LOCUS       NM_019419               2154 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 6 interacting protein 1
            (Arl6ip1), mRNA.
ACCESSION   NM_019419 XM_133792
VERSION     NM_019419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Lim,J.H., Kang,H.M., Kim,D.H., Jeong,B., Lee,D.Y., Lee,J.R.,
            Baek,J.Y., Cho,H.S., Son,M.Y., Kim,D.S., Kim,N.S. and Jung,C.R.
  TITLE     ARL6IP1 gene delivery reduces neuroinflammation and
            neurodegenerative pathology in hereditary spastic paraplegia model
  JOURNAL   J Exp Med 221 (1) (2024)
   PUBMED   37934410
  REMARK    GeneRIF: ARL6IP1 gene delivery reduces neuroinflammation and
            neurodegenerative pathology in hereditary spastic paraplegia model.
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Foronda,H., Fu,Y., Covarrubias-Pinto,A., Bocker,H.T., Gonzalez,A.,
            Seemann,E., Franzka,P., Bock,A., Bhaskara,R.M., Liebmann,L.,
            Hoffmann,M.E., Katona,I., Koch,N., Weis,J., Kurth,I., Gleeson,J.G.,
            Reggiori,F., Hummer,G., Kessels,M.M., Qualmann,B., Mari,M.,
            Dikic,I. and Hubner,C.A.
  TITLE     Heteromeric clusters of ubiquitinated ER-shaping proteins drive
            ER-phagy
  JOURNAL   Nature 618 (7964), 402-410 (2023)
   PUBMED   37225994
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Zhou,G.F., Tang,J., Ma,Y.L., Fu,X., Liu,J.Y., Yang,R.Z.,
            Zhang,H.S., Cai,X.H., Wang,J.W., Xie,X.Y., Song,L., Luo,B.,
            Chen,J., Chen,L., Deng,X.J. and Chen,G.J.
  TITLE     ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer
            pathology through FXR1-dependent BACE1 translation initiation
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2220148120 (2023)
   PUBMED   37216506
  REMARK    GeneRIF: ARL6IP1 mediates small-molecule-induced alleviation of
            Alzheimer pathology through FXR1-dependent BACE1 translation
            initiation.
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Pinson,M.R., Chung,D.D., Mahnke,A.H., Salem,N.A., Osorio,D.,
            Nair,V., Payne,E.A., Del Real,J.J., Cai,J.J. and Miranda,R.C.
  TITLE     Gag-like proteins: Novel mediators of prenatal alcohol exposure in
            neural development
  JOURNAL   Alcohol Clin Exp Res 46 (4), 556-569 (2022)
   PUBMED   35187673
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Lui,H.M., Chen,J., Wang,L. and Naumovski,L.
  TITLE     ARMER, apoptotic regulator in the membrane of the endoplasmic
            reticulum, a novel inhibitor of apoptosis
  JOURNAL   Mol Cancer Res 1 (7), 508-518 (2003)
   PUBMED   12754298
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Pettersson,M., Bessonova,M., Gu,H.F., Groop,L.C. and Jonsson,J.I.
  TITLE     Characterization, chromosomal localization, and expression during
            hematopoietic differentiation of the gene encoding Arl6ip,
            ADP-ribosylation-like factor-6 interacting protein (ARL6)
  JOURNAL   Genomics 68 (3), 351-354 (2000)
   PUBMED   10995579
REFERENCE   10 (bases 1 to 2154)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131788.3, AK152565.1 and BC046792.1.
            
            On Jul 28, 2009 this sequence version replaced NM_019419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046792.1, AF172088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC131788.3         7946-7996
            52-2124             AK152565.1         2-2074
            2125-2154           BC046792.1         2048-2077
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.44 cM"
     gene            1..2154
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /note="ADP-ribosylation factor-like 6 interacting protein
                     1"
                     /db_xref="GeneID:54208"
                     /db_xref="MGI:MGI:1858943"
     exon            1..157
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     exon            158..291
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     exon            292..411
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     exon            530..614
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     exon            615..2135
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /note="hexamer: AATACA"
     polyA_site      2052
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /note="major polyA site"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /note="hexamer: ATTAAA"
     polyA_site      2135
                     /gene="Arl6ip1"
                     /gene_synonym="Aip-1; AIP-6; Arl6ip; ARMER; mKIAA0069"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggaaag gcagctagcc tatataagca gactgcgggg cgttcccccg cgctcgggtt
       61 gccttgctgg tgttgggggg atagtgtgtg ttcgctcgtt gataaccgcg agtctggaac
      121 gatggcggag ggggataacc gcagcagcaa cctgctggcc gtggagactg caagtcttga
      181 agagcagctg caaggctggg gagaggtgat gctgatggct gacaaagtcc ttcgatggga
      241 aagagcctgg tttccacctg ccatcatggg tgtggtttcc ctgctgttcc tgattatcta
      301 ttatctcgat ccatctgtgc tgtctggtgt ttcctgcttt gttatgtttt tgtgcctggc
      361 tgactacctt gttcccattc tagcaccaag aatttttggc tctaataaat ggaccactga
      421 acaacagcaa agatttcatg aaatctgcag taatctagta aaaactcgac gcagagctgt
      481 gggctggtgg aaacgcctct tttccctaaa ggaagaaaag cctaaaatgt acttcatgac
      541 catgatcatt tctcttgctg cggtggcttg ggtgggacag caagttcaca acctgcttct
      601 cacctacctg attgtgacat ttgtgctgtt gcttcctgga ctaaaccaac atgggatcat
      661 tctgaagtac attggaatgg ccaaaaggga gataaacaaa cttctcaagc aaaaagaaaa
      721 gaaaaatgag tagtgtggct gccgcggagt gtgccctggc cctgggcact gaagtgttac
      781 agtggctcgt tgcttccctc actctgccct tgttaataga aattctcaca ggccaggctc
      841 tgtgcgggct ctagtgccag gtgtagctgg gtacattccc cgtcagtgtg acttcctttc
      901 attttgacaa cttccttcct ttaagatgct aagtggtgaa ctttactgtt ttgtacagtg
      961 aactgtgact ttgttgatgt ttgctttagc tatattcaag gcagtggtct gtggctacag
     1021 gaagctggtt ctactgtctg cttaacaaac tgtctttgtg agtacagaga ttgggtttac
     1081 cacttctgct gaggagacca cttaaaattc attcctgagt ttccactgtg ggagaatacc
     1141 catggaataa gataaaaaat taattccaca ccctagtgtg tgtaagttcc tcgctcatag
     1201 gaaatgcaac agtttgaggg agcattgccc ctttgttcct gtgaggactg gcaggctttg
     1261 actgacctct cattcccttt gcactgcttc aggttagttc tagtccataa tggcctttga
     1321 gcagcaagct ttcagaagat tatatttgag gattgtagca gtttctttgt ttcagattgt
     1381 cagctgactt aaaatgtttg tgactttcct gtaagggcag ccagggataa aagtatcctt
     1441 tgttcaatga gtagaaaact agattatcta ttaatattta agaccaggaa aaaaaaaaaa
     1501 gaggcttaag agtaagcctg gaaaatctca cttgttttcg tagtattggc tgtatttcag
     1561 tgcctccagc tttgcacttg agagacaagt gtttactgct gtttgacttt ccccttgaca
     1621 tttctcagaa aaatgcaggg ctgcagctga gagcagactg ctgattggtg actctggtct
     1681 gcctagcttt tgcaactctt taagcttact gtgatcacgt gccctctcag tagggggctt
     1741 ttagagcagt tgaaatctgc agaactgaac ctctgagggc caaaatagga catttgggaa
     1801 caactcctta acccatgaac tagctgtaac atagtttgtg gatccatgca ctgatgctgt
     1861 gaagcctgcc cctgtgtgta tctgttctct cacctcccta gcactgtaag cagcggtgcc
     1921 tcttgtagca tgtgtgtttg ttttttaatg tttcatgact cccactttga ttttacatgt
     1981 tttcttgtaa ataagcctgc cttcctacct ggaatttgtg tgtgtgtgac taatacatgt
     2041 tctacgagtt aactactttg gcagttttaa tcatttcttc tttgttttgt ggtaaagggg
     2101 aaaaattaaa aaccagttgg aacccttttg tctcaaaaaa aaaaaaaaaa aaaa
//
