LOCUS       NP_031514                712 aa            linear   ROD 14-OCT-2024
DEFINITION  aryl hydrocarbon receptor nuclear translocator 2 isoform a [Mus
            musculus].
ACCESSION   NP_031514
VERSION     NP_031514.3
DBSOURCE    REFSEQ: accession NM_007488.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 712)
  AUTHORS   Choi,J., Jung,S., Kim,J., So,D., Kim,A., Kim,S., Choi,S., Yoo,E.,
            Kim,J.Y., Jang,Y.C., Lee,H., Kim,J., Shin,H.S., Chae,S. and Keum,S.
  TITLE     ARNT2 controls prefrontal somatostatin interneurons mediating
            affective empathy
  JOURNAL   Cell Rep 43 (9), 114659 (2024)
   PUBMED   39180750
  REMARK    GeneRIF: ARNT2 controls prefrontal somatostatin interneurons
            mediating affective empathy.
REFERENCE   2  (residues 1 to 712)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   3  (residues 1 to 712)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 712)
  AUTHORS   Lowenstein,E.D., Rusanova,A., Stelzer,J., Hernaiz-Llorens,M.,
            Schroer,A.E., Epifanova,E., Bladt,F., Isik,E.G., Buchert,S.,
            Jia,S., Tarabykin,V. and Hernandez-Miranda,L.R.
  TITLE     Olig3 regulates early cerebellar development
  JOURNAL   Elife 10, e64684 (2021)
   PUBMED   33591268
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 712)
  AUTHORS   Sharma,N., Pollina,E.A., Nagy,M.A., Yap,E.L., DiBiase,F.A.,
            Hrvatin,S., Hu,L., Lin,C. and Greenberg,M.E.
  TITLE     ARNT2 Tunes Activity-Dependent Gene Expression through
            NCoR2-Mediated Repression and NPAS4-Mediated Activation
  JOURNAL   Neuron 102 (2), 390-406 (2019)
   PUBMED   30846309
  REMARK    GeneRIF: In the absence of synaptic excitation, ARNT2 recruits the
            NCoR2 co-repressor complex to suppress neuronal activity-dependent
            regulatory elements and maintain low basal levels of inducible
            genes. in response to heightened neuronal activity, ARNT2 recruits
            NPAS4 to activity-dependent regulatory elements to induce
            transcription and thereby increase somatic inhibitory input.
REFERENCE   6  (residues 1 to 712)
  AUTHORS   Wines,M.E., Tiffany,A.M. and Holdener,B.C.
  TITLE     Physical localization of the mouse aryl hydrocarbon receptor
            nuclear translocator-2 (Arnt2) gene within the c112K deletion
  JOURNAL   Genomics 51 (2), 223-232 (1998)
   PUBMED   9722945
REFERENCE   7  (residues 1 to 712)
  AUTHORS   Jain,S., Maltepe,E., Lu,M.M., Simon,C. and Bradfield,C.A.
  TITLE     Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor
            mRNAs in the developing mouse
  JOURNAL   Mech Dev 73 (1), 117-123 (1998)
   PUBMED   9545558
REFERENCE   8  (residues 1 to 712)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
REFERENCE   9  (residues 1 to 712)
  AUTHORS   Drutel,G., Kathmann,M., Heron,A., Schwartz,J.C. and Arrang,J.M.
  TITLE     Cloning and selective expression in brain and kidney of ARNT2
            homologous to the Ah receptor nuclear translocator (ARNT)
  JOURNAL   Biochem Biophys Res Commun 225 (2), 333-339 (1996)
   PUBMED   8753765
REFERENCE   10 (residues 1 to 712)
  AUTHORS   Hirose,K., Morita,M., Ema,M., Mimura,J., Hamada,H., Fujii,H.,
            Saijo,Y., Gotoh,O., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and tissue-specific expression of a novel basic
            helix-loop-helix/PAS factor (Arnt2) with close sequence similarity
            to the aryl hydrocarbon receptor nuclear translocator (Arnt)
  JOURNAL   Mol Cell Biol 16 (4), 1706-1713 (1996)
   PUBMED   8657146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101776.7 and AC101659.12.
            
            On Mar 5, 2013 this sequence version replaced NP_031514.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.5162.1,
                                           SRR9219379.25085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.35 cM"
     Protein         1..712
                     /product="aryl hydrocarbon receptor nuclear translocator 2
                     isoform a"
                     /note="ARNT protein 2"
                     /calculated_mol_wt=77772
     Region          36..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61324.2)"
     Site            42
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q61324.2)"
     Region          62..124
                     /region_name="bHLH-PAS_ARNT"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in aryl hydrocarbon receptor nuclear
                     translocator (ARNT) and similar proteins; cd18947"
                     /db_xref="CDD:381517"
     Site            order(64..65,68..69,72,75..76,80,101..102)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381517"
     Site            order(79,82,85..86,103,106..107,110,112..114,116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381517"
     Region          137..243
                     /region_name="PAS"
                     /note="PAS fold; pfam00989"
                     /db_xref="CDD:395786"
     Region          336..436
                     /region_name="PAS_11"
                     /note="PAS domain; pfam14598"
                     /db_xref="CDD:464214"
     Region          573..712
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61324.2)"
     CDS             1..712
                     /gene="Arnt2"
                     /gene_synonym="bHLHe1; Hif-2b; mKIAA0307"
                     /coded_by="NM_007488.4:109..2247"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS59733.1"
                     /db_xref="GeneID:11864"
                     /db_xref="MGI:MGI:107188"
ORIGIN      
        1 matpaavnpp emasdipgsv alpvapmaat gqvrmagamp arggkrrsgm dfddedgegp
       61 skfsrenhse ierrrrnkmt qyitelsdmv ptcsalarkp dkltilrmav shmksmrgtg
      121 nkstdgaykp sflteqelkh lileaadgfl fvvaaetgrv iyvsdsvtpv lnqpqsewfg
      181 stlyeqvhpd dveklreqlc tsensmtgri ldlktgtvkk egqqssmrmc mgsrrsficr
      241 mrcgnapldh lplnrittmr krfrnglgpv kegeaqyavv hctgyikawp pagmtipeed
      301 advgqgskyc lvaigrlqvt sspvcmdmsg msvpteflsr hnsdgiitfv dprcisvigy
      361 qpqdllgkdi lefchpedqs hlresfqqvv klkgqvlsvm yrfrtknrew llirtssftf
      421 qnpysdeiey victntnvkq lqqqqaelev hqrdglssyd lsqvpvpnlp agvheagksv
      481 ekadaifsqe rdprfaemfa gisasekkmm ssasasgsqq iysqgspfpa ghsgkafsss
      541 vvhvpgvndi qsssstgqni sqisrqlnqg qvawtgsrpp fpgqpsktqs safgigsshp
      601 ypadpssysp lsspaassps gnaypslanr tpgfaesgqs ggqfqgrpse vwsqwqsqhh
      661 gqqsgeqhsh qqpgqtevfq dmlpmpgdpt qgtgnynied fadlgmfppf se
//
