LOCUS       NP_081696                226 aa            linear   ROD 02-MAY-2024
DEFINITION  arpin [Mus musculus].
ACCESSION   NP_081696 XP_133556
VERSION     NP_081696.1
DBSOURCE    REFSEQ: accession NM_027420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 226)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 226)
  AUTHORS   Dang,I., Gorelik,R., Sousa-Blin,C., Derivery,E., Guerin,C.,
            Linkner,J., Nemethova,M., Dumortier,J.G., Giger,F.A.,
            Chipysheva,T.A., Ermilova,V.D., Vacher,S., Campanacci,V.,
            Herrada,I., Planson,A.G., Fetics,S., Henriot,V., David,V.,
            Oguievetskaia,K., Lakisic,G., Pierre,F., Steffen,A., Boyreau,A.,
            Peyrieras,N., Rottner,K., Zinn-Justin,S., Cherfils,J., Bieche,I.,
            Alexandrova,A.Y., David,N.B., Small,J.V., Faix,J., Blanchoin,L. and
            Gautreau,A.
  TITLE     Inhibitory signalling to the Arp2/3 complex steers cell migration
  JOURNAL   Nature 503 (7475), 281-284 (2013)
   PUBMED   24132237
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110903.25.
            
            On Aug 30, 2004 this sequence version replaced XP_133556.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051261.1, BC031379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.27 cM"
     Protein         1..226
                     /product="arpin"
                     /note="UPF0552 protein C15orf38 homolog; arp2/3 inhibition
                     protein"
                     /calculated_mol_wt=25062
     Region          1..224
                     /region_name="UPF0552"
                     /note="Arp2/3-interacting proteins Arpin; pfam10574"
                     /db_xref="CDD:463152"
     Region          202..226
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0A3.1)"
     Region          211..226
                     /region_name="Necessary and sufficient fopr interaction
                     with ARPC2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0A3.1)"
     CDS             1..226
                     /gene="Arpin"
                     /gene_synonym="2610034B18Rik"
                     /coded_by="NM_027420.4:21..701"
                     /db_xref="CCDS:CCDS21390.1"
                     /db_xref="GeneID:70420"
                     /db_xref="MGI:MGI:1917670"
ORIGIN      
        1 msriyqdsal rnkavqsarl pgtwdpathq ggngillege lvdvsrhsil dahgrkeryy
       61 vlyiqpscih rrkfdpkgne iepnfsatrk vntgflmssy kveakgdtdr ltlealkslv
      121 nkpqllelte sltpdqavaf wmpesemevm elelgtgvrl ktrgdgpfid slaklelgtv
      181 tkcnfagdgk tgaswtdnim aqkssernta eireqgdgae deewdd
//
