LOCUS       NM_001164504            7321 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus arkadia (RNF111) C-terminal like ring finger ubiquitin
            ligase 2C (Ark2c), mRNA.
ACCESSION   NM_001164504 XM_001481319 XM_129042
VERSION     NM_001164504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7321)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7321)
  AUTHORS   Kelly,C.E., Thymiakou,E., Dixon,J.E., Tanaka,S., Godwin,J. and
            Episkopou,V.
  TITLE     Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon
            extension
  JOURNAL   PLoS Biol 11 (4), e1001538 (2013)
   PUBMED   23610558
  REMARK    GeneRIF: Ark2C is expressed in the nervous system in mice, and its
            loss leads to motor neuron axon extension and muscle innervation
            deficits.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY256046.1, BY279218.1, BY727947.1, BB619563.1, CF745657.1,
            AC102135.12 and BC066016.1.
            
            On or before Aug 30, 2009 this sequence version replaced
            XM_001481319.1, XM_129042.8.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1517678.1,
                                           SRR7652917.613056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY256046.1         1-18
            19-391              BY279218.1         1-373
            392-613             BY727947.1         306-527
            614-861             BB619563.1         1-248
            862-1255            CF745657.1         36-429
            1256-4210           AC102135.12        39534-42488         c
            4211-7321           BC066016.1         1-3111
FEATURES             Location/Qualifiers
     source          1..7321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.28 cM"
     gene            1..7321
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /note="arkadia (RNF111) C-terminal like ring finger
                     ubiquitin ligase 2C"
                     /db_xref="GeneID:225743"
                     /db_xref="MGI:MGI:2444521"
     exon            1..95
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1078
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /EC_number="2.3.2.27"
                     /note="arkadia 2; arkadia-like protein 2C; E3
                     ubiquitin-protein ligase RNF165; ring finger protein 165"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARK2C"
                     /protein_id="NP_001157976.1"
                     /db_xref="CCDS:CCDS50327.1"
                     /db_xref="GeneID:225743"
                     /db_xref="MGI:MGI:2444521"
                     /translation="MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQ
                     PQQLAPDFPLAHPVQSQPGLSAHMAPAHQHSGTLHQSLTPLPTLQFQDVTGPSFLPQA
                     LHQQYLLQQQLLEAQHRRLVSHPRRNQDRVSVHPHRLHPSFDFGHQLQTPQPRYLAEG
                     TDWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQ
                     LHFLALQGLNPSRHTSAVRESYEELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRP
                     QDSKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPI
                     CRVDIETQLGADS"
     exon            96..411
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            412..522
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            523..652
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            653..757
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            758..853
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            854..960
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     exon            961..7300
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /note="hexamer: AATAAA"
     polyA_site      5062
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /note="major polyA site"
     regulatory      7272..7277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /note="hexamer: AATAAA"
     polyA_site      7300
                     /gene="Ark2c"
                     /gene_synonym="2900024M11Rik; Akd2; G630064H08Rik; Gm96;
                     Rnf165"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcagcc gccgccgctg cgcgaggagc caggatggtc ctggtccacg tcggctatct
       61 cgtgcttcca gtgtttggct ctgtgcgaaa cagaggtgcc ccctttcaaa ggtctcagca
      121 tcctcacgct acctcctgcc gccacttcca cctgggcccc ccacagccgc agcagctagc
      181 cccggacttc ccgctggccc accccgtgca gtcgcagccg ggcctcagcg cccacatggc
      241 cccggcccac cagcacagtg gcacgctgca ccagtcgctg accccgctgc ccaccctgca
      301 gttccaggac gtcacaggtc cctccttcct acctcaggcc ctgcaccagc aatacctgct
      361 gcagcagcag ctcctggaag ctcagcaccg caggctcgtc tcgcatccca ggcggaatca
      421 ggatcgagtg tctgtccacc cccaccgcct tcaccccagc ttcgactttg gccaccaact
      481 gcagacacct cagccccggt atctggctga gggcactgac tgggatctca gtgtggacgc
      541 cggcttgagt cctgcccagt tccaggtgcg gcccatccct cagcactatc agcattactt
      601 ggcaactcct cgaatgcacc acttcccgag aaactcctcg tccacacaga tggttgtcca
      661 tgaaattcga aactaccctt acccccagct tcacttcctc gccctccagg gactaaatcc
      721 tagccggcac acctctgctg ttcgggagag ctatgaggag ctgctgcagc tggaggacag
      781 gctgggaaac gtgacccgag gcgctgtaca gaacaccatt gagagattca ccttccccca
      841 caagtataag aagcgaagac cccaggacag caagggcaag aaagatgaag gggaagagtc
      901 agacacagat gagaaatgca caatttgtct gtctatgttg gaggatgggg aagatgtgag
      961 acgcctacct tgtatgcatc tcttccacca actgtgtgtg gaccagtggc tcgccatgag
     1021 caagaaatgc cccatctgcc gagtggacat tgagacacag ctaggagccg acagctgagg
     1081 gaggagctag ccagtggaca ccccgtttcc ttcaccaggt ccccccccca cggccatagc
     1141 ccttgcagcc aaactttgcc ttctgagcca tttgacgtag agaagaagcc tgcaagcaca
     1201 tttttttttt ctttttggtg gaaagaggag ttggtagcgg tgtctgaggg agaggagggg
     1261 tagggtggga agacccaccc atcaggaatg gtgactgcct catcgccttg ctgtgcagct
     1321 gggagggagc tggccgtgcc tagagcaggg gcgggaaggg ggcgccccag ctgctgagga
     1381 ctggatgtta tctcgagggt actagctggt gatcggcccc tcaatcctga cctttgaggg
     1441 attgtgtata tacctcttga ccacgtagaa accatgtagg ggtctctagc tattctgtgg
     1501 atggcagcca gagcatgtta gcttaagaaa aatgtcgtgt gtggtgctct cgtcatctgt
     1561 ggtggacatg tcgctattac tgaactcgca ccaaatattt ctcattgagt ttcttgtttt
     1621 ggtgcctgac cgaaccaacc aaccaaccaa ccaaccaacc aaccaacgac agccccaatc
     1681 ttcccatctt tatgagcgaa aagaaaaaaa aagaaaaagg aaaaaaaaaa aaagaaaaat
     1741 caaaggtgaa aaacaaacaa acaaacaaac aagccaaatt ctgtttacgg tgaaaaaagt
     1801 tgataatttt tcacccaggt tgggaggggg gaatcctcgt ttgttgtttt gttttttttt
     1861 cccccttggg ctttgttttt ctcatgttta cagtgcacgg agtgtaagag gggatgggct
     1921 taaaaggagc agactgggtc tcactgggtt tctgaggctt tcaggcaagg tgaggagggc
     1981 agaaccccag ccagtgaggg ggttccccac cttgcagtgg gctcctcagt cctcaggccc
     2041 atggcttagc cccagtagct ttcctaggtt ccacactgaa ccagggagga caatgcctcc
     2101 agctacagcc taccctctag ccccacccca ccccaagagc gtgttcctgg gagccagcag
     2161 cccctgctca ctccagttcc taaccttcta tcctgagctc tcatcttgcc acaaagaggc
     2221 aatgtagcca ctgcctccct atgcaaaaat attaaccaga tgaatcagac ggcacagcat
     2281 cggcagtgta gacttggcct cggctaaagt gctctcagtt agcattgggc atcagggcaa
     2341 gtccacaacc ttgcgagcaa cttgagcttc ctccaggatc ctgcttgatt agaccctcag
     2401 agatagccat tgtttcgaga ctccttggct gggctgggag gcccttgccc ctagcctcat
     2461 gatcctctga ttcttctgtg atcttgggaa attccttttc tttctctgtg cctcagtttc
     2521 cgtctccttc cagtggggag aaagaaccgt gtgtccccat gccccccccc cccgccccac
     2581 atcacctaga tctgagagtt aacaccctcc agccctgatg tgctttcggt tctctcaggg
     2641 gagtctctga gggtttagtg agaaaggaga cggaaagtcc caagtgacac agtattagtg
     2701 tatgctttct gtaccgctcc gagagatggg aggacagagt tctggaggtg ggggaaatct
     2761 gccaaattct aactcgagtg tagctcttag ttgtgtgcag aaaataccag gtctcctggc
     2821 attctttaac tgtcctttgc cccttactct tctcaaccca cctcctctct tccctcctcc
     2881 ccctcccctc ctccctccac ttcttctccc ccacctcatt tgcactgctc tcggaaacct
     2941 caacccgtag ccagtcttag tgtcctcgta tgctcagagc aggaaatggt atgctgatca
     3001 gataaaagga gaaattccac gaagttaaac aagcccagga taagttttgg agtcgtgacc
     3061 aaaaaaaatg acagtggcca attggacttg agagagatcc ttccaggaca accatcgtga
     3121 aggaatggct gcctgcctca tcccaggccc cgtcttctgg tgtgtccttc aatctctgtg
     3181 gactgcctat tggggtaggg gggcagcagg tgttgaggaa ggtgatcact caggcgatgt
     3241 ctcggcctgg cggaactctg aggagtggag gaacagcaca cagtgcttat ggtgaaggtc
     3301 aggcgtgctg agtgtggcct cagtcaactc tggtcgccat cgagaacacg gtctccagta
     3361 caaaggctgg cccaggaaag aaagtcaggg tgttagaaag ctgccgacca aaagccacaa
     3421 gaacttgtga cttctttcct gctgctcctc tgatggctgt gtccaagccg tgatgtcctc
     3481 tgaagatggc tgtggctcag aggtcattgg gggtggtcta ggtgggtcac tcctctctga
     3541 ggccactctg ttctttcctt tgaggctctc ctgaaaggct ggtaggaaaa gagattggca
     3601 gggacccagg agggaactgg aaccagtgtc ccagattcta gtcctggctc ttcactggca
     3661 aactgggaga tgctggaaat ccccaacccc atcccaatgg cttgctgggc ctcagcgtcc
     3721 tcagctgtga cacagggaag ttgattggat gctccctaaa tttctcccaa aacacatcca
     3781 gtgattcttc ctaacatcaa cacatccttc acctctgtag agttgccctc agccagcctt
     3841 gccgctgaga ggtctcctgt gcgcacatac atacacctgc ttccgaggcc ctggcacaca
     3901 ggccgagtga gagggcaggg cgggttcggc ttgcttcctt tttgttcagg ctctttgaac
     3961 gctccaggct aacattagga cctgggcagg gtaggggttg atccttcacc cccctcccct
     4021 ttccacgtac ttggagtcct tgtgccctgg agcagctccc atttccaggc cgagggtggg
     4081 agggctgccg attgggtgga gaaaagccag tgcctctgcc cagtcctccg actggtcagg
     4141 aagccaggaa ggagcggcga tgaggcaggt ccaggcctca gcatctcaca tccaccatat
     4201 ccaggagaga gacatgcgca gttctcctgc tcaactcaag ggactcagac ccttttctga
     4261 ctgagacgca tgagtgcctt tgacaagttg ggcctcctaa ccgcagccac ggcgcagcag
     4321 gtccacctcg gacaccaatc aacgccacgc cacgaatcca gctgggcaca ggcagagggc
     4381 agctggggct gcacgttgtt cctccacctg ccaaggaccc cagtctcccc ggtcaccctc
     4441 gccaccacct gtgacaggcc tcaagctcct ctcccgcaaa ggcccccagc ctccgtgcaa
     4501 gcattcttaa actctttacg cctaacgaac aagcacagtt ttttcaacgg tgaagaaaaa
     4561 gcaccagact tgttttcctg aagaaatccc ccaagcccca accccgcctg tgggacaaac
     4621 attccccgcg tggggctgta gcaacgtctg tcaggtcccc cttgtgtttc atctcctgcg
     4681 cgcgcgtaga gcaaatgcta gagcgatttc agctgataga aaaacaaaaa agaaaaaaaa
     4741 aacacaaaaa aattaaaaaa aaacatggca cgttgctagt ttacagggtt ttgtgagttt
     4801 aaatgcctta tatttaacaa tcataattta tgactaactt gtagatatcg tgggttctta
     4861 tttaattatt tttatagttg ttttgcattt ttaattataa tttatttatt tagaaaggat
     4921 actaatgttt tttattgctc ctattacctc attttggcgt cgtttctggg agtggaatgc
     4981 tttgcatgcg ttggtacgat gacaactgcg aaacaaacaa acaaacaaac aaaccatttt
     5041 aaataaaagt ctgcgaactt tattttgtcc aaactatcag ggtgtgtgat tgcaagctgt
     5101 cctactgtgg tgctggcctc tttggataca ttccatacga aatgcaaacc tttgattctg
     5161 tatgctgtga tctagtgaca agctccaata tagtgagtgt atttagcaca tatataaata
     5221 ttatttgcac tcgtcagcag actggggtaa tcctttcact tgtcactcgt gccccctccc
     5281 ccaggcctct ttccccacct caagtctgct ctctgtcttc cctcccctcc ctacattcct
     5341 aagccctctc atccctctat cccgaggaca gttactaagc tatacttggg atcccactca
     5401 gaaggtttca gaactggggt ccttcagaca caatgaatat gctcatctga aagagaggct
     5461 gttttattag gtggggccca gaaggcccgc tctgatcaag ggtaagtcag tccctggacc
     5521 ccctgagtca gtcctcagct ccgagagagg gagtctagaa gggtgatctc ttggttcacc
     5581 ctgattaaga aagaatatgt caccgtccca ggtgagacca cacaggtggg tctctctctc
     5641 tctctctctc ttctctctct ctctcctctc tctctctctc ctctctctct cctctctctc
     5701 tctctctcct ctctctctct cctctctctc tctctctcct ctctctctct cctctctctc
     5761 tcctctctct ctcctctctc tctcctctct ctctcctctc tctctcctct ctctctcctc
     5821 tctctcctct ctctctcctc tctctctcct ctctctctct ctcctctctc ctctctctct
     5881 cctctctctc tctcctctct cctctctctc tcctctctct ctctctctct ctctctctct
     5941 ctctctctct ctctcgggag agatgaaaag ggaaagggtg aaaggaagac aaggagagga
     6001 atggggaaca tggggaacag agagagtcag ttaggaatca ccttagaggt ctgctcatag
     6061 cagcggccca cagagtcctc tctatacaac atcctgcaga tgcaaagact agctagatat
     6121 gtccttgggt ttgcaacatg gactctctca aggttaggtg gtcagtccta gagaaggagc
     6181 ggatggcata gaagacccag accatggtgt ggggatttct cccaccccta atcttgtctg
     6241 gagcctttgt ggttaggata ccagtcattg acaagaactt ggggagcagc agaattatat
     6301 cctgctttct ccccagcacc ccctcccctt tgcctatgtt tcacggaggc tgcagacaga
     6361 gagggcctgc tgtggactta gagggctctg agtccagttt cattagctgt gtgagcaacg
     6421 gcaagggacc ttaaggaagt ggaccctgga ttaagcccgg aacactggca tgctgacctt
     6481 cctctctcct tctcctccta actcagccct cctcctcctc ctaactcaac cctcctcctt
     6541 ctcggctctt gacatcactg cctttgcctg gtgggtagct ccaccttcca cgggaagccc
     6601 catgggtttg catagctctg gcacggagga gagaaaccca agagctgggg ttgccacacc
     6661 acctacccgt gtggctagac cacgtgtgac ccctcagctc catccccggg acggggtgtc
     6721 ttgcttgctg ctgcccagct tctcttctgc ctctaccctg gagccttgct tttcttggag
     6781 atggcctgtg gagtcaccca ccacgccggt ggagcacaat taccacactg ccaggcctgg
     6841 cagacactgc ctcccgcaga gctcctcgcg ggctcgctgt gctgttgtgt ggggccagag
     6901 taggacaggc cctatgctcc ggctggcaat gccccgctcc tgagcctccc caccctgtgg
     6961 ggtgagcttt attcccctca gctgtggtga gggctgcacc aggtcctccg agggggctgt
     7021 ttgttgcccc tggtaagtga aaggattacc ttcagtgttg attgtccttt ttttgtaatc
     7081 ctcctgccgt tctgttctgt tgtgtgctgt gcaacatttt gctacataga ctattttata
     7141 gcagaaagct agaaaaatat ttattatgac tactaaagca atagtgtatc aatgaatggg
     7201 cggagacatt aggaattgtg taaatgctta gattcacttt gggtggattt ttttgtactt
     7261 tatttataac taataaaaat gatctgcatt gctaactaca aaaaaaaaaa aaaaaaaaaa
     7321 a
//
