LOCUS       NP_077153                163 aa            linear   ROD 30-APR-2024
DEFINITION  ADP-ribosylation factor-like protein 2-binding protein isoform 1
            [Mus musculus].
ACCESSION   NP_077153
VERSION     NP_077153.1
DBSOURCE    REFSEQ: accession NM_024191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 163)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 163)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 163)
  AUTHORS   Moye,A.R., Bedoni,N., Cunningham,J.G., Sanzhaeva,U., Tucker,E.S.,
            Mathers,P., Peter,V.G., Quinodoz,M., Paris,L.P.,
            Coutinho-Santos,L., Camacho,P., Purcell,M.G., Winkelmann,A.C.,
            Foster,J.A., Pugacheva,E.N., Rivolta,C. and Ramamurthy,V.
  TITLE     Mutations in ARL2BP, a protein required for ciliary microtubule
            structure, cause syndromic male infertility in humans and mice
  JOURNAL   PLoS Genet 15 (8), e1008315 (2019)
   PUBMED   31425546
  REMARK    GeneRIF: Study identified multiple ciliopathy phenotypes associated
            with mutations in ARL2BP in human patients and in a mouse knockout
            model. Spermiogenesis is impaired, resulting in abnormally shaped
            heads, shortened and mis-assembled sperm tails, and loss of
            axonemal doublets. ARL2BP is required for the structural
            maintenance of cilia as well as of the sperm flagellum, and that
            its deficiency leads to syndromic ciliopathy.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 163)
  AUTHORS   Moye,A.R., Singh,R., Kimler,V.A., Dilan,T.L., Munezero,D.,
            Saravanan,T., Goldberg,A.F.X. and Ramamurthy,V.
  TITLE     ARL2BP, a protein linked to retinitis pigmentosa, is needed for
            normal photoreceptor cilia doublets and outer segment structure
  JOURNAL   Mol Biol Cell 29 (13), 1590-1598 (2018)
   PUBMED   29718757
  REMARK    GeneRIF: ARL2BP is necessary for photoreceptor ciliary doublet
            formation and axoneme elongation.
REFERENCE   5  (residues 1 to 163)
  AUTHORS   Davidson,A.E., Schwarz,N., Zelinger,L., Stern-Schneider,G.,
            Shoemark,A., Spitzbarth,B., Gross,M., Laxer,U., Sosna,J.,
            Sergouniotis,P.I., Waseem,N.H., Wilson,R., Kahn,R.A., Plagnol,V.,
            Wolfrum,U., Banin,E., Hardcastle,A.J., Cheetham,M.E., Sharon,D. and
            Webster,A.R.
  TITLE     Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2
            binding protein, cause autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 93 (2), 321-329 (2013)
   PUBMED   23849777
REFERENCE   6  (residues 1 to 163)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (residues 1 to 163)
  AUTHORS   Muromoto,R., Sekine,Y., Imoto,S., Ikeda,O., Okayama,T., Sato,N. and
            Matsuda,T.
  TITLE     BART is essential for nuclear retention of STAT3
  JOURNAL   Int Immunol 20 (3), 395-403 (2008)
   PUBMED   18234692
  REMARK    GeneRIF: BART is essential for the transcriptional activity and
            nuclear retention of STAT3
REFERENCE   8  (residues 1 to 163)
  AUTHORS   Sharer,J.D., Shern,J.F., Van Valkenburgh,H., Wallace,D.C. and
            Kahn,R.A.
  TITLE     ARL2 and BART enter mitochondria and bind the adenine nucleotide
            transporter
  JOURNAL   Mol Biol Cell 13 (1), 71-83 (2002)
   PUBMED   11809823
REFERENCE   9  (residues 1 to 163)
  AUTHORS   Sharer,J.D. and Kahn,R.A.
  TITLE     The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning,
            and initial characterization
  JOURNAL   J Biol Chem 274 (39), 27553-27561 (1999)
   PUBMED   10488091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159929.1, AK018229.1 and AC123826.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150513.1, BC024708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..163
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.65 cM"
     Protein         1..163
                     /product="ADP-ribosylation factor-like protein 2-binding
                     protein isoform 1"
                     /note="ADP-ribosylation-like 2 binding protein;
                     ADP-ribosylation factor-like protein 2-binding protein;
                     binder of ARF2 protein 1; ARF-like 2-binding protein"
                     /calculated_mol_wt=18623
     Region          20..134
                     /region_name="ARL2_Bind_BART"
                     /note="The ARF-like 2 binding protein BART; pfam11527"
                     /db_xref="CDD:463288"
     CDS             1..163
                     /gene="Arl2bp"
                     /gene_synonym="1700010P10Rik; 1700027H16Rik;
                     6330544B05Rik; BART; Bart1"
                     /coded_by="NM_024191.2:265..756"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22545.1"
                     /db_xref="GeneID:107566"
                     /db_xref="MGI:MGI:1349429"
ORIGIN      
        1 mdaleeesfa lsfssasdae fdavvgcled iimddefqll qrnfmdkyyq efedteenkl
       61 tytpifneyi slvekyieeq lleripgfnm aaftttlqhh kdevagdifd mlltftdfla
      121 fkemfldyra ekegrgldls sglvvtslck ssstpasqnn lrh
//
