LOCUS       NM_007488               6025 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus aryl hydrocarbon receptor nuclear translocator 2
            (Arnt2), transcript variant 1, mRNA.
ACCESSION   NM_007488
VERSION     NM_007488.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6025)
  AUTHORS   Choi,J., Jung,S., Kim,J., So,D., Kim,A., Kim,S., Choi,S., Yoo,E.,
            Kim,J.Y., Jang,Y.C., Lee,H., Kim,J., Shin,H.S., Chae,S. and Keum,S.
  TITLE     ARNT2 controls prefrontal somatostatin interneurons mediating
            affective empathy
  JOURNAL   Cell Rep 43 (9), 114659 (2024)
   PUBMED   39180750
  REMARK    GeneRIF: ARNT2 controls prefrontal somatostatin interneurons
            mediating affective empathy.
REFERENCE   2  (bases 1 to 6025)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   3  (bases 1 to 6025)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6025)
  AUTHORS   Lowenstein,E.D., Rusanova,A., Stelzer,J., Hernaiz-Llorens,M.,
            Schroer,A.E., Epifanova,E., Bladt,F., Isik,E.G., Buchert,S.,
            Jia,S., Tarabykin,V. and Hernandez-Miranda,L.R.
  TITLE     Olig3 regulates early cerebellar development
  JOURNAL   Elife 10, e64684 (2021)
   PUBMED   33591268
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6025)
  AUTHORS   Sharma,N., Pollina,E.A., Nagy,M.A., Yap,E.L., DiBiase,F.A.,
            Hrvatin,S., Hu,L., Lin,C. and Greenberg,M.E.
  TITLE     ARNT2 Tunes Activity-Dependent Gene Expression through
            NCoR2-Mediated Repression and NPAS4-Mediated Activation
  JOURNAL   Neuron 102 (2), 390-406 (2019)
   PUBMED   30846309
  REMARK    GeneRIF: In the absence of synaptic excitation, ARNT2 recruits the
            NCoR2 co-repressor complex to suppress neuronal activity-dependent
            regulatory elements and maintain low basal levels of inducible
            genes. in response to heightened neuronal activity, ARNT2 recruits
            NPAS4 to activity-dependent regulatory elements to induce
            transcription and thereby increase somatic inhibitory input.
REFERENCE   6  (bases 1 to 6025)
  AUTHORS   Wines,M.E., Tiffany,A.M. and Holdener,B.C.
  TITLE     Physical localization of the mouse aryl hydrocarbon receptor
            nuclear translocator-2 (Arnt2) gene within the c112K deletion
  JOURNAL   Genomics 51 (2), 223-232 (1998)
   PUBMED   9722945
REFERENCE   7  (bases 1 to 6025)
  AUTHORS   Jain,S., Maltepe,E., Lu,M.M., Simon,C. and Bradfield,C.A.
  TITLE     Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor
            mRNAs in the developing mouse
  JOURNAL   Mech Dev 73 (1), 117-123 (1998)
   PUBMED   9545558
REFERENCE   8  (bases 1 to 6025)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
REFERENCE   9  (bases 1 to 6025)
  AUTHORS   Drutel,G., Kathmann,M., Heron,A., Schwartz,J.C. and Arrang,J.M.
  TITLE     Cloning and selective expression in brain and kidney of ARNT2
            homologous to the Ah receptor nuclear translocator (ARNT)
  JOURNAL   Biochem Biophys Res Commun 225 (2), 333-339 (1996)
   PUBMED   8753765
REFERENCE   10 (bases 1 to 6025)
  AUTHORS   Hirose,K., Morita,M., Ema,M., Mimura,J., Hamada,H., Fujii,H.,
            Saijo,Y., Gotoh,O., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and tissue-specific expression of a novel basic
            helix-loop-helix/PAS factor (Arnt2) with close sequence similarity
            to the aryl hydrocarbon receptor nuclear translocator (Arnt)
  JOURNAL   Mol Cell Biol 16 (4), 1706-1713 (1996)
   PUBMED   8657146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101776.7 and AC101659.12.
            
            On Sep 9, 2022 this sequence version replaced NM_007488.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.5162.1,
                                           SRR9219379.25085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC101776.7         12653-12791
            140-254             AC101776.7         60978-61092
            255-302             AC101776.7         68079-68126
            303-516             AC101776.7         75091-75304
            517-730             AC101776.7         78691-78904
            731-833             AC101776.7         111671-111773
            834-899             AC101776.7         117387-117452
            900-985             AC101776.7         117764-117849
            986-1062            AC101776.7         136796-136872
            1063-1197           AC101776.7         138519-138653
            1198-1272           AC101776.7         140475-140549
            1273-1424           AC101659.12        958-1109
            1425-1497           AC101659.12        7533-7605
            1498-1621           AC101659.12        8416-8539
            1622-1721           AC101659.12        10770-10869
            1722-1860           AC101659.12        13127-13265
            1861-2011           AC101659.12        13901-14051
            2012-2148           AC101659.12        24942-25078
            2149-6025           AC101659.12        26290-30166
FEATURES             Location/Qualifiers
     source          1..6025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.35 cM"
     gene            1..6025
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /note="aryl hydrocarbon receptor nuclear translocator 2"
                     /db_xref="GeneID:11864"
                     /db_xref="MGI:MGI:107188"
     exon            1..139
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            140..254
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            255..302
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            303..516
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            517..730
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            731..833
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            834..899
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            900..985
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1062
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1197
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1272
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1424
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1497
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1621
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1721
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1860
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2011
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2148
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..6025
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6001..6006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /note="hexamer: AATAAA"
     polyA_site      6025
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /note="major polyA site"
ORIGIN      
        1 accgcccgca ccttcctttg tgtggcgcgg ccgcggcggc gctggcccgc gccgggtccc
       61 cgtccccgcc cccgcccccg cccggcgctc cggtcccttc ccggcaagat ggcaaccccg
      121 gccgccgtca accctccgga gatggcgtca gacataccag gatctgtggc cttgcctgtt
      181 gcccccatgg cagccaccgg acaggtgaga atggcagggg ccatgcctgc ccgaggagga
      241 aagcgtcgat ccggaatgga cttcgatgac gaagatggtg aaggtcccag taaattctca
      301 agagagaacc acagtgagat tgagcggcgc aggcggaaca agatgactca atatattacg
      361 gaactctccg acatggttcc cacctgcagt gcactggcta ggaagccaga caagctgacc
      421 atcctgcgca tggcggtctc gcacatgaag tccatgaggg gcaccggcaa caaatcgact
      481 gacggcgcct acaagccttc cttcctcact gagcaggaac tgaagcatct catcctggaa
      541 gccgctgatg gatttctgtt tgtggtggca gctgagacag ggagagtcat ctacgtgtct
      601 gattcggtca ctcctgtcct gaaccagcca cagtcagagt ggtttgggag cacgctttat
      661 gagcaggtgc accctgatga cgtggagaaa ctgagggaac agctgtgcac ttcggaaaac
      721 tccatgacag gccgcatcct ggacctgaag actgggacag tgaagaagga gggacagcag
      781 tcatccatgc gcatgtgtat gggctctcgg cgctccttca tctgtaggat gaggtgtgga
      841 aacgctccct tggaccacct gcctttgaac agaataacca ccatgaggaa aaggttcagg
      901 aatggccttg gccctgtgaa agaaggagaa gcccagtatg ctgtggtcca ctgcacaggt
      961 tacatcaagg cttggccacc agcaggaatg accatacccg aagaagacgc tgatgtcgga
     1021 caaggcagta aatattgcct cgtggcaatt gggaggctcc aggtgaccag ctctcctgtg
     1081 tgcatggaca tgagcggcat gtcagtgccc acagagttcc tgtcacggca caactctgat
     1141 gggattatca cgtttgtgga ccccagatgc atcagtgtga ttggctacca gccccaggac
     1201 cttctgggaa aggatatttt ggaattttgc caccctgagg atcagagcca cctacgggag
     1261 agcttccaac aggtggttaa gctgaagggc caagtgctgt cggtcatgta tcggttccgc
     1321 accaagaacc gggagtggct gttgatccgt accagcagct tcaccttcca gaacccctac
     1381 tctgatgaga tcgagtacgt catctgcacc aacaccaatg tcaagcaact tcagcaacag
     1441 caggcagaac tggaggtaca tcagcgagat gggctgtcgt catatgactt atctcaggtc
     1501 ccagtaccca acctacccgc tggtgttcac gaggccggga agtctgtgga aaaggcagat
     1561 gcaatcttct cccaagagag agaccctcgt tttgctgaga tgtttgcagg catcagtgca
     1621 tctgagaaga agatgatgag ctcagcctca gcatcaggca gccagcagat ctactcccaa
     1681 ggaagtccat tccctgccgg gcactcgggc aaggccttca gctcttccgt ggtccatgtg
     1741 cctggagtga atgacattca gtcctcctcc tcaacgggac agaacatatc ccagatctct
     1801 cggcagctga accagggcca ggtggcatgg acaggcagcc gtccaccgtt cccagggcag
     1861 cccagcaaga cgcagtcatc tgccttcgga attggatcaa gccaccctta cccggctgac
     1921 ccttcatcct acagtcctct ctccagccca gctgcctcct caccaagtgg aaacgcatac
     1981 cccagtcttg ccaacaggac tccagggttt gctgagagtg gacagagtgg cgggcagttc
     2041 cagggccggc cctcggaggt ctggtcccag tggcagagcc agcatcacgg acagcagagc
     2101 ggtgagcagc actcgcatca gcagcctggc cagactgaag tgttccagga catgctaccc
     2161 atgccgggcg acccgacgca ggggactggc aactataaca tcgaggactt tgctgacctg
     2221 ggcatgttcc ctccattttc tgagtagctt caggcaaagc caggcttcta ctgcccagac
     2281 gctattatca tgccatagat gcccatgttc aaagagggtc cccctcaccc agcttgccct
     2341 gctgtagaac ccccagaaat ctcccttatt ccccatcctc cctggacatg gcatcacctg
     2401 gctctaaccc acagccctgg cttcttgggt ttgggatctt tgtatttatt gtactttatc
     2461 tgtgtgctcg gaagggggcc gccagggtct taaatcccat tgtgaataat ctattaatgg
     2521 acaatttgca cccatcaagt gtttgcttga tccacaatgg ctggcagtac cagcaggtct
     2581 gcctggtgca gaagctgggt ttctttctgc tttttcacgg ctgctgcctc ggaggcttgg
     2641 tgtcagagtg aaaggcagtg acctctgcat tctgtgctgg agccaggagc acaggatggg
     2701 agtctcccac actagctgtc cttgacggcc tggggccagg tgtgctttaa acctgagaat
     2761 caacgttgtg gcttggtaga tgtactgtgg cgtgttggtg tgtgtggcca gtgagagtga
     2821 gaagccgtcc ccattcagct gcatttcaaa ggaaagcgtg actggggcct gggagctggg
     2881 ctgactccct ggaagccagg gctggggagc tgcccactct gtagtcagtt ctttggtccc
     2941 ctgccctttt acagacatac tttacttctt aaagtctcta gtccttctgt cctatgcgag
     3001 cactcacgct tctcttacta agcctgaggg acagtgtcct gattccataa aggtcactgc
     3061 atcctccctg ctctgcatct gagcagagct gttttctgcc cagcgccttc agaaagtcag
     3121 acccagtcct cctctgtaca gggttaggat acctcgactc taagtgtccc tgacaccttc
     3181 tgctcagtaa cttggaaaga agatggggcc acactctggg tggaaaaggg tgccttgggc
     3241 cacctgaacc tctgtcctca tcaggcagga gaggcaaggg tacctcaggg cagacacagc
     3301 caggcgcctg tgaggccaga gactctgttc tgcccaagct tctacaaaga cctgaattcc
     3361 tcagtggtct taaggtagaa ctatgaacta acttctagaa caatggttct cagcctgtgg
     3421 gctgtgttgg ggatgccaga caaccatttc acaggggccg catatcagat accctgcata
     3481 ttaggtagtt acaaacgata catacataac agtagaaaat cacacttata aaatagcaat
     3541 gaaaatgatc ttacggttag ggtcaccact acatgaagaa ctatattaaa gggtcacaga
     3601 gttaggaagg ttgagaacca ctgttctaga agtgtcttgc tggcttatct ctgacatcag
     3661 agtccctgtg tcagtcagat ttaaagagct tcagattcca cccattccac cctgcccctc
     3721 cctcactcca tgtgctgctc tgagttctct ctggcttttg ggaagctggg agtacaagag
     3781 gctccagggt gcgcaggggc ggaatgagcc tggagattaa gagcctgggg gcaccactcc
     3841 attcagaagc taagctctgc cagtgtttgc acaggactca cttgcaaagt ttgcttggct
     3901 cagcagactg cccttggcag caacccaccc taggggatcc cgttcctgac aaactccagc
     3961 cccagagacc ttaggcagct ttgaatcctt ccatggagag tagtgacaca gtcagagctt
     4021 catcccagac tcagaacccc caaacagtct ctcctggagc tggccccagg tggtgagcat
     4081 aagttacaaa agggaaaaca aggcccaaag ctggcttcag gagcaaagaa tgctttgtag
     4141 tgtagaacag cccttgacct ttagcttgtg aattaagagg tgtggaagct atgggtttgg
     4201 ttttattgcc ttgggtggga agtgggggct tttcttgggt gtgacagccc tgggctcagg
     4261 gccctaaggt ctgcagaaga aataggacag gattcttgct tgctatcatt tcatgctttc
     4321 tctctgttaa gaagttgagg gtaaagccaa ctcagtcctt ggtcctggga gcagaggtgg
     4381 aggattgttc ggcaacccag acaatagcaa gcactgcttt caatggttcc tgcgtctccc
     4441 cagtcttatc tagggagttc catgggctag aaggtgggga tttaggcggg cctgagttct
     4501 ggatcttttc catacctctt cggcttctat gttgtgattc tccaaaacac atgtggagga
     4561 ggtggtgggg ggagaagtca gaaatgaaga atcccacccc acaaggactt ctctcaccca
     4621 agtatttttt gaaacacaca ggagtcagaa tcaatgccat tatcctgcaa aagatgtccc
     4681 ttcatatgtc ccctgcagag gaagccaata tactggtcct ccagttaata tccttccagc
     4741 tacctgtcct ggtgatggtc ttagcaggct agggatggat agggtatgct ggcttcctgc
     4801 agttctatac ctcatcactt cattcgctgc tgaagtccaa ttggctcctc gtgggcagag
     4861 caagcaggaa agggacatgc aaggaccacc tgagtcattg gtaaggacac aggagctcta
     4921 gaagaatggg ccatacatag actgcccggc cagccaagga tggttctaga accctgcctc
     4981 cctgtcactc ctgtttgttt cactgtggtt tcagggagcg ggtgagccag cgtgcgcatc
     5041 cacattcatc aagctcagct cagcgtgttc ttgcatcata aagtgactat tgtgggtagt
     5101 agtatttgga ttggtgacat aacctgctga ggaactccca ctcccctgtc attaggatag
     5161 tgaggcccca ggttagccca ctggcaacca agcacactcc cttcagctct gagctagaga
     5221 tctggcaggt ccaggaagtg agttctgcaa tctccttctg caacacagtc cagccgatga
     5281 atagtagcca ctcccaatgt gagctcagcc tgtctcacaa gcaaaaacaa gccgtttgct
     5341 aatccctaat agcaaggcaa aattaaagcc ctctttgtat gtggccatgg attgctatgt
     5401 cctaacttgc ccatccatcc ttccctccca tcccctcctg agctgatgct cacctaaagt
     5461 gccaccactg gagatattga agtaagaagg gtcatgagct caggagttca agacctacct
     5521 gggcaacata atgaaactaa tcttaaagac aaatatatag ctgagtaact tggccacctt
     5581 tcatgtggtg agaagtcacc agctccctgg ctgccagctt cctccattgc ctagaatctg
     5641 ggacagcttt gaagacatag ctccatgtgt gacatgccat gtcttgtgca ctaagctggg
     5701 ctagttcagg tagcctgcaa atccttgtgg ctactggcta taacaaaatg gagcttttca
     5761 caggtcatcc agggcccagc tgtttgcttt gtctaaccgt ctctttcctt aaagaaaact
     5821 tcacaagcag gcttccaaga acagcaagca cttactcgtc tctctcttag cctttcttat
     5881 ggatgtgaac tgtgctgtgg gtaaatcatt tgtatttctt gaatgttctg tatgactaac
     5941 aggtattaag tcactgggta tatgtataac taatgtaact gccttttaaa ttttcattac
     6001 aataaaaaat gactttgctc tgaaa
//
