LOCUS       NM_001288625            5207 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus AT-rich interaction domain 3A (Arid3a), transcript
            variant 2, mRNA.
ACCESSION   NM_001288625 XM_006513200
VERSION     NM_001288625.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5207)
  AUTHORS   Renaux,E., Baudouin,C., Schakman,O., Gay,O., Martin,M.,
            Marchese,D., Achouri,Y., Rezsohazy,R., Gofflot,F. and Clotman,F.
  TITLE     Arid3c identifies an uncharacterized subpopulation of V2
            interneurons during embryonic spinal cord development
  JOURNAL   Front Cell Neurosci 18, 1466056 (2024)
   PUBMED   39479525
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5207)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5207)
  AUTHORS   Chen,R., Huang,B., Lian,M., Wei,Y., Miao,Q., Liang,J., Ou,Y.,
            Liang,X., Zhang,H., Li,Y., Xiao,X., Wang,Q., You,Z., Chai,J.,
            Gershwin,M.E., Tang,R. and Ma,X.
  TITLE     A+T rich interaction domain protein 3a (Arid3a) impairs
            Mertk-mediated efferocytosis in cholestasis
  JOURNAL   J Hepatol 79 (6), 1478-1490 (2023)
   PUBMED   37659731
  REMARK    GeneRIF: A+T rich interaction domain protein 3a (Arid3a) impairs
            Mertk-mediated efferocytosis in cholestasis.
REFERENCE   4  (bases 1 to 5207)
  AUTHORS   Shinton,S.A., Brill-Dashoff,J. and Hayakawa,K.
  TITLE     Pla2g2a promotes innate Th2-type immunity lymphocytes to increase
            B1a cells
  JOURNAL   Sci Rep 12 (1), 14899 (2022)
   PUBMED   36050343
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5207)
  AUTHORS   Wang,Q., Li,N., Guo,X., Huo,B., Li,R., Feng,X., Fang,Z., Zhu,X.H.,
            Wang,Y., Yi,X., Wei,X. and Jiang,D.S.
  TITLE     Comprehensive analysis identified a reduction in ATP1A2 mediated by
            ARID3A in abdominal aortic aneurysm
  JOURNAL   J Cell Mol Med 26 (10), 2866-2880 (2022)
   PUBMED   35441443
  REMARK    GeneRIF: Comprehensive analysis identified a reduction in ATP1A2
            mediated by ARID3A in abdominal aortic aneurysm.
            Erratum:[J Cell Mol Med. 2022 Sep;26(17):4740. doi:
            10.1111/jcmm.17484.. PMID: 36063151]
REFERENCE   6  (bases 1 to 5207)
  AUTHORS   Rajaiya,J., Hatfield,M., Nixon,J.C., Rawlings,D.J. and Webb,C.F.
  TITLE     Bruton's tyrosine kinase regulates immunoglobulin promoter
            activation in association with the transcription factor Bright
  JOURNAL   Mol Cell Biol 25 (6), 2073-2084 (2005)
   PUBMED   15743806
  REMARK    GeneRIF: The ability of Bright to enhance immunoglobulin
            transcription critically requires functional Bruton's tyrosine
            kinase .
REFERENCE   7  (bases 1 to 5207)
  AUTHORS   Nixon,J.C., Rajaiya,J. and Webb,C.F.
  TITLE     Mutations in the DNA-binding domain of the transcription factor
            Bright act as dominant negative proteins and interfere with
            immunoglobulin transactivation
  JOURNAL   J Biol Chem 279 (50), 52465-52472 (2004)
   PUBMED   15456761
  REMARK    GeneRIF: identify regions within Bright that are required for the
            DNA binding activity of Bright and for its function as a
            transcription factor
REFERENCE   8  (bases 1 to 5207)
  AUTHORS   Goebel,P., Montalbano,A., Ayers,N., Kompfner,E., Dickinson,L.,
            Webb,C.F. and Feeney,A.J.
  TITLE     High frequency of matrix attachment regions and cut-like protein
            x/CCAAT-displacement protein and B cell regulator of IgH
            transcription binding sites flanking Ig V region genes
  JOURNAL   J Immunol 169 (5), 2477-2487 (2002)
   PUBMED   12193717
  REMARK    GeneRIF: Variations in Bright binding and matrix attachment region
            activity contribute to localized control of accessibility and
            therefore nonrandom gene use during V(D)J recombination.
REFERENCE   9  (bases 1 to 5207)
  AUTHORS   Kortschak,R.D., Reimann,H., Zimmer,M., Eyre,H.J., Saint,R. and
            Jenne,D.E.
  TITLE     The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene
            structure, and mapping to D19S886, a marker on 19p13.3 that is
            strictly linked to the Peutz-Jeghers syndrome
  JOURNAL   Genomics 51 (2), 288-292 (1998)
   PUBMED   9722953
REFERENCE   10 (bases 1 to 5207)
  AUTHORS   Herrscher,R.F., Kaplan,M.H., Lelsz,D.L., Das,C., Scheuermann,R. and
            Tucker,P.W.
  TITLE     The immunoglobulin heavy-chain matrix-associating regions are bound
            by Bright: a B cell-specific trans-activator that describes a new
            DNA-binding protein family
  JOURNAL   Genes Dev 9 (24), 3067-3082 (1995)
   PUBMED   8543152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141283.1 and BP763961.1.
            
            On Jan 5, 2014 this sequence version replaced XM_006513200.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141283.1, SRR11927934.4936457.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4883              AK141283.1         2-4884
            4884-5207           BP763961.1         49-372              c
FEATURES             Location/Qualifiers
     source          1..5207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..5207
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:13496"
                     /db_xref="MGI:MGI:1328360"
     exon            1..60
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..714
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1027
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1100
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1284
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1532
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1829
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1928
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..5207
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5177..5182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /note="hexamer: ATTAAA"
     polyA_site      5204
                     /gene="Arid3a"
                     /gene_synonym="Bright; Dri1; Dril1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacctcg tccctatccg atccagacgg atggagatgt agacgcggcc tggagactcg
       61 gagtctgcag gtgcttgaat gagcccaaca ccagtctctg cccctgggtg cctgacgtaa
      121 caaggatccc actggtggct cctggcatgc cccactagcc ttcagcctga gttggcagcc
      181 cctgtctctg ccagccgcca ccctgcactg ttccggctcc cccgaggtcc ccacgctgca
      241 gtgcggccaa gacccttccc cgcaggggcc acccccacca actgcccctg gtgcccgggg
      301 tggcccggcc cgcagggcca tgaagctgca ggctgtgatg gagactctca ttcagaggca
      361 gcagcgtgcc cggcaggaac tggaggctcg gcaggctcca ccacccccac cacctgagcc
      421 cactggagtc cgggcacgga ccaccatgac agatgaggac agggagcctg agaatgcccg
      481 gatgcatagg actcagatgg ccgcactggc tgccatgcga gctgctgctg ccggcttggg
      541 acatccgtcc tctcccgggg gctctgagga tgggcctccc atctctgggg atgaagacac
      601 agcccgggaa gggactctga gttcacctgc cctgcatgga agtgtcctgg agggagcagg
      661 acacgctgag ggagataggc atttgatgga cgtgggctct gatgatgatg acacgaagtc
      721 caagtgggaa gagcaagagc tggaagaact gggggaggag gaagaggagg aggaagagga
      781 agatgacttt gaagaagagg aggaggaaga agaaggcctg ggccccccag agtctgccag
      841 cctgggcact gcaggcctgt tcacccgcaa ggccccgccc gcccaggctt tccgtggaga
      901 cggtggtccc aggatgctga gtggccctga gcgtctggga cctggcccag cccaccccag
      961 tcatatggca tcccagatgc caccaccgga ccatggggac tggacctttg aggagcagtt
     1021 caaacagctc tatgaactgg atgcggaccc caagaggaaa gagttcctgg atgacctttt
     1081 cagcttcatg cagaagcggg gcactccagt gaaccggatc cccatcatgg cgaagcaggt
     1141 cctcgacctg ttcatgttgt atgtgctggt gaccgagaag ggcggcctgg tagaggttat
     1201 caacaagaaa ctgtggaggg agatcaccaa ggggctcaac ctgcctacct ccatcaccag
     1261 tgctgccttc acacttcgga cacagtacat gaagtatctt tacccctatg agtgtgagag
     1321 gcgaggcctg agcagcccca acgagctcca ggccgccata gacagcaatc gcagggaggg
     1381 caggcgccag agcttcggtg gctcactctt tgcctactca cccagtggag cccacagcat
     1441 gctgccctca cccaagctac cggtgactcc cctgggcctc gctgccagca ccaatggcag
     1501 ttccatcacc ccagcgccca agatcaagaa agaggaagac tcggccatcc ccatcacagt
     1561 cccaggccgc ctacctgtat ctttggcagg ccaccctgtt gtcgcagccc aggctgcggc
     1621 ggtgcaagct gcggcagccc aagcagccgt tgcggcccag gcagccgccc tggagcaact
     1681 ccgggagaag ctggaatcca cagagcctcc agaaaagaag atggccctag tggccgatga
     1741 gcaacagcga ctcatgcagc gagctgtgca gcagagcttc ctggccatga cagcccagct
     1801 gcccatgaac atccgcatca acagccaagc ctctgagagc cgccaggact cagccgtgag
     1861 tctcaccagt gccaacggga gcaacagtat tagcatgtcc gtggagatga atggtattgt
     1921 atacacaggt gtgttgttcg ctcagccacc acctcctaca gcaccttccg cccccggcaa
     1981 agggggcgtc agcagcatcg gtaccaacac caccacgggc agccggacag gagccagtgg
     2041 cagcactgtc agcggcggcc aggtggggct gccgggggtg tctacaccca ccatgtcttc
     2101 tacctcaaac aactccttgc cttaaaggaa accaagttgc atggctgccc acctgccaca
     2161 gggaccacac ggccacacag gggaacctgg gacgtcagaa gaatcccagt gggccggtag
     2221 attcccaagg agccacactg acgccaaaaa agagagagag agagagaaag agagagagag
     2281 agagagaaag aaagaaagaa tatatatata tatatatata tatatacata tatagaaaga
     2341 tagatagatg gagaaacaga tttaataaat cagggcaaag caaagaacac ttgaatctct
     2401 caggtttcgg agactccaag aaatggattt gatgagggcc accaaggcaa cctcgaagcc
     2461 gaaggaggtc ccctttccag aggcttccac ggggttttgc ttgagcagcc cattcaagca
     2521 cgtctgttta cctcatgaat cccggcactg cgtgttcaca attttttgtt ttgtttttgt
     2581 tttttttttc tttttttgtt ccttggtctt tagccatagt tccttttgga aaaaccaacc
     2641 ttggaagcta tgaatttttc ttttcttttt aaaacaagat ctccgcattc agaacgcaat
     2701 tttaaaaaag ggtttggggt ttctgatttt gtaaatattc tattttattc ttgagggcag
     2761 ggattggatc ttaggaagaa tctatctgta tatctatata tttgtgttca ttcagggaaa
     2821 cagacttttt ttaaaaaaag agaaaagcaa aataccagcc atggtcggtc cccacccttg
     2881 tcaccccaga gcccttgcgt gtcctgcagt gcccctggct cagctaggag atgctggctt
     2941 tcagcagttt ccacagttcg gtcaggctgg ccctgcccac tggctccatc attcaggaac
     3001 ctggattgct tacccaggac acagaatgtt ctagaaacgg gtaggggagc catggagtgc
     3061 agtggcctcc tgtgcctcag ggatgacagt gctggattct ctttgcctgg ataggttgct
     3121 ttcaagagac agatgcaaca acgggcctag ctcagggcaa ggactagact tgagtcacag
     3181 cctcctgtgt tccatctctc ttcctctttg tcactcccct tgctgggaca acacctgaat
     3241 gtgacagtag tcaaccggga aggatcctgc tgtctcttcc ataggagcca aactaggcat
     3301 ggcggcacac cctgtcatcc cagctcttag gaggatgagg cagggggatg gagagagttc
     3361 aaggtcatcc ttggctacat atagaggctg aggccagcct gagctacttg aaaccctatc
     3421 tcaaagaagc aaaataagac caggctgggt agtggcacat acttttaatc ccagcactct
     3481 gcgagtagac cagcctggtc ttacagttaa tttcaggctg cccagggcta cacagtgaaa
     3541 tcctgtcaaa caacaacaac aaaaccaaaa aacgttgatt ccttttggct ggagctgcat
     3601 acatactctc tgctggacgg aggaacctgt cctggactca gcctggtctc cattcccaag
     3661 tgggcagtgc tgggttctcc tggaagagga gtggggcata tgcagacctg ggagctggga
     3721 cctgcttgtt cctcagcccc aggagccatg aacccccaag tgtatgctat ggggatcggg
     3781 ccctcttttg tcctgtctca ggttgtcaac acaccccttc catccttcca ggagggggtg
     3841 ccgcctattt ggaggggagg gagatctcaa cttttccttc tggaagcttc tgcctgcccc
     3901 gttttggggc cactgtctta gccgcacaat cattcctggt caagggtgtt gaggggtcct
     3961 tgtcccttct gacaaccctg tccaaagtcc acctccatgg gtaactggct cagggatata
     4021 gcagccagcc tcctgtgtcc ctagtggggt ctatctgagg gggtcacctt ggtgggcaca
     4081 tgcaaggcaa gtttctttct acctcaggtc ttttgatgcc aaaaagaaaa agaaatgcgc
     4141 ccaggtcacc cacttgtctg gtcaccttct caatgcccat ggtgggaact tggtgtccac
     4201 ttgtatctca ggctctgtga gtgaccagaa gcgccagatc ctaactcagg ggaccttgcc
     4261 ccccatggct ctgtgactgt agtggggtgc cccctgctgg gcatactcag cagcccttct
     4321 tggtcctgtc tgtgcctcag ttgccccatt aggccttcgc atggggttca gttggcaccc
     4381 atgcagactg gagtggggtc agagctgggg tcgttactgt ccacctggta cctcagggct
     4441 tggcgtgggg caggtgagac acccaaactc agggcaaagg gtggaggggc aggcacaggc
     4501 tgcttctaga accttcctgg tcacccttac gcaggccacc aggctgtgtg tctgtctgtc
     4561 tgtccagctg cagtgggtgg gtagggatgg ggtttgggga cagctgggtt aatgatttct
     4621 gagggttatg catctgtaca gtctattttt ttttctttca ttttaatcat ttttacacac
     4681 tttgggtttt tttttccccc acctccacat aattttggct tttgtggatt ttatttttcc
     4741 ttctgggtaa atgtgagctg ggctgttttg ttaggaacag gggaattttt gtttcttggg
     4801 ggtgggaagg gcttgtccga cagcctgggg gttgcacaca aactcaggta aaagtgaaaa
     4861 aataaataag tggattttaa aaaaattaaa ttaaaaaaaa gaaaaaaaaa agaaaaaact
     4921 gttttctacc tctggtcagg cccctgtggt cagttcccgc ccaggctgtg gcctgaggcc
     4981 cacaatggtc acagctgtgc ggaatattca ggaaaattca gctattaaca ggaaaactca
     5041 gacaacaatg gggtaaggtg tgatttttga aatttttaaa aagaaacact gaaagtttac
     5101 attttatgac cttattgtgg attgtattta aacctcagaa atatttaacg ggcttgtaac
     5161 cctgtaaatc agtgatatta aagagttgag acacttctgt gaaagaa
//
