LOCUS       NM_027870               3401 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus armadillo repeat containing, X-linked 3 (Armcx3),
            transcript variant 1, mRNA.
ACCESSION   NM_027870
VERSION     NM_027870.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Izquierdo-Villalba,I., Mirra,S., Manso,Y., Parcerisas,A., Rubio,J.,
            Del Valle,J., Gil-Bea,F.J., Ulloa,F., Herrero-Lorenzo,M.,
            Verdaguer,E., Beninca,C., Castro-Torres,R.D., Rebollo,E.,
            Marfany,G., Auladell,C., Navarro,X., Enriquez,J.A., Lopez de
            Munain,A., Soriano,E. and Aragay,A.M.
  TITLE     A mammalian-specific Alex3/Galphaq protein complex regulates
            mitochondrial trafficking, dendritic complexity, and neuronal
            survival
  JOURNAL   Sci Signal 17 (822), eabq1007 (2024)
   PUBMED   38320000
  REMARK    GeneRIF: A mammalian-specific Alex3/Galphaq protein complex
            regulates mitochondrial trafficking, dendritic complexity, and
            neuronal survival.
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Gavalda-Navarro,A., Mirra,S., Manso,Y., Sanchez-Infantes,D.,
            Giralt,M., Soriano,E. and Villarroya,F.
  TITLE     The armadillo-repeat containing X-linked protein 3, ARMCX3, is a
            negative regulator of the browning of adipose tissue associated
            with obesity
  JOURNAL   Int J Obes (Lond) 46 (9), 1652-1661 (2022)
   PUBMED   35705702
  REMARK    GeneRIF: The armadillo-repeat containing X-linked protein 3,
            ARMCX3, is a negative regulator of the browning of adipose tissue
            associated with obesity.
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Mirra,S., Gavalda-Navarro,A., Manso,Y., Higuera,M., Serrat,R.,
            Salcedo,M.T., Burgaya,F., Balibrea,J.M., Santamaria,E., Uriarte,I.,
            Berasain,C., Avila,M.A., Minguez,B., Soriano,E. and Villarroya,F.
  TITLE     ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by
            Dietary Lipotoxicity
  JOURNAL   Cancers (Basel) 13 (5), 1110 (2021)
   PUBMED   33807672
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Du,J., Zhang,X., Zhou,H., Miao,Y., Han,Y., Han,Q. and Wang,E.
  TITLE     Alex3 suppresses non-small cell lung cancer invasion via
            AKT/Slug/E-cadherin pathway
  JOURNAL   Tumour Biol 39 (7), 1010428317701441 (2017)
   PUBMED   28705116
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Zhou,J., McCarrey,J.R. and Wang,P.J.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Lopez-Domenech,G., Serrat,R., Mirra,S., D'Aniello,S., Somorjai,I.,
            Abad,A., Vitureira,N., Garcia-Arumi,E., Alonso,M.T.,
            Rodriguez-Prados,M., Burgaya,F., Andreu,A.L., Garcia-Sancho,J.,
            Trullas,R., Garcia-Fernandez,J. and Soriano,E.
  TITLE     The Eutherian Armcx genes regulate mitochondrial trafficking in
            neurons and interact with Miro and Trak2
  JOURNAL   Nat Commun 3, 814 (2012)
   PUBMED   22569362
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Mou,Z., Tapper,A.R. and Gardner,P.D.
  TITLE     The armadillo repeat-containing protein, ARMCX3, physically and
            functionally interacts with the developmental regulatory factor
            Sox10
  JOURNAL   J Biol Chem 284 (20), 13629-13640 (2009)
   PUBMED   19304657
  REMARK    GeneRIF: Sox10 is a membrane-associated factor whose
            transcriptional function is increased by direct interactions with
            ARMCX3
REFERENCE   8  (bases 1 to 3401)
  AUTHORS   Coveney,D., Ross,A.J., Slone,J.D. and Capel,B.
  TITLE     A microarray analysis of the XX Wnt4 mutant gonad targeted at the
            identification of genes involved in testis vascular differentiation
  JOURNAL   Gene Expr Patterns 7 (1-2), 82-92 (2007)
   PUBMED   16844427
  REMARK    Erratum:[Gene Expr Patterns. 2008 Sep;8(7-8):528]
REFERENCE   9  (bases 1 to 3401)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   10 (bases 1 to 3401)
  AUTHORS   Hsia,N. and Cornwall,G.A.
  TITLE     DNA microarray analysis of region-specific gene expression in the
            mouse epididymis
  JOURNAL   Biol Reprod 70 (2), 448-457 (2004)
   PUBMED   14561649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772348.2, CJ071609.1 and BU505969.1.
            
            On Dec 1, 2017 this sequence version replaced NM_027870.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004598.1, AK030729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL772348.2         41394-41409
            17-320              CJ071609.1         2-305
            321-919             BU505969.1         180-778
            920-3401            AL772348.2         43817-46298
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.25 cM"
     gene            1..3401
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /note="armadillo repeat containing, X-linked 3"
                     /db_xref="GeneID:71703"
                     /db_xref="MGI:MGI:1918953"
     exon            1..179
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            180..258
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..320
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..390
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..3401
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..1677
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 3"
                     /protein_id="NP_082146.2"
                     /db_xref="CCDS:CCDS30400.1"
                     /db_xref="GeneID:71703"
                     /db_xref="MGI:MGI:1918953"
                     /translation="MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSG
                     DVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRAR
                     RAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIR
                     DLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTVTSRLNS
                     SVQLAGLRLLTNMTVTNEYQHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAM
                     TRELLRAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLF
                     FFLKEFQVCADKVLGIESRHDFQVRVKVGKFVAKLTERMFPKSQE"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /note="hexamer: AATAAA"
     polyA_site      2036
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /note="major polyA site"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
                     /note="hexamer: AATAAA"
     polyA_site      2128
                     /gene="Armcx3"
                     /gene_synonym="1200004E24Rik; ALEX3"
ORIGIN      
        1 ggggaaccga gttggtggat tacgtcgctc tcacgtgacc aagagctgac gtgtgcagaa
       61 gtccttcttg tcctggtcgt tgttcccgtc tgagtaccag ctccctatta ccctgagggc
      121 gggcgagtgc agccgagaaa agaaggaggc ggaaaagaaa ttgtcccaga tccctgcagt
      181 ctttccgtag gttgcggtac aacgccaggc aagagaagag gaaggaaatt aaccagatcg
      241 gtgaaggtcg agttgagggt ctgctgtagc aggtggcact gcttgaacca agggaggaac
      301 tttcccccgg atcagtagag atcagaaaga ctgttgggcg tggcataacc cacaggaaag
      361 gaagaagggg caagctgctg ttttaaggag gtttacctct gtaagcaatt actgtggcct
      421 tgaagtgact tgaagaagat cactctccac aggactgcac tcaggcccga aggcctcttc
      481 ccttatcttg agtgactact ctatttcttg gtccctgccg ttgccaggga cgattgcatg
      541 ggctacgcca ggaaagtagg ctgggtgact gcaggtctgg tgattggggc tggagcctgc
      601 tattgcattt acagattgac ccgaggaaga aagcagaaca aggagaaaat ggctgagggt
      661 ggctctggtg atgtggatga tgctggggac tgttctgggg ccaggtataa tgactggtct
      721 gatgatgatg atgacagtaa cgagagcaag agtatagttt ggtacccacc ttgggcccgg
      781 attggcactg aagcagggac cagagccaga gccagggcaa gagccagggc taccagggct
      841 cgaagagctg tacagaaaag ggcttctcct aattcagacg atactgtttt gtcacctcaa
      901 gagttacaga aagtactttg tttggttgag atgtctgaaa agccttatat tcttgaagca
      961 gctttaattg ctctgggtaa taatgctgct tatgcattta atagagatat tattcgagat
     1021 ttgggtggtc tcccaattgt tgcaaagatt ctcaatacac gagatcccat tgttaaggaa
     1081 aaggctttaa ttgtcctaaa taacttgagc gtgaatgccg aaaatcagcg caggcttaag
     1141 gtatacatga atcaagtgtg tgatgacaca gtcacttccc gattgaattc ctctgtgcag
     1201 ctggctggac tcagattgct taccaatatg actgttacta acgagtatca gcatatcctt
     1261 gctaattcca tttcagactt ctttcgttta ttttcagcgg ggaatgaaga aaccaaactt
     1321 caggttctga agctcctttt gaatctggct gaaaatccag ccatgactag agaactgctc
     1381 agggctcagg tgccatcttc actgggctcc ctctttaata agaaggagta caaagaggtt
     1441 attcttaaac ttctgatcat ttttgagaat atcaatgaca atttcaaatg ggaagagaac
     1501 gagcctgctc agaatcactt tagtgagggc tccctttttt tcttcttaaa agaatttcaa
     1561 gtgtgtgctg ataaagttct aggaatcgag agccgtcatg atttccaggt gcgagtcaag
     1621 gttggaaagt ttgtggccaa actgactgaa aggatgttcc caaagagtca ggaataactt
     1681 ggtggctttg tagtgtagca gcagcagcac accttgtaaa ctattctttt tctccacgtt
     1741 gtttatatgg caaaggaacc ctttcagctg ccaattttga atgatgaata tcatactgta
     1801 tcaccgatgt tgatatttaa ccaagtttgt cttcaggtat aagtttaatg aatgtacatc
     1861 actacttgtc ctgaaacatg tcgcatttta ttttgctgcc cacattgaaa catttttctg
     1921 ttccctccct ataagtgaca gcgaatcaat tcatcctaag taggcccctt tctgtcatta
     1981 tcattgattt tatttgtgca tcttcaataa agttttatgt taatgctgga aagaaacaac
     2041 agaagaagaa aggaactagt ctgtcttttg gtttataatc tagttgtaga gacaagaaac
     2101 atacaaataa aaaaaaccac ccaaaacacc cccacaaaac tcaagattat ttagagcata
     2161 cattctgata gatgtgtgcc ttcaggacaa agagggggca aaggatttgg tggctgactc
     2221 cataagtcag gttaaagctt cagggaggac agagccatcg aaagggagcc ctgaatgggg
     2281 tagagaagtt agttgcattc catgagacca gagtcaaggg gaaatgatgt gagaaagaca
     2341 ttaagttagg ggactttatg gtagtcaaaa cagcagcctt cgagtgtggg gactagcact
     2401 aaataaatgt ttattaaatc tagaaaacca tgggaaacgc attgcaggag gcttcttgaa
     2461 tgtattttta actagaaaag aactgggctc agtataaatg tcctccccac acaatgtgtt
     2521 atcaaggaga gtgtagcaaa atggatactt tccaactctg gtggtgggca tttggcaata
     2581 cagatcggta agccttaaaa gaggtaaacc ttttatccta aggggagaac tgcataattg
     2641 gccagagagc attatgtgca aggccgctct tgtcagcact gtcttacagt agtaacatgg
     2701 ggaacacctt cagtgtccga cattctgaat tgactaaata aagaatgtcg acgctgtgtg
     2761 agaaatgtgc tgatggagct cagtattgct agaaaaaaag ataatcatcg cacattgtta
     2821 agtgagcaag gtaagttaga tatttagaat atgattacat attgtgtgtg tgagtgtgtg
     2881 tggttaaatc atgtttaaaa tgacactaaa atctatggaa ttatatatac ccaataagta
     2941 ctaagagtta tatttggatg aaagataatg agtggtactt actttttgta cttatattca
     3001 tctatgtttc cttgtttatc aaagaatgtt ggttctctca ggaaaggttt ggaaaacggc
     3061 aagtactgga gggcagcagc tgattcattt gaatgtgtac tgagtagaaa acctttaggc
     3121 ccaaactcag gtggtttgaa gtttcctctt cagaatgata gaggatggtg ctgataaggc
     3181 tgtttgggag gtttatatga gagaatttag gcaaagtctc tacattattc tggcatatag
     3241 cagcagttac ttaagaaatg tgagtacctt taagtaccca gaatgtagtt tcgatgggtt
     3301 ttggttgact tttgttttgc tggggcattc tgctatgttt cagtgtcatt taataaataa
     3361 taataataac aacaataata aaggttaaca tttattaagt g
//
