LOCUS       NM_011790               3975 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus ariadne RBR E3 ubiquitin protein ligase 2 (Arih2),
            transcript variant 1, mRNA.
ACCESSION   NM_011790
VERSION     NM_011790.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Lv B, Zhang XO and Pazour GJ.
  TITLE     Arih2 regulates Hedgehog signaling through smoothened
            ubiquitylation and ER-associated degradation
  JOURNAL   J Cell Sci 135 (16) (2022)
   PUBMED   35899529
  REMARK    GeneRIF: Arih2 regulates Hedgehog signaling through smoothened
            ubiquitylation and ER-associated degradation.
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Wang H, Bei L, Shah CA, Hu L and Eklund EA.
  TITLE     HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression
            of Triad1
  JOURNAL   J Immunol 194 (11), 5375-5387 (2015)
   PUBMED   25895533
  REMARK    GeneRIF: HOXA10 gene disruption exhibited an overwhelming and fatal
            emergency granulopoiesis response that was characterized by tissue
            infiltration with granulocytes, but reversed by re-expression of
            Triad1 in the bone marrow.
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Raz V, Buijze H, Raz Y, Verwey N, Anvar SY, Aartsma-Rus A and van
            der Maarel SM.
  TITLE     A novel feed-forward loop between ARIH2 E3-ligase and PABPN1
            regulates aging-associated muscle degeneration
  JOURNAL   Am J Pathol 184 (4), 1119-1131 (2014)
   PUBMED   24486325
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3975)
  AUTHORS   Lin AE, Ebert G, Ow Y, Preston SP, Toe JG, Cooney JP, Scott HW,
            Sasaki M, Saibil SD, Dissanayake D, Kim RH, Wakeham A, You-Ten A,
            Shahinian A, Duncan G, Silvester J, Ohashi PS, Mak TW and
            Pellegrini M.
  TITLE     ARIH2 is essential for embryogenesis, and its hematopoietic
            deficiency causes lethal activation of the immune system
  JOURNAL   Nat Immunol 14 (1), 27-33 (2013)
   PUBMED   23179078
  REMARK    GeneRIF: essential for embryogenesis, and its hematopoietic
            deficiency causes lethal activation of the immune system
REFERENCE   6  (bases 1 to 3975)
  AUTHORS   Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G,
            Menke A, de Witte T, Lowenberg B, Jansen JH and van der Reijden BA.
  TITLE     The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth
            of primary myeloid progenitor cells
  JOURNAL   Blood 106 (13), 4114-4123 (2005)
   PUBMED   16118314
  REMARK    GeneRIF: proteasomal degradation of proteins that are ubiquitinated
            by Triad1 affects the clonogenic growth of primary myeloid
            progenitor cells
REFERENCE   7  (bases 1 to 3975)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3975)
  AUTHORS   Aguilera M, Oliveros M, Martinez-Padron M, Barbas JA and Ferrus A.
  TITLE     Ariadne-1: a vital Drosophila gene is required in development and
            defines a new conserved family of ring-finger proteins
  JOURNAL   Genetics 155 (3), 1231-1244 (2000)
   PUBMED   10880484
REFERENCE   9  (bases 1 to 3975)
  AUTHORS   Martinez-Noel G, Niedenthal R, Tamura T and Harbers K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
REFERENCE   10 (bases 1 to 3975)
  AUTHORS   van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B and
            Jansen JH.
  TITLE     TRIADs: a new class of proteins with a novel cysteine-rich
            signature
  JOURNAL   Protein Sci 8 (7), 1557-1561 (1999)
   PUBMED   10422847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571271.12 and BC051998.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_011790.6.
            
            On Oct 25, 2017 this sequence version replaced NM_011790.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1-3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052422.1, SRR7345562.4029110.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CT571271.12        77589-77624         c
            37-3975             BC051998.1         9-3947
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..3975
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /note="ariadne RBR E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:23807"
                     /db_xref="MGI:MGI:1344361"
     exon            1..180
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            181..242
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            243..585
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1812
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /EC_number="2.3.2.31"
                     /note="isoform a is encoded by transcript variant 1;
                     protein ariadne-2 homolog; E3 ubiquitin-protein ligase
                     ARIH2; ARI-2; ubcM4-interacting protein 48; ariadne 2;
                     ariadne homolog 2; RING-type E3 ubiquitin transferase
                     ARIH2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARIH2 isoform a"
                     /protein_id="NP_035920.1"
                     /db_xref="CCDS:CCDS23534.1"
                     /db_xref="GeneID:23807"
                     /db_xref="MGI:MGI:1344361"
                     /translation="MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASD
                     VEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASVLKVSHSVAKLILVNFHWQVS
                     EILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFC
                     RSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYV
                     ESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWL
                     TKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGS
                     EYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKI
                     QERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLE
                     AEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT"
     exon            586..653
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            654..717
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            718..868
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            869..990
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1100
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1218
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1269
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1291
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1443
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1587
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1656
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1740
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..3952
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcgcggcg cagaacactt ccggagctgc gggggacggc tctgccggag gaagctgcgc
       61 gggcctgagc cgcgtccgcc ggctgcctcc gctgccgcta cgcctccgtc agcctggttt
      121 ggtctggctt gacctggtcc ggccggcctg ggctctgcgg ccgcgaggtc gcggctcccg
      181 atggaaatcc tatgacagac agtttgggtg atatctgcag gaaagatctt taaacattac
      241 agaagacaat acacgctaat gcatttgaga aaacgataaa aattgggggt agggaaaaaa
      301 gcaactgttt ctgcaacttt gctggatgtt aagatgtctg tggacatgaa cagccaaggg
      361 tcagatagca atgaagagga ctatgaccca aactgtgagg aagaggaaga agaggaagag
      421 gaccctgggg acatagagga ctactatgtg ggagtagcca gtgatgtgga gcagcagggg
      481 gctgatgctt ttgatcctga agagtatcag ttcacttgct tgacctataa ggagtctgag
      541 ggcgccctcc atgaacatat gaccagctta gcctctgtct taaaggtatc tcattcagtt
      601 gcaaaactta tattagttaa tttccactgg caagtctcag agattctgga caggtacagg
      661 tctaattctg ctcagctgct tgttgaggct cgagttcaac ctaatccatc caaacatgtc
      721 cccacagccc atccccctca ccactgtgca gtgtgtatgc aatttgtgcg gaaggaaaac
      781 ctactctctc tggcctgcca acatcagttt tgccgaagct gttgggaaca gcattgctca
      841 gtgcttgtca aagatggtgt tggtgtagga atctcatgta tggctcagga ttgtccactt
      901 cgaacaccag aggactttgt atttcccttg cttcccaatg aagaattgag agataaatac
      961 aggcgctacc tctttaggga ctatgtggag agccatttcc agctccagct gtgccccggt
     1021 gcagactgcc ccatggttat ccgggtacag gagcctagag cccgccgagt gcagtgcaat
     1081 cggtgcagcg aggtcttctg tttcaagtgt cgacagatgt atcacgcccc cacagactgc
     1141 gccacaatcc ggaaatggct caccaagtgt gcagacgact ccgaaacggc taactacatt
     1201 agtgctcaca ctaaagactg tcccaagtgc aacatctgca tcgagaagaa tggaggctgt
     1261 aatcacatgc aatgctccaa gtgtaagcac gacttctgct ggatgtgtct aggagactgg
     1321 aagacgcatg gtagtgagta ctatgaatgt agtcggtaca aggagaatcc tgacattgtc
     1381 aaccagagcc agcaagcaca ggccagggag gccctcaaga agtacttgtt ctactttgag
     1441 aggtgggaaa atcacaacaa aagcttgcag ctggaggcac aaacatatga gcggattcac
     1501 gagaagattc aggagagggt tatgaacaac ctgggaactt ggattgactg gcagtaccta
     1561 cagaatgctg ccaagctctt agccaagtgt cgatataccc tgcagtacac ctatccatat
     1621 gcatactaca tggaatccgg tcccaggaag aagctgtttg aataccagca ggctcagctg
     1681 gaggctgaga tcgaaaacct ttcatggaaa gttgagcgtg cagacagcta cgacagaggg
     1741 gacttagaaa accagatgca catagcagag cagcggagga gaaccctgct aaaggatttt
     1801 cacgacacct aaactgggct gtggctgtgc cggggtgagg aagatgtagc tgtgaggccg
     1861 cccggctgcc ctcctgcagg ctgtaggctc tgcctttcac cacccaggca acagccaggg
     1921 ccccactcct gaaagacact ggcaacacac ctcttagccg atttgttttc tcctcatctt
     1981 tttgattttt atttctacca gggtagaggc cgcgttgagc tggcctctaa tgaggacttt
     2041 acatttcccc tggatggttg ttgggcggga gggaactttt ttttcctgaa tggctattaa
     2101 tagtattaga tcattacaac ttatgtaatt ttcaaaggtt gtacgattat aaaggaaaga
     2161 ggcaaagcat agataacaca gagcccgatt aaaataaatt ggcattggag tgcttcaccc
     2221 tttagctatt tgacttagaa tgtaacttga tactgcccag ccactgagcc tcagcgtgtc
     2281 tgcactgccg ggggccctgg gacggcccct gctttccagc atcatgtttg actggagccg
     2341 gagtcctggg gaaggtgcac gggtggcaga gagtaggaaa ctgagttggc ctgcataata
     2401 ggatggagca cacagttact tacctggcct tagctggaca gccagggcac agagcagagc
     2461 aaggtcgcac tgcaggcttg cttttagtct tgaatgtgag gtttttcgct aagtcaggcc
     2521 atccagacca gcaccacagc agaggtgggc taccacacct ctggacttgg agactggttc
     2581 agcatggtgc ttccttttgt ttcttaaaga aaagaaatcc acctttgaga ggagttgttc
     2641 cccagatgag tttctttttc cttggttgtt ccttttgatc cagtattcaa gtggtgtact
     2701 ctgacctggg tcactgtctt gtgttcttat gaacagagtt catgaggtca gagttcagca
     2761 tggctcttag accaagggca tgggtcttgt ggctcaagag ctaggtttgc acaagttctt
     2821 tttctgttca cctagagtgt ggccagaagc tgctccaggg tggggtgtgt ttctctttgc
     2881 ctagttgcag ctgccagaag tccccatctc tatggtctgg gagtctaagg ccaggagaat
     2941 ccctggtttg tggtctcagt tcctgtacta gaaggggctg gccagaagaa aggaccagtt
     3001 cttgcacagt caagtgcaag ggaacaggca gcttgcctgg tgtccttcct atcttgaacc
     3061 tggtcctgtg ggcctttgaa aagttagatc tgtgatctct ggggtttcca tggctttgtt
     3121 cagtgcctcc cctctgagac tggcagagct gtctatactt gacaggacct ccttgaactc
     3181 ctaggagagc ctatagagaa atctgtgaat attatgatgc agattctttg atattcatac
     3241 attttcacct ccagtcagca atttcctagg taccatgtaa agctgtaaaa ttgaattatt
     3301 cttgaagcca ggtgacagct gtgacgcctg gggtacatgg agctgcacgt cctctcccac
     3361 ctcctcaggt gttttgtctc ttcatgtcat ccctgacaag tgaggttggg aggtggattg
     3421 ggagtaatag tatagtagag tatggtgagt gaaccctaac accaatggga gctgattgtg
     3481 acccaggagt gtccctgctg caggcccagg gtggctgtga tgctctgtta gcacacagac
     3541 ctttccatca agtcctgcca gtggcactgc cgtgacacag caccagagtt gcagctctgc
     3601 agcctaactc ccccttggta ctttctgaac tgcacagctg ccatcctcca ctcctcagct
     3661 gtgaccctga ccattggcac tgcaggaggc tctgccaacc tgtagctggt ggcgtctcat
     3721 ctgtggaaac ctttgttttt gcaccctcag tggttgtcct tgttaacatc agaacatctg
     3781 aaaggtcagg cagaggtagg gtttggcttg gtgtttttac cctgcaaagg gtagagaaag
     3841 gtgtttccat gacctgacca gattcttgtc tttcttcaaa gaaaagttga ggtaatgtca
     3901 tctcgaaaag ttgagtgatt tattcaaaat aaactcattt tctgattata aaaaaaaaaa
     3961 aaaaaaaaaa aaaaa
//
