LOCUS       NM_007487               3657 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 4A (Arl4a), transcript
            variant 1, mRNA.
ACCESSION   NM_007487
VERSION     NM_007487.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3657)
  AUTHORS   Lin,S.J., Lin,M.C., Liu,T.J., Tsai,Y.T., Tsai,M.T. and Lee,F.S.
  TITLE     Endosomal Arl4A attenuates EGFR degradation by binding to the
            ESCRT-II component VPS36
  JOURNAL   Nat Commun 14 (1), 7859 (2023)
   PUBMED   38030597
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3657)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3657)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 3657)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   6  (bases 1 to 3657)
  AUTHORS   Schurmann,A., Koling,S., Jacobs,S., Saftig,P., Krauss,S.,
            Wennemuth,G., Kluge,R. and Joost,H.G.
  TITLE     Reduced sperm count and normal fertility in male mice with targeted
            disruption of the ADP-ribosylation factor-like 4 (Arl4) gene
  JOURNAL   Mol Cell Biol 22 (8), 2761-2768 (2002)
   PUBMED   11909968
  REMARK    GeneRIF: Reduced sperm count and normal fertility in male mice with
            targeted disruption of the ADP-ribosylation factor-like 4 (Arl4)
            gene.
REFERENCE   7  (bases 1 to 3657)
  AUTHORS   Lin,C.Y., Huang,P.H., Liao,W.L., Cheng,H.J., Huang,C.F., Kuo,J.C.,
            Patton,W.A., Massenburg,D., Moss,J. and Lee,F.J.
  TITLE     ARL4, an ARF-like protein that is developmentally regulated and
            localized to nuclei and nucleoli
  JOURNAL   J Biol Chem 275 (48), 37815-37823 (2000)
   PUBMED   10980193
REFERENCE   8  (bases 1 to 3657)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   9  (bases 1 to 3657)
  AUTHORS   Jacobs,S., Schurmann,A., Becker,W., Bockers,T.M., Copeland,N.G.,
            Jenkins,N.A. and Joost,H.G.
  TITLE     The mouse ADP-ribosylation factor-like 4 gene: two separate
            promoters direct specific transcription in tissues and testicular
            germ cell
  JOURNAL   Biochem J 335 (Pt 2) (Pt 2), 259-265 (1998)
   PUBMED   9761722
REFERENCE   10 (bases 1 to 3657)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048606.1 and AC131921.9.
            
            On Feb 15, 2006 this sequence version replaced NM_007487.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY071979.1, AK048606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1668              AK048606.1         2-1669
            1669-3657           AC131921.9         26485-28473
FEATURES             Location/Qualifiers
     source          1..3657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     gene            1..3657
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /note="ADP-ribosylation factor-like 4A"
                     /db_xref="GeneID:11861"
                     /db_xref="MGI:MGI:99437"
     exon            1..114
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /inference="alignment:Splign:2.1.0"
     exon            115..3657
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..804
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /note="ADP-ribosylation factor-like 4;
                     ADP-ribosylation-like 4"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 4A"
                     /protein_id="NP_031513.1"
                     /db_xref="CCDS:CCDS25890.1"
                     /db_xref="GeneID:11861"
                     /db_xref="MGI:MGI:99437"
                     /translation="MGNGLSDQTSILSSLPSFQSFHIVILGLDCAGKTTVLYRLQFNE
                     FVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDS
                     VDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSST
                     PWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /note="major polyA site"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="Arl4a"
                     /gene_synonym="Arl4"
ORIGIN      
        1 agagcggcgc ggaggtctcg gttgagagga gctgtggcgt gttcctcgcg gggagagaga
       61 gagagacaca tcagccaatg tccctccatt ggaatcccga ctccagcccg ggagcaatcg
      121 cgtagcccga tcacccagga agagaaattg taagcagata agaagaacgc gttcagtttg
      181 agacaccatt tgcagctgga aatggggaat ggactgtcag accagacttc catcctgtcc
      241 agcctgccgt cctttcagtc ctttcacatt gttattctgg gtttggactg tgctggaaag
      301 acaacagttt tatacaggct gcagttcaac gaatttgtaa ataccgtacc taccaaagga
      361 tttaacactg agaaaattaa ggtaaccttg ggcaattcca aaacagtcac ttttcacttc
      421 tgggatgtag gtggtcaaga gaagttaaga ccactgtgga agtcatacac ccgatgcaca
      481 gatggtattg tgtttgtggt ggactctgtc gatgttgaga gaatggaaga agccaaaact
      541 gaacttcata aaataactag gatatccgaa aatcagggag tccctgtgct tatagttgct
      601 aataaacaag acctgaggaa ctcgctctct ctctcagaga ttgagaagtt gttagcaatg
      661 ggggaactga gctcatcgac tccttggcat ttgcagccca cctgtgcaat cataggagat
      721 gggctaaagg aaggactcga gaaactacat gatatgataa ttaaaaggag aaaaatgttg
      781 cggcaacaga aaaagaagag atgaatggca gtacctttta tattggtgtg gaataggttt
      841 tcctgggtct gatttctgac aagctgaaga gtgtctacag cctggtttgc ctgtctgccc
      901 tcatggatgc tattaaagct ttgttttgtt gaacagtcag atacccaact ctgttgcctt
      961 gtggaagatg agtcaatgca atgcttctta aagtggtctc ttctccctga cccacaaatc
     1021 ttttggtact accattttgg gaagtcaaaa aaggctagta attgaccaga aaacaatttt
     1081 gtggaaattt gacctgaagt tagtgaaata aaactttgaa gagtgtatgc cctagtgttt
     1141 tgtgcttgta tcttttgggg ggaagccttt gccaagaaat tgcaaacgag gctttgtaaa
     1201 cacaaaatgc taatgaatgg aaatgttaag ggagatcagt gtgtacacat gcacacacag
     1261 ctaagttgaa cacgctgcga taagaaggaa gtattttttc tggaggtttt gacaaggtgg
     1321 tttttaacgt tattctggaa acaatttaat gctatctctt taattctaga aaatgtttaa
     1381 tttagttggt ctagcattaa ttaaaatatt tggggtatat tcaagtgcat gggttagttt
     1441 tcctgacaag catgttttgg tgtatagttt ttagaaatag ctatgcatct gtctacacag
     1501 gtttaaaaca acattttggg gtcttggagc tattgtagaa atagttcatt gtcagaagcg
     1561 cactattact tgaacctaaa aaatgactga tgtaaatatg agtatgttga ctaaatacat
     1621 atgcttgaat acatgaatgg atttatagag aaagtggtgg tgaattcagt tagagggaat
     1681 tactgtaata catagtctct aaatgatcta gttaaaagat acttgttttg ttactattta
     1741 ccggatggaa acggattttt ttcatatatt tttgtagcat tttgggagaa atgaaagctt
     1801 tataattact tgatacaccg tggaatgaaa atgtaaggta cctttcagta tgtgctctga
     1861 gctttaattt tttttgttaa ttggctgaac agtatttcca gagcttccta gctctggttg
     1921 taggaagaaa tggtacagta gtgcagatag caattaggag cctagaaaat gaacgggaga
     1981 agtagcaaag ccattttaag acaattaact ggtgctgttt cttctgtaat aaaaacaaaa
     2041 tgaaattaca aggaggggag agctttcatt tttctctcca ggaagactta tttccagaaa
     2101 tcacatacag caaatcagca tgtttcctat gtttgaagcc aacagctgtt tgtactgaaa
     2161 tcaccaaagg aagtgcactt tgctaacagg actcggtttg atttttgagc ttttactttt
     2221 ttttttcttt tcagtgacac aggtgaattt ttggaacttt gattcttgtt acaaaatgac
     2281 gtagcaccca gtggagcgtc catgtcaaat gtgcctgtgt taggagtaga gctgtggaga
     2341 atagttacca ataaacagct ggaggcatta ggataacaat ctcacttgga gtttatatgt
     2401 atttccactt ctgtagcttt taattagatg tgtaagaaga acgtttatca gctggaatgt
     2461 ttagttttat actagtgtgg attttctctg gtgaggtttc cacagaaggc tagtttctgg
     2521 gggttcaccc cacccccacc ccacccttta ctgagttcag tattctcccc caaatcccta
     2581 gtcttgatgg gatcataaag ctggttttcc tcaattctaa atcagtgtaa attttcactc
     2641 tgcttttaac tgggaggcag atctctgagt tcaaggacag ccagggatac ataaagagac
     2701 cctgtctcaa acaaaacaaa acaaaacaaa agtttgtgtt cactagctct tgacccttgt
     2761 tctgtacctt agaattggac catcaagtcc atgttgttct tatttataga acagcaaaat
     2821 ggccattgca taaattgtat ttatgtgagc cacttcaatt aaaaatttaa gttcaaaatg
     2881 tatatcacct attaaagcta ttaatcacat aagctaatga atctatgtag gtttttaatt
     2941 ttaagttaaa aagtatcctt tttcaaagta tatttgtctt tttaaagtgt cagggatcaa
     3001 actctgggcc tcctgtatgt gaagcagtca tcaatgaact acatctccca acacctaaag
     3061 tgtatttcta aaatagttaa ctgtattgga aatgagttgg tttatacaaa gtattaattg
     3121 ggttaaacat tctaatttaa aattactact agcaagcaaa gttttaaaat atcctttgat
     3181 acttaaagag tcatatatcc aaacttatgc taaaatagat tataaatgtt atggtttagc
     3241 ctagataaat tcattaataa tcataaaatc cttacaggaa gctaaaaact gcagtgttag
     3301 gatatgtaga tggaagtcaa tgactactag tctgtaggta actggatgat agcttaagaa
     3361 tgagagtaaa gggcacataa ttagaatgtt ttggtacgag ttgggattat gggtacaatg
     3421 ggtgcttgcc tatcaggtac agggctctgg gtttgagtgc tagcactgca aaggaaaaat
     3481 aaatcactta ccagaatggc ttgtttagaa gagtttaatt gtttatagtg gccatgagag
     3541 aaatctggta tagtgtatca gtgttctatt taatgtaatg gttttatcat ataaacgatg
     3601 attttagcgg taacaaaaca caaaatgttt cttcaaaata aattaatgca acttgga
//
