LOCUS       NM_001034858            4865 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus armadillo repeat containing 2 (Armc2), mRNA.
ACCESSION   NM_001034858 NM_183279 XM_136978 XM_891870 XM_908555 XM_920910
VERSION     NM_001034858.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4865)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4865)
  AUTHORS   Martinez,G., Coutton,C., Loeuillet,C., Cazin,C., Muronova,J.,
            Boguenet,M., Lambert,E., Dhellemmes,M., Chevalier,G.,
            Hograindleur,J.P., Vilpreux,C., Neirijnck,Y., Kherraf,Z.E.,
            Escoffier,J., Nef,S., Ray,P.F. and Arnoult,C.
  TITLE     Oligogenic heterozygous inheritance of sperm abnormalities in mouse
  JOURNAL   Elife 11, e75373 (2022)
   PUBMED   35451961
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4865)
  AUTHORS   Coutton,C., Martinez,G., Kherraf,Z.E., Amiri-Yekta,A., Boguenet,M.,
            Saut,A., He,X., Zhang,F., Cristou-Kent,M., Escoffier,J., Bidart,M.,
            Satre,V., Conne,B., Fourati Ben Mustapha,S., Halouani,L.,
            Marrakchi,O., Makni,M., Latrous,H., Kharouf,M., Pernet-Gallay,K.,
            Bonhivers,M., Hennebicq,S., Rives,N., Dulioust,E., Toure,A.,
            Gourabi,H., Cao,Y., Zouari,R., Hosseini,S.H., Nef,S.,
            Thierry-Mieg,N., Arnoult,C. and Ray,P.F.
  TITLE     Bi-allelic Mutations in ARMC2 Lead to Severe
            Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in
            Humans and Mice
  JOURNAL   Am J Hum Genet 104 (2), 331-340 (2019)
   PUBMED   30686508
  REMARK    GeneRIF: bi-allelic mutations in ARMC2 cause male infertility in
            humans and mice by inducing a typical 'multiple morphological
            abnormalities of the flagella' phenotype, indicating that this gene
            is necessary for sperm flagellum structure and assembly
REFERENCE   4  (bases 1 to 4865)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY123606.1, BM942469.1, AC165442.1, AK131686.1, AK141039.1 and
            BX636716.1.
            
            On or before Jun 4, 2008 this sequence version replaced
            NM_183279.1, NM_001034858.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.717778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY123606.1         1-39
            40-669              BM942469.1         23-652
            670-688             AC165442.1         42884-42902
            689-805             AC165442.1         50004-50120
            806-1020            AK131686.1         1-215
            1021-1499           AK141039.1         1353-1831
            1500-1664           AK131686.1         695-859
            1665-3445           AK141039.1         1997-3777
            3446-4498           AC165442.1         126823-127875
            4499-4865           BX636716.1         2-368               c
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.77 cM"
     gene            1..4865
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /note="armadillo repeat containing 2"
                     /db_xref="GeneID:213402"
                     /db_xref="MGI:MGI:1916449"
     exon            1..190
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..446
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2793
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 2"
                     /protein_id="NP_001030030.2"
                     /db_xref="GeneID:213402"
                     /db_xref="MGI:MGI:1916449"
                     /translation="MLSSNDQKLEKLDSFYRPPVSKQRTSAEIISEARNALRTVRTQR
                     PFTPREDQRKLFGPASSRSPENRPPSSFSLHASSFELSDSKPISGTRLRPLELKPKAP
                     ASPGTEDACLSFPKAPLDPAKIRKISGARARFYRAASQGMLLPDRSPPAAHSKTVDES
                     SKPVSVGSSTARRNGTHLTASSATGQLKSPPLLTCDQGFQETTEQEVSLLSQLRRGGD
                     PGKRRARASSCPSSSDLSRKETRAASRASSQEQETDTEVDEVFWKARIVPILHELENE
                     EDIEEMCAACTQLHRTLEEARMLGKKFKRRTVLLKALYKLVDADSDPLSLKLAKLILA
                     LKVSGKNLLNVCKLIFKISRNEKNDTLMQEDNILESLLEVLRAEELQSNTEAFLYCMG
                     ALKFVSGSPGFLTEMVNKGAVEILAQLIKEMTEDTEKHGVCLPDSGHLLVQTTATLRN
                     LVDSPLTRSKLLNMGAFPHLCTVMEQHADDKDICTNIARIFSKLTSYRDCCAALASYS
                     RCYALFLSLLNKYQKNQDLVIRIVFILGNLTAKSNQARELFSRETGSVETLLTLFQSF
                     YHHKENSPKLQLSEAKPQAEAEDVLVKLTRVLANIAIHPRIGPVLAANPRVVGLLLRT
                     LESKSLGDCEELVINTIAAINNLSFYQVKSSVLQHRKLYVAELLLRLLVSNNMERILE
                     AVRVFGNLSQDHDVCNFLMQKNVHKFMITLLEAKHQDICFSACGVLLNLTVDKEKRAI
                     LKEGGGIKKLVDCLRDFGPSDWQLACLVCKTLWNFSENITNASECFGDDVANTLLILL
                     STFLDEELALNGSFDQDLESYHRLHWETEFKPVAQQLLQRIQSHHSLLEPLPVPSF"
     exon            447..519
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..688
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..878
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..955
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1054
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1230
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1333
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1557
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1703
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1803
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2104
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2227
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2341
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2474
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2635
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..4865
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4844..4849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4865
                     /gene="Armc2"
                     /gene_synonym="2610018I05Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcctcctggt ccctgctgcc ctgcgagagc gggaaggccg tcacactccg ccggggtcta
       61 agtgtctagc gcttgtcaca ggtgttttga gtcgagcccg gattccccaa ccagcaccta
      121 ctccagcgca tcccgcttcg ctctgcggcg tcctggatct gtaggctgac cgctcggcct
      181 gcagcgaaag ggtgtgtctc tgaagagcgt tttagtttaa aaggaaagat gctgtcttcc
      241 aatgaccaga aactcgaaaa gctggattcc ttttatcgac ctccagtgtc caaacagagg
      301 acaagtgcag aaatcataag cgaagcacga aatgccttaa gaacggttag gacccaaaga
      361 ccatttacac cccgtgaaga ccaaaggaag ctatttgggc ctgcctcgtc aagaagccca
      421 gaaaacaggc ctccttcctc cttcagcctt cacgcttcca gctttgagtt atccgattcc
      481 aagcctatct ctgggactcg tctcaggcca cttgagctga aacccaaagc tccagcatct
      541 cccggcacag aggatgcctg cctctccttc cctaaagctc cactggaccc tgcaaagata
      601 agaaaaatca gtggggcccg agcacgcttc tacagggctg cgtcccaggg aatgcttctg
      661 cctgacagat cccctcctgc cgcccactca aagaccgtgg acgaatccag caaacccgtt
      721 agcgtgggga gttctacagc gagaaggaat gggactcatt tgacagcttc cagtgccact
      781 ggccagttaa agagtccccc acttctcacc tgcgaccaag gtttccaaga aaccacagag
      841 caagaagtgt ccctactgtc tcagctccga cgtggagggg accctgggaa acggcgtgcc
      901 agggcctcct cgtgccctag cagctcagac ctgagcagga aggaaaccag ggcagcctcc
      961 agagctagct cacaggaaca ggagacagac acagaagtag atgaagtctt ctggaaagca
     1021 cggattgttc ccattttgca tgaattagaa aacgaagaag acattgaaga gatgtgtgca
     1081 gcctgcaccc agctccatcg cacgctggag gaagcgcgca tgctcggaaa gaagttcaag
     1141 cgaagaactg tcctgctgaa ggctctgtat aagctagtgg atgctgactc ggacccgctc
     1201 agcctgaagc ttgccaaact tatcctagca cttaaagtga gtggaaagaa ccttcttaac
     1261 gtctgcaaac tgatatttaa aatcagcagg aacgagaaga acgacaccct gatgcaggag
     1321 gataacatcc tggaatcatt actggaggta ctgagagctg aagagctgca aagtaacacc
     1381 gaggcttttc tctactgcat gggggctctg aaattcgttt ccggaagccc ggggtttctt
     1441 actgagatgg tcaacaaggg tgcagtggaa atattggcac agctgataaa ggaaatgacg
     1501 gaggacacgg agaagcacgg cgtctgcctg cctgattctg gccatttgct agtgcagaca
     1561 accgcgacct tgagaaactt agtcgattca ccactgacga gaagcaagct cctgaacatg
     1621 ggggcctttc cccatctctg cacagtgatg gaacagcatg cagacgacaa ggacatctgt
     1681 accaacatcg ccagaatctt tagcaaacta acctcttacc gcgactgctg tgcagccctg
     1741 gccagctatt ccaggtgtta cgccttgttt ctgagtctat tgaacaaata ccagaagaac
     1801 caggacttag taattcgaat tgtttttatc cttggcaacc tgacagcgaa gagtaaccag
     1861 gcccgggaac ttttctccag agagactggg agcgtggaaa ctctgctcac gctgttccag
     1921 agcttctatc accacaagga gaactcacca aagctgcagc tctcagaagc caagccacag
     1981 gcagaggccg aggacgtgtt ggtcaagctg acccgtgtcc ttgccaacat cgccattcac
     2041 ccgcgcattg gcccagtgct ggccgccaac cctcgggtgg tgggcctgtt gctgagaact
     2101 ctggaatcca agtcactggg cgactgcgag gagctggtga tcaacaccat agcagccatc
     2161 aacaatctgt ccttctacca agtgaagagc tctgtcctac aacacaggaa gctgtatgtt
     2221 gctgaactgc tcttaaggct ccttgtgagt aacaacatgg agaggattct ggaggctgtg
     2281 cgagtcttcg gaaatctctc ccaggaccat gacgtctgca atttcctcat gcagaaaaat
     2341 gtacacaagt tcatgatcac attgctggaa gccaagcacc aggacatttg cttctctgcc
     2401 tgtggggtcc tcctgaatct cacggtggac aaggagaagc gagccattct gaaagaaggt
     2461 ggtggcatta aaaagttagt ggattgtttg agagacttcg gccctagtga ttggcagctg
     2521 gcctgcctgg tgtgcaagac gctgtggaac ttcagtgaaa acatcaccaa cgcatccgag
     2581 tgttttggag atgatgtcgc caacacactc ctcatcctct tgtcgacatt tttagatgaa
     2641 gaactagccc tgaatggcag ttttgaccaa gacttagaaa gctaccacag gctccactgg
     2701 gaaacggagt tcaagcctgt ggcccagcag cttctgcaac gcatccagag ccaccactcg
     2761 ctcctggagc ccctgcctgt cccttctttc taacgcgaca gacacaggcc acgggcagaa
     2821 ctgggaaggc agatcgccct cacgctcagg aaatggtaaa agcatggaag cttttcagta
     2881 ttcacatacg ttgagcgttt ttaaagtact gattttagcg aatagcctaa gtgttttgaa
     2941 agaaataagc acctcttttt ctaggtatta cagaaaatgg atatatatat tctcctatga
     3001 gaggtatgag atggaaatat atgcatttct aagacttctc tttctatttg ctttgaaaac
     3061 acttagaaaa gacccttaaa gatcccagtg acaaccttgg agtgagcaag cttgtcaggt
     3121 cactagctaa gggacagtgc aatgaagacg gaggctttgt ccacgggaag agtggcccac
     3181 cctctgctgt agctcttact acatcaagac atgagttgct ctccttgtcc taagagaagg
     3241 aagaagcaga gaggagagag agctacgtgg agggctggtg atgtagctca gcggcagacc
     3301 acttgactcc caggttcaag gccctgggtt tgatccccag cgagggagta aaaggaacta
     3361 ctgctttagg tcatctgtcc ttttagattt ttagggcttt tctttttctt ttgtttgttt
     3421 ggcctgtatg tatatttatg taccctgtgc atgcagtacc tgtggaggca agaagaggcc
     3481 atcagatccc ctgagattgc tgtcatagat ggttgtgagc ctctatgtgg gggctgggaa
     3541 ttgaactcag gtctgctgca agagcagcca gtgttcttaa ccactgagcc atctctccag
     3601 cccctacttt taaaatattt ttaaaatttt aatttgtgtc tgtctgtctg tctgtctgaa
     3661 taaacacatg ttgtatgtct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3721 gtttccttga atccagaagt gggtatcagc ccctagaact ggagttacag gtggttttaa
     3781 gctgctggac atgggtgctt ggagccaaac tcaggccttc tggaagagca gcgagtgctg
     3841 ttaactgctg agccatactg cagccccagc catctacttc ttgaatgaag taaaacagat
     3901 gaaaaagtac ctttcttttc atttgaaata gtaaccgaat tagatgggct gtccccctca
     3961 ttagaacata tccaagagag atgatataac agattagaga gtacacagtt agctataagg
     4021 catccctttt tgactcctat ctctctgctg ctgggggtgg ggtactttag acaattaact
     4081 aaatttcttg agtcatattg taaagtgaga atattacctc tctttatttt agtgtatgca
     4141 ttagttaggg ttcttagaag aataggatat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4201 gtgtatctcc tacctctctc tctctctctc tctctctctc tctctctctc tctctctctg
     4261 tatatagtaa aagatttatt aggttgctta ctggctggga aacccaagaa tggctgtctg
     4321 agttttggag atgtgaggag ccagtatctc accagtccag gaggctgagt gccccagcag
     4381 cctcagtctg gtgctgaaga ctgaaggatt cctggagagc atccgatctt caggccatgc
     4441 tagagactga agcagctggg ttcccaagcc gatgaggaag cagcactggc agaaacagag
     4501 tggatgcact tgccagcctg agcaaaagta gaacggcaga aagcccacgt ttgccttaga
     4561 cctctttgca gctgggttgc ctcagggaga gcgagcagct gacactgagg ggagggaagg
     4621 atgtccgttc tcccccccac ccccacagag aagctttcta ggaaataccc tgccaggcag
     4681 acatatctta gtaggtccca gagctaattg gggtgaccac caatattaac acacaacata
     4741 gtttagagca aagccttaat cagcaggttg tgggcacaca ctgtaattat tatgatgaga
     4801 gtctgtttgc tcgcttgtct caggaggata aaattcgcct ctgaataaat tatttaaaaa
     4861 ccaaa
//
