LOCUS       NM_022992               1339 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ADP-ribosylation factor-like 6 interacting protein 5
            (Arl6ip5), mRNA.
ACCESSION   NM_022992
VERSION     NM_022992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Li,X., Liu,J., Zhou,Y., Wang,L., Wen,Y., Ding,K., Zou,L., Liu,X.,
            Li,A., Wang,Y., Fu,H., Huang,M., Ding,G. and Zhou,J.
  TITLE     Jwa participates the maintenance of intestinal epithelial
            homeostasis via ERK/FBXW7-mediated NOTCH1/PPARgamma/STAT5 axis and
            acts as a novel putative aging related gene
  JOURNAL   Int J Biol Sci 18 (14), 5503-5521 (2022)
   PUBMED   36147468
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Zhou,Y., Liu,J., Li,X., Wang,L., Hu,L., Li,A. and Zhou,J.
  TITLE     JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by
            JWA-Mediated Anti-Oxidation/Inflammation Signaling
  JOURNAL   Antioxidants (Basel) 11 (6), 1067 (2022)
   PUBMED   35739964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Aoyama,K., Bhadhprasit,W., Watabe,M., Wang,F., Matsumura,N. and
            Nakaki,T.
  TITLE     GTRAP3-18 regulates food intake and body weight by interacting with
            pro-opiomelanocortin
  JOURNAL   FASEB J 32 (1), 330-341 (2018)
   PUBMED   28904020
  REMARK    GeneRIF: Glutamate transporter-associated protein 3-18 (GTRAP3-18),
            an anchor protein that retains interacting proteins in the
            endoplasmic reticulum, is a critical regulator of food intake and
            body weight by interacting with POMC. GTRAP3-18-deficient mice
            showed hypophagia, lean bodies, and lower blood glucose, insulin,
            and leptin levels with increased serum and brain alpha-MSH levels,
            leading to AMPK inhibition.
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Zhao,X., Wang,R., Xiong,J., Yan,D., Li,A., Wang,S., Xu,J. and
            Zhou,J.
  TITLE     JWA antagonizes paraquat-induced neurotoxicity via activation of
            Nrf2
  JOURNAL   Toxicol Lett 277, 32-40 (2017)
   PUBMED   28428137
  REMARK    GeneRIF: Protective effect of JWA against paraquat neurotoxicity
            involves regulation of the MEK/PI3K-Nrf2 axis.
            Erratum:[Toxicol Lett. 2019 Jan;300:119. doi:
            10.1016/j.toxlet.2018.08.014.. PMID: 30190152]
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Butchbach,M.E., Guo,H. and Lin,C.L.
  TITLE     Methyl-beta-cyclodextrin but not retinoic acid reduces
            EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression
  JOURNAL   J Neurochem 84 (4), 891-894 (2003)
   PUBMED   12562531
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Ikemoto,M.J., Inoue,K., Akiduki,S., Osugi,T., Imamura,T., Ishida,N.
            and Ohtomi,M.
  TITLE     Identification of addicsin/GTRAP3-18 as a chronic
            morphine-augmented gene in amygdala
  JOURNAL   Neuroreport 13 (16), 2079-2084 (2002)
   PUBMED   12438930
  REMARK    GeneRIF: 98% identity with that of rat GTRAP3-18; upregulated in
            the amygdala by repeated administration of morphine
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Butchbach,M.E., Lai,L. and Lin,C.L.
  TITLE     Molecular cloning, gene structure, expression profile and
            functional characterization of the mouse glutamate transporter
            (EAAT3) interacting protein GTRAP3-18
  JOURNAL   Gene 292 (1-2), 81-90 (2002)
   PUBMED   12119102
  REMARK    GeneRIF: inhibits EAAT3-mediated glutamate uptake; highly conserved
            protein and genomic organization amongst vertebrates
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC155724.8.
            
            On Nov 17, 2006 this sequence version replaced NM_022992.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003897.1, D87211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC155724.8         96850-97054
            206-423             AC155724.8         115595-115812
            424-1339            AC155724.8         118458-119373
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.91 cM"
     gene            1..1339
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /note="ADP-ribosylation factor-like 6 interacting protein
                     5"
                     /db_xref="GeneID:65106"
                     /db_xref="MGI:MGI:1929501"
     exon            1..205
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..596
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /note="addicsin; protein JWa; ARL-6-interacting protein 5;
                     prenylated Rab acceptor protein 2; glutamate transporter
                     EAAC1-interacting protein; ADP-ribosylation factor-like
                     protein 6-interacting protein 5; ADP-ribosylation-like
                     factor 6 interacting protein 5"
                     /codon_start=1
                     /product="PRA1 family protein 3"
                     /protein_id="NP_075368.1"
                     /db_xref="CCDS:CCDS20384.1"
                     /db_xref="GeneID:65106"
                     /db_xref="MGI:MGI:1929501"
                     /translation="MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQ
                     TNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTAFV
                     MVVMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKT
                     PMGIILDALEQQEDNINKFADYISKARE"
     exon            206..423
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1339
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /note="hexamer: AATACA"
     polyA_site      1334
                     /gene="Arl6ip5"
                     /gene_synonym="5930404D22Rik; addiscin; Aip-5; Gtrap3-18"
                     /note="major polyA site"
ORIGIN      
        1 cgaaggcgaa gctcgcgaag cagaggaaca tggacgtgaa cctcgccccg ctccgtgcct
       61 gggacgattt cttcccgggc tctgatcgtt tcgcccggcc ggacttcagg gacatttcca
      121 aatggaacaa ccgtgtagtg agcaatctgc tctattacca gaccaactac ctggtggtgg
      181 ctgccatgat gatttcggtt gttgggtttc tgagcccctt caacatgatc ctcggaggag
      241 tcattgtggt gctggtgttc atggggttcg tgtgggcagc gcacaataaa gacatcctcc
      301 gccggatgaa gaagcagtac ccaacggcct tcgtgatggt ggtcatgcta gccagctact
      361 tcctcatatc catgttcggg ggtgtcatgg tctttgtgtt cggcatcact cttcctttgc
      421 tgttgatgtt catccacgca tccctgagac ttcgcaacct caagaacaag ctggaaaata
      481 aaatggaggg aatcggcctg aagaaaactc cgatgggcat tatcctggat gccttggaac
      541 agcaggaaga taacatcaac aaatttgctg actacatcag caaagcgagg gagtaagcac
      601 agcccgccca gtgacggggc cccgcagcag gaatccggtt gcactttccc ccttgttcag
      661 acccattttc agtctgtggt ttttaaacag aaggtgcacg tcttaccacc cacctctcca
      721 aggcatcatg catgcacagg cccactgcta agatctccga tatgacccat agaaggcctc
      781 agaaactgca aaaatacaga cccactctcc cgttgtgtct gaagtgtccg gtgtgctttt
      841 gaaaaagagt gtggattaga cggccacagt gccatcttat cgtagggaag aagtccctgt
      901 agagcctgga ggcaatgtgg aggacatgaa gatcagttaa agtcgaggat gttgtgtgtc
      961 agcctgtttc taatgctgtc tgacatcccc tccaaaatcc cctaagactc tgatgtgtcg
     1021 ggtatgttag tttagcggta ttatttttgt tgttttaaaa ccagaggcta tcacttgggc
     1081 acctgtttga tgtgcagtgg aaactgggtc agccagttgt ttatattttg tttacgaata
     1141 tgaaggtagc tgtttaggac aatgttttgt taaattttgt aaaattttta aaagggttag
     1201 taatatgctt tcaccagcag gtgtttcttg caaactaaat gtcaacctcc tggggtaggg
     1261 gtggggggtg gggggatggt tacaactctg taacttctgt tattcttgtt aagaataaat
     1321 acaatagaac caaacttga
//
