LOCUS       NM_026577               3540 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus ADP-ribosylation factor-like 13B (Arl13b), mRNA.
ACCESSION   NM_026577
VERSION     NM_026577.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3540)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3540)
  AUTHORS   Inskeep,K.A., Crase,B., Dayarathna,T. and Stottmann,R.W.
  TITLE     SMPD4-mediated sphingolipid metabolism regulates brain and primary
            cilia development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470011
REFERENCE   3  (bases 1 to 3540)
  AUTHORS   Augiere,C., Campolina-Silva,G., Vijayakumaran,A., Medagedara,O.,
            Lavoie-Ouellet,C., Joly Beauparlant,C., Droit,A., Barrachina,F.,
            Ottino,K., Battistone,M.A., Narayan,K., Hess,R., Mennella,V. and
            Belleannee,C.
  TITLE     ARL13B controls male reproductive tract physiology through primary
            and Motile Cilia
  JOURNAL   Commun Biol 7 (1), 1318 (2024)
   PUBMED   39397107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3540)
  AUTHORS   Kim,S.E., Kim,H.Y., Wlodarczyk,B.J. and Finnell,R.H.
  TITLE     Linkage between Fuz and Gpr161 genes regulates sonic hedgehog
            signaling during mouse neural tube development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39369306
REFERENCE   5  (bases 1 to 3540)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3540)
  AUTHORS   Zeng,H., Hoover,A.N. and Liu,A.
  TITLE     PCP effector gene Inturned is an important regulator of cilia
            formation and embryonic development in mammals
  JOURNAL   Dev Biol 339 (2), 418-428 (2010)
   PUBMED   20067783
REFERENCE   7  (bases 1 to 3540)
  AUTHORS   Weatherbee,S.D., Niswander,L.A. and Anderson,K.V.
  TITLE     A mouse model for Meckel syndrome reveals Mks1 is required for
            ciliogenesis and Hedgehog signaling
  JOURNAL   Hum Mol Genet 18 (23), 4565-4575 (2009)
   PUBMED   19776033
REFERENCE   8  (bases 1 to 3540)
  AUTHORS   Heydeck,W., Zeng,H. and Liu,A.
  TITLE     Planar cell polarity effector gene Fuzzy regulates cilia formation
            and Hedgehog signal transduction in mouse
  JOURNAL   Dev Dyn 238 (12), 3035-3042 (2009)
   PUBMED   19877275
REFERENCE   9  (bases 1 to 3540)
  AUTHORS   Zhang,H., Ables,E.T., Pope,C.F., Washington,M.K., Hipkens,S.,
            Means,A.L., Path,G., Seufert,J., Costa,R.H., Leiter,A.B.,
            Magnuson,M.A. and Gannon,M.
  TITLE     Multiple, temporal-specific roles for HNF6 in pancreatic endocrine
            and ductal differentiation
  JOURNAL   Mech Dev 126 (11-12), 958-973 (2009)
   PUBMED   19766716
REFERENCE   10 (bases 1 to 3540)
  AUTHORS   Caspary,T., Larkins,C.E. and Anderson,K.V.
  TITLE     The graded response to Sonic Hedgehog depends on cilia architecture
  JOURNAL   Dev Cell 12 (5), 767-778 (2007)
   PUBMED   17488627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK021270.1, AK016794.1, CF741686.1 and AC154309.1.
            
            On Sep 13, 2016 this sequence version replaced NM_026577.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1274736.1,
                                           SRR7974084.12527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK021270.1         2-61
            61-1105             AK016794.1         7-1051
            1106-1628           CF741686.1         93-615
            1629-3540           AC154309.1         124005-125916       c
FEATURES             Location/Qualifiers
     source          1..3540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 36.43 cM"
     gene            1..3540
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /note="ADP-ribosylation factor-like 13B"
                     /db_xref="GeneID:68146"
                     /db_xref="MGI:MGI:1915396"
     exon            1..356
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1581
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /note="ADP-ribosylation factor-like 2-like 1; ARL2-like
                     protein 1; protein hennin"
                     /codon_start=1
                     /product="ADP-ribosylation factor-like protein 13B"
                     /protein_id="NP_080853.3"
                     /db_xref="CCDS:CCDS28261.1"
                     /db_xref="GeneID:68146"
                     /db_xref="MGI:MGI:1915396"
                     /translation="MFSLMANCCNLFKRWREPVRKVTLVMVGLDNAGKTATAKGIQGE
                     HPEDVAPTVGFSKIDLRQGKFQVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDEE
                     RMEETKETMSEVLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLC
                     QIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKRE
                     RAERVRKLREEREREQTELDGTSGLAEIDSGPVLANPFQPIAAVIIENEKKQEKEKKK
                     QTVEKDSDVGLLEHKVEPEQAAPQSEADCCLQNPDERVVDSYREALSQQLDSEDEQDQ
                     RGSESGENSKKKTKKLRMKRSHRVEPVNTDESTPKSPTPPQPPPPVGWGTPKVTRLPK
                     LEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDTIS"
     exon            357..427
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            428..677
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            678..783
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            784..986
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1092
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1318
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1435
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1504
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..3540
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /note="hexamer: AATAAA"
     polyA_site      2343
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /note="hexamer: AATAAA"
     polyA_site      3528
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /note="major polyA site"
ORIGIN      
        1 gggtcttccg agcttcggga acgtcagcac gtcgacgcgg gggttttctc tggtgtccca
       61 ctgacgccgc tcctgtgttc ctgagccagt gttcgggctg tcccggggcg gctggcggac
      121 tcggttaggg gccggacccc gcgatctgtc cgggtcaccg ccctcccggc ctgccctctt
      181 tccggtccac actagggacg cctgaggccg tggggtccct gagctgggcc ggggagctcg
      241 gggctcatcc cctcctcccg aggctcggat gggaggtggc gggaggagag acctgggatg
      301 ttcagtctga tggccaactg ctgcaacttg ttcaagcggt ggcgggagcc tgtcagaaag
      361 gtgacacttg tgatggtcgg ccttgataat gctggtaaaa cagccacagc aaagggaatc
      421 caaggagagc atcctgaaga cgtagctccc actgttggct tttctaaaat tgatctgaga
      481 caaggaaagt tccaagttac catctttgac ttaggaggtg gaaaaagaat tcggggaatt
      541 tggaagaatt attatgctga atcctatggg gtaatatttg ttgtggattc cagtgatgag
      601 gagagaatgg aagaaacaaa ggagacaatg tccgaagtgc taagacaccc gaggatatca
      661 ggaaagccta tattggtgct ggccaacaag caagacaagg agggggcttt aggcgaagcg
      721 gatgtgattg agtgtctctc gctggagaag ctggtcaacg agcacaagtg cctgtgtcag
      781 atcgaacctt gttcagcagt cttgggatat ggaaagaaaa ttgacaagtc cattaaaaag
      841 gggctttatt ggctactgca tatcattgca aaggactttg atgccttaag tgaacgcatc
      901 cagaaagaca caactgaaca gcgagctctt gaggaacaag agaaacgtga gagggctgaa
      961 cgagtccgga agttaaggga agaaagagaa cgagagcaga cggaacttga tgggaccagt
     1021 ggtctggctg agattgactc aggaccagtt cttgcgaatc ctttccaacc cattgcagct
     1081 gtaatcattg agaatgaaaa gaagcaggaa aaagagaaaa agaagcagac cgtggagaag
     1141 gacagtgatg ttggtctcct agaacataaa gtggagccag agcaagcagc gcctcagagt
     1201 gaggcagatt gctgcctcca aaaccctgac gagcgagtgg tggacagtta cagggaggca
     1261 ctgtcgcagc agctggacag tgaggatgag caggaccagc gagggtcaga gtccggggaa
     1321 aacagtaaga agaaaaccaa gaaactaaga atgaaaagga gtcatcgggt agaaccagtc
     1381 aatacagacg agtctactcc aaagagtccc acgcctcccc aacctccccc tcctgttggc
     1441 tggggaaccc ccaaagtcac tagacttcca aaacttgagc ctcttggtga aacacgtcac
     1501 aatgatttct atgggaagcc gctgcctccc ctggctgtgc gacagagacc taacggtgat
     1561 gctcaggaca cgatctcata accaagtcgg atgggttggt cctttttata tcagcaaggt
     1621 gaactgagac ctttccccaa agcagaaaag ccctgaatgc tgatgatggg caagacaacc
     1681 ataatgattt cagggaagaa agaatatcca agaacttgac ctgataatgt acttctccat
     1741 cttctgtggt taaagcagaa aggaaacaaa atgaccagta gctgaaaaga gcatctggcc
     1801 acgtaagcag tcatggcatc gatgctctgg tttacacatc ccgacttttg gacatactcc
     1861 tgaagaaaaa cctcacaagt tgagccaatg gactctacat acctgattat ttaataatct
     1921 gtatttctat gcattaaaca tgttttataa gatatatgta catgaaaggg gaattcctgg
     1981 gaaattataa tctaaatttt aactattttt atattttttt ctaaaccttt tgtttaagtt
     2041 tgctattgta ttgactacgc tctttctaca gatgctctgt ttaaactgtc tggatagaaa
     2101 gttgatttac tgtacacact tgaagtgtac aagcatgtat gctttgtgat aacattgttt
     2161 ctaaaatgta cactccatct tgatgtaatt ttaaaatagt tactatttta aaaagcaaat
     2221 tctcagatct ttaatctacc aaattacatg atttgagagt ggtacccaag gagagaattc
     2281 agttctgttg ttgctgttca ttttccttgg tgatgatatc aataaatgtt aagatgtgtg
     2341 aaataccttt aagaaaataa ctaaaattgt taaattagaa aaatgtatcc tgtgggataa
     2401 tgattcaaaa tcctcacccc ccccccccca agggactaga ccttctctga gttcagggcc
     2461 ctctctgtgc tctctgtcag cagcttcatt gactgcttgg gttgttttct ttcgtccatg
     2521 ccttgaaatt aaaggtaaaa ggctcctgag ggtctagaga cttcaggttt ccagccagca
     2581 tggctgtaca aataaagatg ttggtgcaag tcctttcata aagcactagt tctaacatga
     2641 cttcttaatt ttagatgaca atattctgct cttgagtgcc attgataagg ttctctgtcc
     2701 aacggccctt taccaaaact tgtagagata ttttagtaat ggatttataa ggtaatattc
     2761 aattggaggc atgcctttaa gtcaaggtga aaataacaaa gatcaagtcc cttctcaccc
     2821 tgttaagatt ggtaccatat actggcaatg aacatacact ggtttctgaa tgtaagtcca
     2881 cctaaggtag attgatctga tcatttgcct tttaaatgtt tataatgtat tgtgttcata
     2941 tttgagctcc ttggacccgg atcagtcagg tcacatgatg ctagttggcc ctggtagtgt
     3001 ttctgtgagt ttgttcattg tacttggcac agtgatgggg aaaaggttta atttctatgc
     3061 aaaacatata tgcaaaatta gcaggtggct cacataagag aaccacaaga caggatgtac
     3121 attctgaact ggattttaga gggaaaagtg ctcatcttct tggttcattt tgtaatattt
     3181 aaattgcctt ttaaaactaa acttatactt ttgctatctt ttaatgctca tctggtttga
     3241 agatattctt gcttcctacc agtgtttact ataaagtaca gtaattactg actctatttc
     3301 atgaaaacag ttttgaaatt gaatgtaaca taaaccggaa tcgatgtttt ctatggcact
     3361 ctcaaaaaat taatgttttc ttaaagctgt atataaaaaa tcctttaaaa actgttttgt
     3421 aaatcctgtc agattttaat atttcagtcc ttattttgtt atacattttc attctattca
     3481 tcatgaatta tataacattt cacacaataa aaaattattt acaatatacc atttatctaa
//
