LOCUS       NM_023142               1555 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus actin related protein 2/3 complex, subunit 1B
            (Arpc1b), mRNA.
ACCESSION   NM_023142
VERSION     NM_023142.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Ni,W., Zhang,J., Wang,B., Liang,F., Bao,L., Li,P. and Fang,Y.
  TITLE     Actin related protein 2/3 complex subunit 1 up-regulation in the
            hypothalamus prevents high-fat diet induced obesity
  JOURNAL   Eur J Neurosci 57 (1), 64-77 (2023)
   PUBMED   36382618
  REMARK    GeneRIF: Actin related protein 2/3 complex subunit 1 up-regulation
            in the hypothalamus prevents high-fat diet induced obesity.
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Cui,X.S., Li,X.Y., Shen,X.H., Bae,Y.J., Kang,J.J. and Kim,N.H.
  TITLE     Transcription profile in mouse four-cell, morula, and blastocyst:
            Genes implicated in compaction and blastocoel formation
  JOURNAL   Mol Reprod Dev 74 (2), 133-143 (2007)
   PUBMED   16998848
  REMARK    Review article
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   DeMali,K.A., Barlow,C.A. and Burridge,K.
  TITLE     Recruitment of the Arp2/3 complex to vinculin: coupling membrane
            protrusion to matrix adhesion
  JOURNAL   J Cell Biol 159 (5), 881-891 (2002)
   PUBMED   12473693
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Jurecic,R., Nachtman,R.G., Colicos,S.M. and Belmont,J.W.
  TITLE     Identification and cloning of differentially expressed genes by
            long-distance differential display
  JOURNAL   Anal Biochem 259 (2), 235-244 (1998)
   PUBMED   9618202
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Mann,M., Latham,K.E. and Varmuza,S.
  TITLE     Identification of genes showing altered expression in
            preimplantation and early postimplantation parthenogenetic embryos
  JOURNAL   Dev Genet 17 (3), 223-232 (1995)
   PUBMED   8565329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153510.1, AK159371.1 and BF660612.1.
            
            On Nov 21, 2007 this sequence version replaced NM_023142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157098.1, AK170759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-837               AK153510.1         2-838
            838-1423            AK159371.1         837-1422
            1424-1555           BF660612.1         43-174
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.03 cM"
     gene            1..1555
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /note="actin related protein 2/3 complex, subunit 1B"
                     /db_xref="GeneID:11867"
                     /db_xref="MGI:MGI:1343142"
     exon            1..86
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            87..169
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1224
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /note="arp2/3 complex 41 kDa subunit"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 1B"
                     /protein_id="NP_075631.2"
                     /db_xref="CCDS:CCDS19856.1"
                     /db_xref="GeneID:11867"
                     /db_xref="MGI:MGI:1343142"
                     /translation="MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWNK
                     VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV
                     RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAG
                     SCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVA
                     WVSHDSTVCLVDADKKMAVATLASETLPLLAVTFITENSLVAAGHDCFPVLFTYDNAA
                     VTLSFGGRLDVPKQSSQRGMTARERFQNLDKKASSEGGAATGAGLDSLHKNSVSQISV
                     LSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK"
     exon            170..274
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            275..497
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            498..605
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            606..812
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            813..888
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1094
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1185
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1551
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /note="hexamer: AACAAA"
     polyA_site      1472
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /note="major polyA site"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
                     /note="hexamer: AAGAAA"
     polyA_site      1493
                     /gene="Arpc1b"
                     /gene_synonym="41kDa; L72; p41-ARC; SOP2Hs"
ORIGIN      
        1 acgaggaagt ggctgcggcg ctgcgcgggt ctcagagccg gttcggcgcg tcgactgtcc
       61 agagtccgcg gccgaggaga cccgaggccc aggagacaag tgactatggc ctaccacagc
      121 ttcctggtgg agcccatcag ctgccatgcc tggaacaagg accgtacaca gatcgccatc
      181 tgccccaaca accatgaggt gcacatctat gagaagagcg gtgccaagtg gaacaaggtg
      241 cacgagctga aggagcacaa cgggcaggtg acaggcatcg actgggcccc tgagagtaac
      301 cgcattgtga cctgcggcac ggaccgcaat gcctatgtgt ggacgctgaa gggccgcacg
      361 tggaagccca cactggtcat cctccggatc aatcgagctg cccgctgtgt gcgctgggcc
      421 cccaatgaga acaagttcgc cgtgggcagc ggctcccggg tcatttccat ctgttatttt
      481 gagcaggaga atgactggtg ggtgtgcaaa cacataaaaa agcccatccg ctccacagtg
      541 ctcagcctgg actggcatcc caacaacgtg ctcctggcag caggctcctg tgacttcaag
      601 tgcaggatct tctctgccta tatcaaggag gtggaagaac ggccagcccc tacaccgtgg
      661 ggctccaaga tgccctttgg ggagctgatg tttgaatcga gcagcagctg tggctgggtg
      721 catggggtct gcttctcggc cagtgggagc cgagttgctt gggtcagcca tgacagcact
      781 gtatgcctgg tagatgctga caagaagatg gccgtggcaa ccctggcctc tgagacatta
      841 ccactcctgg ccgtcacctt catcacagaa aatagtctag tggcagcggg ccacgactgc
      901 ttcccggtgc tgtttaccta tgacaatgct gcggtgacat tgagcttcgg tggccggctg
      961 gatgtaccca agcagagctc ccagcgtggc atgacagccc gagagcgctt ccagaacctg
     1021 gacaagaagg ccagctctga ggggggtgca gccactgggg ccggcctgga ttcactgcac
     1081 aagaacagtg tcagccaaat ctcggtgctc agcgggggca aggccaagtg ctcacagttc
     1141 tgcactacag gcatggatgg cggcatgagc atctgggacg tgaagagcct ggagtcagcc
     1201 ttgaaggacc tgaaaatcaa atgagctgtg cagactagac tgctgccctc atcccagctg
     1261 ctgggaggga gggaaagggg gtcggggagg ctaagggctg ctttgctaaa tgtttctagg
     1321 atgcagtaca ctgctacaaa ggaagaggca ggaggggaac tgcctattta acaaaatgtg
     1381 ccttttaaag aaatactctt tattgcaaac caaaaacaag gccaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaac aaacaaccca aaacccaaaa aatacaagaa acaaaaaccc aaagcacaat
     1501 gctggtcatg aactgcttca aaatgtgggc taataaacat accaaatgtg aaaaa
//
