LOCUS       NM_029711               1643 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus actin related protein 2/3 complex, subunit 2 (Arpc2),
            transcript variant 1, mRNA.
ACCESSION   NM_029711 XM_001000077 XM_001000089 XM_001000108 XM_001000119
            XM_129773 XM_901710 XM_901712 XM_901713 XM_922647 XM_922652
            XM_922657 XM_989557
VERSION     NM_029711.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Ronzier,E., Laurenson,A.J., Manickam,R., Liu,S., Saintilma,I.M.,
            Schrock,D.C., Hammer,J.A. and Rotty,J.D.
  TITLE     The Actin Cytoskeleton Responds to Inflammatory Cues and Alters
            Macrophage Activation
  JOURNAL   Cells 11 (11), 1806 (2022)
   PUBMED   35681501
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Nicolai,L., Schiefelbein,K., Lipsky,S., Leunig,A., Hoffknecht,M.,
            Pekayvaz,K., Raude,B., Marx,C., Ehrlich,A., Pircher,J., Zhang,Z.,
            Saleh,I., Marel,A.K., Lof,A., Petzold,T., Lorenz,M., Stark,K.,
            Pick,R., Rosenberger,G., Weckbach,L., Uhl,B., Xia,S., Reichel,C.A.,
            Walzog,B., Schulz,C., Zheden,V., Bender,M., Li,R., Massberg,S. and
            Gaertner,F.
  TITLE     Vascular surveillance by haptotactic blood platelets in
            inflammation and infection
  JOURNAL   Nat Commun 11 (1), 5778 (2020)
   PUBMED   33188196
  REMARK    Erratum:[Nat Commun. 2022 Aug 8;13(1):4645. PMID: 35941111]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1643)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1643)
  AUTHORS   Ma,T., Samanna,V. and Chellaiah,M.A.
  TITLE     Dramatic inhibition of osteoclast sealing ring formation and bone
            resorption in vitro by a WASP-peptide containing pTyr294 amino acid
  JOURNAL   J Mol Signal 3, 4 (2008)
   PUBMED   18289379
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1643)
  AUTHORS   Moepps,B., Nuesseler,E., Braun,M. and Gierschik,P.
  TITLE     A homolog of the human chemokine receptor CXCR1 is expressed in the
            mouse
  JOURNAL   Mol Immunol 43 (7), 897-914 (2006)
   PUBMED   16084593
REFERENCE   8  (bases 1 to 1643)
  AUTHORS   Grove,M., Demyanenko,G., Echarri,A., Zipfel,P.A., Quiroz,M.E.,
            Rodriguiz,R.M., Playford,M., Martensen,S.A., Robinson,M.R.,
            Wetsel,W.C., Maness,P.F. and Pendergast,A.M.
  TITLE     ABI2-deficient mice exhibit defective cell migration, aberrant
            dendritic spine morphogenesis, and deficits in learning and memory
  JOURNAL   Mol Cell Biol 24 (24), 10905-10922 (2004)
   PUBMED   15572692
REFERENCE   9  (bases 1 to 1643)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1643)
  AUTHORS   DeMali,K.A., Barlow,C.A. and Burridge,K.
  TITLE     Recruitment of the Arp2/3 complex to vinculin: coupling membrane
            protrusion to matrix adhesion
  JOURNAL   J Cell Biol 159 (5), 881-891 (2002)
   PUBMED   12473693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247669.1, AK151513.1, BY440113.1 and BF462332.1.
            
            [WARNING] On Jul 24, 2024 this sequence was replaced by
            NM_029711.3.
            
            On Oct 26, 2017 this sequence version replaced NM_029711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151513.1, SRR8865135.26682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY247669.1         2-61
            61-1404             AK151513.1         2-1345
            1405-1625           BY440113.1         177-397
            1626-1643           BF462332.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.49 cM"
     gene            1..1643
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /note="actin related protein 2/3 complex, subunit 2"
                     /db_xref="GeneID:76709"
                     /db_xref="MGI:MGI:1923959"
     exon            1..383
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1212
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /note="arp2/3 complex 34 kDa subunit"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 2"
                     /protein_id="NP_083987.1"
                     /db_xref="CCDS:CCDS35612.1"
                     /db_xref="GeneID:76709"
                     /db_xref="MGI:MGI:1923959"
                     /translation="MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYH
                     ISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPEPGYNVSLLYDLENL
                     PASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDR
                     VTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGD
                     NIGYITFVLFPRHTNATARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKV
                     LNRARPDAEKKEMKTITGKTFSSR"
     exon            384..418
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            419..531
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            532..577
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            578..764
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            765..858
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            859..985
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1086
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1187
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1626
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="Arpc2"
                     /gene_synonym="2210023N03Rik; 34kDa; p34-Arc"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgggg gctgggcggg gaccgggatc gtcaagtaag gcggcggcgg aggcggcggc
       61 ggctcggcag gcgggttgaa gcttcggggg ccaggtcggt cgggtggtgg ctgcctgcta
      121 caggcagcgc gtgccgggcc agcgcgtgtg tccgcctctc cccaccccgc tccccgtccc
      181 cttctcccct cacctaccgc acccagcccc cctcgtcagg ggcagcgggg ccgctccctc
      241 cgtcctaccc tcgattgccc accctcaccg cccttgtttc tccttcccct gcccggggca
      301 gccgccgcca tgatcctgct ggaggtgaac aaccgcatca tcgaggagac gctcgcgctc
      361 aagttcgaga acgcggccgc cggaaacaaa ccagaagctg tagaagtaac atttgcagat
      421 tttgatggcg tcctttatca tatttcaaat cctaatggag acaaaacaaa agtgatggtc
      481 agtatttctt tgaaattcta caaggaactt caggcacatg gagctgatga gttgttaaag
      541 agagtgtatg ggagcttctt ggtaaatcca gaaccaggat ataatgtttc tttgctatat
      601 gacctggaaa atctacctgc atccaaggat tctattgtgc atcaggctgg catgttgaag
      661 cgaaattgtt ttgcctctgt gtttgagaaa tacttccaat tccaagaaga gggcaaagaa
      721 ggagagaaca gagcagttat ccattatagg gatgatgaga ccatgtatgt ggaatctaag
      781 aaagacagag tcacagtagt cttcagcacg gtttttaaag atgacgacga tgtggtcatc
      841 ggaaaggtgt tcatgcagga gttcaaagaa ggacgaagag ccagccacac agccccccag
      901 gtccttttca gccacaggga acctcctcta gagctgaaag acacagatgc tgctgtgggt
      961 gacaacattg gctacatcac ctttgtgctg ttccctcgcc acaccaatgc cactgctcga
     1021 gacaacacca tcaacctgat ccacacgttc cgggactatc tgcactacca cattaagtgc
     1081 tctaaggcct atattcatac acgaatgcga gcaaaaacat ccgacttcct taaggtgctc
     1141 aaccgtgcac gcccagatgc cgagaaaaaa gaaatgaaaa caatcacggg gaagactttt
     1201 tcatcccgct aactcttggg aactgaggag gaagcgctgt cgaccgaagg ctggactgct
     1261 tgctactgga taatcgtagc ccttcatgtt gcaccttctc caggttcttg agggattctc
     1321 catttgggtt ccattttgta cgagtttggc aaataacctg cagaaacgag ctgtgcttgc
     1381 aaggacttga tagttcctaa gaattaaaaa aaaaaaaaaa attccacttg atcaacttaa
     1441 ttccctttta tttttcctcc ctcactcccc ttccttttcc aagctgtttg ctttgcaata
     1501 tgttactggt aatgagttgc aggtaatgca atcttaactt gttttcttct aagtatttga
     1561 gttcaaaact cctgtatcta aagaaatacg gttggggtca ttaataaaga aaatctttct
     1621 atcttaaaaa aaaaaaaaaa aaa
//
