LOCUS       NM_027420               2184 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus actin-related protein 2/3 complex inhibitor (Arpin),
            mRNA.
ACCESSION   NM_027420 XM_133556
VERSION     NM_027420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Dang,I., Gorelik,R., Sousa-Blin,C., Derivery,E., Guerin,C.,
            Linkner,J., Nemethova,M., Dumortier,J.G., Giger,F.A.,
            Chipysheva,T.A., Ermilova,V.D., Vacher,S., Campanacci,V.,
            Herrada,I., Planson,A.G., Fetics,S., Henriot,V., David,V.,
            Oguievetskaia,K., Lakisic,G., Pierre,F., Steffen,A., Boyreau,A.,
            Peyrieras,N., Rottner,K., Zinn-Justin,S., Cherfils,J., Bieche,I.,
            Alexandrova,A.Y., David,N.B., Small,J.V., Faix,J., Blanchoin,L. and
            Gautreau,A.
  TITLE     Inhibitory signalling to the Arp2/3 complex steers cell migration
  JOURNAL   Nature 503 (7475), 281-284 (2013)
   PUBMED   24132237
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110903.25.
            
            On Apr 30, 2007 this sequence version replaced NM_027420.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051261.1, BC031379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC110903.25        31923-32034         c
            113-188             AC110903.25        28573-28648         c
            189-321             AC110903.25        26343-26475         c
            322-528             AC110903.25        24942-25148         c
            529-692             AC110903.25        24396-24559         c
            693-2184            AC110903.25        22129-23620         c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.27 cM"
     gene            1..2184
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /note="actin-related protein 2/3 complex inhibitor"
                     /db_xref="GeneID:70420"
                     /db_xref="MGI:MGI:1917670"
     exon            1..112
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..701
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /note="UPF0552 protein C15orf38 homolog; arp2/3 inhibition
                     protein"
                     /codon_start=1
                     /product="arpin"
                     /protein_id="NP_081696.1"
                     /db_xref="CCDS:CCDS21390.1"
                     /db_xref="GeneID:70420"
                     /db_xref="MGI:MGI:1917670"
                     /translation="MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDV
                     SRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKV
                     EAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRL
                     KTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDG
                     AEDEEWDD"
     exon            113..188
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            189..321
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            322..528
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            529..692
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..2184
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /note="major polyA site"
     polyA_site      1726
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
ORIGIN      
        1 agggcctcgg cgtggggaaa atgagccgca tctaccagga tagcgccctc cgcaacaagg
       61 ccgtgcagag cgcgcgcctg ccgggaacct gggaccctgc cacccaccaa gggggaaatg
      121 gcatcttgct ggagggggag ctcgtggatg tatctcggca cagcatcttg gatgcccatg
      181 gcaggaagga gcgctactat gtgctgtata tccagcccag ctgtatccac aggcgtaagt
      241 ttgaccccaa gggaaatgaa attgagccca acttcagtgc caccaggaag gtgaacacag
      301 gcttcctcat gtcatcttac aaggtggagg ccaagggcga cacagaccgg ctcaccctgg
      361 aggcgctgaa gagcctggta aacaagcccc agctgctgga attgacagag agcctcaccc
      421 cagaccaggc ggtggcattc tggatgcctg agtcagagat ggaggtcatg gaactcgaac
      481 tggggactgg agtgcgatta aaaactcggg gtgatggtcc cttcatagat tccttagcca
      541 aactggagct ggggacagtg accaagtgta attttgctgg tgatggaaag acgggagctt
      601 cctggacaga caatatcatg gcccagaagt cttcagagag gaacacagca gagatccgag
      661 agcaaggaga cggggcagag gacgaggaat gggatgactg aggtgcctcc tcaactagac
      721 cagcatctgg gatggtgtcg ctgagaagtg gccacaccaa cttctgcctt ggagagatca
      781 ggctgtcaag cagaatatca ttgaacaccc tctgatgaaa tcaaacccaa gacctcagta
      841 ctcaccaagg gtctccaggc tatggctttt gtatgtctgt ggccctcatt ggatgcaagg
      901 ctagctttcc tagatctatc tccagtattc ctttccctag gtagcaggca tggactagat
      961 gagtcctcca aggtacacaa ttgacaaagg ctccttgtct gagtccagag ggactcaggg
     1021 ggtaagagcg ccggctcttt ccaatcctgc agttttctcc tttttttgct ttctaccctg
     1081 tgccagcttc tttttgtgcc tctgttctcc tgtcccagtc ttcctctgtc tgttcttccc
     1141 tgtcccacac ccaagatacc acttcattat ttctattcag ctctgtgcct ctgtgggctt
     1201 tcctgcctta gatctctgtc ttagggctct tactgctcca atgaaacccg acgacccaaa
     1261 gcaacttggg gagggaaggg tttatttcac tcacagatcc gtagaacagt tcatcaccag
     1321 taaagcagtg agagcaggag ctcaagcagg gcaggaacct ggaggcagga gcagagagcg
     1381 tggtgtgctg caaactggct cgctctgttt gctttcttct agaacccagg accaccagcc
     1441 cagtaatggc attacctaga atgggctggg ccggggtact ctagcttctg tcaggttgac
     1501 ataaagctag ttatcacaca cctatctggc tgctgtccta aagatgccat ttttgggaag
     1561 gccttcagcc ttcccagctg tgtctagccg gtccacaagt cttgactcat tccactgggc
     1621 caacttttta tatttttaaa atattttctt tttaataaat agtgctggta cttaaaccta
     1681 gtgctccatg cttgctaggt gagtgatcca ccactgtcta caccaacaag tcccagaccg
     1741 tattttttgg tatgactctt tttgttgttt tgtacttgga gaacttctta ggagtgagta
     1801 ctcttcggga aagaattcct ccacacgact gggttcttgt ctcgtgttta tggtcttcta
     1861 gctgagtcac aatcctagac gagaacccca gtcttagtgt gcccctgctc agccctgtga
     1921 caagatctgg aacggaagtc tacacgtctt gagtgtgacc atggcaggtg tacgcatcct
     1981 gcctgatcct gggaaaaagg gtgagggagg acagggatta ctgatccgac ttcatggttc
     2041 aaactcaatg acagatgctt tctgtcacca gtactgacaa tactgagttc ttcctgatgc
     2101 tagtgcttaa gttaagtact tggagtagtc tgtcacaaca accctatgat gtacatagga
     2161 taaatatccc catttttgat acat
//
