LOCUS       NM_026011               2928 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 8B (Arl8b), mRNA.
ACCESSION   NM_026011
VERSION     NM_026011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Ghosh,S., Dellibovi-Ragheb,T.A., Kerviel,A., Pak,E., Qiu,Q.,
            Fisher,M., Takvorian,P.M., Bleck,C., Hsu,V.W., Fehr,A.R.,
            Perlman,S., Achar,S.R., Straus,M.R., Whittaker,G.R., de
            Haan,C.A.M., Kehrl,J., Altan-Bonnet,G. and Altan-Bonnet,N.
  TITLE     beta-Coronaviruses Use Lysosomes for Egress Instead of the
            Biosynthetic Secretory Pathway
  JOURNAL   Cell 183 (6), 1520-1535 (2020)
   PUBMED   33157038
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Hashimoto,K., Yamaguchi,Y., Kishi,Y., Kikko,Y., Takasaki,K.,
            Maeda,Y., Matsumoto,Y., Oka,M., Miura,M., Ohata,S., Katada,T. and
            Kontani,K.
  TITLE     Loss of the small GTPase Arl8b results in abnormal development of
            the roof plate in mouse embryos
  JOURNAL   Genes Cells 24 (6), 436-448 (2019)
   PUBMED   31038803
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Saitoh,S.I., Saitoh,Y.M., Kontani,K., Sato,K. and Miyake,K.
  TITLE     ADP-ribosylation factor-like 8b is required for the development of
            mouse models of systemic lupus erythematosus
  JOURNAL   Int Immunol 31 (4), 225-237 (2019)
   PUBMED   30753473
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Schiefermeier,N., Scheffler,J.M., de Araujo,M.E., Stasyk,T.,
            Yordanov,T., Ebner,H.L., Offterdinger,M., Munck,S., Hess,M.W.,
            Wickstrom,S.A., Lange,A., Wunderlich,W., Fassler,R., Teis,D. and
            Huber,L.A.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Mrakovic,A., Kay,J.G., Furuya,W., Brumell,J.H. and Botelho,R.J.
  TITLE     Rab7 and Arl8 GTPases are necessary for lysosome tubulation in
            macrophages
  JOURNAL   Traffic 13 (12), 1667-1679 (2012)
   PUBMED   22909026
  REMARK    GeneRIF: Arl8B is required for LPS-stimulated lysosome tubulation
            in macrophages.
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Haraguchi,T., Yanaka,N., Nogusa,Y., Sumiyoshi,N., Eguchi,Y. and
            Kato,N.
  TITLE     Expression of ADP-ribosylation factor-like protein 8B mRNA in the
            brain is down-regulated in mice fed a high-fat diet
  JOURNAL   Biosci Biotechnol Biochem 70 (7), 1798-1802 (2006)
   PUBMED   16861820
  REMARK    GeneRIF: Arl8B plays an important role of Arl8B in neurite
            formation.
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Okai,T., Araki,Y., Tada,M., Tateno,T., Kontani,K. and Katada,T.
  TITLE     Novel small GTPase subfamily capable of associating with tubulin is
            required for chromosome segregation
  JOURNAL   J Cell Sci 117 (Pt 20), 4705-4715 (2004)
   PUBMED   15331635
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY261755.1, AK144177.1 and AC132443.3.
            
            On Sep 22, 2006 this sequence version replaced NM_026011.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.310437.1,
                                           SRR1660815.193030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY261755.1         2-33
            33-2758             AK144177.1         4-2729
            2759-2928           AC132443.3         122314-122483
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.87 cM"
     gene            1..2928
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /note="ADP-ribosylation factor-like 8B"
                     /db_xref="GeneID:67166"
                     /db_xref="MGI:MGI:1914416"
     exon            1..319
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..757
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /EC_number="3.6.5.2"
                     /note="ADP-ribosylation factor-like 10C; small G protein
                     indispensable for equal chromosome segregation 1;
                     ADP-ribosylation factor-like protein 10C; novel small G
                     protein indispensable for equal chromosome segregation 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 8B"
                     /protein_id="NP_080287.1"
                     /db_xref="CCDS:CCDS39586.1"
                     /db_xref="GeneID:67166"
                     /db_xref="MGI:MGI:1914416"
                     /translation="MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQ
                     FSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADRE
                     KIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCY
                     SISCKEKDNIDITLQWLIQHSKSRRS"
     exon            320..400
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..474
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..568
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..636
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..707
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2928
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /note="hexamer: AATAAA"
     polyA_site      2762
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /note="major polyA site"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /note="hexamer: AATAAA"
     polyA_site      2928
                     /gene="Arl8b"
                     /gene_synonym="2610313E07Rik; 3100002J04Rik; Arl10c; gie1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggggggg tagggcgagt catatgaccc gctgggcttc ctggctccgg ccgtcgctgc
       61 cgccagcctc tgtctgcccg cgtcgcgcca ggggccccgc cgaagagccg ttggcgggtt
      121 cggggccgat acccgctcgt gggaaagagt gtccgctgtc gtccgcgccc gtccacgctc
      181 gcagccggcc gccgccatgc tggcgctcat ctcccgcctg ctggactggt tccgttcgct
      241 cttctggaag gaggagatgg aactgacgct cgtggggctg cagtactccg gcaagaccac
      301 cttcgtcaat gtcatcgcgt ccggtcaatt cagtgaagat atgataccca cagtgggctt
      361 caacatgagg aaagtaacta aaggcaacgt cacaataaag atctgggaca taggcggaca
      421 gccccggttc cggagcatgt gggagcggta ctgccgagga gtcaatgcaa ttgtttacat
      481 gatagatgct gcagatcgag aaaagataga agcctctcga aatgaactgc ataatcttct
      541 agataaacca cagttacaag ggattccagt actagtactt ggaaacaaga gagatcttcc
      601 aaatgccttg gatgagaaac agctaattga gaaaatgaac ctgtctgcta ttcaggatag
      661 agaaatttgc tgctattcaa tttcttgcaa agaaaaggat aatatagata tcacacttca
      721 gtggcttatt caacactcaa aatcccggag aagctgagac ctcttcttcg tcttccagtc
      781 cccttggctc taaccttaga actcctgtcg ttcctctgaa gtacttccca ggacatggtc
      841 cttcctaaac ccaagaaatt gcctttttca gagtttattt ctcatgtgca ctgctgaaga
      901 tgtgtattcc tatccttcat agcaaatcag ctggagttgt catgataaaa gtcagcacac
      961 actaaaaggc ttcatatacg tgtctagtgt gttgaggcct ctttcctttc tattttaaac
     1021 acccacattt ttgaccatct taattaagaa aattgcatat taccattctg gtctttctgg
     1081 gccagatttt tgtattggtt ttcagtaaat gtctacctat ttcattacag agtccagtag
     1141 cttctactac tggtatggac ttgatgcagc atggaatttc tagtgccacc cacagtattt
     1201 agaaaacctt taagcctgac tgatgtggga tacggacata ctgtttatcc catctcacac
     1261 atgcatgtga aatgtagact tacactgtag gaataattgg tctgtcagag ttaacagagg
     1321 caccaggtca gaatagtagc ttccttacac tggagatttc ctacctggtg aatttttaaa
     1381 aaccttctgc tttctgaaac tcctttgtca gcagatagcg tctggggagg tgggaggagt
     1441 cacagcatgc tcttttctat ctgtccagat cattaggttt ttttttcccc cttttaacac
     1501 acttttttaa agggatggga attgaagttt tttttttttt tctcaaaagc tttcatgaat
     1561 ttagagcatt ctagctaatg taataaaacc ctttaagaat gtccgacttc atctgaatcc
     1621 acgtctgttc tttgtctcca ggcacccacc ctgtgctgct gcatgccacc cttaattcct
     1681 gactttttat atctagtcat gaaggtgact ttcagcacaa aggacactta taaacaaatt
     1741 cttatttttt tcttaccaat gtaaggtttg gcactctttt cactggtgcc actagactta
     1801 ttgattgtga caactctaga cctgcctgct ttatctaatg taatcatgcg caatgtctac
     1861 aggttgtttg atgatcggcc acacagagaa cggaggaacc aatgctgttt attgtttgct
     1921 atgatacaga gctgtacaaa aacttacaat gaacatattt tgtagcttag tgatctccac
     1981 gtacataaag ggacatatta atactggttg acttgtaaat tgatactcat gccgatgtag
     2041 tagatagacc ccatgctccc acctgcttat gtgttgctca cactgtgtgt gatttgtctc
     2101 ttatgttaag cagcacctat gtcaacagta catattcaga tgtgttgagc actccaggtg
     2161 tagtcagtag gaagttcttt tactgagtac cgttttaatt tatagactgc cacggcctta
     2221 agaacattct ggacagataa ctgcaccatg ttgcacaggc actacttgtt ctctccattc
     2281 tcattcttac tgagtaggac ctgggctgga aagttctctt cttattcacg gaggcaggtt
     2341 gcactcttcc tgaattggat gggtggtttg aataaaggga tatttaaact ttgctcctgt
     2401 agcccgacat gactaatggt cactgtgaac catttcaaag aatgtggcaa cttgcttatg
     2461 cctaaaagga gggattggaa ccagaatgtt taactaagcg gggactgcat aagttcttgt
     2521 taattgacct atggaaacct taatttgttt atgtgtcttt ccattgcttt ccagcatttc
     2581 aggacatcta aaagctacta ccaacatttt cctgtgcata acctctgcat gtgaaaacct
     2641 aacagttact gaactttgta aatacgtaaa ttttttattt aggtgtggat gcattttttg
     2701 tctgtttact gctcctctca gctttattca ataaacttgc attttgaggg ttgcattgac
     2761 aattttacct taaaatgtat catgatgaaa agacgcagac ctttggactc gagtgggaag
     2821 ataatcactc tggaaagggc tccacagact gtgctggaag gtggctgcct cagctggccg
     2881 aggtgttgat gggatgaact agaaataaac ttttacagtg tctacaga
//
