LOCUS       NM_029466               6901 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 5B (Arl5b), mRNA.
ACCESSION   NM_029466
VERSION     NM_029466.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6901)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   2  (bases 1 to 6901)
  AUTHORS   Kitai,Y., Takeuchi,O., Kawasaki,T., Ori,D., Sueyoshi,T., Murase,M.,
            Akira,S. and Kawai,T.
  TITLE     Negative regulation of melanoma differentiation-associated gene 5
            (MDA5)-dependent antiviral innate immune responses by Arf-like
            protein 5B
  JOURNAL   J Biol Chem 290 (2), 1269-1280 (2015)
   PUBMED   25451939
  REMARK    GeneRIF: Our results, therefore, suggest that Arl5B is a negative
            regulator for MDA5.
REFERENCE   3  (bases 1 to 6901)
  AUTHORS   Vergnes,L., Lee,J.M., Chin,R.G., Auwerx,J. and Reue,K.
  TITLE     Diet1 functions in the FGF15/19 enterohepatic signaling axis to
            modulate bile acid and lipid levels
  JOURNAL   Cell Metab 17 (6), 916-928 (2013)
   PUBMED   23747249
REFERENCE   4  (bases 1 to 6901)
  AUTHORS   Sebald,E., Krueger,R., King,L.M., Cohn,D.H. and Krakow,D.
  TITLE     Isolation of a new member of the ADP-ribosylation like factor gene
            family, ARL8, from a cartilage cDNA library
  JOURNAL   Gene 311, 147-151 (2003)
   PUBMED   12853149
  REMARK    GeneRIF: The expression pattern of the mouse ortholog Arl8 revealed
            differential tissue expression and an alternate transcript was seen
            in brain that was age-dependent.
REFERENCE   5  (bases 1 to 6901)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929268.6.
            
            On Feb 22, 2019 this sequence version replaced NM_029466.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.353558.1, AK053731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL929268.6         7460-7714
            256-316             AL929268.6         20279-20339
            317-464             AL929268.6         21960-22107
            465-548             AL929268.6         25264-25347
            549-700             AL929268.6         27102-27253
            701-6901            AL929268.6         28396-34596
FEATURES             Location/Qualifiers
     source          1..6901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.98 cM"
     gene            1..6901
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /note="ADP-ribosylation factor-like 5B"
                     /db_xref="GeneID:75869"
                     /db_xref="MGI:MGI:1923119"
     exon            1..255
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..749
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /note="ADP-ribosylation-like factor 8; ADP-ribosylation
                     factor-like 8; ADP-ribosylation factor-like protein 8"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 5B"
                     /protein_id="NP_083742.3"
                     /db_xref="CCDS:CCDS15704.2"
                     /db_xref="GeneID:75869"
                     /db_xref="MGI:MGI:1923119"
                     /translation="MGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHT
                     SPTIGSNVEEIVVKNTHFLMWDIGGQESLRSSWNTYYSNTEFIILVVDSIDRERLAIT
                     KEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCAL
                     TGEGLCQGLEWMTSRIGVR"
     exon            256..316
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     exon            317..464
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     exon            465..548
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     exon            549..700
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     exon            701..6901
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6879..6884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /note="hexamer: AATAAA"
     polyA_site      6897
                     /gene="Arl5b"
                     /gene_synonym="4930587A11Rik; Arl8"
                     /note="major polyA site"
ORIGIN      
        1 gcagaccgag cgactacggg tcggggctgg gctcagcgcg ctgcgaacaa aggagtctgc
       61 ggcggttccc ggctccgcgg aggaccaaag cttcgctgga ctcttgaggc tccgcggctc
      121 cggatcggct tcccctcggt tccaccgcgg gcgccgcggc acctgccgcc gagtgctgcc
      181 caggaagtct gtcccgtccg gggctcatga tggggctgat cttcgctaaa ctgtggagcc
      241 ttttttgtaa ccaagagcac aaagtaatca ttgtgggact ggataacgcg gggaaaacca
      301 ccattctgta tcagttctta atgaatgaag tagttcatac ttctccaacc ataggaagca
      361 atgttgaaga aatcgttgtg aagaacactc atttccttat gtgggatatc ggtggtcaag
      421 aatctctgag gtcatcctgg aacacctatt actcaaacac agagttcatc attcttgttg
      481 tggatagcat tgacagggaa cgcctggcta ttacgaaaga agaattatac agaatgttgg
      541 cccatgagga tttaaggaaa gctgcagtcc ttatctttgc aaataaacag gatatgaaag
      601 ggtgcatgac agcagctgaa atctccaaat acctcaccct aagttcaatc aaggaccacc
      661 cgtggcacat ccagtcgtgc tgtgcgctca caggagaagg gttgtgccaa ggtctagagt
      721 ggatgacctc caggattggt gtgagataat ttttttgctt gaaaaagact tctctattta
      781 ttcggtgata tgaacatttt tcctaatacc tttggctgct gaggcagcag catgtttaat
      841 ttatgacaac acaaacctcc aagtgacgct tgaatcaagt gccactgtac tggaacataa
      901 agatgttttc ttaccttcgt ttcccatgta ctaatctcgg tcggacgagc ataacgtgtc
      961 actatgttgt agaagccgga ctcttctgac tgtattctaa ctcttcagtg actgccttgt
     1021 taaaaaccat ttgtcatata tttcctgaca tctgaagttt cgttatgtcc tttataacca
     1081 gtttctttca cctcttggcc accatgctct ttccgagata ctggtttgac agaatagtag
     1141 tgggaaccgg catgtattat ttatttatcc agcactaagc attctttgct ctacaaaccc
     1201 tttttgtctt ttggacagaa ttaattacag tgaagaaaat ctacctagac gtccgtgtcc
     1261 cccccacccc cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1321 tgtgtaaaca tcacaaatac ttgcgtttaa attttcctca cctcattgca tgtgatagta
     1381 caattttaag ttactctttg catgggaatt atttagtcca tttatttata taaggaatta
     1441 agctcacttt cctaccaacc atatttggtt aaaaactaat gaaggtgaag catgagttta
     1501 aaacccagct tcagtgataa acactattgg ctccatctag tagctaagat gtttcagtgt
     1561 gtgtgtaact ggcagaattt gtaaaaacac accaatgtaa attagagcca ggacacttgg
     1621 agtatgtttt tctgtcagtt tcctatctgc tttattatca gtgtaacctt cgcagttttg
     1681 tcagagatac cacccctgct ctggcagcag acttagcata gacagttctt ttgctttctt
     1741 aggtttgtag tagtggctgt cagagcatcg ttatcaccag cagtatatta ctgaaaggca
     1801 taataacatg gtctttccat aaatgtggct gtggatgatg tgaaagaggc ttcaaattct
     1861 ttttgcccca cctcctgtct ctgtgtaggt agaattgttc ctaaactctt atagggtgct
     1921 ctgaatctat tcctagcttt agaatgttcc tatgagactc agtgttcatg ttctgtctgt
     1981 ttgtttgttt ggctggtttt cgtgtttgtt ttgttttgtt ttgatagggt ttccctcagg
     2041 agtccttgcc ctggaactca ctaggtagac cagactgtca tagtcttagc catgtagatg
     2101 gtttaattgg ttacagaaat ggaaggaaag ggcccaatgc tgaagtcaga cttactgggc
     2161 agtgttaatg gttcccaaag cagttgtcta agatgaaagt aagaatgaac ccttaagttg
     2221 aaaaggggac acgtgttgtc attagcccta tctgtgtcat ctggctcatc tgccttatga
     2281 aagggataaa gtgtgtatgt actaaggggt agttcttagg ttttttttca gtatttttca
     2341 tttagatcaa aataagcttc agtgttcata aatacctgct caaaattggt attttaattt
     2401 cagggttttt gtatgtaaga tgccttaaat tttactctct tttgggttgt actcatttgt
     2461 tatatttagt taatttagtt gaatttgata ctactttttt tttagtgttt gtccccttga
     2521 tctgagaaag tagttagagg gaaatttttc tgaacttttg ggaattgttt aaactttgaa
     2581 tctttttctt agtgattcta tgtgaagtaa aggataagtt taattttttc ttgtgtgttg
     2641 taaatataac tcataatcaa agatgagaga gaaaagcaga tataaatcag tgtgtatggt
     2701 gcatggtggt tgaggggtgg ggatgggaac tgagaaaata ccagttactg aaagcacact
     2761 ttgcctgaat tttactttgt tatattattt accataaata ttaaataata cttctcataa
     2821 gcctgtcctc agaaaaagaa tatttaatgt cccaatattt ctgcttatga aataattttc
     2881 tgccttcttg aatctagtaa gattggctgg ttcaattttc ttctatcaga taatatggtt
     2941 attttttata ttaccacatc agcattatat tgaaagtgtt ttttaatagt tgattgtatt
     3001 ttgtcaaaca gctactagta tagatgcaga tttgctattt aattgttgaa agtacagttt
     3061 attttacttg taaatccttt ttaaaggcac atgattcatt tggactagaa gcaactgctg
     3121 ttagttattt ggaaatggaa tcagcattca agtagatgtt gtgctgttga ttggataggg
     3181 ctccttggga agttcctgtg agacctttgc aggggctttt catcagcctt gctgtttgtt
     3241 cagtaggaaa ctagctatgc tttactccaa gagaatgttt ggaccccaat aagcatagga
     3301 tgctagagag tttcacttga acatttgcta taaatcgaat gactgtaaaa tattatttca
     3361 tgaacttgta aatgtgtgat gggtgccttt gttattttga gatgagttct cagttttttt
     3421 actctgttct ttcaaggtca cgtcaacagg gatgagatgg aggggagtgg ctatgtttca
     3481 cattctcctt tgtctctata tgttatttag taaagtctgt attgtacaga gctcctcccc
     3541 ccagactggc tctacccctc cagattatct tgtattgtta atttaaaaat gaagaaatta
     3601 agttttacct tagaatcttc tcaacatgtt acagctaaaa atgaaaaaca aaacaaaaca
     3661 aaaaaaaccc tttgcaaatc acgtgtgcca tttccttacc tgagcatgtt gtcacctaga
     3721 agcacatttg agaatcactg tagatgtagc acttgctttt gtaagggaat gcactaaata
     3781 tttttattgt taatgtgata taatttctta aaacctgaaa tattaatata tgttacctat
     3841 tgaaaattgg ggggttgaat ctataatggt tgcttttagg ttcttgtgtt agcattctta
     3901 aggggatact gcttttattc tatatacact agagaaacaa catatacatt tcattcttga
     3961 aaggactagc tttacataac tcccatagga atagtgtttt gtaacatggg gagtgtctgg
     4021 agacagagct tcaggtagcc aaggtgagca gcagcaccag gccaggatgc tcctgcttcc
     4081 ccatcccagt gctgggattg ccgtaggcat tttgattgaa tataatttaa ctttcattgt
     4141 agcataaaga ggaaacagtt ggttttccct gtggaaagaa tgagggattc agacaatgct
     4201 gtaaacaata ttccctgacg ctaccaagcc tggccaccaa gaactctttg aagaggaggt
     4261 tttaagtctt tggttttgta tctcaacaga ttatgagcag aattgtttcc aaggccattg
     4321 agtcccccgc tgtgttaact gtggattagc agcagactgg gattgtgcat tgtgcctcca
     4381 cactctggtg atttattggc acttatctct agaggccgat tttatgtgcc aacttacctg
     4441 tggctttgaa acaaaatcct cacacacctg aactttagtt ttgaaggtcc tttatcttct
     4501 gtcaggggtc acctcaagat acagcttcta gtcttgtcta ggcacacatt gcaaagcctg
     4561 tctcaagagg tggattctga tctcaatctg cccatttatc gtgtatctag ttgatttaag
     4621 acactattgt tcatggccat ctttttgttc ttcccaaagt gaggaccttt taaataagcc
     4681 aagcctcaaa tatgtgttct gtttaatatt ctgaagcctt acgcactgtc actatttttt
     4741 caaatctaaa ctaataagag gaatgcttgt agtggtgcac ctgggtggtc ttactcactg
     4801 tgtgatcccc acccgagcat cacgtcctct agtgtgtata caacacagta tggagaaata
     4861 gctttccttt ggcttaagct gaatttctaa ctaaagacag tgcaaaggac aagttatatt
     4921 caccaaaaaa tggcttagaa ttgcttctaa gcagcaccca tgtgttttgg aaacccactt
     4981 ctacaaaact taccttattt ttctggcttt tctgactgga tagaagtggt tagtgtgtgt
     5041 gttcactgct tctaaggcat cctaaacact tggcttggca gtgctgaaag agtatcatca
     5101 gccaggacat cagtgtgtta cagactgaag cccacttggc tgtgaaaatg gctgcttttt
     5161 aaggtcattg gttttcatgt cttctcatct ttattcattt aatattagtg tgaagactga
     5221 aatccaagag ccagggttgg ggggaaaaag atatatttta agaattatag gtgaccaaag
     5281 ctatatagag gtcaatagac ctaggtgctc tacactgcat ttcatatggc tggaaagcct
     5341 gaagactggt tagcctgcta ggatggaatc gggacctgta ctcacacaga ggcttcttga
     5401 tttttttttt ttaaaggcca gtcctctgca ttttctccat gctatgtgta gatggagtct
     5461 agaaatcaga acatctgaat gaatgaaaag gttttcttgc acaacttgtg aatttttaat
     5521 ttaaaaataa ttattacctc attttttact ccacagagtg ctttgcttaa gtgtcaaagc
     5581 ttccataaaa cccccttcac ccaaatgtct ttgaatatgc agaatgccct gctagaggca
     5641 gtgtgagtgc tgggccggat ttttgttttc tttgtttccc agcaagaagg tgaccaggta
     5701 cacttgagca aagcacccag tatttaattc cttacagaaa ggagaggaaa ggtctgcagt
     5761 tggactgatg gtatgctaac accgcaaatg actgtcattt gatctcagaa gttcaggatt
     5821 gattgctatg ttttagctct aattgtgaga aacagtagtc attttagtct taaattttcc
     5881 ctcaggaaat tcagggagac tgagccttcc ttcccccacc tccgtttatt ctcttggagt
     5941 aaactttcag tctcatggtg aatgtttttc atccaaattt catcttgaaa gagcttagct
     6001 gctgttttca ctgaaattgt gaaatacagt gacgattatg gcattttcca attatgagat
     6061 cattttctgt ttctccatgc tgctctcttt ctcagaacat agtttaagat aaggaaagag
     6121 caagctcctg gcagttccgg cttcactgtt gcgtttattc taatgggagt ataatgatca
     6181 taattgaaca ttctcgtctt cacacataac ttggtgcttt ataacagtaa ggagaaacag
     6241 gccctggatt cgttatactt ttagcttgga ttgtaaaact ctttaaatgt gcatgtatgt
     6301 tcattttata agatttaaat atacattatt atctattaca tctcaggctc tgcaagtggt
     6361 ctgacagtat ctttgccaag cagcttggtt caaaagacca tattattaat aggatcaagg
     6421 tgggccctct ggtgttcaca gaggaggaaa cagtgtcttt catatcacat actgcttcgg
     6481 aaccctaagg aagaaactga tgcgtgcgcc attgctctga tacttaagtg ctaaccaaga
     6541 aactgtcaaa gcaaatacca aaagcatttc gcaccctcac gccccacaca tgcttccaaa
     6601 cttgtttgat tatgaggttg ttgaaagaaa atgttttttg aattttaaca ttttccacta
     6661 tcatgaaatg cttcttttat atgttaggtc atattcatga ttttcttatt tcttcaatta
     6721 tgttctaatg aattgtgtgc atgccaactt acccaaggaa aaagatgcag tttgctctgg
     6781 actgttaatc tgttagagag gttttggctc ctttgcaatc atggtgcaat atagcatgat
     6841 atccatttgt tttcagtcca cagttttatt tttgtcataa taaatacttt ttcagtatga
     6901 a
//
