LOCUS       NM_178670               5188 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus arkadia (RNF111) N-terminal like PKA signaling
            regulator 2N (Ark2n), transcript variant 1, mRNA.
ACCESSION   NM_178670
VERSION     NM_178670.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Ng,Y.K., Blazev,R., McNamara,J.W., Dutt,M., Molendijk,J.,
            Porrello,E.R., Elliott,D.A. and Parker,B.L.
  TITLE     Affinity Purification-Mass Spectrometry and Single Fiber
            Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25
  JOURNAL   J Proteome Res 23 (4), 1285-1297 (2024)
   PUBMED   38480473
  REMARK    GeneRIF: Affinity Purification-Mass Spectrometry and Single Fiber
            Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Blazev,R., Carl,C.S., Ng,Y.K., Molendijk,J., Voldstedlund,C.T.,
            Zhao,Y., Xiao,D., Kueh,A.J., Miotto,P.M., Haynes,V.R., Hardee,J.P.,
            Chung,J.D., McNamara,J.W., Qian,H., Gregorevic,P., Oakhill,J.S.,
            Herold,M.J., Jensen,T.E., Lisowski,L., Lynch,G.S., Dodd,G.T.,
            Watt,M.J., Yang,P., Kiens,B., Richter,E.A. and Parker,B.L.
  TITLE     Phosphoproteomics of three exercise modalities identifies canonical
            signaling and C18ORF25 as an AMPK substrate regulating skeletal
            muscle function
  JOURNAL   Cell Metab 34 (10), 1561-1577 (2022)
   PUBMED   35882232
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Kelly,C.E., Thymiakou,E., Dixon,J.E., Tanaka,S., Godwin,J. and
            Episkopou,V.
  TITLE     Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon
            extension
  JOURNAL   PLoS Biol 11 (4), e1001538 (2013)
   PUBMED   23610558
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162291.13 and AC102195.14.
            
            On Feb 22, 2019 this sequence version replaced NM_178670.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087799.1, SRR11927933.397969.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC162291.13        158389-158655
            268-1052            AC162291.13        197696-198480
            1053-1220           AC102195.14        106690-106857
            1221-1347           AC102195.14        116792-116918
            1348-5188           AC102195.14        124658-128498
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.38 cM"
     gene            1..5188
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /note="arkadia (RNF111) N-terminal like PKA signaling
                     regulator 2N"
                     /db_xref="GeneID:212163"
                     /db_xref="MGI:MGI:2444951"
     exon            1..267
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1052
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1220
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1347
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..5188
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5166..5171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /note="hexamer: AATAGA"
     polyA_site      5188
                     /gene="Ark2n"
                     /gene_synonym="8030462N17Rik; Akd2"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcgga acggcctctg gtgacatttt cttggggcgg cgcggacgac tgaagggaat
       61 ttggtgttgg aggctgcgga ggcggcgagc tcctctctgc cccgctgcag gggctccagc
      121 cgcgctcctc tgctcgccgc tgggagtcgt ctgaggagaa gggggcggcg gggccgagtc
      181 tgcggcccgt caagcgccgc ccggggtggg cgcgtgcccc gacggggcgc gcggggccgg
      241 cgaggaggcg cggacggcgg ggcgcaggct gcttccctgt tgcacctttg atatcgtttc
      301 ctagactccg ttccatgatt taatttggaa ttctgagatg aagatggagg aggcagtggg
      361 aaaagttgaa gaactcattg agtctgcagc cccaccaaaa gcatctgaac aagagacagc
      421 caaggaagaa gatggctctg tagaactgga atctcaagtt cagaaagatg gtgtagctga
      481 ctctacagtt ctctcttcaa tgccctgttt gttgatggaa ctgagaaggg actcttcaga
      541 gtctcagtta gcatccacag agagtgacaa gcccacaact ggccgagttt atgagagtga
      601 ctcctctaat cattgcatgc tttccccttc ctctagtggc catttggctg attcagatac
      661 attgtcttct gttgaagaga atgaaccctc gcaagcagaa acaaccgtgg aaggagatac
      721 ttcaggagtg tctggtgcca ctgttggacg aaagtctcgg cggtcccgtt ctgaaagtga
      781 aacatctact atggctgcca agaaaaaccg gcaatccagc gataagcaga atggcagagt
      841 caccaaggtt aaaggtcatc ggagccaaaa gcacaaggag aggatcagac tactgaggca
      901 gaaacgggag gcagctgcaa ggaagaagta caacctgctg caggacagta gtaccagtga
      961 cagtgacctg acttgtgact caagcacgag ttcctcagat gatgatgacg aggtttcagg
     1021 gagcagcaag acaatcactg cagagatacc agatggacct ccagttgtag ctcattatga
     1081 tatgtctgac accagctctg acccagaagt gataaatgtg gacaatttat tggcggctgc
     1141 agtagttcaa gagcacagta attcagtagg cggccagaac acaggagcta cctggaggac
     1201 cagcgagctt ctagaggcag gtcatttgga tccaggattc ctggcaagtg acaagacatc
     1261 agttggcagt gcaccactta acgaagaaat taatatcgcc tcttcagata gcgaagtgga
     1321 gattgtgggt gttcaggagc acgcaaggtg tgctcacccc cgaggaggcg tgatccagag
     1381 tgtctcttcc tggaagcatg gctctggccc gcagtatgtg ggctcccggc ccgcacagtc
     1441 atggactgct gtgaccccgc agcagacgtg ggcttcgcca gcagaggtcg tcgaccttac
     1501 cttggatgag gatagcagac gcaaatacct actgtaatgc agtgtcactg tccctctgca
     1561 ctgttccttc cagcgcctct ctgtgacatg gaagttcatt tcctagcttc agcttccgaa
     1621 gctgtgtgtg gcatttgtgg gatggaaatt catggtaact ccccctttta ttaaaataat
     1681 tcacttagga aaataactta gcacagagaa ataatttttt cttttcctca acaagaaaat
     1741 gagaatggtg gattttatta ggcagcttca ttttgctcgg tgacctacct taaagtcact
     1801 ctccatttag aataatattt tacttactag gcaaaatgga tttcaggttt tgagtcttat
     1861 atttattttt ctgtataatg aatttaatat ctagctgtga ccactctctg tctgcgtcac
     1921 tgtcacccct ggtcttgggc atttgcacac ttatcagtca ggacctcatt ggcacctggt
     1981 agggcatgtg catttagaaa acccttcctt agatgtggaa gacagaagta ttataaaata
     2041 tatttttcct ttagcttact tcttctgcct tctttcctga cacagctctt tgtctgtttg
     2101 ccataacaca aatatttgaa atgccccctt ttatttccaa atactattaa ggggactcag
     2161 ttggtctctt tgttgcaata attcacaatt gtttgagact atctggatat ctgaggagtg
     2221 cattgagaga tcagtgggaa atctgtacct ctcaactttt ttctcctggt ttattcaaac
     2281 agtaagcaga catggaaacc tgttcctgga gcagggcgac tgtaaaaggc cgggtggcat
     2341 ccggatatgt aggcacttgc aaatctgagc gcacagtgcc ttgtctcatg tctgcttgct
     2401 ccatagaggg tgtgaccact gtttaactgg acccgggctg tgtttgagta gttttcttct
     2461 ctgccttcta aaaatatgta tacaagagaa atcaaaatat accataagaa atcagatgca
     2521 aagcacattg atagtactgt cttaacagta tttaaaacaa ttagtaaagg gtcatagaaa
     2581 cttcagggac tttaggaaat gccagcagag gaattttgtg gcatcactta ctaccttttt
     2641 tcctataatg ttgtagttac tagtgaagta cttttaaaaa gcaataccta gaattagaac
     2701 actatgtgtt gtgcagaggg ggagtgaagt aatattggct cagaagacat cacatgtttc
     2761 tggttttgtt ttcatgcggt gttgctatgt tctttgcctt ccctcctcaa ataccttggt
     2821 gacatcctca ttacaggatg agacccacca cttttattca gtgcacacac attgaccaag
     2881 gacctactct gtacaaagca ctgtgcaggg tggatgtttg gaggccctga gaagaatgag
     2941 acacagcctg cctgcatgct cctgcatggg tctgcctggc tccatctgcc tggcctttct
     3001 gttttcttac atgaagacag gtttattcat tattctcctg gttgttcagt tcttgtgtag
     3061 actccttctg tagggatgca tttgagcatg tgctcgatga tgttgtctgg cgtaatctca
     3121 tttgacctgc cctctgctca ccaccttctc atcttttctt cagtctacta ctgtcctgct
     3181 aaccaggctg taaagccatg atctccagtg tcagtgcatc attgctcact ctcctagata
     3241 gaaaccaaag acccagaggc cagagcaaaa cagagcttct ggaaactcac tgctgggtta
     3301 tctttgcact ttcacatctt gctttaggat taatttattg agttttactg ttacacattt
     3361 ttttttttta cttgaattaa aatactcaac aaagcagaaa cataatttct ggtctgtgtt
     3421 ttccagaaaa tcattggtaa gagaatacag tggagggtat gacttgaagt ttttgcagct
     3481 tatatctatc tccccgaatg gcacagcccc attttaaaga atgttttcgc attacttatt
     3541 ttcatgttaa aaatgttctg ttcaagtcta cacaacagat agtttccctg acattttctt
     3601 tagtcttttt agccatcccc tttctttggg tgtgctgcgg actgggttag aggggagttg
     3661 cagccaggct cttttctggc cctttatctt aggttgcaca cagatgctcc tggtatccga
     3721 ccctgactac ttgatttggt gcatcagaac gagcgttaga cattaatatg caagtgaagg
     3781 gaagcttggg gcagtctgct ctctctagca agtatggaac tttcccactt cccatctcat
     3841 aaccaattat gggggcagtt gaactcctcc gttattacta catccaggag agtggaaatg
     3901 tgatttctgg caaggtatta gtcaaattct gtgacataca actctcatac attggaaatt
     3961 tctttaaaag tattgtttcc taatcagact tttacattgg taccatgagt tctttatgct
     4021 ttgccaagac attgtttgag ggatatagtg ggatcataga ttggtttatg ccataaatgt
     4081 gattaattcc cttcccctcc cctccaattt gaagaaccag aaccagaacc agaaccagaa
     4141 gcagaagcag aaacctggct gtttgtcact ggcggttcta gtgcagctac agagccgtgg
     4201 ttctcaacct gtgggtcacg gcccctttag gggcgaacga ctctttcacg ggttgcagcg
     4261 tcaggaaggt tgagaactaa ctgtagacta acggacgcca tcagtatgag agatcagccc
     4321 tagcatgcgc ttgtcagcac agttccaaag catgacctgc ctggtttgct agttcagtca
     4381 tttgttcacc tactgttagc aaattagcac cacaaggaat ttaagacaga tgttgcctgc
     4441 ttcttttgta ctgtgtcacg ggcttgcaaa agcctggggc acaatttagt cttagttttg
     4501 actttttttt tttttttttt tttttttttt tgttaaaggc aaagagccga gccccaattc
     4561 ctgtttccct gtatgtgtgt gatgtgactt ccatgtgtat ataaaactat tgcaccctaa
     4621 ccaaacttcc tcagactgtg cactgtttgt tgaaaataat cacgtatttt agttcaatgc
     4681 tgttgtattt tttcttttta tttaaaacac tacttattct ctaacaaatt tcaaagggta
     4741 gtgatctaaa aaaatcactg gaaactagga aatgtttctg ttgttgcttt gttctttaaa
     4801 gagtgcaaag gtcacggaat cttttgctct tcttaccttg aacatgaatt gtcagccatt
     4861 gtgtggctag gaaccagtgc acttggcgtt cacagatctg ctgttgctgg gactgagcgt
     4921 ggacttgatg cagtgacaac aaatcactgc gtagacggaa tgttttccaa atgtgcaact
     4981 caagtttgta aaatgaattt ggttctttac atcattattt aggttttgtt tccatttagt
     5041 atttaatggt ctttggagaa aaaaaaaaca gagtgttata tatatatttt ttggtgcaag
     5101 ataagatttt gttttttgaa ataagtctgt agcataaagg ttaaactatt ttaagataaa
     5161 ataaaaatag agtgtattta aacagtga
//
