tagagaatct tgtactgctg gtctgaagat tgtttaaatg
     3181 actcaaggca gtcatgacaa ggcctctatt tgttacttcc acagttagaa ttagttgttc
     3241 tttttacttg atgtaaccaa agtatacctc taagtatgta ttggtagtca ttactaagtc
     3301 agacttgtat tcttgatctg aatatcacag tcttatcaaa actgaactat caacccaaac
     3361 tctgtaaact tattgtttga tggtcagaag caggtagcct ctgggaagag ctattctgat
     3421 ggttaccaag gccctgtctg tgagagcttc atcagatcac ccaaccttca gactcattac
     3481 ttttatcgtg acccaattcc ctcaccatgt ccacccctga agcccactgt aagcacttca
     3541 cttacatttt ctaaagcacc gtcttgatct catttggcat gaactgccag caacccaaga
     3601 ctctttctcc aacttgtcac tgctactttt agaaattggg atcacaactt gtggtgtctc
     3661 ctgtatagct aagtgaactc ttactagttc caaccttcaa aggagataga ccttgagttt
     3721 catcctataa atgactggtg gtggtgacac gcataaatgt atgtttgtat ggtatttatc
     3781 aactaaatag cagtagaagt agagatctaa ctcctttagt atcgtgccct caaatctatc
     3841 aatgcatctc caccatttga tatgcaatag gacactgcct gtacgcagag ggccaacata
     3901 aatgcctttt cttgttaaag atgtctgtag agttggcagt taatgctaaa gtttgtcaaa
     3961 tagctcgtcc aaacttacac ttgtaaaata caccccgaat aaatggatct acctaatttt
     4021 tattgatttt aa
//
