LOCUS       NM_001166377            2491 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus armadillo repeat containing, X-linked 1 (Armcx1),
            transcript variant 1, mRNA.
ACCESSION   NM_001166377
VERSION     NM_001166377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Li,Q., Ni,H., Rui,Q., Ding,J., Kong,X., Kan,X., Gao,R. and Shen,H.
  TITLE     Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport
            Pathway Involving Miro1 After Traumatic Brain Injury
  JOURNAL   Neuroscience 545, 111-124 (2024)
   PUBMED   38492796
  REMARK    GeneRIF: Armcx1 Reduces Neurological Damage Via a Mitochondrial
            Transport Pathway Involving Miro1 After Traumatic Brain Injury.
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Lu,D., Wang,Y., Liu,G., Wang,S., Duan,A., Wang,Z., Wang,J., Sun,X.,
            Wu,Y. and Wang,Z.
  TITLE     Armcx1 attenuates secondary brain injury in an experimental
            traumatic brain injury model in male mice by alleviating
            mitochondrial dysfunction and neuronal cell death
  JOURNAL   Neurobiol Dis 184, 106228 (2023)
   PUBMED   37454781
  REMARK    GeneRIF: Armcx1 attenuates secondary brain injury in an
            experimental traumatic brain injury model in male mice by
            alleviating mitochondrial dysfunction and neuronal cell death.
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Xu,X., Li,H., Lu,S. and Shen,Y.
  TITLE     Roles of syntaphilin and armadillo repeat-containing X-linked
            protein 1 in brain injury after experimental intracerebral
            hemorrhage
  JOURNAL   Neurosci Lett 809, 137300 (2023)
   PUBMED   37187340
  REMARK    GeneRIF: Roles of syntaphilin and armadillo repeat-containing
            X-linked protein 1 in brain injury after experimental intracerebral
            hemorrhage.
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2491)
  AUTHORS   Cartoni,R., Norsworthy,M.W., Bei,F., Wang,C., Li,S., Zhang,Y.,
            Gabel,C.V., Schwarz,T.L. and He,Z.
  TITLE     The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial
            Transport during Axon Regeneration
  JOURNAL   Neuron 92 (6), 1294-1307 (2016)
   PUBMED   28009275
  REMARK    GeneRIF: Armcx1 is upregulated after axotomy in a model with robust
            regeneration. Armcx1 overexpression enhances mitochondrial
            transport in adult retinal ganglion cells. Armcx1 also promotes
            both neuronal survival and axon regeneration after injury, and
            these effects depend on its mitochondrial localization.
            Erratum:[Neuron. 2017 May 3;94(3):689. doi:
            10.1016/j.neuron.2017.04.028.. PMID: 28472662]
REFERENCE   7  (bases 1 to 2491)
  AUTHORS   Holmfeldt,P., Ganuza,M., Marathe,H., He,B., Hall,T., Kang,G.,
            Moen,J., Pardieck,J., Saulsberry,A.C., Cico,A., Gaut,L.,
            McGoldrick,D., Finkelstein,D., Tan,K. and McKinney-Freeman,S.
  TITLE     Functional screen identifies regulators of murine hematopoietic
            stem cell repopulation
  JOURNAL   J Exp Med 213 (3), 433-449 (2016)
   PUBMED   26880577
  REMARK    Erratum:[J Exp Med. 2016 Oct 17;213(11):2525. doi:
            10.1084/jem.2015080609232016c.. PMID: 27679570]
REFERENCE   8  (bases 1 to 2491)
  AUTHORS   Lopez-Domenech,G., Serrat,R., Mirra,S., D'Aniello,S., Somorjai,I.,
            Abad,A., Vitureira,N., Garcia-Arumi,E., Alonso,M.T.,
            Rodriguez-Prados,M., Burgaya,F., Andreu,A.L., Garcia-Sancho,J.,
            Trullas,R., Garcia-Fernandez,J. and Soriano,E.
  TITLE     The Eutherian Armcx genes regulate mitochondrial trafficking in
            neurons and interact with Miro and Trak2
  JOURNAL   Nat Commun 3, 814 (2012)
   PUBMED   22569362
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2491)
  AUTHORS   Roma,G., Cobellis,G., Claudiani,P., Maione,F., Cruz,P., Tripoli,G.,
            Sardiello,M., Peluso,I. and Stupka,E.
  TITLE     A novel view of the transcriptome revealed from gene trapping in
            mouse embryonic stem cells
  JOURNAL   Genome Res 17 (7), 1051-1060 (2007)
   PUBMED   17540781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY129959.1, AK147002.1, CJ238664.1 and CF580092.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.258185.1, AK147002.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY129959.1         1-50
            51-1989             AK147002.1         2-1940
            1990-2445           CJ238664.1         208-663
            2446-2491           CF580092.1         1-46                c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.24 cM"
     gene            1..2491
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /note="armadillo repeat containing, X-linked 1"
                     /db_xref="GeneID:78248"
                     /db_xref="MGI:MGI:1925498"
     exon            1..113
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..205
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..298
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..487
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..586
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..2470
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             704..2074
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 1"
                     /protein_id="NP_001159849.1"
                     /db_xref="CCDS:CCDS30398.1"
                     /db_xref="GeneID:78248"
                     /db_xref="MGI:MGI:1925498"
                     /translation="MGRTREAGCVAAGMVIGAGACYCVYRLTWGKDENEKLWDEEEEE
                     EEEEEEKSCSDKTEKELKTNVGVGARGKPQDDSKSKVEVNVGPENGPGVKKEVHPESQ
                     SGGGLEAKAKALFKTLKEQARAKAGRGIRLPNISRNRTLTSSLPCPGGRGGGCHPGRT
                     GSRARNRTSGKVKRKNRSKSNKAPATAWPVRKGKFSFPYKIDDILSAPDLQKVLNILE
                     RTNDPFTQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTRDPIIREKTYNALNN
                     LSVNSENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPD
                     FFALLFLGNHFTKIQTMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNI
                     LTLFENINDNIKSEGLASSRKEFSRSSLFFLFKESGVCVKKIKALASHKDLVVKVKVL
                     KVLTKL"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /note="hexamer: AATAAA"
     polyA_site      2470
                     /gene="Armcx1"
                     /gene_synonym="3010033I09Rik; ALEX1"
                     /note="major polyA site"
ORIGIN      
        1 gtgagccgaa gcctacgtgt gcagacctcc tcctaattct ggtctacctt agtgtttgct
       61 ctctctgtta ttgttgagag caggcaggcc tgctgcggaa ggaagaggag aagggtgcag
      121 caccttttgg aacaaagaaa taatcaacat cgaatttctg catgtcaatt taaagctgag
      181 actgtctgcg acctgcatat aagtggaaaa aatggccgac caccgcaaga aggagtgtcg
      241 ggatgtagct gtatagcatc ggggcgttgt cagctgagtc cagagaactg ggggcagggt
      301 gcctgtatct gtggctctcg ctccagacta aaccaagaag cagggaaggg aggaaaactt
      361 cccagaatca agtaggtcca aggaagaagt gtgatgacac tgtttggagg tcgctggggt
      421 agacgataat ggtgactatg aactcgagtg gacagactca cagactttct ctgcacccct
      481 tctcctgatc tgcaagaggc tggaaaggag gaagaaactt cttggatctc tgagggtata
      541 tgtgagggtg tctctgtgac cctgactcaa gacatctgct gcaagggtat cactgtatct
      601 gctgttgtag ctgctcctaa cctgcagaat ctgaagactt tacctctgac ctgagaacaa
      661 gtcagctctg tgtccagctt aagagattca ccccagctgt acgatgggtc gcacccggga
      721 agctggatgt gtggctgcag gcatggtcat tggggctggt gcctgctact gtgtatacag
      781 actgacctgg ggaaaagatg agaatgagaa gttgtgggat gaggaagagg aggaagagga
      841 ggaagaggag gaaaagtctt gtagtgacaa aactgagaaa gaacttaaga ctaatgttgg
      901 ggtaggggcg agaggcaaac ctcaagatga ctcaaagtcc aaggttgagg tgaatgtggg
      961 acctgagaat ggtccaggtg taaagaaaga agtgcaccca gaatcccaga gtgggggtgg
     1021 actagaggct aaggccaagg cccttttcaa gactctaaag gaacaggcac gtgcaaaggc
     1081 aggcagaggc ataaggcttc ctaacatctc taggaatagg accctgacat caagtttgcc
     1141 ttgcccagga ggcaggggtg gaggctgcca cccgggaagg actggttcta gggctaggaa
     1201 caggacaagt gggaaagtca agagaaagaa ccgaagcaag agcaacaagg ctccagccac
     1261 agcatggcct gtacgcaagg gcaagttcag ctttccctat aaaattgatg atattctgag
     1321 cgcccctgat cttcaaaagg tcctgaacat cctggagaga acaaatgacc cttttactca
     1381 ggaagtagca ctggtcacac tgggtaacaa tgcagcatat tcatttaatc aaaacgccat
     1441 ccgtgagctg ggtggagtcc ccattattgc aaagctgata aaaacaagag accccattat
     1501 tagggaaaag acttacaatg ctcttaataa cttgagcgtt aattctgaga atcagggcaa
     1561 gattaagact tatatcagtc aagtgtgtga cgataccatg gtttgccgct tggactcagc
     1621 cgtccagatg gctggattaa gactccttac caacatgact gtaactaatc actaccaaca
     1681 tttgctttcc tattctttcc cagatttctt tgctttgtta ttcctgggaa accacttcac
     1741 caagatacag actatgaaac tgattataaa ttttactgaa aacccagcca tgacaagaga
     1801 gctggtcagt tgtaaagtac cttcggaatt gatttctctg tttaataaag aatgggatag
     1861 agagattctt cttaacattc ttaccctctt tgaaaatata aacgataaca taaaaagtga
     1921 agggcttgca tcctccagga aggaattcag caggagctca ctgtttttct tatttaaaga
     1981 gtctggagta tgtgtgaaga aaatcaaagc attagcaagc cataaggatc tggtggtcaa
     2041 agtgaaagtt ctaaaagtct taacaaaatt ataattttag atctgttcta aacaacactg
     2101 atgtgatgtt tcttaagttt gcacgtggga acaatgcatt ttgtgaattc ttaggttttc
     2161 attgcgcttg tgtagcaaag ggatcctttg agctgctatt taggaataat gaacatcaca
     2221 gattatcaat acccattgat gctggcttta gattgagcca ctttaagtat gccaaatata
     2281 tattagggct tgcacaaaga aaacatttat taaacttgct atctaggttg agatattttt
     2341 attgtttaac taaactgaca gtgaagtaac tatatgtcat aaataagcta tacttttgta
     2401 ttgatttaaa tttgttcatc taagagttgt gctttatcaa taaagttatg tttaagcaga
     2461 aggaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
