LOCUS       NM_001081195            5780 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus AT-rich interaction domain 4A (Arid4a), mRNA.
ACCESSION   NM_001081195 NM_170595 XM_354675
VERSION     NM_001081195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5780)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   3  (bases 1 to 5780)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5780)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   5  (bases 1 to 5780)
  AUTHORS   Wu,R.C., Zeng,Y., Chen,Y.F., Lanz,R.B. and Wu,M.Y.
  TITLE     Temporal-Spatial Establishment of Initial Niche for the Primary
            Spermatogonial Stem Cell Formation Is Determined by an ARID4B
            Regulatory Network
  JOURNAL   Stem Cells 35 (6), 1554-1565 (2017)
   PUBMED   28207192
REFERENCE   6  (bases 1 to 5780)
  AUTHORS   Wu,M.Y., Tsai,T.F. and Beaudet,A.L.
  TITLE     Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic
            modifications and suppresses an imprinting defect in the PWS/AS
            domain
  JOURNAL   Genes Dev 20 (20), 2859-2870 (2006)
   PUBMED   17043311
REFERENCE   7  (bases 1 to 5780)
  AUTHORS   Wilsker,D., Probst,L., Wain,H.M., Maltais,L., Tucker,P.W. and
            Moran,E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
REFERENCE   8  (bases 1 to 5780)
  AUTHORS   Gonzalo,S., Garcia-Cao,M., Fraga,M.F., Schotta,G., Peters,A.H.,
            Cotter,S.E., Eguia,R., Dean,D.C., Esteller,M., Jenuwein,T. and
            Blasco,M.A.
  TITLE     Role of the RB1 family in stabilizing histone methylation at
            constitutive heterochromatin
  JOURNAL   Nat Cell Biol 7 (4), 420-428 (2005)
   PUBMED   15750587
  REMARK    GeneRIF: The retinoblastoma binding protein 1 shows a marked
            genomic instability, which is coincidental with decreased DNA
            methylation, increased acetylation of histone H3 and decreased
            tri-methylation of histone H4 at lysine 20 (H4K20).
REFERENCE   9  (bases 1 to 5780)
  AUTHORS   Meehan,W.J., Samant,R.S., Hopper,J.E., Carrozza,M.J., Shevde,L.A.,
            Workman,J.L., Eckert,K.A., Verderame,M.F. and Welch,D.R.
  TITLE     Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with
            retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone
            deacetylase complex and represses transcription
  JOURNAL   J Biol Chem 279 (2), 1562-1569 (2004)
   PUBMED   14581478
  REMARK    GeneRIF: RBP1 and the mSin3 histone deacetylase complex bind to
            BRMS1 and repress transcription
REFERENCE   10 (bases 1 to 5780)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132325.4 and AC112794.4.
            
            On or before Jun 3, 2008 this sequence version replaced
            NM_170595.1, XM_354675.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.164469.1,
                                           SRR1660817.153568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC132325.4         138231-138425
            196-253             AC132325.4         139355-139412
            254-364             AC132325.4         141638-141748
            365-430             AC132325.4         144457-144522
            431-521             AC132325.4         145764-145854
            522-601             AC112794.4         92904-92983         c
            602-696             AC112794.4         92728-92822         c
            697-829             AC112794.4         90122-90254         c
            830-909             AC112794.4         84990-85069         c
            910-986             AC112794.4         83903-83979         c
            987-1153            AC112794.4         82733-82899         c
            1154-1226           AC112794.4         69959-70031         c
            1227-1321           AC112794.4         68717-68811         c
            1322-1419           AC112794.4         68465-68562         c
            1420-1651           AC112794.4         66769-67000         c
            1652-1911           AC112794.4         62755-63014         c
            1912-2109           AC112794.4         60062-60259         c
            2110-2194           AC112794.4         58201-58285         c
            2195-2336           AC112794.4         57362-57503         c
            2337-3470           AC112794.4         54024-55157         c
            3471-3575           AC112794.4         53546-53650         c
            3576-3782           AC112794.4         43432-43638         c
            3783-3929           AC112794.4         42486-42632         c
            3930-5780           AC112794.4         30742-32592         c
FEATURES             Location/Qualifiers
     source          1..5780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.39 cM"
     gene            1..5780
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="AT-rich interaction domain 4A"
                     /db_xref="GeneID:238247"
                     /db_xref="MGI:MGI:2444354"
     exon            1..195
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..253
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..4033
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="AT rich interactive domain 4A (Rbp1 like);
                     retinoblastoma-binding protein 1; ARID domain-containing
                     protein 4A; AT rich interactive domain 4A (RBP1-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     4A"
                     /protein_id="NP_001074664.1"
                     /db_xref="CCDS:CCDS36471.1"
                     /db_xref="GeneID:238247"
                     /db_xref="MGI:MGI:2444354"
                     /translation="MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQ
                     DNTTQLVQDDQVKGPLRVGAIVETRTSDGSIQEAIISKLTDASWYTVVFDDGDERTLR
                     RTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESS
                     EEEDEDKRRLNDELLGKVVSVASTAESTGWYPALVVSPSCNDDVTVKKDQCLVRSFID
                     SKFYSIARKDIKELDILTLPESELCARPGLRRASVFLKGRIVPDNWKMDISEILESSS
                     SDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKPP
                     VLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKY
                     LYGFEEYCRSANIQFRTIHHHEPKVKEEKKDFEDSMDEALKEAPEMPLLDVKSEPEEN
                     TDSNSESDREDTELKSPRGRRKIVRDANCIKKEIEEEKIEDKFLRDDLENKDAGDDDD
                     DGDPAAKREHELLFGRKSTPKNKEKKIKKPEDSERDSDEEEEKSQEREETESRCDSEG
                     EDEEDDTEPCLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDE
                     WVKADRIIWPLDKGGPKKKQKKKVKNKEDSEKDEKRDEERQKSKRGRPPLKSTFSPNM
                     PYSLSKTSNSEGKSDSCSSDSEADDQLEKSSGGEDLSPDVKEELEKNENAHDDKLDEE
                     NPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKG
                     RRSKTKDLSLELIKISPFGQEEAGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEK
                     KLKRKILGQQSPEKKLRLDNGMEMTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGM
                     PSLTAEPDQGLQELTSEKSDSPAEEEPVHTPLKEEEDAMPLIGPETLVCHEVDLDDLD
                     EKDKTSIEDVVVEGSESNSLASVPPALPPVAQHNFSVASPLTLSQDESRSIKSESDIT
                     IEVDSIAEESQEGLCERESANGFEASVASGACSIIAHERESREKGQKRPSDGNSGLIA
                     KKQKRTPKRTSAAAKTEKNGAGQSSDSEDLPAMDSSSNCTPVKRLTLPKSQKLPRSPA
                     RTSPHIKDAEKEKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY
                     MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR"
     exon            254..364
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..430
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..521
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..601
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..696
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..829
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..909
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..986
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1153
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1226
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1321
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1419
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1651
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1911
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2109
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2194
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2336
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..3470
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3575
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3782
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3929
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..5780
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="hexamer: AATAAA"
     polyA_site      5021
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="major polyA site"
     regulatory      5480..5485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="hexamer: ATTAAA"
     polyA_site      5499
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
     regulatory      5679..5684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="hexamer: AACAAA"
     polyA_site      5699
                     /gene="Arid4a"
                     /gene_synonym="A630009N03; A630067N03Rik; Rbbp1"
                     /note="major polyA site"
ORIGIN      
        1 aataggagtt cgtgtagaag cgagtctgct caacagcttg ttatttggtg gattgtggca
       61 gtaaatcggg gcgagtgggg gaacccggcg caggaactgc cgctgcggcc gggagcggtg
      121 ctgcccggac ggggacccac ggcgatcagt ggggcggcag actggagagc tgacagcgct
      181 ctgcacccgc agtagcgccc gggaagagaa ctcgaggaag ctggaacccc acaggtcacc
      241 agtcaagatg aaggcggcag atgagcctgc ctacctgaca gtgggaactg atgtcagtgc
      301 caagtaccga ggggccttct gtgaggcaaa gatcaagact gtgaaaaggc tggtgaaagt
      361 caaggtactt ctgaagcagg ataacacaac acagttggtg caagatgacc aagtaaaggg
      421 ccctttaaga gttggagcta ttgtagaaac aaggacatct gatggatcta tccaggaagc
      481 tattatcagc aaattgacag atgctagttg gtatactgtg gtgtttgatg acggtgatga
      541 gagaactctg aggcggacct cactttgcct gaaaggggag agacattttg ccgagagtga
      601 gactctggat cagcttcctc taacaaaccc agagcatttt gggacgccag tcattgcaaa
      661 gaagaccaac agagggagga ggtcctcact gcctatcact gaagacgaaa aggaagaaga
      721 aagcagcgaa gaggaagatg aagataagag gcgtctcaat gacgaattat taggaaaagt
      781 tgtaagtgtg gcctccacag cagagagcac tggatggtac cctgctttgg ttgtctctcc
      841 cagctgcaat gatgacgtca cagtgaaaaa agatcagtgt ttagttcgat catttattga
      901 ttctaaattt tattctatag caagaaagga cattaaggaa ctggacattc tcactctacc
      961 agaatctgag ctctgtgcta ggccagggct gcgaagagca agtgtcttcc taaaaggtag
     1021 gattgttcct gataattgga aaatggatat aagtgaaatc cttgagtcct ccagcagtga
     1081 tgacgaagaa tgcccagctg aggaacatga agaggagaag gaaaaagagg ccaaaaagga
     1141 ggaagaagag ctgcctgagg aagagcttga tcctgaggag agggacaatt tcctccaaca
     1201 gctttataag tttatggaag acagaggtac tccgatcaac aaaccacctg ttttgggcta
     1261 taaagatctc aatctcttca aactctttag actggtctat catcaggggg gatgtggcaa
     1321 tattgacagt ggtgctgtat ggaagcaaat ttatatggac cttggcattc caattttgaa
     1381 ttcagctgct tcctacaatg taaaaactgc ttatagaaaa tatctctatg gttttgagga
     1441 gtactgccgt tctgcaaata ttcagttcag aactattcac caccatgaac caaaagtaaa
     1501 agaggaaaaa aaagactttg aagactcaat ggacgaagct ctaaaagagg ccccggaaat
     1561 gcctttgctg gacgtgaaga gtgagcccga ggagaatacg gactcaaaca gtgaaagcga
     1621 cagagaagac acagagctaa agtcgccaag agggagaagg aaaattgttc gagatgcaaa
     1681 ctgtatcaag aaggaaatag aggaagagaa aatcgaagac aaattcctcc gagatgattt
     1741 agaaaataag gacgcaggtg atgacgatga cgatggcgac ccagcagcga agagagagca
     1801 tgagctgctg ttcgggagga agagcacacc aaagaacaaa gagaagaaga ttaaaaagcc
     1861 agaggactct gagagagact cagatgaaga ggaagagaag agccaagaga gggaagagac
     1921 tgagagccgg tgtgactcgg aaggggagga cgaggaggac gacacagagc cctgcctgac
     1981 gggaaccaaa gtgaaggtca agtacggacg aggaaaaact cagaaaattt atgaagccag
     2041 catcaaaagc acggagatgg acgacgggga gattctgtac ctagtgcact actacggatg
     2101 gaacgtcaga tatgatgaat gggtaaaagc tgacaggata atctggccct tggacaaagg
     2161 tggaccaaag aaaaaacaaa agaagaaagt taagaataaa gaagatagtg aaaaggacga
     2221 aaagagggat gaagagaggc agaagtccaa acggggaaga ccacctttaa aatctacttt
     2281 ttcgccaaac atgccataca gtttatctaa gacgtcaaac agtgaaggaa aatcagactc
     2341 ctgttcatct gatagtgagg cagacgacca gctggagaag agctcagggg gtgaagatct
     2401 ttctcctgat gtcaaagaag aattggaaaa aaatgaaaat gcacatgatg ataaactaga
     2461 tgaagaaaac ccaaagattg tacatatatc aaaagaaaac gacaggactc aggcacagcc
     2521 ctcagacacc ctgacggtgg aggcagggga cagcgatcaa attgtgcata tttttggaga
     2581 caaagtggac caagtagaag aatttaagaa acaggtggaa aagtctccca aagggaaggg
     2641 aaggcgcagc aagacaaaag acctttcgtt agaacttata aagatttcac ctttcggcca
     2701 ggaggaagca ggcagcgaag ctcatgggga cgttcatagc ctggagtttt cttcactaga
     2761 atgtaaaaac ttttcttcta ctgaagatga catcgaccca tatgagaaag aaaaaaagtt
     2821 gaaacgaaaa atcctgggac agcaatcccc agaaaaaaaa ttgagacttg ataatggcat
     2881 ggaaatgaca actggagtgt cccaagagag gtctgacgat ggcgcgggag ccgagggcat
     2941 gaaaggcgca cacgtggaac agcactttga aacagaaggt gaagggatgc catcgctgac
     3001 agccgagccc gaccagggcc ttcaagaact gactagtgag aaatcggaca gtccagccga
     3061 agaagaaccg gtgcacacgc cactcaaaga agaggaggat gcgatgcctc tgatcgggcc
     3121 tgaaaccttg gtttgccatg aggtagacct ggatgattta gatgagaagg ataagaccag
     3181 tattgaggat gtggtagtag aaggctctga gtctaactct ctggcttccg taccacctgc
     3241 cttacctcct gtagcacagc ataacttttc cgtagcttcc ccactcactc tcagccaaga
     3301 cgagtcccga agtataaaga gtgagagtga cattacaatt gaagttgata gcatcgccga
     3361 agaatcacaa gaaggcctct gtgagaggga atcggcgaac gggtttgaag ccagtgttgc
     3421 ctctggtgcc tgtagtataa ttgcacacga gcgagagagc agagagaagg gtcagaaaag
     3481 gccaagcgat ggaaatagtg gattaattgc aaaaaagcaa aagcgaaccc caaagcggac
     3541 aagtgctgca gccaaaactg aaaagaacgg agcaggacag agcagtgaca gcgaggacct
     3601 ccccgccatg gacagctcca gtaactgcac cccagtgaag cgccttaccc tgcccaagtc
     3661 acagaagctg ccacggtctc ctgcaagaac ctcgcctcac atcaaagatg cagagaagga
     3721 gaagcaccga gagaagcatc cgaactcctc ccccaggaca tacaagtgga gcttccagct
     3781 caatgaatta gataatatga acagtacaga gagaatctct tttctccaag aaaaactaca
     3841 ggaaatcaga aaatactaca tgtctttgaa gtctgaagtt gcaaccatcg acagaaggag
     3901 gaaaagattg aaaaagaaag acagagaagt gtctcacgca ggagcgtcaa tgtcctctgc
     3961 ttcatcagac actggaatga gcccttcttc atcgtctccc ccccaaaatg tacttgctgt
     4021 agagtgcagg tgatgaacag ttctccaccc cacagcagtt tgctgccatg gacataaatc
     4081 cccaaaccct gaaatacaac cacagaaagc actcagccgg ctaagtatat ccttcctgta
     4141 tagtttccag gattgtatct agaccctcct ctctcctttt tttattgttg cagaaaataa
     4201 gcttattaat aattgaaggt taggcagcct gccatattgg tcataatttt tcctctgtat
     4261 tttctttctt tctttctttt tttttttgtg tgtgtgtgtg tgatagagaa aaaaaagggc
     4321 acttagcaaa atggaatttg tataataaag ctttcaagtg ttctagaaat catagacaag
     4381 cgcacacaac agacaggaga gcattatctg gttagcagtt actgctgcac tttcactgag
     4441 atgcattgaa cacttggtga gtagggggtt gattttgttt tattcttgta ttattataat
     4501 tattataata attattatta atgttgattt tttattcatt tcaattttgt ggaagcactt
     4561 gctatgtaga actgccaaag tatatgtgca gcagtgtgcc caggtttaaa agtgtaaatg
     4621 ggacaaaata aattgtgaaa ggaagtgtag ttgactgaaa actgcagttg taataagtct
     4681 tccacttttt ataggacttt tgagcacaca attatgcaaa tattttaatg tttattaatg
     4741 tttacagtgg aattgtgaat aagttttcag tggactatct tatcccttga caaaaatatt
     4801 ttgtcttttt tctatgtaat ttcagagttt ttattttgtt acaaaaatac aaaaatgaaa
     4861 tatataacaa caatgaagtt atttaacaag atttctaaag ctgaaaattt tgtgtaaaat
     4921 aaggtattat cttgcaactt gttaaatata tttattcaga cattggatgg ttgtattttt
     4981 atgtattttt taaaatatta ataaaattga aaaaaagaca attctaggtt aattcactct
     5041 ttggatggca gtagtggtca gctgcccctt ttgcaggggg ctgtgtctgc agccgcgggt
     5101 gctgcagggc gtctgtctca accttcccaa ccgagcagct gagagtgggc atctgggtca
     5161 ctcaagtctg tccttgttta gaaactttgg cagtcctcgt atttaaacca ctttgaggat
     5221 cacatttttg gttgccctta agatgctttg tcacagtttt tgtgttcgct gtactgccga
     5281 ataaatttta tatctcccaa agtcaagatg caacagtcac gtaaagccac tatgtattct
     5341 ttgtctgtga attgttacac agactgatac atttgtaaat aattcttcca aaatcatgta
     5401 tttaaagcag ttttgcatat acattatgtt aaaaaaaagg tgattttttt aaaaagcatt
     5461 tttaaactca tgtttgtaca ttaaaggggt tgttttgaag cctccttttc tgtgtttata
     5521 tgctgtagtg tggtagcccg gggggttttg accctgaggg cggacagagg cacagcacat
     5581 tgctacagca gagcattacc gaaattatat ttctccacgt catcttgcca cattgtgaac
     5641 ctgggattca gacttcttcc attttctcag agaattaaaa caaaaaagta ctcttgtaat
     5701 atgaactttc ctgtcttttc tttgcaaaca gaagtatctc aatgtcaaat aaaaaggagc
     5761 ccagtgggcg tgtcttaaac
//
