LOCUS       NM_172595               3324 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus ADP-ribosylation factor-like 15 (Arl15), mRNA.
ACCESSION   NM_172595
VERSION     NM_172595.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Bai,Y., Bentley,L., Ma,C., Naveenan,N., Cleak,J., Wu,Y.,
            Simon,M.M., Westerberg,H., Canas,R.C., Horner,N., Pandey,R.,
            Paphiti,K., Schulze,U., Mianne,J., Hough,T., Teboul,L., de
            Baaij,J.H.F. and Cox,R.D.
  TITLE     Cleft palate and minor metabolic disturbances in a mouse global
            Arl15 gene knockout
  JOURNAL   FASEB J 37 (11), e23211 (2023)
   PUBMED   37773757
  REMARK    GeneRIF: Cleft palate and minor metabolic disturbances in a mouse
            global Arl15 gene knockout.
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Gupta,N., Soriano-Ubeda,C., Stein,P., Savy,V., Papas,B.N.,
            Ardestani,G., Carvacho,I., Alfandari,D., Williams,C.J. and
            Fissore,R.A.
  TITLE     Essential role of Mg2+ in mouse preimplantation embryo development
            revealed by TRPM7 chanzyme-deficient gametes
  JOURNAL   Cell Rep 42 (10), 113232 (2023)
   PUBMED   37824328
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Rocha,N., Payne,F., Huang-Doran,I., Sleigh,A., Fawcett,K.,
            Adams,C., Stears,A., Saudek,V., O'Rahilly,S., Barroso,I. and
            Semple,R.K.
  TITLE     The metabolic syndrome- associated small G protein ARL15 plays a
            role in adipocyte differentiation and adiponectin secretion
  JOURNAL   Sci Rep 7 (1), 17593 (2017)
   PUBMED   29242557
  REMARK    GeneRIF: ARL15 plays a role in adipocyte differentiation and
            adiponectin secretion
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Zhao,J., Wang,M., Deng,W., Zhong,D., Jiang,Y., Liao,Y., Chen,B. and
            Zhang,X.
  TITLE     ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT
            phosphorylation in the IR/IRS1/AKT pathway by interacting with
            ASAP2 and regulating PDPK1 activity
  JOURNAL   Biochem Biophys Res Commun 486 (4), 865-871 (2017)
   PUBMED   28322786
  REMARK    GeneRIF: In conclusion, we have identified that ARL15 acts as an
            insulin-sensitizing effector molecule to upregulate the
            phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT
            insulin pathway by interacting with its GAP ASAP2 and activating
            PDPK1. This research may provide new insights into GTPase-mediated
            insulin signalling regulation and facilitate the development of new
            pharmacotherapeutic targets for insulin sensitizati
REFERENCE   6  (bases 1 to 3324)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   7  (bases 1 to 3324)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3324)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3324)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3324)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126939.5 and AC154862.2.
            
            On Jan 12, 2022 this sequence version replaced NM_172595.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052164.1, AK039965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC126939.5         60297-60452
            157-301             AC126939.5         188003-188147
            302-361             AC126939.5         199820-199879
            362-570             AC126939.5         233338-233546
            571-3324            AC154862.2         77998-80751
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.02 cM"
     gene            1..3324
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /note="ADP-ribosylation factor-like 15"
                     /db_xref="GeneID:218639"
                     /db_xref="MGI:MGI:2442308"
     exon            1..156
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..723
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /note="ADP-ribosylation factor related protein 2;
                     ARF-related protein 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 15"
                     /protein_id="NP_766183.1"
                     /db_xref="CCDS:CCDS36785.1"
                     /db_xref="GeneID:218639"
                     /db_xref="MGI:MGI:2442308"
                     /translation="MSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSG
                     KTSLLSELCSESPENVVSTTGFSIKAVPFQNAVLNVKELGGADNIRKYWSRYYQGSQG
                     VIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFE
                     LEPLARGKRWILQPCSLDDVDTLKDSFSQLINLLEEKDHEAVRM"
     exon            157..301
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..361
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..570
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            571..3324
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3301..3306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /note="hexamer: AATGAA"
     regulatory      3307..3312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
     polyA_site      3324
                     /gene="Arl15"
                     /gene_synonym="A430036I03; Arfrp2; C230032K13Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttcgctgtt gctggctttt tcaggagctg ctcgctggca gcccgagacg ctgctgcttt
       61 tttttttttt ccgggttcgg agccattccg gatgctttag gctgccggat gtctgatctc
      121 cggataactg aggcgtttct gtacatggat tatctgtgtt ttcgagcgct ttgctgcaag
      181 ggaccaccac ctgcgcgccc tgaatatgac ttggtttgca taggtctcac gggctccggg
      241 aaaaccagcc tgctgtccga gctctgcagc gaaagcccgg agaacgttgt gtcgaccaca
      301 ggttttagta taaaggcagt gccattccag aatgccgttt tgaatgtaaa agaacttgga
      361 ggagctgaca atatccggaa atactggagc cgctactacc aaggatctca aggggtcata
      421 ttcgtattag acagtgcctc ttcagaggat gacttagaaa ctgctaggaa cgaactgcac
      481 tccgctctcc agcacccaca gctatgcact ttaccctttt tgatattggc caatcatcaa
      541 gacaagccag cagctcgctc agtacaagag atcaaaaagt attttgaact tgaaccactg
      601 gcccgtggaa agcgctggat cctgcagccc tgctctctgg atgatgtgga cacactgaag
      661 gacagcttct cccagctcat aaacttgtta gaagaaaaag accacgaggc agtgagaatg
      721 tgagacctga cacagaagtt ccgggaaagc ctcgaacccg ccgtgttcgt tccccatcgt
      781 gattccatgt tggtatcgag actggcccgg cttcggtatc tacttgcctc tagctatttc
      841 agactttcat ctctctgcta acgtgactat tctgataagt caggtggatt atcatcggca
      901 ttaacgtcaa gtacacacta ctgagagaga actgattctc tggttaccac taattatctt
      961 caccgcatgt ctcttcctcc tgttggtcta agaatctctt ctctgctttg tgctaaagtg
     1021 gatggaactc acagaaacga gacccgttct gaagacctca gaaaggctca tgtggtttca
     1081 ctaacttctc tggacttggg atcagaagat tctgtctgag actccacacg atggatacgc
     1141 cattgatatt tccgtgatct cttaggggtt ggaggttttt ttttttttac attttatttt
     1201 atctcatctg gttttcatat tgttttcttg tgtgtgtgag gatattgact ttgtaggctg
     1261 agtgaaaatg gcggcccaaa acttcaccca gtcatcttct ctggctctga aaaactctag
     1321 aaagtagaca tggaagaatt gaaaaactct agaaagtaga catggaagaa ttgaaaaact
     1381 ctagaaagta gacatggaag aattgcttgg tcctgcctgc ggccgtgtcc cctgccttag
     1441 gaggagggca tcctagctaa gggagtggga accagtttag gcaagaacag gcaccactga
     1501 tttgaatctg aactcctcaa atatttttaa cgtcattagt ctgcataaaa ccgagctgca
     1561 acatacgcat cggcctttcc tagaaatcag aaatgtttga atgaaatctg gaaaatggct
     1621 tttcaaataa ttaacataac agccaaagtc taattcacgg ttaggactta agctggcatg
     1681 ggtttgatga agctcaaaga ggaaccccgt tatttattca tcaaaggcta atgtcactta
     1741 ggggagtgtg ctcattgagt tgttaaaggt ctgtcagtac ttttattata aacctctatt
     1801 ttcaggggtg tcaatgtgcc cttagagtat gctgggctac agcagataaa taaactcagt
     1861 ctgaaactaa tttttttcca cttaatttaa atgatacaat tgcctagagt aaaatgtaca
     1921 gttttagtaa gatttagcac ctttgacctt tttgaaatca ggactaatct atgaatattc
     1981 aggttcatag atgaaatatt ctttggcata tcttgtagac acttgaccac tcattaaaat
     2041 actaagtggc caaatgatag aaaactgctc cctaagccca agcaataaaa aaaccatgtc
     2101 tgtcattttt aggtagtgta gactgatacc ccgatgccac agacttaggg ccatatttat
     2161 cacagggtga caggaaacct tgtgactctc cagaggagag tcctcagaac cctgcacagt
     2221 gctcaaatgc agtatttgtg atttcatctt gtaaatggat tttaataaaa aagaccccac
     2281 acttctttaa gcttatatat atatacatat atatgtatgt atatatgtat atatatatat
     2341 atatatatgg catggcccag agaaggaccc atgataattc attttgtcta aagtatcctt
     2401 gaatattttt aaaactgtga cgatccacag gcagcacaaa cctttaatcc acatgagcag
     2461 ttaaacgatt cctgttttta ttttgtccct cccgtgctca tcttccatga aaataaataa
     2521 atgaatgatt ttttttttcc gggctttgct ctccctgcaa gttcattaaa tgcagaatgt
     2581 tgtcttttga ggatcttgtg gccgaacgct ccttgccatc tgttaaatga cttcccgttg
     2641 tctgtgtgtg ttcatgtgcg ccagtgatgg gcttctccac agcccccgag actgtctgag
     2701 gcgtcgcagc cgtcagaatg aaaacattat caatcagtac ccaacaacag ctgtttttga
     2761 caagtttctg tctgacgcct gatgctttac aactgtcaat aaggctcttt ctttgtctag
     2821 caggtcgcag ctcgctgtct tactgcttct tcttggcatc ctggactctg taaccctaga
     2881 atttactgtg tttgggaaac ccaggtgggg gaggggaggg gggaaagggg aggggacatt
     2941 cgtcttgttc ttacttttgt gtgaggtgcc acaggtgtct tggtttgcat attcaaagat
     3001 ataggaaaac agtctgttgt gtatttcctc agtgagcatc ttgttatatt tatggaagtg
     3061 acccattttt gtaccttctt agctaaagcg gttgcctctt tttatactgg caattaattt
     3121 atataagact ttgtatctac catagtttac agtattggtt gctggataac tgccatatcg
     3181 ccctgtcttt ctatggagat ttactctatc cagacttaaa agttgacagg ctcacatggg
     3241 catttgctag gcaacaagaa cttgccctat tcacaattta tatgatttcc actgtcttgc
     3301 aatgaaaata aatgctgagt agaa
//
