LOCUS       NM_019665               1512 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 6 (Arl6), transcript
            variant 1, mRNA.
ACCESSION   NM_019665 XM_001002346
VERSION     NM_019665.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Ye,F., Nager,A.R. and Nachury,M.V.
  TITLE     BBSome trains remove activated GPCRs from cilia by enabling passage
            through the transition zone
  JOURNAL   J Cell Biol 217 (5), 1847-1868 (2018)
   PUBMED   29483145
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Kawasaki,M., Izu,Y., Hayata,T., Ideno,H., Nifuji,A.,
            Sheffield,V.C., Ezura,Y. and Noda,M.
  TITLE     Bardet-Biedl syndrome 3 regulates the development of cranial base
            midline structures
  JOURNAL   Bone 101, 179-190 (2017)
   PUBMED   27170093
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Beales,P.L.
  TITLE     Lifting the lid on Pandora's box: the Bardet-Biedl syndrome
  JOURNAL   Curr Opin Genet Dev 15 (3), 315-323 (2005)
   PUBMED   15917208
  REMARK    Review article
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Takada,T., Iida,K., Sasaki,H., Taira,M. and Kimura,H.
  TITLE     Expression of ADP-ribosylation factor (ARF)-like protein 6 during
            mouse embryonic development
  JOURNAL   Int J Dev Biol 49 (7), 891-894 (2005)
   PUBMED   16172987
  REMARK    GeneRIF: ARL6 was expressed in the neural plate and probably in the
            somites
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   Fan,Y., Esmail,M.A., Ansley,S.J., Blacque,O.E., Boroevich,K.,
            Ross,A.J., Moore,S.J., Badano,J.L., May-Simera,H., Compton,D.S.,
            Green,J.S., Lewis,R.A., van Haelst,M.M., Parfrey,P.S.,
            Baillie,D.L., Beales,P.L., Katsanis,N., Davidson,W.S. and
            Leroux,M.R.
  TITLE     Mutations in a member of the Ras superfamily of small GTP-binding
            proteins causes Bardet-Biedl syndrome
  JOURNAL   Nat Genet 36 (9), 989-993 (2004)
   PUBMED   15314642
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Ingley,E., Williams,J.H., Walker,C.E., Tsai,S., Colley,S.,
            Sayer,M.S., Tilbrook,P.A., Sarna,M., Beaumont,J.G. and Klinken,S.P.
  TITLE     A novel ADP-ribosylation like factor (ARL-6), interacts with the
            protein-conducting channel SEC61beta subunit
  JOURNAL   FEBS Lett 459 (1), 69-74 (1999)
   PUBMED   10508919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279441.1, AK160666.1 and CO040545.1.
            
            [WARNING] On Mar 1, 2025 this sequence was replaced by NM_019665.4.
            
            On May 17, 2008 this sequence version replaced NM_019665.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.3797.1, AK003778.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               BY279441.1         50-232
            184-1468            AK160666.1         3-1287
            1469-1512           CO040545.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..1512
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /note="ADP-ribosylation factor-like 6"
                     /db_xref="GeneID:56297"
                     /db_xref="MGI:MGI:1927136"
     exon            1..410
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..560
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..998
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation-like factor homolog ARL6;
                     ADP-ribosylation factor-like protein 6;
                     ADP-ribosylation-like 6"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 6 isoform
                     1"
                     /protein_id="NP_062639.3"
                     /db_xref="CCDS:CCDS28259.1"
                     /db_xref="GeneID:56297"
                     /db_xref="MGI:MGI:1927136"
                     /translation="MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQS
                     QDIVPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKDGQAIIFVIDSSDKLRM
                     VVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDSVTSVKVSQLLCLESIKDKPWHIC
                     ASDAIKGEGLQEGVDWLQDQIQAVKT"
     exon            561..622
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..691
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..786
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..916
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..972
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1496
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1475..1480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="Arl6"
                     /gene_synonym="1110018H24Rik; 2210411E14Rik; BBS3"
                     /note="major polyA site"
ORIGIN      
        1 ggctccccgt gtcttccgtg ctcacactct cgctaacaga gttcctctgc gggaatcagg
       61 ccattaattt ttttacccag agctctccag ccgcagaaag gagaacctgt gggcggacac
      121 ctacgacgcc cgggtgggcg tggctttggg accggaagaa gctcccgttg ccaagggaac
      181 gccgcgcgcc ggggcgcctg ctcagccact gatgctcgca tcctgggtga accggctgtt
      241 tctcccaact tgtagaaggg gctgtgcttg ggacaaggga accttcctac ggaggcatag
      301 agaggaaggc tgaggctccg gggaagatcc caccgcggaa acgggtacaa gagtgcgtcc
      361 tttcctgtcc ttgtcagccc cttggccttt ggattggcgt caaagatcag ttgctcttta
      421 aatatttaag ccgcgatatg ggcttgctgg acagactttc aggtttgctt ggcctgaaga
      481 agaaggaggt tcatgttctg tgcctggggc tggataacag tgggaaaacc acaatcatta
      541 acaagctgaa gccttccaac gctcaatctc aagatatagt tccaaccata ggatttagca
      601 tagagaaatt caagtcctcc agtttgtctt ttacagtgtt tgacatgtca ggtcaaggaa
      661 ggtacaggaa tctctgggaa cactattata aagatggaca agccattatt tttgtcattg
      721 atagtagtga taagttaaga atggttgtgg ccaaagaaga gcttgatacc cttctgaatc
      781 acccagatat taagcaccgt cgaattccaa tcttgttctt tgcaaacaaa atggacctta
      841 gagactcagt gacctctgtg aaagtgtctc agttgctgtg cttagagagc attaaagaca
      901 agccgtggca tatttgtgct agtgacgcca tcaaaggaga aggcctgcag gaaggcgtgg
      961 actggctcca agatcagatc caagctgtga agacgtgaag agatagtccc tggagacctc
     1021 agtgattttt caatgaatgg aatctgcgta aggcatactg gttaatctca aatttatttt
     1081 aaaagatata tgtaactgag aattttttaa accacattct gcttgctttg gtggactctg
     1141 gaagaacgtt ttaagggctt taggacttga gacattgtta atctggccat tactatacaa
     1201 aatctaataa ttctttggaa ctccttagtt accaacttct tgtaaaagtc tacatcattg
     1261 tgataagtag aatatataaa taccacttat aagccatctc aatatcctat catgatttat
     1321 gatatatttg atgtattttt attttcaatt gttttctaaa agtttagttc attgtatgac
     1381 tttgaagtgc aaattgtgtt agcgaaacac ctttaaagat ttataaggga tcccaggtaa
     1441 ttagtatata tgaaattttt attgtgtcac tatcaataaa aaatgaaata caccaaaaaa
     1501 aaaaaaaaaa aa
//
