LOCUS       NM_026552               2271 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus actin related protein 2/3 complex, subunit 4 (Arpc4),
            transcript variant 1, mRNA.
ACCESSION   NM_026552
VERSION     NM_026552.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Nikalayevich,E., Letort,G., de Labbey,G., Todisco,E., Shihabi,A.,
            Turlier,H., Voituriez,R., Yahiatene,M., Pollet-Villard,X.,
            Innocenti,M., Schuh,M., Terret,M.E. and Verlhac,M.H.
  TITLE     Aberrant cortex contractions impact mammalian oocyte quality
  JOURNAL   Dev Cell 59 (7), 841-852 (2024)
   PUBMED   38387459
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Rivera,C.A., Randrian,V., Richer,W., Gerber-Ferder,Y.,
            Delgado,M.G., Chikina,A.S., Frede,A., Sorini,C., Maurin,M.,
            Kammoun-Chaari,H., Parigi,S.M., Goudot,C., Cabeza-Cabrerizo,M.,
            Baulande,S., Lameiras,S., Guermonprez,P., Reis e Sousa,C.,
            Lecuit,M., Moreau,H.D., Helft,J., Vignjevic,D.M., Villablanca,E.J.
            and Lennon-Dumenil,A.M.
  TITLE     Epithelial colonization by gut dendritic cells promotes their
            functional diversification
  JOURNAL   Immunity 55 (1), 129-144 (2022)
   PUBMED   34910930
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Figueiredo,A.M., Barbacena,P., Russo,A., Vaccaro,S., Ramalho,D.,
            Pena,A., Lima,A.P., Ferreira,R.R., Fidalgo,M.A., El-Marjou,F.,
            Carvalho,Y., Vasconcelos,F.F., Lennon-Dumenil,A.M., Vignjevic,D.M.
            and Franco,C.A.
  TITLE     Endothelial cell invasion is controlled by dactylopodia
  JOURNAL   Proc Natl Acad Sci U S A 118 (18) (2021)
   PUBMED   33903241
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Zhao,Y., Schoeps,B., Yao,D., Zhang,Z., Schuck,K., Tissen,V.,
            Jager,C., Schlitter,A.M., van der Kammen,R., Ludwig,C.,
            D'Haese,J.G., Raulefs,S., Maeritz,N., Shen,S., Zou,X., Kruger,A.,
            Kleeff,J., Michalski,C.W., Friess,H., Innocenti,M. and Kong,B.
  TITLE     mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote
            KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic
            Carcinogenesis
  JOURNAL   Gastroenterology 160 (5), 1755-1770 (2021)
   PUBMED   33388318
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   Krndija,D., El Marjou,F., Guirao,B., Richon,S., Leroy,O.,
            Bellaiche,Y., Hannezo,E. and Matic Vignjevic,D.
  TITLE     Active cell migration is critical for steady-state epithelial
            turnover in the gut
  JOURNAL   Science 365 (6454), 705-710 (2019)
   PUBMED   31416964
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2271)
  AUTHORS   van der Kammen,R., Song,J.Y., de Rink,I., Janssen,H., Madonna,S.,
            Scarponi,C., Albanesi,C., Brugman,W. and Innocenti,M.
  TITLE     Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like
            disease hallmarked by hyperactivation of transcription factor Nrf2
  JOURNAL   Development 144 (24), 4588-4603 (2017)
   PUBMED   29113991
REFERENCE   9  (bases 1 to 2271)
  AUTHORS   DeMali,K.A., Barlow,C.A. and Burridge,K.
  TITLE     Recruitment of the Arp2/3 complex to vinculin: coupling membrane
            protrusion to matrix adhesion
  JOURNAL   J Cell Biol 159 (5), 881-891 (2002)
   PUBMED   12473693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155287.6, AK017993.1 and AK133626.1.
            
            On Dec 19, 2009 this sequence version replaced NM_026552.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133626.1, AK153380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC155287.6         211188-211201
            15-777              AK017993.1         16-778
            778-934             AK133626.1         726-882
            935-2271            AK133626.1         884-2220
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.76 cM"
     gene            1..2271
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /note="actin related protein 2/3 complex, subunit 4"
                     /db_xref="GeneID:68089"
                     /db_xref="MGI:MGI:1915339"
     exon            1..96
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..600
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arp2/3 complex 20 kDa subunit"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 4
                     isoform 1"
                     /protein_id="NP_080828.1"
                     /db_xref="CCDS:CCDS20417.1"
                     /db_xref="GeneID:68089"
                     /db_xref="MGI:MGI:1915339"
                     /translation="MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSK
                     ELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFF
                     ILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIV
                     AEEFLKNF"
     exon            97..215
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            216..327
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            328..423
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            424..594
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            595..2271
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /note="hexamer: ATTAAA"
     polyA_site      1477
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
                     /note="major polyA site"
     polyA_site      1761
                     /gene="Arpc4"
                     /gene_synonym="20kDa; 5330419I20Rik; p20-Arc"
ORIGIN      
        1 tcggagactg cggctgcgcc tctctcgaaa gggcaggcgt cgcgggtccg ggcacttccg
       61 cacttccgct ttccggccca gacagcgccc gcgatgactg ccactctccg cccctacctt
      121 agtgccgtgc gggccacgct gcaggctgct ctctgcctgg agaacttctc ctcccaggtc
      181 gtggaacgac acaacaagcc agaggtcgaa gtcaggagta gcaaagaact gctattacag
      241 cctgtcacca tcagcaggaa tgagaaggaa aaggttctta ttgaaggctc catcaactct
      301 gtccgggtca gcattgctgt gaagcaggcc gatgaaattg agaagatttt atgccataaa
      361 ttcatgcgct tcatgatgat gcgagcagag aacttcttta tccttcgaag gaaacctgtg
      421 gagggatatg acatcagctt tctcatcacc aacttccaca cggagcagat gtacaaacac
      481 aagctggtgg actttgtaat ccacttcatg gaggagatcg acaaggagat cagtgagatg
      541 aagctgtcgg tcaatgcccg ggctcgtatc gtagctgagg agttcctcaa gaatttttaa
      601 aacatctagc tggatctcgc agccttcccc tcggcctccc tgtgtctctg cgtctgcaaa
      661 ggtgtcctgg agtcactccc cggagcagcg gtgcagcagc agcagccgga agctgggttg
      721 ggtgggcatt ggatgtggga ggtgggtgtg gtgtgcttgc tagctgtgca gaaaggcagc
      781 agtgggcctg ccccatagcc acatgtgtct gctctggcta gtttctgatg ctcagtcccc
      841 tggaccggga cagacttttt ttttaaacgt cttgaaacct aaactctgtg cttgtagaag
      901 actgtaacct ttttgtcttt tttttttttt ttttaaacaa acaaaaaaac caacctccag
      961 ctccagtggc tgtgactggc cccagtgatt gtaccttatt ggtcgctgtg gtctgggcgg
     1021 gcctggagcc agaaggcgac tatttttccc gagccacccc cggtggggaa agagggaaat
     1081 ttcagactac agtttttttc ccttgctgtc ttacaagcct ccttaggcct agtagagagg
     1141 cggtatggac cctctactag cctcctgagt cctgcctgaa gatgcccact gcactggttg
     1201 ggaacaaggg ctgaatctat gattgccggg caggcctagg agcgggggcc cagaagccag
     1261 gcaaacttct ggccgtaggg gccacccggt gtccatccga ccccttccag ctgagaggcc
     1321 caaggtttgc ccgtctgggt gcagggcctg tgctgcaggt ccagaggtga gtcctgcctg
     1381 ctcgggctcc tctgctccca tgctcgctgt ctcggattct gatgaactcc cctcccccct
     1441 aattaaagtc tcttcctgcc ccttcggggc tgcatgaggt ctgtgctctg tgtgggtgtg
     1501 tgaaaggatg cgtgttttga tgccttggag ccttgtggct ggcatttggg tctggagcag
     1561 cccaccagac aattttgtca tcgatcccgg ccaagggccc caactcggag cacttcacta
     1621 cagccaagca ccgtcattct gaaggcggtt tctgcccaga cagagatgcg gtgcttccac
     1681 agcctgcttc cattctagct ttcggggacc ccaggaacca tgatcctact ttgtggataa
     1741 gaagagtcat ttcccacgct acctaacctt gttagtctga ctggtgcctc agcaggtgtt
     1801 gggggtaact cggtattgaa catgctggga acttccgttg gatagtgctc actcctcaag
     1861 taagcagtcc tttctctcgc tgtgtcctga tacttggaga cctgtgaact ctatgccatt
     1921 atccctgtca cacaggggct aggtgaagta gttgatctct ctaccttctg tttaacttgt
     1981 gtatgctggc catctgtact gacatccagt cctactttga caaaactcag ttccaggaaa
     2041 aatgaggtct gtctgcagac aggccgatga gagtggtgta cctagttgga agaggggggt
     2101 atggggctta caggagaggt tgtcagggaa agcttagaaa atatttggcc ttgagccagg
     2161 tatggtggct cacacttgta attctagctc ttggaaattg gagacaggag gacttttgag
     2221 ttctaggcca tactggaagt acactgtctc aaaataaaga gtatatgtga g
//
