LOCUS       NM_001172205            5699 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus AT-rich interaction domain 5A (Arid5a), transcript
            variant 1, mRNA.
ACCESSION   NM_001172205
VERSION     NM_001172205.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5699)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 5699)
  AUTHORS   Li,X., Hua,S., Fang,D., Fei,X., Tan,Z., Zheng,F., Wang,W. and
            Fang,M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   3  (bases 1 to 5699)
  AUTHORS   Taylor,T.C., Li,Y., Li,D.D., Majumder,S., McGeachy,M.J.,
            Biswas,P.S., Gingras,S. and Gaffen,S.L.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   4  (bases 1 to 5699)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5699)
  AUTHORS   Nyati,K.K., Hashimoto,S., Singh,S.K., Tekguc,M., Metwally,H.,
            Liu,Y.C., Okuzaki,D., Gemechu,Y., Kang,S. and Kishimoto,T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   6  (bases 1 to 5699)
  AUTHORS   Zaman,M.M., Masuda,K., Nyati,K.K., Dubey,P.K., Ripley,B., Wang,K.,
            Chalise,J.P., Higa,M., Hanieh,H. and Kishimoto,T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (bases 1 to 5699)
  AUTHORS   Masuda,K., Ripley,B., Nyati,K.K., Dubey,P.K., Zaman,M.M.,
            Hanieh,H., Higa,M., Yamashita,K., Standley,D.M., Mashima,T.,
            Katahira,M., Okamoto,T., Matsuura,Y., Takeuchi,O. and Kishimoto,T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (bases 1 to 5699)
  AUTHORS   Masuda,K., Ripley,B., Nishimura,R., Mino,T., Takeuchi,O., Shioi,G.,
            Kiyonari,H. and Kishimoto,T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (bases 1 to 5699)
  AUTHORS   Amano,K., Hata,K., Muramatsu,S., Wakabayashi,M., Takigawa,Y.,
            Ono,K., Nakanishi,M., Takashima,R., Kogo,M., Matsuda,A.,
            Nishimura,R. and Yoneda,T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (bases 1 to 5699)
  AUTHORS   Wilsker,D., Probst,L., Wain,H.M., Maltais,L., Tucker,P.W. and
            Moran,E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, AK149839.1 and AK029237.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156376.1, AK149839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY196834.1         2-22
            22-1853             AK149839.1         2-1833
            1854-5699           AK029237.1         1662-5507
FEATURES             Location/Qualifiers
     source          1..5699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     gene            1..5699
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="AT-rich interaction domain 5A"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
     exon            1..104
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1873
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="isoform 1 is encoded by transcript variant 1; AT
                     rich interactive domain 5A (Mrf1 like); modulator
                     recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 1"
                     /protein_id="NP_001165676.1"
                     /db_xref="CCDS:CCDS48239.1"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
                     /translation="MAAPPAKGNTEQSEEGDLPQLPVSPKPDDEQSRSQSPTQLQDSP
                     EAGGEQEEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTG
                     RRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPPTKPRKQYKM
                     AKELRGDDGTTEKLKKAKDSEERRVEQTTPGKTKSDATGQTQLPCQGSSRDSTEQLGP
                     VSGPSPPLTGASSCPEAYKRLLSSFYCKGAHGIMSPLAKKKLLAQVSKAEALQCQEEG
                     CRHGARSPNKDIQDSPQNLRGPAENSEHQLTPREGLQAPGGSTRMEAQVGPCPTAPMF
                     SGCFHAYPTEVLKPVSQHPRDFFSGLKDRVLLGPPGKEEGPTTKESHLVWGGDANHPS
                     AFHKGSTRKRSFYPKPKACWVSPMAKVPTERPGAPSPHPSSPGLGSKRGLEEEGFAHG
                     GKKLRAVSPFLKEVDSKETGGKPAAPGLAVSCLLGPTPGPTPPEAYRGTMLRCPLNFT
                     GSADPLKGQASLPFSPLVIPAFPAHLLATTGSSPMAASLMHFPPTPYDAVLRNRLGPA
                     SSAWHMPPVTTYAAPHFFHLNTKL"
     exon            105..223
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..344
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..397
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..495
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..661
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..5699
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="hexamer: AATAAA"
     polyA_site      2198
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="major polyA site"
     regulatory      4626..4631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="hexamer: AATAAA"
     regulatory      4630..4635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /note="hexamer: AAGAAA"
     polyA_site      4646
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
     polyA_site      4659
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
     polyA_site      5693
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
ORIGIN      
        1 agtcgagcgg cgccggtagt cagtcgcgcc gagagcgctg ggacaggacg gctgtgcgtg
       61 tagagggtct ctgcatagcg acgcgcgctc tcgctgggcc atggcagcac ctccggccaa
      121 agggaacaca gagcagtcag aagaaggtga cctcccgcag cttcctgtat cccccaagcc
      181 agatgatgag cagagcagga gccagagccc cacccagctc caggactccc ctgaggcagg
      241 tggggagcag gaggaggaac aggccttcct ggtcagcctc tacaagttca tgaaggagcg
      301 acacacgccc atcgagaggg tgccccatct tggcttcaag cagattaacc tgtggaagat
      361 ctacaaggca gtggagaagc tgggggccta tgagctggtg acaggccgcc gcctctggaa
      421 gaacgtgtat gatgaacttg gcggtagccc aggcagcacc agtgcggcca catgcacacg
      481 ccgccactat gagaggctgg tcctcccata tgtgcggcat ctgaaggggg aggacgacaa
      541 gccactgcct cctaccaagc ccaggaagca atacaagatg gccaaggagc tgaggggaga
      601 cgatgggacc actgagaagc tgaagaaggc caaggactca gaggagaggc gggtggagca
      661 gaccacgcca ggaaagacca aatcagatgc cactggccag acacagcttc cctgccaggg
      721 atcctcgagg gacagcacag aacagctggg cccagtatct ggaccctctc caccactcac
      781 gggtgctagt agctgccctg aggcctacaa gcggctcttg tcaagctttt actgcaaagg
      841 ggcgcatggc atcatgtcac cactggccaa aaagaaactc ctggcccagg tcagcaaggc
      901 agaggccttg cagtgccaag aagagggctg tcgccatgga gcaaggagcc ccaacaagga
      961 cattcaagac agtccccaga acctaagagg gccggctgag aactctgaac accagctaac
     1021 cccccgggaa ggattgcagg cccctggtgg gagcaccagg atggaggccc aagtgggccc
     1081 ctgccctaca gcccccatgt tctcaggctg ttttcatgcg taccccaccg aggtgctgaa
     1141 acctgtcagc cagcacccta gggacttctt ctccggcctt aaagacaggg tgctgttggg
     1201 accacctggt aaagaagaag gtccgacaac caaagagtcc catctggtgt ggggtgggga
     1261 tgccaaccac ccctctgcat tccataaagg cagcacaaga aaaagaagtt tctaccccaa
     1321 acccaaagcc tgctgggtgt ctcccatggc caaggtccct actgagaggc ctggagcccc
     1381 atcccctcat cccagtagcc caggtcttgg cagtaagcgc ggcttggaag aagagggatt
     1441 cgctcatggt ggcaagaaac tgagggcagt gtctcccttt ctgaaggagg tggattccaa
     1501 ggagactggg ggcaagcctg cagcccctgg cttggctgta tcctgtctac tgggcccaac
     1561 cccggggccc actcctccag aggcctacag gggcaccatg ctgcggtgtc ctctaaactt
     1621 caccggtagc gcagaccctc tgaagggcca ggcctcactc cccttcagcc ccctggtcat
     1681 ccctgctttc ccagcccacc ttctggctac aacaggctcc tcacctatgg ctgccagcct
     1741 gatgcatttc cctcccacgc cctatgacgc tgtcctacgc aacagactgg gtccagcttc
     1801 gtctgcctgg cacatgccac ccgtcacaac ctatgcggca cctcacttct tccacctcaa
     1861 caccaaactg taggccagag cctatcctgc tatgctgtgg aggatttgat gggcagctgc
     1921 cgccattatc tcaggcctga gccgactacc cagattccca ggccagtgag gctccccgag
     1981 tctgtgtctc tctggtacag acagcaggga ggcagtgggg cttgtctgaa tgaagcagcc
     2041 cgggcccaaa gccaggggac caagttgtgg taagatcatg aaagtacctg agctggtatt
     2101 ttctctccac tgagaggccg gggagctagt tggcagctca aggcatccag gttggccatg
     2161 aaagacccaa taaaaagaca ctggtgtgat tgcactcagc cctggggtgt acagcactgg
     2221 atgtttgcaa ggggaggtga ggcaggagca agtgtgtagg tgtggtgacc aatgtgcgag
     2281 caaagatgaa aggaggccac tctggcctgg ctgccatcac cccactggaa gggtggcagg
     2341 gccagagcca aactcagcct ctggtgcaca gatgaacagc tgtgattcct ttcgctccag
     2401 ctccagcctc ggggcacctg actgttgagg ttgccacggt gccaaagccc agagcacact
     2461 ggtgacctgt gagacaagat ggaggggctg tgtcactgca accctctgag ctgagccaca
     2521 cgcccccatc ccagaaggcc tcgggtcttt cagtgaacgg catcacttgc tctgagaggt
     2581 tcttgctgtg ttgctcaggt tagtctcgga ctcccgacct aaagaattcc tgctgcggcc
     2641 ttctcagtag ctggaactac tggtgtgaac ctgtgaagag gggatttgtg ggagctcaca
     2701 taaaacccaa gtgaatctgt cctggtagtg ggcagacctg tgagcccagc tgcctagtgt
     2761 tcccagtgag cgacctgtca cattcacacc tactttcctg ttctacatac tgggtgaagg
     2821 gtagagggga cccatctcta cctgtgaatc tgttgccaag tcacagtgat atttacctgt
     2881 ggttgctcca ggtgcccaca cagaaatccc atggcttggc acccattcct accttggaca
     2941 tggcttgctc tgccagtccc aaggagactg tcagtacagc ttcacactgt tcctggaaag
     3001 gcagtgccac tgtggaccag agatgccagg atgccagtga gccaagtcaa cagatggtta
     3061 ctgacctaca tcatgggaac tcaccctgtt cctgacctca ggccatgggt aggagggcaa
     3121 gtttttatgg cccccttagt tcacaggcgg aatggccaag gccagagaca gcaggtgtca
     3181 ttgaggatgt ctggctctgg gaaacgggtg gccagggaaa gcagctgcct gtggaaaaga
     3241 gctgggacac aggtgtcctc caagaccagg tagctagagg gtaagggtcc cactgatgca
     3301 tcttgcaact ccccaccttc cttctggaga taccaggatg ccagcctgag tattcagatg
     3361 acaagccctg agctcctggc taccccactg cacccatgtg ctacctgtct gggagctttt
     3421 acagccccgt gaggagggat tctaggctag caaatgccct ggctgttggg ctgtacactg
     3481 tggggtcagg tcccaggata gacagagggt accttcgtgc gtgcgtggaa ggatcccctt
     3541 catctacaaa gtaacactag tctcaacctg ctcaaaggtg gcgtatgaca gacagcctga
     3601 taatggtagc ttgttccaag ctgcaggaac ggagccctct gcaggttcat ctggagaata
     3661 cacagctggg agggtagggt gtgtggcttt ctgggttgta ctccactctg cttcagcaaa
     3721 aactctagaa atgaatgcac atcaggcttc ctgggaaatc ttgggacttt gcacccatgc
     3781 gctagcccca catgattctc cttccttctg tgaatgagag aactcagctc agaggtgact
     3841 ccaaacactg tggtacacac accttcctat gttcacttgt gtccctaaca ggttccccca
     3901 gaggacccac aggccagcaa agctcttggc gtctgtgtcc agggcataac ttgtggtctg
     3961 agcctacttc caaatcattc gtgacatttg agctaataat ggtgggagga ggcagaggcc
     4021 actctggtat ttgtgctgac cccacccctg tccgtggtcc tggctcattt ccctggaaac
     4081 agcttaagtg tgatgagttg ggcattcagt gggaaatacc tttgtttgcc ttgggtgtca
     4141 aagcatgctg cccctgtaac tgtcttaggt ggcattggtt agcattacat gtgcatctcc
     4201 cacacgaggc aagtatcacc accgccatag ttgtttggtt ggttggtttt cttggcttct
     4261 ttttaagaca ggatttctct gtgtagccct ggctgacctg gaacttactc tgtagaccag
     4321 gctggtctct aatagaggtc caccctctgc ctctacttgg attaaagata tgcaccacca
     4381 tgcccagcaa ccacctcgcc cagcaaccat cagagtttta aaccgaatgg ctgggaattt
     4441 tcctttgaag accttgcgaa tggctacagg aggtgatgga gaaacagcag caagtccccg
     4501 agggagtggc gagagagtgg ggccaggagc caggggggct gttgggcagg gacggaggaa
     4561 gccagagatg acttaggctg catttagaac cttctagtcc aggaggcagt tgggctttta
     4621 tgtgaaataa agaaagatgg aagagagtcc tggctcccag atttggttgt ttgctttatg
     4681 gtgctaggga tggaaccctg gacatttttt atgctcagca agctctgatc acttgctgca
     4741 tcccagccct ggactctggc aagtggtagg tgtggacact ggagactaga acagagtagg
     4801 gaacgtatcc ttggagatgg cagagtcaac atctggacac aggtctggag atgctgcgga
     4861 cacatctggc cagcgtgtct gtttatactg tgagcagagt gagtgtgggg gctgggcttg
     4921 gagaagggaa gcgagctagg cagtgatcac agtagagcaa agccgtccaa gggcacagcc
     4981 agggcacaag agctcgggtt tccacttgac cttagcagcg tgagtatcat tgcacctagg
     5041 aggccggctg gacacaatct caaggcaagg gacaactaag caccactcca gtgggagccg
     5101 aagtggctgc atgaagggca tcaacagaga accagggaat gaagtgggga tggggggagg
     5161 gagttgggaa cagtgggtaa gatctctaga ctgcagatct tggtgtgctg tggggacttg
     5221 atggggtggg tgcacatgag aggcttggct gaatcagcag ctattggttg ctggatgagc
     5281 tagagcaaga aggggtcaac agagctcagg catgggggac tttgaaacaa gggcagcggg
     5341 catgctgggt gggcacagcc gccagggtaa ggtgtgtagg cacaggaaag gaggtgatgg
     5401 ggcctcagca aaaaacacag cacaggaggc aagaagcaaa ggttaccttc cacatgaagt
     5461 tgctgggctg gccagagcct tagactggca gaatagacat tagagaaggc cagaggcaat
     5521 gaaaaacttc atggctttaa aggaatttta aatcaagagc agaggctgcc tggcatgttt
     5581 agatgtgttt gttttctagt gtgctggatg gaacccagag ccttgggtat gctgggcaag
     5641 tatccaacac tgagctatat catttggtgt tttttaaaaa aaagaattaa caatatttg
//
