LOCUS       NM_177305               3967 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 4C (Arl4c), mRNA.
ACCESSION   NM_177305
VERSION     NM_177305.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3967)
  AUTHORS   Truong,T.T.K., Fujii,S., Nagano,R., Hasegawa,K., Kokura,M.,
            Chiba,Y., Yoshizaki,K., Fukumoto,S. and Kiyoshima,T.
  TITLE     Arl4c is involved in tooth germ development through
            osteoblastic/ameloblastic differentiation
  JOURNAL   Biochem Biophys Res Commun 679, 167-174 (2023)
   PUBMED   37703759
  REMARK    GeneRIF: Arl4c is involved in tooth germ development through
            osteoblastic/ameloblastic differentiation.
REFERENCE   2  (bases 1 to 3967)
  AUTHORS   Han,J.S., Hino,K., Li,W., Reyes,R.V., Canales,C.P., Miltner,A.M.,
            Haddadi,Y., Sun,J., Chen,C.Y., La Torre,A. and Simo,S.
  TITLE     CRL5-dependent regulation of the small GTPases ARL4C and ARF6
            controls hippocampal morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (37), 23073-23084 (2020)
   PUBMED   32873638
  REMARK    GeneRIF: CRL5-dependent regulation of the small GTPases ARL4C and
            ARF6 controls hippocampal morphogenesis.
REFERENCE   3  (bases 1 to 3967)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3967)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   5  (bases 1 to 3967)
  AUTHORS   Matsumoto,S., Fujii,S., Sato,A., Ibuka,S., Kagawa,Y., Ishii,M. and
            Kikuchi,A.
  TITLE     A combination of Wnt and growth factor signaling induces Arl4c
            expression to form epithelial tubular structures
  JOURNAL   EMBO J 33 (7), 702-718 (2014)
   PUBMED   24562386
REFERENCE   6  (bases 1 to 3967)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 3967)
  AUTHORS   Sun,D., Zhang,J., Xie,J., Wei,W., Chen,M. and Zhao,X.
  TITLE     MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1
            and ARL7
  JOURNAL   FEBS Lett 586 (10), 1472-1479 (2012)
   PUBMED   22673513
  REMARK    GeneRIF: describe that miR-26, an LXR-suppressed miRNA, inhibits
            the expression of the ATP-binding cassette transporter A1 (ABCA1)
            and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes
            which play critical roles in cholesterol efflux
REFERENCE   8  (bases 1 to 3967)
  AUTHORS   Hong,C., Walczak,R., Dhamko,H., Bradley,M.N., Marathe,C.,
            Boyadjian,R., Salazar,J.V. and Tontonoz,P.
  TITLE     Constitutive activation of LXR in macrophages regulates metabolic
            and inflammatory gene expression: identification of ARL7 as a
            direct target
  JOURNAL   J Lipid Res 52 (3), 531-539 (2011)
   PUBMED   21187453
  REMARK    GeneRIF: an important role of LXRs in the coordinated regulation of
            lipid metabolic and inflammatory gene programs in macrophages
REFERENCE   9  (bases 1 to 3967)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   10 (bases 1 to 3967)
  AUTHORS   Jacobs,S., Schilf,C., Fliegert,F., Koling,S., Weber,Y.,
            Schurmann,A. and Joost,H.G.
  TITLE     ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup
            of the ARF family characterization by rapid nucleotide exchange and
            a nuclear localization signal
  JOURNAL   FEBS Lett 456 (3), 384-388 (1999)
   PUBMED   10462049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU709624.1, BC055769.1 and AC115303.6.
            
            On May 21, 2009 this sequence version replaced NM_177305.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK080743.1, BC055769.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BU709624.1         31-70
            41-1993             BC055769.1         1-1953
            1994-3967           AC115303.6         171868-173841       c
FEATURES             Location/Qualifiers
     source          1..3967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.85 cM"
     gene            1..3967
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="ADP-ribosylation factor-like 4C"
                     /db_xref="GeneID:320982"
                     /db_xref="MGI:MGI:2445172"
     exon            1..3967
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..1106
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="ADP-ribosylation factor-like 7"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4C"
                     /protein_id="NP_796279.2"
                     /db_xref="CCDS:CCDS15146.1"
                     /db_xref="GeneID:320982"
                     /db_xref="MGI:MGI:2445172"
                     /translation="MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPT
                     IGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLE
                     EAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPA
                     CAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR"
     regulatory      1977..1982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="hexamer: AACAAA"
     polyA_site      1996
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="major polyA site"
     regulatory      3945..3950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="hexamer: AATAAA"
     polyA_site      3967
                     /gene="Arl4c"
                     /gene_synonym="A630084M22Rik; Arl7; LAK"
                     /note="major polyA site"
ORIGIN      
        1 ggggccggcg ccctccggcc gcagcaggct ggtggcggcg gcggcggtag cagcagcgcc
       61 tagtactgca gggacagcaa ggcagctacg ctaactcgga cgccggggaa gcccgcgccc
      121 cgcctgcgcc tttgcggcgc tcccgggagc cggagctaga gcagctccga ggtgcgccga
      181 gaccagaggc tgctgcagag ccgcggtgcg ggagagccgc aggtcgagcc gggctaccgc
      241 gcaaggcgca gacatcctac accgcggcgt ctgtccgtgg cggctgcgcg agagacaaag
      301 cctccggaga aagatgcccg cggagcacgc accaggcggg ccagggagcc ggcccctccg
      361 agcctaagcg cgcctggccg tgcgccgcgg ggacgccgag accccaccgg gtccagcaac
      421 gggcggggcc caggtgcgcc cggccgcaga gggcctgtga ctgctcgggg ggcggcgccc
      481 tcccgccgca gccgcagtcg cagtggccgg cgccgcagcg aggagccatg ggcaacatct
      541 cctccaacat ctcggccttc cagtctctgc acatcgttat gctgggcttg gactcggccg
      601 gcaagactac ggtgctctac cggctcaagt tcaacgaatt cgtgaacact gtgcccacta
      661 tcggcttcaa caccgagaag atcaaactga gcaacggcac tgccaagggc atcagctgcc
      721 acttctggga cgtgggcggc caggagaagc tacggccgct gtggaagtcc tacagccgct
      781 gcacggacgg catcatctac gtggtggatt cggtggacgt ggaccggctg gaggaggcca
      841 agacggagct gcacaaggtg accaagtttg cggagaacca gggcacaccg ctcctggtta
      901 tcgccaacaa gcaggatctg cctaagtcgc tgccggtggc cgagattgag aagcaactgg
      961 cgctgcacga gctcatcccg gccaccacct accatgtcca gccggcgtgc gccatcatcg
     1021 gcgagggcct caccgagggc atggacaagc tctatgagat gatcctgaaa cgcaggaagt
     1081 ctctcaagca gaagaagaag cggtaatgcg ctagagcagc gatctggagc aaggctgagc
     1141 gagcaagcca gtgagtgaat gaatggacgt ctgggttgag cgagaacccg cgaacaaaga
     1201 caacgaacca aagcgatgat tcgaattttt aaaacacgat ctctgtatcc aaatacagga
     1261 cttggagact taagccgggt gtggaggctg catagccacc catctcgtca cctgccccac
     1321 ccccccaccc cagctcagag gaccttttgt ctataatgct tgagctaccg gtgggatagg
     1381 gtggggggga ccggtgggga gtggacgtga ggacgcaagg gtcccgtggt gtgccctctg
     1441 gccccaggtg ggaagcttgg atgtcagaga gacaaaagcg atttcttctt gctccagcag
     1501 ggccagaagt tcagactgcc cagcccccac tgcggggggg aatcacgtgt gagttacctg
     1561 aggtatgcag ttcacacaga accctggggg gggatacccg aaaggggacg ggtaggcgct
     1621 ggagtgtact gatgggaggg tggggatgac cgctcctttc attctggagc tatggaaact
     1681 gagtaatttt atggcacagg gcaggtccct gttgcgattt catttgtcct actctgggcc
     1741 caaaggaggt ggtggtttga ggccatccag aggactgcct cggaccatgc ggcagctgga
     1801 aggcccagga tgctgtgttt ctggacttgg ctgggaatgg cctggaagac gccactttcc
     1861 aggggtgggt gtgtgtggtt ttgttgagaa ctgcttttca gcctgggatg agacctcttc
     1921 cagatggcct aggccctgtc cgtgtgcagg tcattctctc gtaaagagac caataaaaca
     1981 aagaacagaa aaaccattgg aggtggtggc agtacaggtg cttaaagggt gagggtctcg
     2041 acattaatgc tgtgtgtgta cgcgcgcgtg cgtgtgtatg tgtgtgtgtg tgtgtgcact
     2101 cggtactgca taatcggcat aaaaactgga ccctctgggt ggaatttaaa aatctctcag
     2161 cctactgatt ggtttggaag accacaccag ctacagatgt gtgctgaatt gcaaaatggt
     2221 tttcttaaca agggggaggg ggtctgataa taatacacgt ggtgataggt ttcagacatt
     2281 taaaaaaaaa aaccaacaaa aaacacttcc acaaataaat tatcttcacc ttaggagaaa
     2341 aggactttgc ccttttgtgg cccttggtac tgcaagtgaa gacatgttca gatttctgag
     2401 ctgggtcttt gtgacctatc tggtttcagt attttactca aaatgtgtca ttagaatatt
     2461 tgatatcact caccagaaga ataaaacccc accttgtaaa agctaacccc gtttgcatgg
     2521 aattgaagag aggaaaagtc tagaggaaga agtcctttgg aaatcaccct ggtgggagcc
     2581 ggcctggcct cagagccagc cagcactttt ggttaaaggc aaacaacaat gagtgcttga
     2641 gaagagaagg aagcaggcgt gtgacgtcat ggtcactggt actcaggcac ttcacagttt
     2701 acttgaaaga ggctttggaa aatagatgaa gtgaaagaat aaatacatat tttttaataa
     2761 ggtaacttta aaaatccttt ataatccgga gtgagtcttg gcttgttaaa agctgtcatt
     2821 tatcttgaaa cacagtatca aaagagaaat ttacaactga ctttgtttct ttttctttta
     2881 atttcccccg ctgaatccat gttttagggt aggagttttt gtttccctcc atggcaacac
     2941 attgctgtgc aaaggaagcc atggttgtga atgagcacgg agttggtcac aatatgagcc
     3001 catccctatt gtccttgaca ctctaggagt caatttaaga accataggca gaaatcatgg
     3061 cttcctgctt gaaacccgat ccttagaaga ttgttttgaa agctgaaatc tagcggccca
     3121 tgctcctttc ttgtgtgttt gatagccctc caatttactg gtcttttttg tatacagagc
     3181 taagcagtgg ttagcagcct gcaggatctg tttacacagc aactgtggat tattggcttc
     3241 tccgtggctg gtcccatggt ctgaagattc tgtatagaat tattaaaaaa aaatccacct
     3301 ttttattttc ttcacaattt cttaagcact ttgacatttt ggtagttcca cgatatggag
     3361 agaataatat atttattttg tgacattgca tatgccaaat aatgtagctt tcctgtgctc
     3421 acaatgcctg tgttccaggt cagtgtccga tcctggcctg cttgaacaat ggcttgggat
     3481 gggtttgtga tgcccccccc ccaaaccatg atcaatactt aagggtgcag ttgactgtta
     3541 gtagttgtgc agtaaagtca agccctgtgg tgtatcagca aatagttaaa aagagtctcg
     3601 gttgatttct gtaacgtttg acctaatgaa atacccattt catctgtgac aacacatagc
     3661 ccagtaaaca tcactgtggt ggtgccatgg gggagttcct agtgacactt ctgccctttg
     3721 ggttcccgta gaggaattcg gcctccctga gcaaggtttg gaatgaatgg tttctgatag
     3781 acacagggag gccagtttgg attgagagct tatttcttca catactctgt ggcggtgttg
     3841 gaacccctgg cttccggttt tggtttccct gtaattctgt cttctcttct ctgtttccat
     3901 tcccccctcc ccttttataa tgcatatatg atgctgtgaa cagaaataaa ctatttctac
     3961 aatcaaa
//
