LOCUS       NM_146205               3852 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus armadillo repeat containing 5 (Armc5), mRNA.
ACCESSION   NM_146205
VERSION     NM_146205.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Uota,A., Okuno,Y., Fukuhara,A., Sasaki,S., Kobayashi,S. and
            Shimomura,I.
  TITLE     ARMC5 selectively degrades SCAP-free SREBF1 and is essential for
            fatty acid desaturation in adipocytes
  JOURNAL   J Biol Chem 300 (12), 107953 (2024)
   PUBMED   39491648
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Luo,H., Lao,L., Au,K.S., Northrup,H., He,X., Forget,D.,
            Gauthier,M.S., Coulombe,B., Bourdeau,I., Shi,W., Gagliardi,L.,
            Fragoso,M.C.B.V., Peng,J. and Wu,J.
  TITLE     ARMC5 controls the degradation of most Pol II subunits, and ARMC5
            mutation increases neural tube defect risks in mice and humans
  JOURNAL   Genome Biol 25 (1), 19 (2024)
   PUBMED   38225631
  REMARK    GeneRIF: ARMC5 controls the degradation of most Pol II subunits,
            and ARMC5 mutation increases neural tube defect risks in mice and
            humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
  REMARK    GeneRIF: New mouse line can be used to study tissue-specific
            effects of Armc5. Armc5 haploinsufficiency leads to Cushing
            syndrome in mice, but only later in life, and this involves PKA,
            its catalytic subunit Calpha, and the Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   Hu,Y., Lao,L., Mao,J., Jin,W., Luo,H., Charpentier,T., Qi,S.,
            Peng,J., Hu,B., Marcinkiewicz,M.M., Lamarre,A. and Wu,J.
  TITLE     Armc5 deletion causes developmental defects and compromises T-cell
            immune responses
  JOURNAL   Nat Commun 8, 13834 (2017)
   PUBMED   28169274
  REMARK    GeneRIF: Study on Armc5 knockout mice revealed that ARMC5 is
            crucial in fetal development and immune responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131111.1 and BC025196.1.
            
            On Jun 18, 2004 this sequence version replaced NM_146205.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131111.1, BC032200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3834              AK131111.1         1-3834
            3835-3852           BC025196.1         1306-1323
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.06 cM"
     gene            1..3852
                     /gene="Armc5"
                     /note="armadillo repeat containing 5"
                     /db_xref="GeneID:233912"
                     /db_xref="MGI:MGI:2384586"
     exon            1..1233
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             771..3551
                     /gene="Armc5"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 5"
                     /protein_id="NP_666317.2"
                     /db_xref="CCDS:CCDS21892.1"
                     /db_xref="GeneID:233912"
                     /db_xref="MGI:MGI:2384586"
                     /translation="MAAARPALTDSLSFCLAQLTAAAGEGPGGGKDPATNETPLGRAL
                     LALRTRHIKAAEGIERFRARGGLRPLLALLRRTAAAGPAPSQAASGSAPSSVASAGST
                     PGHAPAAESLLTPSLPMRLRKTLDLALSILANCCTEGACRAEVRRLGGILPLVTILQC
                     VKTDSIQNRTARALGNLAMEPESCRDIHSAGAVPFLVESLTACQDSQCLQSIVRALRN
                     LADSPQHRLALAQQGAVRPLAELLATAPDPALTAALVRALLELSRGCSRACAEQLSLG
                     GALGPLVSLASHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRSPG
                     GSSSATQQPLVRAVCLLCREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVG
                     FLYDTGALGKLQALGLVPLLARQLCGEAGEEEEEGIEAASWDFPEERTSGQAEGGSFR
                     SLRLWLISEGYAAGPGDISPDWSPERCPMPEPSESVSPTPGQTSMSTPRTLRKPGRIP
                     AATPEEPWGQEGPALLLLSRFSQAPDPSGALVTGPALCGLLAYVTGAPGPPNPRALRI
                     LARLTCNPACLEAFVRTYGAALLRAWLVLGVSPDDWPVPHARPVHRSQHRELGEMLLQ
                     NLTVQAESPFGVGALTHLLLSGSPEDRVACALTLPFICRKPTLWRRLLLDQGGLRLLL
                     TALTQPAPHPLFLFFAADSLSCLQGLVSPTASPVPLPALPLELDSPPPCLYEPLLGPA
                     PAPAPDLHFVLDSGLQLPAQRAASAAASPFFRALLSGSFAEAQMDLVPLRGLSPGAAW
                     PVLHHLHGCRGCGAALGPVPPPGQPLLGSKAEEALEAAGRFLLPALEEELEEAVGRIH
                     LSPRGGPESVGEVFRLGRPRLAAHCARWTLEPGQCPRKRALALTGLVEAAGEEAGPLT
                     EALLAVVMGIES"
     exon            1234..1341
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2128
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2625
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2758
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..3834
                     /gene="Armc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3809..3814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Armc5"
                     /note="hexamer: ATTAAA"
     polyA_site      3834
                     /gene="Armc5"
                     /note="major polyA site"
ORIGIN      
        1 gttctccagc agcttagccc catctagatt ctccctggtc acttctggag ccgcaagttc
       61 cattgcggcc gaaaagcgct cggtttccta aatgccaccc gtttaactca tcagcacagt
      121 tggagaacgg ggcactggag gcttggaggc cggtaccgga aacggaaagg tccccaagcc
      181 cgagagactc taggaagtgg cagcgaactt tcccggtagg tttaactctt tcattcgctt
      241 ggcgagacct ttctgtcggg aacttagcac ttttgaaacg gcttggggtt ctgcgagtct
      301 gtcagtccgg ctttcggagc cattgatcac cgcgctttga gggttgccaa tcaagtctga
      361 acgtcgccga caaggacgta ccgggagcga agtggctaag tcacgttggg gagcacagga
      421 cagcactaag actccaccgc ggggcgtctg atcctaggag caacagttca ctcttcggcc
      481 ccgggaggag tttctcaccc acttaaactg cactaagctt ggcgccgact acatatccca
      541 gcatgcaccg cacgcgcctc ttactttccc acagataaat accattctcg ccatgtcttc
      601 tgcgactgtg caagtaccgg agttccagaa tctagaactt gaacttccga ctcgcaagat
      661 aactgcggcg gcgctattcc gaggagcagc ctggccacgc ccccctcttc cagttccgct
      721 ctctcagagt accggcgaga cgcggggcgg agcctgaggc ccgggccaag atggcggctg
      781 cgagaccggc ccttacggac tcgctctcgt tttgcctcgc gcagctcacg gcggcggccg
      841 gggaggggcc aggtggggga aaggacccag ctaccaacga gacacccctg ggccgcgcgc
      901 tcttagctct tcgcacgcgc cacatcaagg cggcagaggg gattgagcgc ttccgggcac
      961 gcggcgggct ccgccccctt ctcgccctgc tccgccgaac ggctgctgcg ggccccgccc
     1021 cgtcccaagc agcctctggc tccgcccctt cgtcggttgc gtcagctggt tctacccctg
     1081 gccacgcccc cgctgccgag tcgctcttga cgccttcgtt gccaatgcgc ctgcgcaaga
     1141 cgctggattt ggcgctcagc attctagcca actgctgtac agaaggggcg tgccgggccg
     1201 aagtgcggag acttggaggc attctccctt tggtgaccat tcttcagtgt gtgaagacag
     1261 acagcatcca gaaccggaca gcgcgtgccc tggggaactt agccatggag cctgagagct
     1321 gcagggacat ccactctgct ggtgctgttc cctttcttgt tgagagcctt accgcctgcc
     1381 aggactcaca gtgcctacag agcatagttc gtgccctccg caacttggca gactcacccc
     1441 agcaccgtct agccctggca cagcaaggag cagtgcggcc actggctgag ctcctggcta
     1501 ccgccccaga ccctgcactg actgcggccc tagtccgtgc tctcttggaa ctcagccgag
     1561 gctgttcccg ggcctgtgct gagcagctaa gtctgggtgg ggcactgggc ccccttgtca
     1621 gcctggcttc tcaccctaaa cgggcaatac gtgaggcagc catcctgatc ctcgccaacc
     1681 tgtgtgctca gggcctggtg cggcctgcac tgggcaatgc aggtggcgtg gaggtgttac
     1741 taggtgagct taggcggcga cggagtcccg gtgggagcag ctcagctact cagcagcccc
     1801 tagtgcgagc tgtgtgcctc ttatgccggg aagccatcaa ccgggctcgg cttcgggatg
     1861 ccggtggttt ggagctgctg atgggtctgc tgcaggaccc cggtgccagt gcctggcacc
     1921 cacgtgttgt ggctgctctt gtaggcttcc tttatgatac tggggccttg ggcaagttac
     1981 aggccctggg acttgtgcct cttctggcca ggcagttatg tggtgaagct ggcgaagagg
     2041 aagaggaagg aatcgaagca gcttcctggg acttccctga ggaacggacc tctgggcagg
     2101 cagagggagg gagcttccga agcctcaggt tgtggctgat ttctgagggt tatgcagcag
     2161 gccctggaga tatctcccca gattggtctc ctgagcgttg tccgatgcca gagccatctg
     2221 agtcagtcag tcctacccct ggccagacct caatgtcgac accccgcact cttcgcaaac
     2281 ctggccgcat ccctgctgcc actcctgagg agccttgggg ccaagagggg ccagccctgt
     2341 tgctgttgtc acgcttctcc caggctcctg acccaagtgg agctctggtg actggcccag
     2401 cactgtgtgg cctgttggcc tatgtgacag gtgcaccagg accaccaaac ccacgcgcac
     2461 ttcgtatctt ggcgcgcctc acctgtaacc ctgcgtgcct tgaggccttt gtgcgcactt
     2521 atggtgcagc gctgctgcgt gcctggctgg tactcggtgt ctcaccagat gactggcctg
     2581 tgccacatgc ccggcctgta caccgaagcc agcaccgaga gctgggagag atgctgctac
     2641 agaacctgac tgtgcaggct gagtccccct ttggagtggg tgccctcacc cacctgctgc
     2701 tctctgggag tcctgaggac cgcgtcgcct gtgcactgac cctacccttc atctgccgga
     2761 agccgactct gtggcgccgc ttacttctgg atcagggtgg cctccgcctc ctcctcacag
     2821 cactaacgca gccagcgcca cacccactct tcctcttctt tgcagcagac tccctgtcct
     2881 gtctccaagg cctggtatct cccactgcaa gcccagtccc tctacctgcc ctgcccttgg
     2941 aacttgactc acctccccct tgcctctacg aacctctgct gggtccggcc cctgccccag
     3001 ctcctgacct gcacttcgtt ctggattcag gcctacagct ccctgctcag cgggctgctt
     3061 cagctgctgc ctcccctttc ttccgggccc tgctatccgg cagctttgct gaagcccaga
     3121 tggatttggt gccgcttcga ggcctgtccc ctggtgcagc gtggcctgtc ttacatcatt
     3181 tgcatggctg caggggctgt ggggctgctc tggggcccgt acccccacct ggtcagcccc
     3241 tgctgggctc caaggccgag gaagctctag aagctgctgg ccgattctta ctgcctgcac
     3301 tggaggaaga gctagaagaa gctgtgggcc gcatccactt gagtccccgg ggtggcccgg
     3361 agtcagtggg cgaggtattc cgtttaggcc ggccccggct ggctgcccac tgtgcacgat
     3421 ggacactaga accagggcag tgcccaagaa aaagggccct ggcccttacg gggctcgtgg
     3481 aagcagcagg cgaggaggca gggcccctca ctgaggcttt gctggctgtg gtaatgggga
     3541 ttgagtcata gtgcatatgc cctaggctaa actattggca tccctgggag aggacccaag
     3601 ggatgagttg gctgtaaagg aggcttctct cagcctgaga gaagactgca gaaggcgcta
     3661 tcctcaggga cggaagagaa aatggaactg gatcccagga tgaagatcta acgatccata
     3721 actcaaaagc caataccaga gtctgtgcag gagtccaagg gacagctcag gcccagggtc
     3781 tggcctgact cagcactatg gtattgaaat taaacacctg agatttgaac actgaaaaaa
     3841 aaaaaaaaaa aa
//
