LOCUS       NM_026369               1897 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus actin related protein 2/3 complex, subunit 5 (Arpc5),
            mRNA.
ACCESSION   NM_026369
VERSION     NM_026369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1897)
  AUTHORS   Sindram,E., Caballero-Oteyza,A., Kogata,N., Chor Mei Huang,S.,
            Alizadeh,Z., Gamez-Diaz,L., Fazlollhi,M.R., Peng,X., Grimbacher,B.,
            Way,M. and Proietti,M.
  TITLE     ARPC5 deficiency leads to severe early-onset systemic inflammation
            and mortality
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37382373
  REMARK    GeneRIF: ARPC5 deficiency leads to severe early-onset systemic
            inflammation and mortality.
REFERENCE   2  (bases 1 to 1897)
  AUTHORS   Qu,G., Zhang,Y., Duan,H., Tang,C., Yang,G., Chen,D. and Xu,Y.
  TITLE     ARPC5 is transcriptionally activated by KLF4, and promotes cell
            migration and invasion in prostate cancer via up-regulating ADAM17
            : ARPC5 serves as an oncogene in prostate cancer
  JOURNAL   Apoptosis 28 (5-6), 783-795 (2023)
   PUBMED   36881291
  REMARK    GeneRIF: ARPC5 is transcriptionally activated by KLF4, and promotes
            cell migration and invasion in prostate cancer via up-regulating
            ADAM17 : ARPC5 serves as an oncogene in prostate cancer.
REFERENCE   3  (bases 1 to 1897)
  AUTHORS   Chang,Y.F., Lee-Chang,J.S., Imam,J.S., Buddavarapu,K.C.,
            Subaran,S.S., Sinha-Hikim,A.P., Gorospe,M. and Rao,M.K.
  TITLE     Interaction between microRNAs and actin-associated protein Arpc5
            regulates translational suppression during male germ cell
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 109 (15), 5750-5755 (2012)
   PUBMED   22447776
  REMARK    GeneRIF: Loss of microRNA-dependent regulation of Arpc5, which
            controls the distribution of germ cell mRNAs between
            translationally active and inactive pools, results in abnormal
            round spermatid differentiation and impaired fertility.
REFERENCE   4  (bases 1 to 1897)
  AUTHORS   Ichikawa,D., Mizuno,M., Yamamura,T. and Miyake,S.
  TITLE     GRAIL (gene related to anergy in lymphocytes) regulates
            cytoskeletal reorganization through ubiquitination and degradation
            of Arp2/3 subunit 5 and coronin 1A
  JOURNAL   J Biol Chem 286 (50), 43465-43474 (2011)
   PUBMED   22016387
  REMARK    GeneRIF: GRAIL functions via the ubiquitination and degradation of
            actin cytoskeleton-associated proteins, in particular Arp2/3-5 and
            coronin 1A
REFERENCE   5  (bases 1 to 1897)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 1897)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   7  (bases 1 to 1897)
  AUTHORS   DeMali,K.A., Barlow,C.A. and Burridge,K.
  TITLE     Recruitment of the Arp2/3 complex to vinculin: coupling membrane
            protrusion to matrix adhesion
  JOURNAL   J Cell Biol 159 (5), 881-891 (2002)
   PUBMED   12473693
REFERENCE   8  (bases 1 to 1897)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF170085.1 and BC060143.1.
            
            On Mar 11, 2009 this sequence version replaced NM_026369.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060143.1, SRR1660817.116277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                CF170085.1         1-94
            95-1897             BC060143.1         1-1803
FEATURES             Location/Qualifiers
     source          1..1897
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.02 cM"
     gene            1..1897
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /note="actin related protein 2/3 complex, subunit 5"
                     /db_xref="GeneID:67771"
                     /db_xref="MGI:MGI:1915021"
     exon            1..326
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            327..399
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            400..576
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            577..1897
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /note="hexamer: AATAAA"
     polyA_site      1897
                     /gene="Arpc5"
                     /gene_synonym="5830443F10Rik; p16-Arc"
                     /note="major polyA site"
ORIGIN      
        1 ggctgaagga tggctgcaag cagaggagga ggccgagccc gctagcgcgc aggcccagaa
       61 gcttgcaagc cgcggctgcc ggcgacgccc cagagcggaa gagggaagtg agtcggaccg
      121 ggctgggctc gctaaaggag aggcaccgcg gaggggcagg ccagcgtcgc gtcgcgatcc
      181 gggatgtcga agaacacggt gtcgtcggcc cgcttccgga aggtggacgt ggacgaatat
      241 gacgagaaca agttcgtgga cgaggaggac ggcggcgatg gccaggccgg gcccgacgag
      301 ggcgaggtgg actcgtgcct acggcaagga aacatgacag ctgctctcca ggctgctctg
      361 aaaaaccccc ctattaacac aaagagccag gcagtgaagg accgtgcagg cagcatcgtc
      421 ttgaaggtgc ttatctcttt taaagctaat gatattgaaa aggcagtgca gtctctggac
      481 aagaacggtg tggacctcct aatgaagtat atttataaag gctttgagag cccatctgac
      541 aacagcagtg ctgtgttgct ccagtggcat gaaaaggccc ttgctgctgg aggagtgggg
      601 tccattgttc gagttttgac tgcaaggaaa accgtgtagt ccagctggaa ctggacaccg
      661 ttcacagaag tgggagttgc tggtataaag accaaaacaa ccaaatggca ccgctgccct
      721 gtgggtagca tctgtttctc tcagctttgc cttcttgctt cctttttcat atctgtaaag
      781 aagaaaatta catatcagtt tcctttaatg aaaattgaaa taatgtggag aaaattttgt
      841 ctcagtgggg atgtttgacc ctttcataac catgtcaata atatgtatca cattctgtaa
      901 tttatattca agtttgattg tgcaatttct aactctgttg cctggtttaa gggttttact
      961 ttatttttaa ccaatactga gagatgtgat caaagttgag gccagtttcc taactcattg
     1021 ctggtcagga agtgatcttt atttttaaaa atgagagact ggcagctatt aacattgcaa
     1081 aactggacca cacttccctt atttaagcaa aatgtgtttc cagggcaagt agtgggtgag
     1141 ccctactacc agtttccagc cttctttccg cttgcctcca gatgatgcta taagtgtaag
     1201 tgtgctactt cctgttagca tccaactttc atggcctctc aatctctttg tggtgaccca
     1261 gggtccggag caaggagtct tgctctatat aaatgtattt acacaatata agcgcctctt
     1321 tggcacaaac atcccatttc cttctggtaa taaggctgcc tggggaaaca gtcccaagtc
     1381 agagacaggc ctccagcagc ctctggatga aatactttca tcagaaataa ggtagctgcc
     1441 ttagccatta cacaagtgtt cactggaaca tttcccatga tttcccgagg acgtcttcag
     1501 tgttcttcag gtaatgggga tctcagaaga tttggttctg atccaaagac acagtctgtg
     1561 tttcagctca gtgtttttaa gaaagaaaaa tgccacatag taaaagaaaa aaagtgttta
     1621 cttcgttgga caaaccaaat tgattctcaa aaaatgaccg gtgcttgtaa aaagttatta
     1681 caaagtagtt ccgaaaccaa ccacctgaat gtgcgtggcc gagagggaat cagcctgctt
     1741 gtctttccct aagatgccaa ctccagagtc actgactgag gtgagaacca gcgcagaaac
     1801 tctataaact gctgtttttg atacctgctc tttttgtttt gttctgtttt gtaaaattat
     1861 gataaacttc agaaaataaa atgtcagtgt tgaataa
//
