LOCUS       NM_025404               1397 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 4D (Arl4d), mRNA.
ACCESSION   NM_025404 NM_031160 XM_001471772
VERSION     NM_025404.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1397)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1397)
  AUTHORS   Geers,B., Hagenstein,J., Endig,J., Ulrich,H., Fleig,L.,
            Sprezyna,P., Mikulec,J., Heukamp,L., Tiegs,G. and Diehl,L.
  TITLE     The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell
            Induction via Control of IL-2 Availability
  JOURNAL   Cells 11 (17), 2639 (2022)
   PUBMED   36078047
  REMARK    GeneRIF: The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell
            Induction via Control of IL-2 Availability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1397)
  AUTHORS   de Lemos,L., Dias,A., Novoa,A. and Mallo,M.
  TITLE     Epha1 is a cell-surface marker for the neuromesodermal competent
            population
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35299237
REFERENCE   4  (bases 1 to 1397)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1397)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1397)
  AUTHORS   Yu,J., Ka,S.O., Kwon,K.B., Lee,S.M., Park,J.W. and Park,B.H.
  TITLE     Overexpression of the small GTPase Arl4D suppresses adipogenesis
  JOURNAL   Int J Mol Med 28 (5), 793-798 (2011)
   PUBMED   21769420
  REMARK    GeneRIF: The results suggest that rapid reduction of Arl4D is
            required for adipogenesis to proceed.
REFERENCE   7  (bases 1 to 1397)
  AUTHORS   Li,R.H. and Churchill,G.A.
  TITLE     Epistasis contributes to the genetic buffering of plasma HDL
            cholesterol in mice
  JOURNAL   Physiol Genomics 42A (4), 228-234 (2010)
   PUBMED   20858711
  REMARK    GeneRIF: analysis identified an epistatic interaction that plays a
            role in the buffering of HDL levels in C57BL/6J mice, and we have
            identified Arl4d as a candidate gene that mediates this effect.
REFERENCE   8  (bases 1 to 1397)
  AUTHORS   Yamauchi,J., Miyamoto,Y., Torii,T., Mizutani,R., Nakamura,K.,
            Sanbe,A., Koide,H., Kusakawa,S. and Tanoue,A.
  TITLE     Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through
            the downstream Arf6, regulate neurite outgrowth in N1E-115 cells
  JOURNAL   Exp Cell Res 315 (12), 2043-2052 (2009)
   PUBMED   19327349
  REMARK    GeneRIF: Arl4D is a previously unknown regulator of neurite
            formation through cytohesin-2 and Arf6, providing another example
            that the functional interaction of two different small GTPases
            controls an important cellular function.
REFERENCE   9  (bases 1 to 1397)
  AUTHORS   Lin,C.Y., Li,C.C., Huang,P.H. and Lee,F.J.
  TITLE     A developmentally regulated ARF-like 5 protein (ARL5), localized to
            nuclei and nucleoli, interacts with heterochromatin protein 1
  JOURNAL   J Cell Sci 115 (Pt 23), 4433-4445 (2002)
   PUBMED   12414990
  REMARK    GeneRIF: developmentally regulated ARL5, with its distinctive
            nuclear/nucleolar localization and interaction with HP1alpha, may
            play a role(s) in nuclear dynamics and/or signaling cascades during
            embryonic development
REFERENCE   10 (bases 1 to 1397)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ830332.1 and BC016113.1.
            
            On or before Jun 4, 2008 this sequence version replaced
            NM_031160.1, XM_001471772.1, NM_025404.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016113.1, AK004126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BQ830332.1         1-34
            35-1397             BC016113.1         1-1363
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..1397
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /note="ADP-ribosylation factor-like 4D"
                     /db_xref="GeneID:80981"
                     /db_xref="MGI:MGI:1933155"
     exon            1..97
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1382
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..805
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /note="ADP-ribosylation factor-like protein 5;
                     ADP-ribosylation factor-like protein 4L; ADP-ribosylation
                     factor-like 5"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4D"
                     /protein_id="NP_079680.1"
                     /db_xref="CCDS:CCDS36336.1"
                     /db_xref="GeneID:80981"
                     /db_xref="MGI:MGI:1933155"
                     /translation="MGNHLTEMAPTASSFLPHFQALHVVVIGLDSAGKTSLLYRLKFK
                     EFVQSVPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVD
                     SAETERLEEARMELHRISKASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELAAA
                     TLTHVQGCSAVDGLGLQPGLEHLYEMILKRKKAPRSSKKRR"
     regulatory      1360..1365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /note="hexamer: ATTAAA"
     polyA_site      1379
                     /gene="Arl4d"
                     /gene_synonym="1110036H21Rik; Arf4l; Arfl4; Arl5; ARL6"
                     /note="major polyA site"
ORIGIN      
        1 ggaaccggag cagcggcact gcaaagtccg ctgtggctga gacgcgacga gtcggtgtct
       61 ggttggcgtg gctcgcggag agtgcggctg gctgaagaca ccccagcttg tgctacctgc
      121 cgttttaagg tctcctcttc ttggcctctg ctggagtccc agacctactc ctgaggtcca
      181 ccctgcaccc tagctcacca tggggaacca cttgactgaa atggccccta cagcctcgtc
      241 ctttctgccg cacttccagg ccctgcatgt cgtcgtcatt gggttggatt ccgcggggaa
      301 gacttccctt ctttaccgtc tcaagttcaa ggagtttgtc cagagcgtcc ccaccaaggg
      361 ctttaatact gagaagatcc gcgtgcccct ggggggttcc cgtgggatca ctttccaagt
      421 gtgggatgtt gggggtcagg agaagcttcg gccactgtgg cgctcctaca cccgccggac
      481 agatggactg gtgtttgtgg tggactctgc agagactgag aggttagagg aagccagaat
      541 ggagttacac cggatcagca aggcttccga caaccagggg gtgccagtgc tggtgctggc
      601 caacaagcag gaccaaccgg gggcactgag tgcagccgag gtggagaaga ggctggcggt
      661 ccgagagctg gcagctgcca cgctcaccca tgtgcagggc tgcagtgctg tggacgggct
      721 gggcctgcag ccaggcctgg aacatttgta tgaaatgatc ctgaagagga agaaggcacc
      781 tcggtcgagc aagaagagac ggtgacccga agctgcccct accctacctg ctagggggtc
      841 agtacacatt atagtcaggc agggcccgtg acctctcagc cagcctgggt gctggatctg
      901 tccaccgcaa aggactgaag gagcataggt ggccctgtgc gccgcagggg ggagggaaga
      961 tgaagtgtct tcattgccct tcacctgaag agggtaggga ggggctgcaa gaccggagaa
     1021 agatgtaaat gctaactcta cctcctacct cggccctggc tctcctgtcc ttccctggca
     1081 ttttatttgg agatatattt ttatctttgc agggggaggg tgtgtagaag gttatccaga
     1141 gagtgcattt gggggtgaat tgagaacatc tccacagtcg aggagagggg tctcctcagc
     1201 tgctcttctc acagctgttc tgtgtctgtg aaaatgccaa gaattctccc cacaattgta
     1261 gatccccggc cctttttata agcctcgagt gtcctctgta ttactgtatt ttgtttgttt
     1321 tttgggtttt tttttttttt tatcatttgc ctgtaagtta ttaaagctgg atgattctgg
     1381 ttaaaaaaaa aaaaaaa
//
