LOCUS       NM_001357286            3998 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus ariadne RBR E3 ubiquitin protein ligase 2 (Arih2),
            transcript variant 4, mRNA.
ACCESSION   NM_001357286 XM_006511728
VERSION     NM_001357286.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Lv B, Zhang XO and Pazour GJ.
  TITLE     Arih2 regulates Hedgehog signaling through smoothened
            ubiquitylation and ER-associated degradation
  JOURNAL   J Cell Sci 135 (16) (2022)
   PUBMED   35899529
  REMARK    GeneRIF: Arih2 regulates Hedgehog signaling through smoothened
            ubiquitylation and ER-associated degradation.
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Wang H, Bei L, Shah CA, Hu L and Eklund EA.
  TITLE     HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression
            of Triad1
  JOURNAL   J Immunol 194 (11), 5375-5387 (2015)
   PUBMED   25895533
  REMARK    GeneRIF: HOXA10 gene disruption exhibited an overwhelming and fatal
            emergency granulopoiesis response that was characterized by tissue
            infiltration with granulocytes, but reversed by re-expression of
            Triad1 in the bone marrow.
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Raz V, Buijze H, Raz Y, Verwey N, Anvar SY, Aartsma-Rus A and van
            der Maarel SM.
  TITLE     A novel feed-forward loop between ARIH2 E3-ligase and PABPN1
            regulates aging-associated muscle degeneration
  JOURNAL   Am J Pathol 184 (4), 1119-1131 (2014)
   PUBMED   24486325
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Lin AE, Ebert G, Ow Y, Preston SP, Toe JG, Cooney JP, Scott HW,
            Sasaki M, Saibil SD, Dissanayake D, Kim RH, Wakeham A, You-Ten A,
            Shahinian A, Duncan G, Silvester J, Ohashi PS, Mak TW and
            Pellegrini M.
  TITLE     ARIH2 is essential for embryogenesis, and its hematopoietic
            deficiency causes lethal activation of the immune system
  JOURNAL   Nat Immunol 14 (1), 27-33 (2013)
   PUBMED   23179078
  REMARK    GeneRIF: essential for embryogenesis, and its hematopoietic
            deficiency causes lethal activation of the immune system
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G,
            Menke A, de Witte T, Lowenberg B, Jansen JH and van der Reijden BA.
  TITLE     The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth
            of primary myeloid progenitor cells
  JOURNAL   Blood 106 (13), 4114-4123 (2005)
   PUBMED   16118314
  REMARK    GeneRIF: proteasomal degradation of proteins that are ubiquitinated
            by Triad1 affects the clonogenic growth of primary myeloid
            progenitor cells
REFERENCE   7  (bases 1 to 3998)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3998)
  AUTHORS   Aguilera M, Oliveros M, Martinez-Padron M, Barbas JA and Ferrus A.
  TITLE     Ariadne-1: a vital Drosophila gene is required in development and
            defines a new conserved family of ring-finger proteins
  JOURNAL   Genetics 155 (3), 1231-1244 (2000)
   PUBMED   10880484
REFERENCE   9  (bases 1 to 3998)
  AUTHORS   Martinez-Noel G, Niedenthal R, Tamura T and Harbers K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
REFERENCE   10 (bases 1 to 3998)
  AUTHORS   van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B and
            Jansen JH.
  TITLE     TRIADs: a new class of proteins with a novel cysteine-rich
            signature
  JOURNAL   Protein Sci 8 (7), 1557-1561 (1999)
   PUBMED   10422847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571271.12.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001357286.2.
            
            On Oct 25, 2017 this sequence version replaced XM_006511728.3.
            
            Transcript Variant: This variant (4) contains an alternate exon
            compared to variant 1. The resulting isoform (b) has a shorter and
            distinct N-terminus compared to isoform a.z.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.15872.1,
                                           SRR1660813.218493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               CT571271.12        77445-77624         c
            181-242             CT571271.12        73149-73210         c
            243-585             CT571271.12        72242-72584         c
            586-631             CT571271.12        57505-57550         c
            632-699             CT571271.12        48275-48342         c
            700-763             CT571271.12        45588-45651         c
            764-914             CT571271.12        44894-45044         c
            915-1036            CT571271.12        43241-43362         c
            1037-1146           CT571271.12        41942-42051         c
            1147-1264           CT571271.12        39849-39966         c
            1265-1315           CT571271.12        38113-38163         c
            1316-1337           CT571271.12        37994-38015         c
            1338-1489           CT571271.12        36818-36969         c
            1490-1633           CT571271.12        36125-36268         c
            1634-1702           CT571271.12        35504-35572         c
            1703-1786           CT571271.12        33550-33633         c
            1787-3998           CT571271.12        31158-33369         c
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..3998
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /note="ariadne RBR E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:23807"
                     /db_xref="MGI:MGI:1344361"
     exon            1..180
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            181..242
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            243..585
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            586..631
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..1858
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /EC_number="2.3.2.31"
                     /note="isoform b precursor is encoded by transcript
                     variant 4; protein ariadne-2 homolog; E3 ubiquitin-protein
                     ligase ARIH2; ARI-2; ubcM4-interacting protein 48; ariadne
                     2; ariadne homolog 2; RING-type E3 ubiquitin transferase
                     ARIH2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ARIH2 isoform b
                     precursor"
                     /protein_id="NP_001344215.1"
                     /db_xref="GeneID:23807"
                     /db_xref="MGI:MGI:1344361"
                     /translation="MLTAIGCVLPMALVSHSVAKLILVNFHWQVSEILDRYRSNSAQL
                     LVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVK
                     DGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGAD
                     CPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYI
                     SAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPD
                     IVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQERVMNNLGTWID
                     WQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERA
                     DSYDRGDLENQMHIAEQRRRTLLKDFHDT"
     exon            632..699
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            700..763
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            764..914
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1036
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1146
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1264
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1315
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1337
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1489
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1633
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1702
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1786
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..3998
                     /gene="Arih2"
                     /gene_synonym="ARI2; TRIAD1; UIP48"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcgcggcg cagaacactt ccggagctgc gggggacggc tctgccggag gaagctgcgc
       61 gggcctgagc cgcgtccgcc ggctgcctcc gctgccgcta cgcctccgtc agcctggttt
      121 ggtctggctt gacctggtcc ggccggcctg ggctctgcgg ccgcgaggtc gcggctcccg
      181 atggaaatcc tatgacagac agtttgggtg atatctgcag gaaagatctt taaacattac
      241 agaagacaat acacgctaat gcatttgaga aaacgataaa aattgggggt agggaaaaaa
      301 gcaactgttt ctgcaacttt gctggatgtt aagatgtctg tggacatgaa cagccaaggg
      361 tcagatagca atgaagagga ctatgaccca aactgtgagg aagaggaaga agaggaagag
      421 gaccctgggg acatagagga ctactatgtg ggagtagcca gtgatgtgga gcagcagggg
      481 gctgatgctt ttgatcctga agagtatcag ttcacttgct tgacctataa ggagtctgag
      541 ggcgccctcc atgaacatat gaccagctta gcctctgtct taaaggccgt tgatgctcac
      601 tgccatcggc tgcgtcctcc ctatggcact ggtatctcat tcagttgcaa aacttatatt
      661 agttaatttc cactggcaag tctcagagat tctggacagg tacaggtcta attctgctca
      721 gctgcttgtt gaggctcgag ttcaacctaa tccatccaaa catgtcccca cagcccatcc
      781 ccctcaccac tgtgcagtgt gtatgcaatt tgtgcggaag gaaaacctac tctctctggc
      841 ctgccaacat cagttttgcc gaagctgttg ggaacagcat tgctcagtgc ttgtcaaaga
      901 tggtgttggt gtaggaatct catgtatggc tcaggattgt ccacttcgaa caccagagga
      961 ctttgtattt cccttgcttc ccaatgaaga attgagagat aaatacaggc gctacctctt
     1021 tagggactat gtggagagcc atttccagct ccagctgtgc cccggtgcag actgccccat
     1081 ggttatccgg gtacaggagc ctagagcccg ccgagtgcag tgcaatcggt gcagcgaggt
     1141 cttctgtttc aagtgtcgac agatgtatca cgcccccaca gactgcgcca caatccggaa
     1201 atggctcacc aagtgtgcag acgactccga aacggctaac tacattagtg ctcacactaa
     1261 agactgtccc aagtgcaaca tctgcatcga gaagaatgga ggctgtaatc acatgcaatg
     1321 ctccaagtgt aagcacgact tctgctggat gtgtctagga gactggaaga cgcatggtag
     1381 tgagtactat gaatgtagtc ggtacaagga gaatcctgac attgtcaacc agagccagca
     1441 agcacaggcc agggaggccc tcaagaagta cttgttctac tttgagaggt gggaaaatca
     1501 caacaaaagc ttgcagctgg aggcacaaac atatgagcgg attcacgaga agattcagga
     1561 gagggttatg aacaacctgg gaacttggat tgactggcag tacctacaga atgctgccaa
     1621 gctcttagcc aagtgtcgat ataccctgca gtacacctat ccatatgcat actacatgga
     1681 atccggtccc aggaagaagc tgtttgaata ccagcaggct cagctggagg ctgagatcga
     1741 aaacctttca tggaaagttg agcgtgcaga cagctacgac agaggggact tagaaaacca
     1801 gatgcacata gcagagcagc ggaggagaac cctgctaaag gattttcacg acacctaaac
     1861 tgggctgtgg ctgtgccggg gtgaggaaga tgtagctgtg aggccgcccg gctgccctcc
     1921 tgcaggctgt aggctctgcc tttcaccacc caggcaacag ccagggcccc actcctgaaa
     1981 gacactggca acacacctct tagccgattt gttttctcct catctttttg atttttattt
     2041 ctaccagggt agaggccgcg ttgagctggc ctctaatgag gactttacat ttcccctgga
     2101 tggttgttgg gcgggaggga actttttttt cctgaatggc tattaatagt attagatcat
     2161 tacaacttat gtaattttca aaggttgtac gattataaag gaaagaggca aagcatagat
     2221 aacacagagc ccgattaaaa taaattggca ttggagtgct tcacccttta gctatttgac
     2281 ttagaatgta acttgatact gcccagccac tgagcctcag cgtgtctgca ctgccggggg
     2341 ccctgggacg gcccctgctt tccagcatca tgtttgactg gagccggagt cctggggaag
     2401 gtgcacgggt ggcagagagt aggaaactga gttggcctgc ataataggat ggagcacaca
     2461 gttacttacc tggccttagc tggacagcca gggcacagag cagagcaagg tcgcactgca
     2521 ggcttgcttt tagtcttgaa tgtgaggttt ttcgctaagt caggccatcc agaccagcac
     2581 cacagcagag gtgggctacc acacctctgg acttggagac tggttcagca tggtgcttcc
     2641 ttttgtttct taaagaaaag aaatccacct ttgagaggag ttgttcccca gatgagtttc
     2701 tttttccttg gttgttcctt ttgatccagt attcaagtgg tgtactctga cctgggtcac
     2761 tgtcttgtgt tcttatgaac agagttcatg aggtcagagt tcagcatggc tcttagacca
     2821 agggcatggg tcttgtggct caagagctag gtttgcacaa gttctttttc tgttcaccta
     2881 gagtgtggcc agaagctgct ccagggtggg gtgtgtttct ctttgcctag ttgcagctgc
     2941 cagaagtccc catctctatg gtctgggagt ctaaggccag gagaatccct ggtttgtggt
     3001 ctcagttcct gtactagaag gggctggcca gaagaaagga ccagttcttg cacagtcaag
     3061 tgcaagggaa caggcagctt gcctggtgtc cttcctatct tgaacctggt cctgtgggcc
     3121 tttgaaaagt tagatctgtg atctctgggg tttccatggc tttgttcagt gcctcccctc
     3181 tgagactggc agagctgtct atacttgaca ggacctcctt gaactcctag gagagcctat
     3241 agagaaatct gtgaatatta tgatgcagat tctttgatat tcatacattt tcacctccag
     3301 tcagcaattt cctaggtacc atgtaaagct gtaaaattga attattcttg aagccaggtg
     3361 acagctgtga cgcctggggt acatggagct gcacgtcctc tcccacctcc tcaggtgttt
     3421 tgtctcttca tgtcatccct gacaagtgag gttgggaggt ggattgggag taatagtata
     3481 gtagagtatg gtgagtgaac cctaacacca atgggagctg attgtgaccc aggagtgtcc
     3541 ctgctgcagg cccagggtgg ctgtgatgct ctgttagcac acagaccttt ccatcaagtc
     3601 ctgccagtgg cactgccgtg acacagcacc agagttgcag ctctgcagcc taactccccc
     3661 ttggtacttt ctgaactgca cagctgccat cctccactcc tcagctgtga ccctgaccat
     3721 tggcactgca ggaggctctg ccaacctgta gctggtggcg tctcatctgt ggaaaccttt
     3781 gtttttgcac cctcagtggt tgtccttgtt aacatcagaa catctgaaag gtcaggcaga
     3841 ggtagggttt ggcttggtgt ttttaccctg caaagggtag agaaaggtgt ttccatgacc
     3901 tgaccagatt cttgtctttc ttcaaagaaa agttgaggta atgtcatctc gaaaagttga
     3961 gtgatttatt caaaataaac tcattttctg attataaa
//
