LOCUS       NM_194262               6113 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus AT-rich interaction domain 4B (Arid4b), transcript
            variant 1, mRNA.
ACCESSION   NM_194262
VERSION     NM_194262.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6113)
  AUTHORS   Young,I.C., Wu,B., Andricovich,J., Chuang,S.T., Li,R., Tzatsos,A.,
            Wu,R.C. and Wu,M.Y.
  TITLE     Differentiation of fetal hematopoietic stem cells requires ARID4B
            to restrict autocrine KITLG/KIT-Src signaling
  JOURNAL   Cell Rep 37 (8), 110036 (2021)
   PUBMED   34818550
  REMARK    GeneRIF: Differentiation of fetal hematopoietic stem cells requires
            ARID4B to restrict autocrine KITLG/KIT-Src signaling.
REFERENCE   3  (bases 1 to 6113)
  AUTHORS   Terzi Cizmecioglu,N., Huang,J., Keskin,E.G., Wang,X., Esen,I.,
            Chen,F. and Orkin,S.H.
  TITLE     ARID4B is critical for mouse embryonic stem cell differentiation
            towards mesoderm and endoderm, linking epigenetics to pluripotency
            exit
  JOURNAL   J Biol Chem 295 (51), 17738-17751 (2020)
   PUBMED   33454011
  REMARK    GeneRIF: ARID4B is critical for mouse embryonic stem cell
            differentiation towards mesoderm and endoderm, linking epigenetics
            to pluripotency exit.
REFERENCE   4  (bases 1 to 6113)
  AUTHORS   Wu,R.C., Young,I.C., Chen,Y.F., Chuang,S.T., Toubaji,A. and Wu,M.Y.
  TITLE     Identification of the PTEN-ARID4B-PI3K pathway reveals the
            dependency on ARID4B by PTEN-deficient prostate cancer
  JOURNAL   Nat Commun 10 (1), 4332 (2019)
   PUBMED   31551414
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6113)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   6  (bases 1 to 6113)
  AUTHORS   Wu,M.Y., Tsai,T.F. and Beaudet,A.L.
  TITLE     Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic
            modifications and suppresses an imprinting defect in the PWS/AS
            domain
  JOURNAL   Genes Dev 20 (20), 2859-2870 (2006)
   PUBMED   17043311
REFERENCE   7  (bases 1 to 6113)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 6113)
  AUTHORS   Wilsker,D., Probst,L., Wain,H.M., Maltais,L., Tucker,P.W. and
            Moran,E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
REFERENCE   9  (bases 1 to 6113)
  AUTHORS   Martin,N., Jaubert,J., Glaser,P., Szatanik,M. and Guenet,J.L.
  TITLE     Genetic and physical delineation of the region overlapping the
            progressive motor neuropathy (pmn) locus on mouse chromosome 13
  JOURNAL   Genomics 75 (1-3), 9-16 (2001)
   PUBMED   11472062
REFERENCE   10 (bases 1 to 6113)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY720039.1, AK041414.1, BC137783.1 and AK034400.1.
            
            On Oct 31, 2013 this sequence version replaced NM_194262.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137783.1, SRR10223971.13209.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY720039.1         2-9
            9-238               AK041414.1         6-235
            239-5980            BC137783.1         1-5742
            5981-6113           AK034400.1         2162-2294
FEATURES             Location/Qualifiers
     source          1..6113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.29 cM"
     gene            1..6113
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /note="AT-rich interaction domain 4B"
                     /db_xref="GeneID:94246"
                     /db_xref="MGI:MGI:2137512"
     exon            1..249
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            250..304
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..4243
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoblastoma binding protein 1-like 1; AT-rich
                     interactive domain-containing protein 4B; sin3-associated
                     polypeptide p180; ARID domain-containing protein 4B; 180
                     kDa Sin3-associated polypeptide; histone deacetylase
                     complex subunit SAP180; breast cancer-associated antigen;
                     AT rich interactive domain 4B (RBP1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein 4B
                     isoform 1"
                     /protein_id="NP_919238.1"
                     /db_xref="CCDS:CCDS36599.1"
                     /db_xref="GeneID:94246"
                     /db_xref="MGI:MGI:2137512"
                     /translation="MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRH
                     DSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLR
                     RSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSD
                     DDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFK
                     DGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSS
                     EAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLG
                     YRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYG
                     FEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKE
                     ETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRAR
                     TEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEF
                     ECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKI
                     VRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKL
                     DLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEH
                     STHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEE
                     DEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTE
                     NSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNS
                     DERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQ
                     TVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPE
                     SPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGN
                     SSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNK
                     KKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDP
                     DLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRR
                     RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR"
     exon            305..415
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            416..481
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            482..572
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            573..652
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            653..744
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            745..883
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            884..963
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1040
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1195
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1268
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1363
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1461
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1702
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1878
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2139
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2224
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2423
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..3638
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3752
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3968
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4115
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     exon            4116..6113
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5850..5855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /note="hexamer: AATAAA"
     polyA_site      5872
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /note="major polyA site"
     regulatory      6010..6015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
                     /note="hexamer: ATTAAA"
     polyA_site      6032
                     /gene="Arid4b"
                     /gene_synonym="BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180"
ORIGIN      
        1 aagcgatgtt tgcccgtcag tcgagtccgg agtgaggagc tcgggcgctg gagcggaggg
       61 agagtctcga gccgcagttt gccgccgcga cggccaccgc ctggacttct gcccggaggg
      121 agccgctgaa ggtcggccgc cgtgttcctc tggagggctg tgagaccggg gcccggacct
      181 ccgtccgaga gggatttttt tgtcgccccc ctccccccgc gagggagccg gagcggccgc
      241 caaacaaagg tgcaggtgaa gctggtgtcg ccgtggggat cgcggcccca gagtcaccat
      301 gaaggccctt gatgaacctc cttatttgac agtgggcact gatgtgagtg ccaaatacag
      361 aggagccttc tgtgaagcca agatcaagac tgcaaaaaga cttgtcaaag tcaaggtgac
      421 ttttagacac gattcttcaa cagtggaagt tcaggatgac cacataaagg gcccactgaa
      481 ggtaggagct attgtggaag tgaagaatct tgatggtgcc tatcaggaag cggttatcaa
      541 taaactgaca gatgcaagtt ggtatactgt ggtttttgat gatggagatg agaagacact
      601 gagaagatct tcattatgtc tgaaaggaga gagacatttt gctgaaagtg aaacactaga
      661 ccagctccca ctcaccaatc ctgagcattt tggcactcca gtcataggaa agaaaacaaa
      721 tagaggaaga agatctaacc atataccaga ggaggagtct tcctcctcat ccagtgatga
      781 cgatgaggag gagaggaaac agactgatga gctactaggc aaagttgttt gtgtagatta
      841 tgttagcttg gagaaaaaga aagcgatgtg gtttcctgca ctggtggttt gtcctgactg
      901 tagtgatgag attgctgtga aaaaagacaa tattcttgtt cggtctttca aagatggcaa
      961 atttacttca gttccaagaa aagatgtcca tgaaattact agtgacactg taccgaagcc
     1021 tgatgctgta ttaaaacaag cctttgatca ggcacttgag tttcacaaaa gtagagctat
     1081 tcctgctaat tggaagactg aattgaaaga agacagctcc agtagtgaag ctgaggagga
     1141 ggaggaggag gaagatgatg aaaaagagaa agaagataac agcagcgaag aagaggaaga
     1201 aatagaacca tttccagagg aaagggagaa ctttcttcag cagctgtata agttcatgga
     1261 ggatagaggt acacctatta acaaacggcc tgtgcttggg tatcgaaatt tgaatctttt
     1321 taagttattc agacttgtgc acaaacttgg agggtttgat aatattgaaa gtggagctgt
     1381 ttggaagcaa gtctatcaag accttgggat ccctgtctta aattcagctg caggatacaa
     1441 tgttaaatgt gcttataaaa agtacttata tggctttgag gagtactgca ggtcggctaa
     1501 tattgacttt cagatggcat tgccagagaa agttcttaac aagccatgta aagattgtga
     1561 aaataaagaa gtaaaagtta aggaagaaag tgaaacagag attaaagaag taaatgtgga
     1621 agacagtaag aacgtgatgc caaaagagga gacgcctgct gaggatgaaa gtgaaagaaa
     1681 agaaaatatc aagccctctc tgggaagtaa aaaaagctta ttagaatgta tacctgcaca
     1741 atctgatgaa gaaaaagaag ctcacattac aaaactcgaa gaaaatgaaa acttggaaga
     1801 taaagacggt ggcagagcta ggaccgagga ggccttcagc acagaggtag atggtgaaga
     1861 agagcaagca cgatctggag atgaaaccaa taaagaagaa gatgaagatg atgaagaaat
     1921 agaagaggag gaggaagaag acgaggaaga agacgaggat gaagatgatg atgacaacaa
     1981 tgaagaagag gagtttgagt gctatccacc aggcatgaaa gtccaagtgc ggtatggacg
     2041 agggaaaaat caaaaaatgt atgaagctag tataaaagat tctgatgtcg aaggtggaga
     2101 ggccctttac ttggtgcatt actgcggatg gaatgtgaga tatgatgaat ggattaaagc
     2161 agataaaata gtaagacctg ctgataaaaa tgtaccaaag atcaaacatc ggaagaaaat
     2221 aaagaataaa ctagacaaag aaaaagacag agatgaaaaa tactctccta agaactgtaa
     2281 acttcgacgc ttgtcaaaat caccgtttca gtcaaatcca tctcctgaga tggtttccaa
     2341 actagatctt gctgatgcca aaaactctga tacagctcat attaaatcta tagaaattac
     2401 ttccattctt aatggactac aagcttctga aagttcggct gaagacagtg agcaggaaga
     2461 tgagagatgt actcaggacg tagataacat tggcaaagac gaatcaaagg tggaacattc
     2521 aacccacagc agaaatgaac tgatttcaaa agaggaacag agtagtccat ctttgctaga
     2581 agaaaacaaa gtccatacag atttggtaat agccaaaaca gtgtcaaaat ctccagaaag
     2641 attaagaaaa gatatggaag caatatcgga agatactgat tttgaagagg aagatgaaat
     2701 cacaaagaag agaaaggatg ttaaaaagga cacaacagac aaggctttaa agccacaaac
     2761 aaaacgtggg aaaagacggt attgcagtgc agatgaatgt ttgcagactg gatcccctgg
     2821 caagaaggaa gacagaacca agagtaaaga gccgctctgc acagaaaaca gtagtaacag
     2881 ctcctcagat gaagatgaag aagaaaagtc caaagcaaag atgacaccaa ccaagaaata
     2941 taatggctta gaagaaaaga gaaaatctct gcggacaact agtttctatt caggattttc
     3001 agaagtagca gaaaaaagga taaagctttt aaataactct gatgaaagac ttcagaacaa
     3061 cagggctaaa gatagaaaag atgtctggtc aagtattcag ggacagtggc ctaagaaaac
     3121 gctaaaggag cttttctctg actcggacac tgaggctgca gcttctccac cccatcctgc
     3181 cccagatgag ggggcagtag aggagtcact gcagactgtg gcagaagagg agagttgttc
     3241 acccattatg gagctagaaa agccactacc tgccagtgtt gacaataagc ccattgaaga
     3301 aaaaccccta gaagttagtg ataggaaaac agaatttccg agcagtggca gtaattcagt
     3361 gctcaatacc ccacctacca caccagagtc gccttcttca gtcactataa cagaagctag
     3421 tcagcagcag tcttctgtca cagtgtcagt gcccctgcct ccaaaccagg aagaggttcg
     3481 aagcattaag agtgaaactg acagcacaat tgaggtggac agtgttgtgg gggagctcca
     3541 ggacctccag tcggagggga atagctcacc agcaggcttt gatgcgagcg tgagttccag
     3601 cagtagcaat cagccagaac cagataaccc agaaaaagcc tgtacaggtc agaaaagagt
     3661 gaaagatact cagggagtag gaagttcatc aaaaaagcag aagagaagcc ataaagccac
     3721 cgtggtgaac aacaaaaaga agggaaaagg cacaaacagt agtgacagtg aagaactctc
     3781 agctggtgaa agtgtgacta agactcagac aatcaagtca gtccccaccg gaatgaagac
     3841 ccacaacagc aagtctccag caagggtaca gtctccagga aaaggtggca ggaatgggga
     3901 taaagaccct gatctcaagg agcctagtaa ccggcttccc aaggtttaca agtggagttt
     3961 tcagacgtcg gacctggaaa atatgacaag tgctgaacgt atctcaattc ttcaagaaaa
     4021 attgcaagaa atcagaaagc attatctgtc tttaaaatct gaagtagctt ccattgatag
     4081 gaggagaaaa cgtttaaaga agaaagagag agaaagtgct gctacatctt cttcctcctc
     4141 ttctccctcg tccagctcca tcacagctgc tgttatgttg acactagctg aaccatcaat
     4201 gtccagtgca tcacagaatg gaatgtcagt tgagtgcagg tgacagcagg acttgctaga
     4261 gcactttgca cttaatggct gttgagggcc acatcttttt ttatactgca cagtggcaca
     4321 caaacacaca aaatcagaca agcactattt tatatttaaa aattatttct tgacaagctg
     4381 acttggcact taagtgcact ttttttatga agaaaaagta caacgaactg cttttcctca
     4441 agcaataatt gtttccaact tgtctgggaa ttgcgtgtgt ctggtaactt gaaggccttc
     4501 cactgtggca gaggaggctt ttcactgcct gtagagacga cacagtaggc agagaaaagg
     4561 tgggccagaa catgtgagaa gacttactgt atatgtattc ccttgtattt tgttaaagct
     4621 ggaacatttg atatttttcc attcatttat taaaaatatg aacctatttt catttgtaca
     4681 agctaattgt tttttaaagc aagtcacttt agggtgactt taattgtata agtcaagcac
     4741 atgtaacaaa ttcaagactt gcagttagtt aacaggatat tattagacat catcctggta
     4801 accaaatatt aaagattctc tttaaaaatg actgaacatg tttacaggtt tgaattaggc
     4861 taaaaggtct gtggtggctt ttcacacccc ttcaaattga aatgggacta ctgtactttg
     4921 ccatttttct ataaatcagt attttttttt aattttgata taatacattg tgtgaaaaaa
     4981 gaaaatggct aataaactgt attaaatctt aaacaatgta taaagattgt acttagccag
     5041 ttcaaagtgt atatttattc ataatgaatt ataacagtta tatttttgtg ttttcttgta
     5101 aatgtttctt ttcccttaaa tacagataat tcatttgtat tgcttatttt attatgagct
     5161 tacaacaaaa agacttcagg aacaaactgt tagaatggtt caaggttgtt tatatgacct
     5221 gcctcacaaa gatggttatt attttaagta taagtagcta gttgggtagt aggcctatac
     5281 aattcaatgc cttgtataaa ctgcagaatg aacgccaagc tgttttcact tgtattgact
     5341 ttatgttgta tgattccaat ctctgtttgg cacttgtatt taattcccca cctttgtaat
     5401 acatttgtat attgcggatg tgttcattga ggctatttaa aacctggcgc tgttaataca
     5461 cagtacttca ctgtacagac cgttttactg ttttaattgt gattctgtgt gctttttttg
     5521 aatgaggctg gcatgtttta tttgttttct ggcaatacat gtgagaatct cgaagcgttt
     5581 tgttgtagat gctaacgtgt cagaatcctt aatcctttac attgaacctt tctaagaaaa
     5641 gcattttcag tcttgtaatg tgtgcttaca gtaactaatt ttgttgaaaa atgatttcaa
     5701 attactcaaa tttgtacaga ctgtaaagat ttgttgacag caaaatgttg aagaaaaaac
     5761 ttatagaata aaactataaa gtatatatta ggatctgcaa acatgatgaa ttatgtaata
     5821 tattgtacaa atgtaagcaa aagctctgaa ataaaatgcc atagtttgtg aatccttgat
     5881 tttgtttgta gaaggtaaag taatttgagt tcactttgta tgtgatgagt gctgagagtc
     5941 catgcagcct gtattaccta tcacaagggc tcacatccgt atcccaaagg gagtgttccg
     6001 ctgttcaaaa ttaaaagtcc ctttatacag tgctgggttg tatagcatgt acttagtgtg
     6061 ctccagtcct tggcttcagt tcgcagcact gcaccaaatc aaaccgtaaa ttc
//
