LOCUS       NM_024191               2095 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 2 binding protein
            (Arl2bp), transcript variant 1, mRNA.
ACCESSION   NM_024191
VERSION     NM_024191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Moye,A.R., Bedoni,N., Cunningham,J.G., Sanzhaeva,U., Tucker,E.S.,
            Mathers,P., Peter,V.G., Quinodoz,M., Paris,L.P.,
            Coutinho-Santos,L., Camacho,P., Purcell,M.G., Winkelmann,A.C.,
            Foster,J.A., Pugacheva,E.N., Rivolta,C. and Ramamurthy,V.
  TITLE     Mutations in ARL2BP, a protein required for ciliary microtubule
            structure, cause syndromic male infertility in humans and mice
  JOURNAL   PLoS Genet 15 (8), e1008315 (2019)
   PUBMED   31425546
  REMARK    GeneRIF: Study identified multiple ciliopathy phenotypes associated
            with mutations in ARL2BP in human patients and in a mouse knockout
            model. Spermiogenesis is impaired, resulting in abnormally shaped
            heads, shortened and mis-assembled sperm tails, and loss of
            axonemal doublets. ARL2BP is required for the structural
            maintenance of cilia as well as of the sperm flagellum, and that
            its deficiency leads to syndromic ciliopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Moye,A.R., Singh,R., Kimler,V.A., Dilan,T.L., Munezero,D.,
            Saravanan,T., Goldberg,A.F.X. and Ramamurthy,V.
  TITLE     ARL2BP, a protein linked to retinitis pigmentosa, is needed for
            normal photoreceptor cilia doublets and outer segment structure
  JOURNAL   Mol Biol Cell 29 (13), 1590-1598 (2018)
   PUBMED   29718757
  REMARK    GeneRIF: ARL2BP is necessary for photoreceptor ciliary doublet
            formation and axoneme elongation.
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Davidson,A.E., Schwarz,N., Zelinger,L., Stern-Schneider,G.,
            Shoemark,A., Spitzbarth,B., Gross,M., Laxer,U., Sosna,J.,
            Sergouniotis,P.I., Waseem,N.H., Wilson,R., Kahn,R.A., Plagnol,V.,
            Wolfrum,U., Banin,E., Hardcastle,A.J., Cheetham,M.E., Sharon,D. and
            Webster,A.R.
  TITLE     Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2
            binding protein, cause autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 93 (2), 321-329 (2013)
   PUBMED   23849777
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Muromoto,R., Sekine,Y., Imoto,S., Ikeda,O., Okayama,T., Sato,N. and
            Matsuda,T.
  TITLE     BART is essential for nuclear retention of STAT3
  JOURNAL   Int Immunol 20 (3), 395-403 (2008)
   PUBMED   18234692
  REMARK    GeneRIF: BART is essential for the transcriptional activity and
            nuclear retention of STAT3
REFERENCE   8  (bases 1 to 2095)
  AUTHORS   Sharer,J.D., Shern,J.F., Van Valkenburgh,H., Wallace,D.C. and
            Kahn,R.A.
  TITLE     ARL2 and BART enter mitochondria and bind the adenine nucleotide
            transporter
  JOURNAL   Mol Biol Cell 13 (1), 71-83 (2002)
   PUBMED   11809823
REFERENCE   9  (bases 1 to 2095)
  AUTHORS   Sharer,J.D. and Kahn,R.A.
  TITLE     The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning,
            and initial characterization
  JOURNAL   J Biol Chem 274 (39), 27553-27561 (1999)
   PUBMED   10488091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159929.1, AK018229.1 and AC123826.4.
            
            On Oct 26, 2013 this sequence version replaced NM_024191.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150513.1, BC024708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               BY159929.1         2-277
            277-1429            AK018229.1         87-1239
            1430-2095           AC123826.4         60949-61614
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.65 cM"
     gene            1..2095
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /note="ADP-ribosylation factor-like 2 binding protein"
                     /db_xref="GeneID:107566"
                     /db_xref="MGI:MGI:1349429"
     exon            1..302
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..364
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..471
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..557
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..654
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..2095
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /note="hexamer: AGTAAA"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /note="hexamer: AATAAT"
     polyA_site      2063
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /note="major polyA site"
     polyA_site      2094
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
ORIGIN      
        1 atagtgacag gaggcggggc tgcgagctcc gtctgcccta acacaccggc ggggtagccc
       61 cgcgagaggc cggcgggcgc tgggcccagc caggagccgc agccccgtcc tcgcgcgatc
      121 gccgggcggg gcgtgggtgc ggccttctgc gggcccttga tgcagttgag gccgcgcggg
      181 tcagagagga tcccggcccg gcggcgggcg cggtaggaag cggcagggcc ccgggcccgg
      241 gccggtgact gcggcgcccc tacgatggac gccctagaag aagagagctt cgcgctgtcc
      301 ttctcctccg cctctgatgc agaatttgat gctgtggttg gatgtttaga ggacattatt
      361 atggatgatg agttccagtt attgcagaga aacttcatgg acaagtacta ccaggaattt
      421 gaagacacag aagagaataa actcacctat acacccattt ttaatgaata tatctccctg
      481 gtagagaagt acattgaaga gcagttgctg gagcgtatcc caggcttcaa catggcggcc
      541 ttcacaacca cgctgcagca ccacaaagat gaggtggctg gcgacatctt tgacatgctg
      601 ctcacattca cggattttct ggctttcaag gagatgttcc tggactacag agcagaaaag
      661 gaaggccgag gactggactt aagcagcggc ttggttgtga cttctctgtg taagtcatct
      721 tctacgccag cttcccagaa caacctgcgg cactaggtcc caccttcgca caaccggtgt
      781 gattgacatg agttcaccag accagcaggc tccgagaaac atgggctaat gatgacaggt
      841 gtatcctgca aagaccctct gtgccacagc cctttgttca tgtgaagtat tgataagtcc
      901 tggaaaacac gactgacctt gctggccctt gtccagaaac tccttcccct agtccgctac
      961 cctcatgttc cctgctccag gtgcttctga gtggctcctc aggcacaggc ccgggttggc
     1021 cacctcacct gggggctgtc ctccagcaac atggtagtgt agtgtgtcaa cagtgtggag
     1081 accacactgt tgtgagccct tcatcctgca ggctttagtg agtctatgtt ctcccagttt
     1141 tcacctgggt ccccttcagg cctcagcctc aatggggctt ttgtttgggc atgttgatct
     1201 agggagttac agaccagctg tctgtcctgg tttctgaatc tcctgcgatt acagcttgat
     1261 tggctgtggg gatccaccga gagagctgcc ctctacccac aagtgaagaa gaactcccga
     1321 ccttacatta gcaatccttt taccagtgag tgagtcctgc tggtcttgat gtagccctac
     1381 tgttctctat gactctaagc attattttta agaaacttat ttttatagat gaaaactcag
     1441 gctaacctag tgagtatgat cttggaatgc ccatgatcaa ccacttaaag atcaaagtat
     1501 tatatgctgt gtgcttcgta gctgtgagtg ttgcgagtgc gaatgtgctt tccgacgggt
     1561 tctccttgct gggcaccaga acaaagaggc tgtgtgctag aagtggaccg cggctctgtc
     1621 aggacagcat gcgaggtgtg cttgtgcatg cttgtgtgca gtccttcgtg taggccagtg
     1681 agctgggggg gttattgggg gtagggactc tgctgtttgt tttcatacaa tctctcctgc
     1741 taagttgatg ctcccctgat ccagctcagc ctgggggtgg gggtgggggc aggacacaga
     1801 tttctggtcc tctgtcatct ttggtggact gccaccaaac agaaagcatg tgtatcacat
     1861 ctctagaaag aagacgaaaa cagttcaaac cctaatgcgt acttttgact ttaactttta
     1921 tagtaaacag actccgtgct gactttccat gtgaccatta gactttaagg gatataagct
     1981 aagctccgtg tttttttctg tagctgtgtg tcatttagta cttttgtaaa atgagtaaaa
     2041 tttgaggtgt ttggcaagaa taatcacttg atgtgcattg tccattttaa tgtat
//
